D:Granulomatous Inflammation

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Disease Term
Synonyms CUTANEOUS GRANULOMA, Dermal Granuloma, Epidermal Granuloma, Granuloma
Documents 277
Hot Single Events 46
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Granulomatous Inflammation. They are ordered first by their relevance to Granulomatous Inflammation and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27 99.28
2 INT173977 Binding of TNF and Ighg1 1 0.03 0.28 0.39 58.16
3 INT75972 Binding of CD1A and CD68 1 0.03 0.45 0.18 39.28
4 INT213970 Vip Positive_regulation of Localization of Cd83 1 0.15 0.41 0.21 32.84
5 INT213974 Vip Positive_regulation of Localization of Mthfd1 1 0.08 0.41 0.17 32.84
6 INT269995 Positive_regulation of Binding of Nfkb2 and Tpx2 1 0.05 0.51 0.21 17.00
7 INT269994 Binding of Nfkb2 and Tpx2 1 0.04 0.51 0.21 16.40
8 INT215395 Csf2 Positive_regulation of Ppara 1 0.12 1.33 0.32 7.20
9 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
10 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51 5.00
11 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99 5.00
12 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99 5.00
13 INT51160 Binding of TAC1 and Tacr1 2 0.28 0.55 1.38 5.00
14 INT177457 Il1 Positive_regulation of Gene_expression of Il6 3 0.16 4.47 1.35 5.00
15 INT294911 Pax3 Positive_regulation of Il6 1 0.06 1.78 1.14 5.00
16 INT213977 Pax3 Negative_regulation of Gene_expression of Il2 1 0.00 0.25 0.86 5.00
17 INT213976 Calca Negative_regulation of Gene_expression of Il2 1 0.03 0.25 0.86 5.00
18 INT213972 Calca Regulation of Mthfd1 1 0.05 0.19 0.8 5.00
19 INT213978 Binding of TAC1 and Tac1 1 0.02 0.36 0.78 5.00
20 INT294908 Pax3 Positive_regulation of Gene_expression of Il1 1 0.03 0.45 0.76 5.00
21 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
22 INT294906 Binding of Pax3 and Tac4 1 0.01 1.15 0.71 5.00
23 INT213971 Mthfd1 Positive_regulation of Gene_expression of Pax3 1 0.00 0.14 0.68 5.00
24 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 5.00
25 INT294910 Pax3 Regulation of Positive_regulation of Il1 1 0.02 2.03 0.42 5.00
26 INT181862 Binding of MPO and PRTN3 2 0.16 1.18 0.38 5.00
27 INT213975 Binding of Iapp and Trav6-3 1 0.00 0.05 0.35 5.00
28 INT318299 Binding of F2 and PRTN3 1 0.01 1.92 0.33 5.00
29 INT294907 Il1 Positive_regulation of Il6 1 0.06 1.45 0.29 5.00
30 INT294905 Binding of Hgf and Pax3 1 0.01 1.54 0.25 5.00
31 INT294912 Binding of Pax3 and Tacr3 1 0.01 1.54 0.25 5.00
32 INT215396 Il4 Positive_regulation of Gene_expression of Ppara 1 0.03 0.23 0.23 5.00
33 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21 5.00
34 INT294904 Binding of Pax3 and Slc12a3 1 0.02 1.9 0.2 5.00
35 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18 5.00
36 INT215394 Binding of Csf2 and Positive_regulation of Ppara 1 0.12 0.49 0.14 5.00
37 INT318387 Binding of Slc40a1 and Hrct1 1 0.02 0.88 0.08 5.00
38 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 5.00
39 INT199041 AGRP Regulation of IGHE 1 0.00 1.39 0.03 5.00
40 INT352392 Binding of ENOSF1 and Recql4 1 0.02 6.62 0 5.00
41 INT205121 Binding of CD4 and CD7 1 0.05 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Granulomatous Inflammation. They are ordered first by their pain relevance and then by number of times they were reported in Granulomatous Inflammation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT12324 Positive_regulation of PRTN3 26 0.70 18.82 4.55 99.36
2 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31 98.88
3 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 98.84
4 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 98.82
5 INT234727 Negative_regulation of Aim1 1 0.37 0.61 0.22 98.72
6 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 98.14
7 INT73341 Positive_regulation of Faah 12 0.65 4.94 4.28 97.62
8 INT133621 Positive_regulation of Gene_expression of Faah 5 0.65 2.07 1.93 97.62
9 INT73338 Gene_expression of Faah 21 0.77 6.72 10.73 97.42
10 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 97.40
11 INT49440 Localization of Cpox 27 0.53 11.26 5.79 97.40
12 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 96.68
13 INT157395 Phosphorylation of MROS 1 0.54 1.27 0.39 93.52
14 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 93.00
15 INT13857 Binding of Sst 11 0.24 2.48 5.76 92.96
16 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 92.16
17 INT73340 Negative_regulation of Faah 134 0.59 38.67 85.03 91.44
18 INT10444 Positive_regulation of Gene_expression of CNR1 18 0.69 8.69 7.84 91.32
19 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 90.84
20 INT10019 Binding of CD8A 57 0.36 31.49 10.08 90.80
21 INT53196 Binding of Cd4 44 0.47 27.28 5.85 90.48
22 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3 90.12
23 INT11807 Gene_expression of Il2 266 0.78 112 64.97 89.72
24 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 89.72
25 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 89.72
26 INT11235 Positive_regulation of IFNA2 27 0.69 15.32 2.57 88.96
27 INT155860 Positive_regulation of ENOSF1 5 0.19 3.15 0.95 88.84
28 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74 88.76
29 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88 88.52
30 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 87.60
