D:Growth Hormone-secreting Pituitary Adenoma

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Disease Term
Synonyms Adenoma Somatotroph, ADENOMAS SOMATOTROPH, Gh Secreting Pituitary Adenoma, Gh Secreting Pituitary Adenomas, Growth Hormone Secreting Pituitary Adenoma, PITUITARY ADENOMA GH SECRETING, Pituitary Adenomas Gh Secreting, Pituitary Growth Hormone Secreting Adenoma, SOMATOTROPH ADENOMA, Somatotroph Adenomas
Documents 10
Hot Single Events 18
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Growth Hormone-secreting Pituitary Adenoma. They are ordered first by their relevance to Growth Hormone-secreting Pituitary Adenoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT243468 Binding of SSTR1 and SSTR5 1 0.05 0.99 0.1 54.72
2 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 5.00
3 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 5.00
4 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 5.00
5 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37 5.00
6 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 5.00
7 INT243465 Binding of GH1 and GOPC 1 0.02 0.99 0.09 5.00
8 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09 5.00
9 INT316552 Binding of SST and Sst1 1 0.03 0.53 0.09 5.00
10 INT243466 POU1F1 Regulation of GH1 1 0.11 1.26 0.08 5.00
11 INT243464 POU1F1 Regulation of PRL 1 0.28 1.26 0.08 5.00
12 INT243467 PCSK1 Positive_regulation of POMC 1 0.08 1.62 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Growth Hormone-secreting Pituitary Adenoma. They are ordered first by their pain relevance and then by number of times they were reported in Growth Hormone-secreting Pituitary Adenoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 100.00
2 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 99.98
3 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 99.28
4 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 96.62
5 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 94.96
6 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 94.32
7 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 93.68
8 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 89.36
9 INT9683 Binding of GH1 57 0.47 21.14 5.99 87.76
10 INT19900 Binding of GHRH 22 0.37 5.75 5 87.44
11 INT695 Binding of POMC 304 0.48 56.66 126.85 85.84
12 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 82.72
13 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 82.72
14 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53 82.72
15 INT1893 Localization of Gh 1041 0.79 340.23 256.58 82.44
16 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 82.40
17 INT49769 Binding of SSTR2 4 0.48 1.39 2.14 82.24
18 INT34777 Localization of IGF1 82 0.80 42.68 8.62 82.16
19 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 77.36
20 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 75.32
21 INT1530 Regulation of Gh 382 0.61 115.96 112.47 74.68
22 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 63.92
23 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 63.92
24 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 60.24
25 INT243480 Gene_expression of SSTR5 1 0.55 4.25 0.85 60.00
26 INT140542 Gene_expression of SSTR2 18 0.65 13.58 3.94 59.20
27 INT425 Localization of PRL 455 0.81 189.64 144.8 59.12
28 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 57.52
29 INT243478 Binding of SSTR5 1 0.29 0.99 0.1 54.72
30 INT243477 Binding of SSTR1 3 0.26 3.49 0.65 53.68
31 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 51.20
32 INT249 Localization of GHRH 215 0.80 78.02 51.87 36.48
33 INT954 Positive_regulation of Gene_expression of GHRH 18 0.50 7.6 1.63 25.00
34 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
35 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
36 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 5.00
37 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
38 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
39 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
40 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
41 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
42 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
43 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
44 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
45 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
46 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 5.00
47 INT5454 Localization of CRH 124 0.79 79.18 41.53 5.00
48 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
49 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 5.00
50 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
51 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
52 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
53 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
54 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
55 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
56 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
57 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
58 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
59 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 5.00
60 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 5.00
61 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
62 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
63 INT31780 Binding of DIO2 17 0.36 10.07 10 5.00
64 INT6019 Positive_regulation of NEUROD1 37 0.67 17.3 8.89 5.00
65 INT12292 Negative_regulation of Positive_regulation of GH1 22 0.58 5.02 8.28 5.00
66 INT61363 Positive_regulation of TFAM 43 0.69 26.43 8.14 5.00
67 INT20922 Positive_regulation of Localization of CRH 18 0.67 11.12 6.79 5.00
68 INT5455 Negative_regulation of Localization of CRH 16 0.49 7.31 6.41 5.00
69 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83 5.00
70 INT67195 Negative_regulation of Gene_expression of SST 7 0.42 6.98 4.88 5.00
71 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
72 INT6021 Binding of PRL 18 0.48 12.55 4.3 5.00
73 INT14930 Regulation of Gene_expression of SST 12 0.45 6.86 3.89 5.00
74 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
75 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05 5.00
76 INT15606 Localization of FSHB 24 0.78 9.16 2.49 5.00
77 INT15604 Gene_expression of FSHB 30 0.56 9.7 2.45 5.00
78 INT27644 Gene_expression of BRD2 23 0.65 6.97 2.23 5.00
79 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94 5.00
80 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
81 INT23491 Positive_regulation of FSHB 14 0.65 7.2 1.79 5.00
82 INT316547 Binding of Sst1 2 0.10 0.84 0.74 5.00
83 INT173234 Gene_expression of Sst1 2 0.14 0.88 0.63 5.00
84 INT243481 Gene_expression of GATA2 3 0.50 3.34 0.62 5.00
85 INT112327 Positive_regulation of Gene_expression of FSHB 5 0.44 3.64 0.39 5.00
86 INT212617 Gene_expression of Sstr3 2 0.41 1.66 0.22 5.00
87 INT163151 Gene_expression of POU1F1 2 0.53 3.08 0.16 5.00
88 INT212618 Positive_regulation of Gene_expression of Sstr3 1 0.05 0.84 0.1 5.00
89 INT98805 Positive_regulation of Negative_regulation of GH1 2 0.36 1.43 0.06 5.00
90 INT243479 Phosphorylation of FSHB 1 0.17 1.43 0 5.00
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