D:Gigantism

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Disease Term
Synonyms Gigantism Pituitary, Pituitary Gigantism
Documents 32
Hot Single Events 23
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Gigantism. They are ordered first by their relevance to Gigantism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT269769 Gh Regulation of Gene_expression of Igf1 1 0.04 0.98 0 42.68
2 INT308432 Binding of PDE4A and Aip 1 0.05 3.1 0.05 36.60
3 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0 36.60
4 INT250531 Ghrh Regulation of Gh 1 0.22 0 0.41 5.00
5 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29 5.00
6 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27 5.00
7 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26 5.00
8 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26 5.00
9 INT250536 Ghrh Positive_regulation of Negative_regulation of Ptpn6 1 0.09 0 0.24 5.00
10 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
11 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 5.00
12 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2 5.00
13 INT250533 Ghrh Regulation of Localization of Gh 1 0.13 0 0.15 5.00
14 INT250535 Ghrh Regulation of Gene_expression of Gh 1 0.31 0 0.15 5.00
15 INT278020 Binding of Gh and Sst 1 0.18 0.16 0.15 5.00
16 INT243468 Binding of SSTR1 and SSTR5 1 0.05 0.99 0.1 5.00
17 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09 5.00
18 INT243466 POU1F1 Regulation of GH1 1 0.11 1.26 0.08 5.00
19 INT243464 POU1F1 Regulation of PRL 1 0.28 1.26 0.08 5.00
20 INT250538 Igf1 Positive_regulation of Gh 1 0.24 0.05 0.06 5.00
21 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 5.00
22 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0 5.00
23 INT278014 Ptprf Regulation of Localization of Gh 1 0.61 0.31 0 5.00
24 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0 5.00
25 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0 5.00
26 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0 5.00
27 INT243467 PCSK1 Positive_regulation of POMC 1 0.08 1.62 0 5.00
28 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0 5.00
29 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0 5.00
30 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0 5.00
31 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0 5.00
32 INT278017 Ptprf Regulation of Igf1 1 0.48 0.31 0 5.00
33 INT308426 Binding of Pde4a and Aip 1 0.02 0.89 0 5.00
34 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Gigantism. They are ordered first by their pain relevance and then by number of times they were reported in Gigantism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1893 Localization of Gh 1041 0.79 340.23 256.58 100.00
2 INT252 Localization of GH1 529 0.80 227.4 122.05 100.00
3 INT425 Localization of PRL 455 0.81 189.64 144.8 100.00
4 INT443 Localization of POMC 1020 0.81 284.52 443.17 100.00
5 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 100.00
6 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 99.76
7 INT249 Localization of GHRH 215 0.80 78.02 51.87 97.36
8 INT197832 Localization of MEN1 1 0.80 11.01 0.63 97.28
9 INT158 Localization of Prl 2431 0.81 378.96 952.2 96.40
10 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 96.00
11 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 93.12
12 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 93.12
13 INT16130 Binding of IGF1 67 0.48 27.43 2.95 93.00
14 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 88.80
15 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 86.48
16 INT151032 Localization of Igf1 49 0.76 26.32 5.71 85.44
17 INT14559 Gene_expression of Igf1 254 0.78 112 34.17 85.44
18 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 84.20
19 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 84.20
20 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 84.20
21 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 83.20
22 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 82.80
23 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 82.80
24 INT115423 Gene_expression of Men1 4 0.47 14.08 0.64 79.08
25 INT308431 Gene_expression of CNC 1 0.01 2.84 0.18 78.72
26 INT1499 Negative_regulation of Gene_expression of Gh 58 0.42 25.17 7.86 77.60
27 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 73.60
28 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45 69.84
29 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41 69.84
30 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49 69.52
31 INT28861 Binding of Gh 61 0.46 25.61 6.38 65.20
32 INT65892 Negative_regulation of Binding of Gh 8 0.32 3.61 1.38 65.20
33 INT5793 Binding of CTS 110 0.48 63.91 40.62 58.88
34 INT27269 Localization of Ghrh 29 0.76 15.42 2.19 47.48
35 INT738 Regulation of POMC 459 0.62 111.19 243.74 43.68
36 INT185295 Gene_expression of RASL12 2 0.13 2.02 0 43.68
37 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77 41.84
38 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 40.88