31 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 87.16
32 INT22383 Binding of IL2 59 0.48 39.06 8.56 86.32
33 INT102979 Negative_regulation of Gene_expression of Pecam1 5 0.40 4.95 2.21 85.84
34 INT164537 Negative_regulation of Gene_expression of Hbb 2 0.06 1.47 0.55 85.84
35 INT23044 Gene_expression of Hbb 13 0.43 5.77 3.1 85.84
36 INT82685 Gene_expression of Pecam1 36 0.76 27.95 9.01 85.84
37 INT155861 Negative_regulation of ENOSF1 3 0.42 3.29 0.63 85.56
38 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 85.44
39 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 84.80
40 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 84.56
41 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 84.08
42 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6 81.96
43 INT274203 Positive_regulation of PABPN1 1 0.16 2.41 0.37 81.80
44 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 81.60
45 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 81.60
46 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 81.56
47 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 79.84
48 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2 79.44
49 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 79.44
50 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 79.20
51 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 76.72
52 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06 75.96
53 INT163535 Negative_regulation of Sgpp1 6 0.13 3.35 1.52 75.96
54 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 75.84
55 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 75.84
56 INT142637 Positive_regulation of Gene_expression of PRTN3 8 0.46 6.23 1.75 75.84
57 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 75.68
58 INT166131 Positive_regulation of Positive_regulation of Col7a1 8 0.46 6.4 1.65 75.28
59 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 75.00
60 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 74.16
61 INT10763 Localization of IL2 157 0.80 81.11 33.21 74.00
62 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 73.56
63 INT252325 Gene_expression of Ahi1 4 0.04 4.81 1.35 72.72
64 INT63309 Localization of GIF 2 0.78 1.14 0.06 72.72
65 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 72.64
66 INT6852 Localization of TNF 883 0.81 705.95 270.84 71.84
67 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 71.84
68 INT15148 Gene_expression of Vip 51 0.77 25.61 18.33 71.44
69 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 70.08
70 INT216124 Negative_regulation of Pcna 3 0.13 2.06 0.19 65.56
71 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 65.44
72 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 65.12
73 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 64.68
74 INT27534 Negative_regulation of Gba 10 0.57 6.23 0.38 63.04
75 INT8910 Negative_regulation of Qrfp 10 0.53 2.8 6.02 61.20
76 INT122041 Binding of Ppara 308 0.48 189.17 51.48 60.40
77 INT49214 Gene_expression of Cd4 269 0.78 154.22 34.05 60.40
78 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 60.40
79 INT215379 Positive_regulation of Binding of Ppara 15 0.66 8.04 2.36 60.40
80 INT272511 Positive_regulation of DMPK 8 0.54 6.85 0.72 59.44
81 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 59.40
82 INT83295 Positive_regulation of Cd68 21 0.39 14.55 2.46 59.40
83 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 58.24
84 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 53.92
85 INT178903 Gene_expression of SNRPF 1 0.42 6.73 3.94 50.40
86 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 48.96
87 INT213962 Transcription of Sstr1 1 0.06 0.19 1.03 46.00
88 INT9660 Regulation of TNF 363 0.62 312.94 139.99 45.36
89 INT66099 Transcription of Sst 8 0.25 4.86 6.96 44.48
90 INT103909 Gene_expression of NOD2 37 0.77 21.9 7.36 43.12
91 INT154227 Regulation of Gene_expression of NOD2 3 0.44 3.38 0.99 43.12
92 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 40.92
93 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 40.40
94 INT72798 Binding of ADA 12 0.47 7.84 3.39 39.68
95 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 38.92
96 INT57699 Positive_regulation of CD1A 11 0.50 8.49 2.93 38.92
97 INT38056 Localization of Crp 71 0.78 53.14 17.03 37.32
98 INT17701 Gene_expression of PTHLH 103 0.78 64.23 8.85 36.40
99 INT21900 Gene_expression of Mthfd1 150 0.75 69.47 27.03 35.44
100 INT244343 Localization of NTM 16 0.73 14.26 0.26 35.28
101 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 35.20
102 INT200107 Gene_expression of SDHA 9 0.37 5.29 1.02 35.20
103 INT202291 Gene_expression of Vipr1 3 0.40 0.47 0.48 34.40
104 INT213967 Positive_regulation of Localization of Mthfd1 4 0.30 2.52 0.46 33.96
105 INT213966 Positive_regulation of Localization of Cd83 1 0.20 0.42 0.23 33.96
106 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 33.48
107 INT10694 Binding of Bche 19 0.48 8.03 4.85 32.88
108 INT186511 Gene_expression of ABRA 1 0.19 1.92 0.42 31.80
109 INT188588 Localization of Mthfd1 20 0.49 9.19 4.37 31.72
110 INT204848 Localization of Cd83 2 0.47 0.5 0.24 31.72
111 INT73252 Positive_regulation of Mthfd1 124 0.59 59.48 18.35 30.80
112 INT213965 Gene_expression of rsm1 7 0.54 4.18 1.29 30.72
113 INT254072 Gene_expression of SEPT5 23 0.16 8.29 1.43 30.00
114 INT295611 Regulation of DNAI1 5 0.23 2.41 0.87 29.60
