D:Gonadal Disease

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Disease Term
Synonyms Disease Of The Gonad, Disorder Gonadal, Disorders Gonadal, Gonad Disorder, GONADAL DISORDER, Gonadal Disorders, Gonadal Dysfunction
Documents 23
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Gonadal Disease. They are ordered first by their relevance to Gonadal Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT39010 App Negative_regulation of Gene_expression of Gnrh1 1 0.05 0.07 0.26 75.00
2 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 5.00
3 INT123229 OXTR Regulation of Localization of PRL 2 0.30 0 0.73 5.00
4 INT89902 SST Positive_regulation of Localization of PRL 2 0.40 0 0.61 5.00
5 INT232424 VIP Positive_regulation of Localization of PRL 1 0.36 0 0.53 5.00
6 INT232427 ABAT Regulation of PRL 1 0.08 0.26 0.45 5.00
7 INT232422 VIP Regulation of Gene_expression of PRL 1 0.40 0 0.37 5.00
8 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 0.09 0 0.37 5.00
9 INT232419 ABAT Positive_regulation of Localization of PRL 1 0.09 0 0.33 5.00
10 INT232425 Binding of ABAT and Positive_regulation of PRL 1 0.09 0.15 0.33 5.00
11 INT232420 PRL Positive_regulation of Regulation of ABAT 1 0.09 0 0.33 5.00
12 INT284891 FSHR Positive_regulation of Gene_expression of PLOD1 2 0.03 1.32 0.11 5.00
13 INT185733 Hpse Positive_regulation of Gene_expression of Tnfrsf11b 1 0.20 0.24 0 5.00
14 INT284892 AMH Regulation of Localization of FSHR 1 0.01 0.18 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Gonadal Disease. They are ordered first by their pain relevance and then by number of times they were reported in Gonadal Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 98.92
2 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 98.92
3 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 98.60
4 INT211970 Negative_regulation of Best1 49 0.14 37.33 2.32 98.34
5 INT425 Localization of PRL 455 0.81 189.64 144.8 95.36
6 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 95.36
7 INT211972 Regulation of Best1 18 0.33 12.04 0.67 91.92
8 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8 77.12
9 INT4289 Positive_regulation of Localization of Gnrh1 202 0.70 12.3 84.01 75.00
10 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 75.00
11 INT39007 Negative_regulation of Localization of App 3 0.10 0.94 0.08 75.00
12 INT2085 Positive_regulation of LH 441 0.70 60.15 191.02 75.00
13 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 75.00
14 INT1438 Localization of Pomc 360 0.81 101.26 116.47 75.00
15 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 75.00
16 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 75.00
17 INT3387 Negative_regulation of Gene_expression of LH 23 0.43 3.14 12.37 75.00
18 INT1436 Negative_regulation of Localization of Pomc 41 0.58 10.85 11.26 75.00
19 INT8337 Negative_regulation of Gene_expression of Gnrh1 14 0.58 4.63 5.32 75.00
20 INT39008 Localization of App 13 0.77 9.07 2.05 75.00
21 INT39009 Negative_regulation of App 6 0.38 3.37 1.07 75.00
22 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73 65.12
23 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21 65.12
24 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 61.92
25 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 58.28
26 INT121136 Negative_regulation of DDC 4 0.57 2.98 1.32 51.84
27 INT232442 Negative_regulation of Gene_expression of DDC 1 0.05 1.44 0.58 51.84
28 INT205995 Gene_expression of SLC7A7 11 0.75 10.61 1.21 51.60
29 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31 51.28
30 INT252 Localization of GH1 529 0.80 227.4 122.05 49.60
31 INT284907 Regulation of Transcription of AGRP 1 0.09 1.01 0.28 47.16
32 INT281403 Transcription of AGRP 4 0.47 1.61 0.27 45.20
33 INT185730 Negative_regulation of Negative_regulation of Dlat 2 0.14 0.35 0.21 41.32
34 INT42317 Negative_regulation of Dlat 21 0.43 3.13 4.11 40.80
35 INT161019 Positive_regulation of Gene_expression of Dlat 6 0.32 1.19 0.79 40.44
36 INT97649 Gene_expression of Dlat 48 0.66 13.77 8.94 39.44
37 INT52980 Positive_regulation of Dlat 20 0.37 5.14 4.06 35.68
38 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 34.80
39 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 34.68
40 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 32.96
41 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 28.96
42 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 27.68
43 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 9.76
44 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
45 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
46 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 5.00
47 INT162 Regulation of Prl 794 0.62 165.01 322.24 5.00
48 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