39 INT161382 Localization of KRT20 25 0.61 12.97 2.13 40.00
40 INT70021 Localization of BCL2 23 0.74 21.6 1.09 40.00
41 INT812 Localization of INS 1026 0.81 515.6 145.31 38.24
42 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 26.04
43 INT85462 Binding of KTWS 3 0.31 2.91 0.54 25.00
44 INT335616 Positive_regulation of RASL12 1 0.08 0.9 0 14.24
45 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55 11.52
46 INT626 Localization of CALCA 289 0.81 125.39 221.15 6.92
47 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
48 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
49 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
50 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
51 INT1530 Regulation of Gh 382 0.61 115.96 112.47 5.00
52 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
53 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
54 INT3214 Localization of Ins1 527 0.80 196.9 79.26 5.00
55 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
56 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
57 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
58 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
59 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
60 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 5.00
61 INT21737 Binding of MC1R 129 0.48 45.45 56.54 5.00
62 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
63 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
64 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
65 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
66 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 5.00
67 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 5.00
68 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
69 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
70 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
71 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 5.00
72 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 5.00
73 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 5.00
74 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
75 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
76 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
77 INT13897 Localization of Sst 65 0.81 14.91 32.24 5.00
78 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
79 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 5.00
80 INT7832 Localization of Cck 39 0.81 6.81 26.54 5.00
81 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
82 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 5.00
83 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
84 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 5.00
85 INT19986 Negative_regulation of Cck 31 0.59 4.32 24.99 5.00
86 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 5.00
87 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04 5.00
88 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04 5.00
89 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
90 INT14506 Regulation of Sst 46 0.62 15.02 22.66 5.00
91 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 5.00
92 INT184895 Gene_expression of MCRS1 46 0.42 56.03 19.44 5.00
93 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
94 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
95 INT84712 Regulation of MC1R 36 0.62 9.34 16.91 5.00
96 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
97 INT2243 Localization of GAST 67 0.81 34.54 16.19 5.00
98 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
99 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
100 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32 5.00
101 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
102 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18 5.00
103 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
104 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
105 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
106 INT15350 Localization of Prl 22 0.81 6.86 10.74 5.00
107 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16 5.00
108 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89 5.00
109 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
110 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
111 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
112 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 5.00
113 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 5.00
114 INT91609 Regulation of Gene_expression of MC1R 11 0.62 2.75 7.34 5.00
115 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32 5.00
116 INT66099 Transcription of Sst 8 0.25 4.86 6.96 5.00
117 INT186142 Gene_expression of Ghrh 45 0.66 34.04 6.94 5.00
118 INT142344 Transcription of Igf1 22 0.69 7.55 6.77 5.00
119 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 5.00
120 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
121 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
122 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
