D:Gingival Overgrowth

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Disease Term
Synonyms Gingival Overgrowths, Overgrowth Gingival, OVERGROWTHS GINGIVAL
Documents 26
Hot Single Events 34
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Gingival Overgrowth. They are ordered first by their relevance to Gingival Overgrowth and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT335307 SLC15A4 Regulation of TIMP1 1 0.01 0.69 0.29 92.00
2 INT252296 TNF Regulation of Gene_expression of Il1 2 0.03 1.28 0.49 87.56
3 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49 87.56
4 INT307755 TNF Regulation of Gene_expression of IL8 1 0.02 0.5 0.14 87.56
5 INT307769 TNF Regulation of Gene_expression of Csf2 1 0.03 0.5 0.14 87.56
6 INT307771 TNF Negative_regulation of Gene_expression of Csf2 1 0.03 0.5 0.14 87.56
7 INT307764 Myoz1 Positive_regulation of Transcription of Il6 1 0.01 0.72 0.21 71.28
8 INT307765 Myoz1 Positive_regulation of Gene_expression of Il6 1 0.01 0.71 0.21 69.28
9 INT335300 SLC15A4 Regulation of CA2 1 0.00 0.19 0.12 51.92
10 INT335293 SLC15A4 Regulation of NA 1 0.00 0.19 0.12 51.92
11 INT335311 Binding of IRF6 and SLC15A4 1 0.00 0.23 0.19 21.08
12 INT335346 SLC15A4 Negative_regulation of Gene_expression of Fos 1 0.02 0.23 0.23 19.24
13 INT335291 SLC15A4 Negative_regulation of NFATC1 1 0.01 0.45 0.51 10.24
14 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73 5.00
15 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
16 INT335299 IRF6 Positive_regulation of TIMP1 1 0.03 0.21 0.19 5.00
17 INT335298 IRF6 Positive_regulation of MMP9 1 0.01 0.21 0.19 5.00
18 INT335306 IRF6 Positive_regulation of MMP3 1 0.03 0.21 0.18 5.00
19 INT335304 IRF6 Positive_regulation of Gene_expression of MMP1 1 0.01 0.21 0.18 5.00
20 INT335302 IRF6 Positive_regulation of MMP1 1 0.01 0.21 0.18 5.00
21 INT335289 IRF6 Positive_regulation of Gene_expression of TIMP1 1 0.03 0.16 0.04 5.00
22 INT335303 Binding of IRF6 and MMP2 1 0.01 0 0 5.00
23 INT335312 SLC15A4 Negative_regulation of TIMP1 1 0.01 0.07 0 5.00
24 INT335295 SLC15A4 Negative_regulation of MMP9 1 0.00 0.07 0 5.00
25 INT335309 IRF6 Positive_regulation of Gene_expression of MMP3 1 0.03 0.07 0 5.00
26 INT335292 IRF6 Positive_regulation of Localization of MMP1 1 0.01 0.06 0 5.00
27 INT335305 SLC15A4 Negative_regulation of MMP3 1 0.01 0.07 0 5.00
28 INT335288 SLC15A4 Negative_regulation of IRF6 Positive_regulation of MMP9 1 0.00 0.07 0 5.00
29 INT335301 Binding of MMP2 and SLC15A4 1 0.00 0 0 5.00
30 INT335310 SLC15A4 Negative_regulation of Gene_expression of MMP1 1 0.00 0.07 0 5.00
31 INT335290 SLC15A4 Positive_regulation of Localization of MMP1 1 0.00 0.06 0 5.00
32 INT335297 IRF6 Positive_regulation of Gene_expression of MMP2 1 0.01 0.07 0 5.00
33 INT335308 SLC15A4 Negative_regulation of MMP1 1 0.00 0.07 0 5.00
34 INT335296 IRF6 Positive_regulation of Localization of SLC15A4 1 0.00 0.06 0 5.00
35 INT335294 IRF6 Positive_regulation of Gene_expression of MMP9 1 0.01 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Gingival Overgrowth. They are ordered first by their pain relevance and then by number of times they were reported in Gingival Overgrowth. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 99.98
2 INT335321 Positive_regulation of Gene_expression of SLC15A4 1 0.03 1.02 0.24 99.96
3 INT75105 Gene_expression of SLC15A4 3 0.19 3.33 0.74 99.64
4 INT187095 Negative_regulation of Positive_regulation of Il1 8 0.14 6.17 1.82 98.92
5 INT51053 Negative_regulation of Positive_regulation of TIMP1 6 0.35 1.67 0.69 98.40
6 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 98.40
7 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 96.88
8 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 96.72
9 INT335332 Regulation of Binding of GCFC2 1 0.09 0.46 0.21 96.68
10 INT74586 Negative_regulation of MMP8 6 0.27 1.68 1.64 96.60
11 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 96.28
12 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 96.28
13 INT335328 Binding of GCFC2 1 0.07 0.46 0.21 96.24
14 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 96.20
15 INT335327 Positive_regulation of SLC15A4 1 0.02 0.91 0.41 94.92
16 INT335325 Negative_regulation of Positive_regulation of SLC15A4 1 0.02 0.45 0.18 94.92
17 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 93.44
18 INT335326 Negative_regulation of GCFC2 1 0.08 0.44 0.17 93.36
19 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 92.00
20 INT335330 Localization of SLC15A4 1 0.04 0.22 0.22 91.08
21 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 90.96
22 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 87.04
23 INT175655 Regulation of MMRN1 16 0.12 9.96 2.12 86.96
24 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 86.28
25 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 86.28
26 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 86.28
27 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 85.04
28 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 84.24
29 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 84.04
30 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 83.84