49 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
50 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
51 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
52 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
53 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
54 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
55 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
56 INT6761 Binding of CALCA 100 0.48 26.71 62.05 5.00
57 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
58 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
59 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
60 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 5.00
61 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
62 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 5.00
63 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 5.00
64 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
65 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 5.00
66 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 5.00
67 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
68 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
69 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 5.00
70 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
71 INT326 Gene_expression of Gnrhr 105 0.76 35.87 34.93 5.00
72 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 5.00
73 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 5.00
74 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
75 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 5.00
76 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 5.00
77 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
78 INT7383 Localization of VIP 53 0.81 17.7 22.65 5.00
79 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
80 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 5.00
81 INT11157 Binding of EGF 88 0.48 53.73 21.25 5.00
82 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
83 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 5.00
84 INT12575 Regulation of Hpse 33 0.59 17.7 18.45 5.00
85 INT18621 Binding of ABAT 28 0.36 9.88 18.04 5.00
86 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
87 INT7414 Regulation of Localization of SST 31 0.60 4.85 17.46 5.00
88 INT912 Localization of FSHR 91 0.79 23.61 15.58 5.00
89 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 5.00
90 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 5.00
91 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
92 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
93 INT7587 Localization of GAL 27 0.78 4.79 14.29 5.00
94 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 5.00
95 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 5.00
96 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 5.00
97 INT30961 Binding of HTR2A 33 0.47 11.44 12.86 5.00
98 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 5.00
99 INT49474 Gene_expression of Hpse 24 0.55 20.11 10.03 5.00
100 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
101 INT2036 Localization of EGF 42 0.77 21.5 9.74 5.00
102 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
103 INT94196 Negative_regulation of Phosphorylation of MAPK1 60 0.59 31.64 9.16 5.00
104 INT10237 Binding of EDN1 40 0.48 16 8.48 5.00
105 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 5.00
106 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3 5.00
107 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 5.00
108 INT4487 Positive_regulation of Positive_regulation of PRL 27 0.70 8.06 8.09 5.00
109 INT6957 Positive_regulation of OXTR 38 0.70 6.55 7.81 5.00
110 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 5.00
111 INT24191 Binding of VIP 14 0.40 2.16 6.2 5.00
112 INT26181 Positive_regulation of Negative_regulation of POMC 12 0.70 1.03 6.14 5.00
113 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 5.00
114 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
115 INT128406 Gene_expression of Pax1 11 0.60 7.18 5.91 5.00
116 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89 5.00
117 INT29290 Regulation of Gene_expression of PRL 13 0.49 6.46 5.23 5.00
118 INT924 Regulation of Localization of FSHR 15 0.45 1.4 5.07 5.00
119 INT58750 Binding of GAL 16 0.47 5.48 4.92 5.00
120 INT4146 Binding of SHBG 49 0.47 31 4.71 5.00
121 INT102583 Gene_expression of Gdf15 26 0.77 15.33 4.52 5.00
122 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
123 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
124 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 5.00
125 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16 5.00
126 INT11370 Positive_regulation of LHB 15 0.28 5.45 4.01 5.00
127 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 5.00