123 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83 5.00
124 INT13857 Binding of Sst 11 0.24 2.48 5.76 5.00
125 INT121801 Binding of Aip 18 0.36 24.1 5.26 5.00
126 INT3215 Regulation of Gene_expression of Ins1 32 0.52 19.83 4.85 5.00
127 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84 5.00
128 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 5.00
129 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
130 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 5.00
131 INT31419 Positive_regulation of Localization of Sst 10 0.70 0.77 3.94 5.00
132 INT142059 Regulation of Ghrh 15 0.59 3.25 3.94 5.00
133 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94 5.00
134 INT19104 Regulation of Gene_expression of Gh 24 0.40 8.42 3.88 5.00
135 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72 5.00
136 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
137 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 5.00
138 INT13896 Negative_regulation of Localization of Sst 8 0.59 0.77 3.5 5.00
139 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44 5.00
140 INT20179 Positive_regulation of Regulation of Gh 12 0.54 3.99 3.42 5.00
141 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
142 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 5.00
143 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12 5.00
144 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
145 INT3463 Gene_expression of Igfals 21 0.39 21.1 2.93 5.00
146 INT61136 Localization of MC1R 8 0.75 2.8 2.85 5.00
147 INT31412 Negative_regulation of Positive_regulation of Ins1 10 0.40 7.14 2.82 5.00
148 INT53906 Positive_regulation of Negative_regulation of Gh 9 0.50 6.72 2.73 5.00
149 INT215029 Negative_regulation of Ghrh 15 0.56 11.37 2.62 5.00
150 INT15606 Localization of FSHB 24 0.78 9.16 2.49 5.00
151 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 5.00
152 INT173236 Binding of Sstr2 8 0.25 1.64 2.41 5.00
153 INT9473 Binding of MUC1 66 0.48 46.77 2.36 5.00
154 INT104290 Gene_expression of Ucp2 21 0.78 12.81 2.34 5.00
155 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
156 INT149451 Gene_expression of Sstr5 3 0.39 1.5 2.24 5.00
157 INT27644 Gene_expression of BRD2 23 0.65 6.97 2.23 5.00
158 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15 5.00
159 INT49769 Binding of SSTR2 4 0.48 1.39 2.14 5.00
160 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95 5.00
161 INT11770 Binding of Lhb 14 0.48 3.57 1.91 5.00
162 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
163 INT114059 Localization of Insr 10 0.46 3.49 1.87 5.00
164 INT142060 Positive_regulation of Ghrh 15 0.66 7.21 1.83 5.00
165 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
166 INT23491 Positive_regulation of FSHB 14 0.65 7.2 1.79 5.00
167 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
168 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
169 INT19342 Regulation of Insr 12 0.24 6.11 1.54 5.00
170 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 5.00
171 INT90491 Binding of Igf1 25 0.44 9.75 1.36 5.00
172 INT114091 Negative_regulation of Aip 6 0.48 4.16 1.3 5.00
173 INT75053 Gene_expression of MC3R 4 0.53 0.41 1.16 5.00
174 INT118131 Negative_regulation of C1s 10 0.07 2.92 1.15 5.00
175 INT62237 Gene_expression of Ptprf 2 0.65 1.63 1.08 5.00
176 INT335619 Positive_regulation of MC3R 2 0.67 0.42 1.03 5.00
177 INT46470 Positive_regulation of Regulation of Ins1 8 0.46 4.51 1.01 5.00
178 INT45079 Binding of Ahr 21 0.44 10.07 1 5.00
179 INT253106 Negative_regulation of Phosphorylation of Ins1 6 0.17 5.62 0.87 5.00
180 INT253811 Negative_regulation of Localization of Cck 2 0.41 0.76 0.86 5.00
181 INT243480 Gene_expression of SSTR5 1 0.55 4.25 0.85 5.00
182 INT250509 Gene_expression of Pou1f1 65 0.76 11.8 0.84 5.00
183 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
184 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81 5.00
185 INT2244 Positive_regulation of Localization of GAST 7 0.68 5.28 0.73 5.00
186 INT278006 Binding of Sstr3 2 0.33 1.07 0.71 5.00
187 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 5.00
188 INT243477 Binding of SSTR1 3 0.26 3.49 0.65 5.00
189 INT243481 Gene_expression of GATA2 3 0.50 3.34 0.62 5.00
190 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61 5.00
191 INT154613 Regulation of Aip 5 0.21 3.86 0.55 5.00
192 INT91209 Binding of VIM 15 0.36 12.02 0.53 5.00
193 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 5.00
194 INT114018 Binding of CD200 5 0.47 2.12 0.52 5.00
195 INT278010 Negative_regulation of Binding of Sst 1 0.20 0.26 0.51 5.00
196 INT278007 Positive_regulation of Ptprr 1 0.08 0.28 0.5 5.00
197 INT250506 Negative_regulation of Positive_regulation of Ghrh 2 0.41 0.14 0.47 5.00
198 INT88202 Gene_expression of Sstr1 3 0.40 1.89 0.47 5.00
199 INT278009 Phosphorylation of Sst 1 0.39 0.68 0.44 5.00
200 INT278005 Positive_regulation of Sstr3 1 0.48 0.38 0.44 5.00
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