115 INT213963 Positive_regulation of Gene_expression of Cd83 1 0.18 0.4 0.2 28.64
116 INT204852 Gene_expression of Cd83 7 0.48 3.15 0.76 28.28
117 INT354026 Positive_regulation of ICOS 1 0.17 2.32 0 26.44
118 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 26.28
119 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 25.00
120 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 24.36
121 INT100650 Gene_expression of Recql4 2 0.42 1.72 0.28 22.36
122 INT101594 Positive_regulation of Cd40 36 0.69 16.14 4.56 21.76
123 INT269970 Positive_regulation of Positive_regulation of Cd40 2 0.50 1.79 0.57 21.76
124 INT188404 Positive_regulation of Binding of Fas 3 0.15 5.22 1.37 20.64
125 INT115889 Binding of Fas 27 0.36 28.87 4.08 20.24
126 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 18.96
127 INT89253 Regulation of Mthfd1 14 0.23 8.1 1.94 18.96
128 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 17.36
129 INT60700 Gene_expression of Itgax 93 0.71 51.89 6.57 17.36
130 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43 17.36
131 INT35683 Gene_expression of Gsr 24 0.46 16.94 3.6 17.36
132 INT87329 Positive_regulation of Gene_expression of Itgax 15 0.64 10.85 0.93 17.36
133 INT274208 Positive_regulation of Gene_expression of Gsr 3 0.14 2.15 0.13 17.36
134 INT269968 Positive_regulation of Binding of Nfkb2 1 0.33 0.26 0.11 17.00
135 INT58432 Positive_regulation of Gsr 12 0.70 9.4 1.94 16.76
136 INT269964 Binding of Nfkb2 1 0.25 0.26 0.11 14.68
137 INT188403 Positive_regulation of Positive_regulation of Fas 3 0.46 4.47 0.63 14.48
138 INT269966 Binding of Relb 1 0.16 0.26 0.11 13.88
139 INT244342 Gene_expression of NTM 1 0.58 0.95 0 12.48
140 INT171117 Binding of Itgam 35 0.36 14.87 2.76 9.32
141 INT113891 Binding of Gsr 5 0.21 4.86 0.42 9.32
142 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 9.28
143 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
144 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
145 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
146 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
147 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
148 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
149 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
150 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
151 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
152 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
153 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
154 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
155 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
156 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
157 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
158 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
159 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
160 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 5.00
161 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
162 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
163 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 5.00
164 INT8534 Localization of Pax3 85 0.59 28.71 82.82 5.00
165 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
166 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
167 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
168 INT8346 Gene_expression of Qrfp 136 0.70 19.49 70.21 5.00
169 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
170 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47 5.00
171 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
172 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
173 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
174 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
175 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
176 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01 5.00
177 INT5770 Binding of Rbm39 88 0.41 13.23 55.5 5.00
178 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
179 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
180 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 5.00
181 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
182 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
183 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
184 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
185 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
186 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
187 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
188 INT4913 Binding of Pax3 52 0.28 9.57 42.67 5.00
189 INT4850 Binding of Tac1 57 0.47 14.25 42.17 5.00
190 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
191 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
192 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
193 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
194 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
195 INT23222 Binding of Phax 52 0.31 7.61 30.4 5.00
196 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
197 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 5.00
198 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
199 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
200 INT22499 Regulation of Calca 42 0.62 17.32 28.02 5.00
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