128 INT39945 Binding of Dlat 27 0.32 14.95 3.88 5.00
129 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
130 INT102585 Positive_regulation of Gdf15 19 0.69 14.78 3.21 5.00
131 INT1577 Negative_regulation of Gene_expression of PRL 24 0.59 7.7 3.15 5.00
132 INT161840 Gene_expression of Tnfrsf11b 17 0.78 12.44 2.63 5.00
133 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4 5.00
134 INT34891 Transcription of PRL 4 0.72 0.69 2.36 5.00
135 INT12033 Binding of PLOD1 15 0.48 8.04 2.3 5.00
136 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96 5.00
137 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92 5.00
138 INT59194 Gene_expression of STS 18 0.59 6.74 1.89 5.00
139 INT40877 Positive_regulation of APOB 35 0.68 32.47 1.86 5.00
140 INT4028 Regulation of HYAL1 8 0.54 1.55 1.8 5.00
141 INT102582 Positive_regulation of Gene_expression of Gdf15 11 0.69 7.66 1.68 5.00
142 INT33496 Positive_regulation of Gene_expression of FSHR 14 0.46 6.05 1.66 5.00
143 INT31047 Localization of HRH2 5 0.75 1.84 1.53 5.00
144 INT211969 Positive_regulation of Best1 34 0.11 14.92 1.44 5.00
145 INT153627 Binding of Mapk1 5 0.36 2.88 1.4 5.00
146 INT1651 Positive_regulation of Negative_regulation of PLOD1 4 0.46 0.49 1.33 5.00
147 INT232445 Positive_regulation of Transcription of PRL 1 0.50 0 1.32 5.00
148 INT132453 Binding of TF 31 0.36 12.98 1.22 5.00
149 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16 5.00
150 INT106459 Negative_regulation of SLC10A4 4 0.24 1.08 1.06 5.00
151 INT159446 Negative_regulation of Gdf15 5 0.58 3.36 1 5.00
152 INT171091 Positive_regulation of SLC10A4 8 0.16 6.27 0.99 5.00
153 INT204156 Gene_expression of HAMP 7 0.75 8.1 0.94 5.00
154 INT39955 Positive_regulation of Negative_regulation of PRL 3 0.70 0.47 0.9 5.00
155 INT185729 Negative_regulation of Gene_expression of Tnfsf11 3 0.52 2.07 0.69 5.00
156 INT70362 Transcription of GH1 9 0.56 2.01 0.69 5.00
157 INT34889 Regulation of Transcription of PRL 2 0.42 0.55 0.67 5.00
158 INT39865 Regulation of Positive_regulation of PLOD1 2 0.27 0.71 0.66 5.00
159 INT232453 Negative_regulation of DNAJA3 1 0.41 0 0.54 5.00
160 INT310529 Positive_regulation of MDFIC 1 0.05 6.21 0.52 5.00
161 INT297528 Transcription of HAMP 3 0.69 3.64 0.5 5.00
162 INT127273 Gene_expression of AMH 24 0.78 9.53 0.47 5.00
163 INT137846 Regulation of Tnfsf11 5 0.48 1.62 0.42 5.00
164 INT174753 Gene_expression of Apoa2 15 0.75 13.82 0.41 5.00
165 INT211968 Localization of Best1 11 0.40 9.33 0.38 5.00
166 INT50530 Binding of MDFIC 2 0.17 1.88 0.38 5.00
167 INT306940 Positive_regulation of HAMP 3 0.49 5.06 0.36 5.00
168 INT211971 Binding of Best1 16 0.22 7.73 0.33 5.00
169 INT241859 Protein_catabolism of SLC40A1 2 0.02 1.22 0.31 5.00
170 INT232449 Negative_regulation of Transcription of PRL 1 0.59 0 0.3 5.00
171 INT310527 Gene_expression of MDFIC 1 0.05 1.87 0.29 5.00
172 INT310513 Gene_expression of Twsg1 1 0.17 3.97 0.28 5.00
173 INT310530 Positive_regulation of Gene_expression of HAMP 3 0.49 4.16 0.28 5.00
174 INT175796 Binding of Hpse 6 0.35 2.19 0.28 5.00
175 INT232452 Positive_regulation of Binding of PRL 1 0.50 0.18 0.27 5.00
176 INT232444 Regulation of Localization of GAL 1 0.44 0.28 0.27 5.00
177 INT243267 Positive_regulation of SLC40A1 4 0.41 2.72 0.22 5.00
178 INT241863 Binding of SLC40A1 4 0.28 3.86 0.22 5.00
179 INT162782 Regulation of Tnfrsf11b 2 0.24 2.09 0.18 5.00
180 INT310528 Negative_regulation of Positive_regulation of HRASLS 1 0.01 1.6 0.18 5.00
181 INT308962 Regulation of SLC7A7 3 0.16 1.2 0.18 5.00
182 INT232448 Positive_regulation of Gene_expression of TRH 1 0.32 0.08 0.17 5.00
183 INT161839 Positive_regulation of Gene_expression of Tnfrsf11b 2 0.47 0.47 0.14 5.00
184 INT310523 Localization of MDFIC 1 0.05 0.83 0.14 5.00
185 INT151342 Positive_regulation of Positive_regulation of FSHR 5 0.20 1.79 0.11 5.00
186 INT192918 Negative_regulation of HAMP 3 0.57 2.29 0.09 5.00
187 INT162781 Positive_regulation of Tnfrsf11b 5 0.27 1.91 0.09 5.00
188 INT310526 Gene_expression of HFE2 2 0.32 1.14 0.09 5.00
189 INT310525 Negative_regulation of Gene_expression of HAMP 1 0.57 0.58 0.08 5.00
190 INT310522 Regulation of Transcription of HAMP 1 0.60 1.36 0.05 5.00
191 INT185732 Transcription of Tnfrsf11b 2 0.31 0.39 0.03 5.00
192 INT200458 Positive_regulation of Tha1 3 0.15 0.78 0.03 5.00
193 INT319126 Negative_regulation of Gene_expression of STS 7 0.07 0.83 0.03 5.00
194 INT296384 Regulation of SLC40A1 2 0.01 0.83 0.03 5.00
195 INT185731 Negative_regulation of Regulation of Tnfsf11 1 0.34 0.89 0 5.00
196 INT290522 Regulation of PPIA 1 0.04 0.18 0 5.00
197 INT185728 Positive_regulation of Positive_regulation of Tnfsf11 1 0.36 0.25 0 5.00
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