D:Heart Arrhythmia

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Disease Term
Synonyms Arrhythmia, ARRYTHMIA TACHYARRHYMIA, Atrial Fibrillation, Atrial Flutter, Bradycardia, Brugada Syndrome, Ecotopic Beats, Extrasystoles, Long Qt Syndrome, PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA, Pre Excitation Syndrome
Documents 267
Hot Single Events 90
Hot Interactions 15

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Heart Arrhythmia. They are ordered first by their relevance to Heart Arrhythmia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT214012 Binding of Ank1 and Nav1 1 0.01 0.51 0.1 99.44
2 INT214011 Negative_regulation of Binding of Ank1 and Nav1 1 0.01 0.51 0.1 99.44
3 INT214014 Binding of Dysf and Nav1 1 0.00 0.5 0.1 98.72
4 INT214016 Dysf Negative_regulation of Binding of Dysf and Nav1 1 0.00 0.5 0.1 98.72
5 INT194100 Binding of MKLN1 and HELT 1 0.01 1.23 0.21 98.16
6 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98 97.80
7 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98 97.80
8 INT309954 Binding of Pkp2 and Nav1 1 0.29 0.29 0.13 93.92
9 INT265264 Binding of NA and SCN5A 1 0.03 0.55 0 91.72
10 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4 90.04
11 INT275159 Agt Positive_regulation of Phosphorylation of Stat3 1 0.04 1.44 0.2 90.04
12 INT265265 SCN5A Regulation of Gene_expression of NAV1 1 0.01 0.16 0 84.32
13 INT275171 Binding of Stat3 and Rac1 Positive_regulation of Rac1 Positive_regulation of Stat3 1 0.01 0.73 0.1 82.88
14 INT275158 Rac1 Positive_regulation of Stat3 1 0.07 0.72 0.1 82.88
15 INT275157 Binding of Stat3 and Rac1 1 0.05 0.71 0.1 80.84
16 INT214015 Negative_regulation of Binding of Dnahc8 and Ank2 1 0.04 1.09 0.04 51.12
17 INT214013 Binding of Dnahc8 and Ank2 1 0.03 1.08 0.04 50.48
18 INT309953 Binding of Atrn and Nav1 1 0.00 0.23 0.53 29.04
19 INT350862 Hist1h1t Regulation of Kcnj5 1 0.02 1.35 1.22 17.96
20 INT350859 Hist1h1t Regulation of Gene_expression of Kcnj5 1 0.02 0.37 0.59 5.00
21 INT350861 Hist1h1t Positive_regulation of Gene_expression of Kcnj5 1 0.02 0.35 0.56 5.00
22 INT350860 Hist1h1t Positive_regulation of Kcnj5 1 0.02 0.54 0.5 5.00
23 INT309298 Binding of NA and ST8SIA2 1 0.00 0 0.28 5.00
24 INT231206 Binding of KCNH2 and KCNQ1 2 0.22 1.04 0.24 5.00
25 INT231223 Binding of KCNQ1 and Nav1 1 0.03 0.59 0.11 5.00
26 INT194101 MKLN1 Positive_regulation of Binding of SCD 1 0.08 1.16 0 5.00
27 INT309955 Binding of Pkp2 and Dsp 1 0.12 0.1 0 5.00
28 INT194102 MKLN1 Regulation of Positive_regulation of SCD 1 0.07 1.13 0 5.00
29 INT309975 Binding of Pygm and Pkp2 1 0.01 0.4 0 5.00
30 INT212413 SLC12A1 Regulation of PRKAB1 1 0.00 0 0 5.00
31 INT309956 Binding of Dsc1 and Dsp 1 0.01 0.1 0 5.00
32 INT309976 Binding of Pygm and Dsp 1 0.00 0.1 0 5.00
33 INT309977 Pygm Positive_regulation of Localization of Pkp2 1 0.01 0.19 0 5.00
34 INT309957 Binding of Dsg1b and Dsp 1 0.01 0.1 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Heart Arrhythmia. They are ordered first by their pain relevance and then by number of times they were reported in Heart Arrhythmia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT149710 Gene_expression of Pvr 10 0.46 8.92 0 100.00
2 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 100.00
3 INT232667 Binding of Pd 17 0.16 20.76 3.58 100.00
4 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 99.96
5 INT140930 Positive_regulation of Gene_expression of Cd40 4 0.64 3.26 0.99 99.82
6 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 99.80
7 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 99.78
8 INT23598 Binding of SCN5A 32 0.40 16 5.35 99.76
9 INT140929 Gene_expression of Cd40 9 0.72 8.76 2.88 99.58
10 INT107454 Positive_regulation of Stat3 43 0.68 19.63 17.69 99.58
11 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 99.44
12 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.40
13 INT157073 Positive_regulation of PKLR 6 0.36 5.48 0.69 99.14
14 INT101008 Gene_expression of Scn5a 5 0.75 26.93 6.06 99.12
15 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 99.12
16 INT194103 Negative_regulation of MKLN1 1 0.21 1.57 0.08 99.12
17 INT35526 Binding of Eef1a2 14 0.34 5.82 1.61 99.04
18 INT58060 Negative_regulation of HMI 30 0.44 11.9 5.06 98.96
19 INT30209 Localization of SCN5A 24 0.72 7.95 5.35 98.62
20 INT90693 Transcription of TNNI3 2 0.55 1.56 0.15 98.48
21 INT34425 Positive_regulation of Negative_regulation of NA 12 0.38 4.17 3.2 98.44