31 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 83.48
32 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 83.48
33 INT130728 Binding of MMP1 14 0.47 4.7 1.95 83.16
34 INT131456 Negative_regulation of MMRN1 14 0.19 9.49 2.29 81.20
35 INT102987 Regulation of MMP3 23 0.60 9.35 9.54 79.80
36 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 79.80
37 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 77.24
38 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 74.24
39 INT49985 Transcription of Il6 62 0.72 40.13 20.29 71.28
40 INT66924 Positive_regulation of Transcription of Il6 18 0.68 11.8 3.53 71.28
41 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 70.40
42 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39 70.40
43 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 65.60
44 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 58.24
45 INT209783 Binding of SLC15A4 2 0.04 1.25 0.3 56.20
46 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 49.36
47 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 48.80
48 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 42.88
49 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 41.92
50 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 37.56
51 INT63169 Positive_regulation of Gene_expression of Selp 35 0.69 21.95 7.16 37.56
52 INT34233 Regulation of Negative_regulation of TIMP1 3 0.27 0.48 0.77 24.32
53 INT335331 Regulation of Negative_regulation of MMP9 1 0.11 0.18 0.17 24.32
54 INT335329 Regulation of Negative_regulation of MMP3 1 0.24 0.18 0.17 24.32
55 INT335319 Regulation of Negative_regulation of MMP1 1 0.07 0.18 0.17 24.32
56 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 24.04
57 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 24.04
58 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18 24.04
59 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 23.12
60 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 23.12
61 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 15.80
62 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 15.48
63 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 13.68
64 INT226449 Negative_regulation of NFATC1 4 0.25 1.28 0.41 5.92
65 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
66 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
67 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
68 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
69 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 5.00
70 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
71 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
72 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 5.00
73 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
74 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
75 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
76 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
77 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
78 INT97798 Localization of IRF6 86 0.73 33.27 20.94 5.00
79 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
80 INT5536 Regulation of NA 74 0.59 16.61 15.36 5.00
81 INT103210 Localization of MMP1 43 0.78 12.15 15.13 5.00
82 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
83 INT99586 Binding of IRF6 60 0.36 27.87 13.2 5.00
84 INT54763 Binding of Il6 82 0.48 63.27 12.89 5.00
85 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
86 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 5.00
87 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
88 INT70816 Negative_regulation of Fos 32 0.58 13 11.18 5.00
89 INT3535 Regulation of CA2 61 0.32 16.48 10.8 5.00
90 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
91 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42 5.00
92 INT108628 Regulation of MMP2 27 0.60 14.85 6.06 5.00
93 INT95616 Gene_expression of Thpo 48 0.78 21.51 5.88 5.00
94 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 5.00
95 INT49405 Gene_expression of Itgal 40 0.75 27.3 4.8 5.00
96 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 5.00
97 INT80696 Positive_regulation of Thpo 16 0.70 13.75 4.49 5.00
98 INT88545 Localization of MMRN1 21 0.78 16.67 4.01 5.00
99 INT181008 Negative_regulation of Localization of IRF6 13 0.14 2.32 2.96 5.00
100 INT120124 Transcription of MMP3 9 0.69 2.15 2.38 5.00
101 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 5.00
102 INT213431 Positive_regulation of Gene_expression of MMRN1 15 0.24 9.91 1.96 5.00
103 INT108724 Positive_regulation of Gene_expression of Thpo 9 0.70 8.12 1.9 5.00
104 INT187123 Negative_regulation of Positive_regulation of MMP9 7 0.42 2.54 1.17 5.00
105 INT307766 Negative_regulation of CADM1 1 0.02 2.13 0.44 5.00
106 INT307763 Regulation of Transcription of Thpo 1 0.36 1.1 0.34 5.00
107 INT307762 Positive_regulation of Transcription of Thpo 1 0.56 1.09 0.34 5.00
108 INT307758 Transcription of Thpo 1 0.58 1.08 0.33 5.00
109 INT307759 Negative_regulation of D7Cwr3P 1 0.00 1.39 0.3 5.00
110 INT335322 Negative_regulation of Gene_expression of SLC15A4 1 0.02 0.19 0 5.00
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