22 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67 98.36
23 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 98.32
24 INT341481 Binding of SCN8A 1 0.28 1.47 1.23 98.26
25 INT194106 Positive_regulation of MKLN1 1 0.25 4.34 0.64 98.12
26 INT168932 Negative_regulation of Bwk1 1 0.25 0.67 0.28 97.92
27 INT9586 Gene_expression of Eef1a2 29 0.65 6.79 11.12 97.16
28 INT143450 Negative_regulation of Scn5a 3 0.43 2.71 0.88 97.08
29 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 97.04
30 INT304424 Negative_regulation of Binding of Pvr 1 0.29 1.92 0 96.88
31 INT304423 Binding of Pvr 1 0.26 1.84 0 96.88
32 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 96.52
33 INT46575 Gene_expression of SCTR 2 0.43 2.83 0.52 96.40
34 INT356333 Positive_regulation of Gene_expression of SCTR 1 0.03 2.16 0 96.40
35 INT284868 Binding of Scn5a 2 0.36 0.7 0.08 96.36
36 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 96.16
37 INT60289 Negative_regulation of PKLR 5 0.21 1.75 0.53 96.16
38 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 95.76
39 INT193622 Positive_regulation of ICA1L 1 0.07 1.51 0.14 95.52
40 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 95.36
41 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 95.16
42 INT84162 Negative_regulation of KCNMA1 26 0.58 5.05 7.58 95.12
43 INT188993 Gene_expression of MKLN1 2 0.38 9.71 1.43 94.80
44 INT341484 Negative_regulation of SCN1A 1 0.53 1.27 0.94 94.76
45 INT46692 Binding of SCN9A 4 0.36 2.55 2.13 94.12
46 INT85297 Positive_regulation of Gene_expression of TNNI3 29 0.50 29.77 1.68 94.08
47 INT110633 Binding of Nav1 15 0.42 4.34 9.38 93.92
48 INT309962 Binding of Pkp2 1 0.45 0.81 0.13 93.92
49 INT297602 Positive_regulation of Tsv 3 0.07 3.36 0.33 93.36
50 INT143451 Negative_regulation of Gene_expression of Scn5a 2 0.43 4.63 1.34 93.20
51 INT214008 Negative_regulation of Ank1 4 0.03 1.49 0.09 92.36
52 INT296812 Negative_regulation of Binding of Scn11a 1 0.02 0.2 0 92.32
53 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 92.24
54 INT139254 Negative_regulation of Per1 12 0.56 3.17 1.62 92.00
55 INT9547 Regulation of TNNI3 25 0.56 14.22 2.22 91.64
56 INT82335 Negative_regulation of Ina 3 0.36 1.11 0.5 91.44
57 INT168046 Positive_regulation of Gene_expression of PRKAB1 5 0.38 4.31 0.08 91.12
58 INT275162 Negative_regulation of Gene_expression of Cd40 1 0.14 1.23 0.06 90.40
59 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66 89.08
60 INT193271 Gene_expression of Brs3 8 0.05 1.25 5.87 89.04
61 INT140388 Localization of Pvr 4 0.61 3.07 0.59 88.92
62 INT97392 Gene_expression of Stat3 27 0.65 14.21 4.06 88.64
63 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 88.64
64 INT85395 Gene_expression of Scn11a 62 0.78 17.97 26.89 88.56
65 INT168043 Gene_expression of PRKAB1 14 0.62 7.01 0.23 88.40
66 INT296818 Binding of Scn11a 1 0.02 0.14 0 87.76
67 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 86.56
68 INT168931 Gene_expression of Bwk1 1 0.40 0.43 0.22 86.44
69 INT24471 Regulation of Brs3 3 0.17 1.56 2.19 86.00
70 INT75183 Negative_regulation of TNNI3 19 0.53 9.34 1.32 85.92
71 INT296809 Negative_regulation of Negative_regulation of Nav1 4 0.38 1.33 1.1 85.88
72 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 85.84
73 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95 85.84
74 INT123557 Gene_expression of Atf3 9 0.78 11.21 5.26 85.84
75 INT17818 Gene_expression of Agtr2 24 0.56 12.96 4.41 85.80
76 INT309965 Positive_regulation of Localization of Ids 1 0.16 0.26 0.13 85.44
77 INT141341 Binding of Egr1 5 0.48 2.65 0.67 85.04
78 INT296820 Binding of Atf3 2 0.35 1.91 0.54 85.04
79 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27 84.76
80 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 84.00
81 INT34664 Binding of Gpt 2 0.36 1.21 0.09 83.84
82 INT309969 Localization of Ids 1 0.24 0.26 0.13 83.00
83 INT38303 Binding of Gpt 21 0.47 15.84 3.43 82.80
84 INT309963 Localization of Pkp2 1 0.74 1.13 0.24 82.20
85 INT145971 Localization of Nav1 20 0.81 10.3 18.11 82.20
86 INT92313 Negative_regulation of Gene_expression of TNNI3 3 0.41 3.07 0.28 82.00
87 INT6164 Positive_regulation of INA 16 0.67 2.19 5.45 81.72
88 INT105974 Positive_regulation of PRKAB1 43 0.67 23.47 4.16 80.88
89 INT212416 Positive_regulation of Binding of PRKAB1 1 0.32 0.39 0 80.88
90 INT204344 Binding of PRKAB1 2 0.24 0.67 0 80.24
91 INT230722 Regulation of Hcm 4 0.37 3 0.21 78.56
92 INT193268 Binding of Brs3 3 0.03 1.56 2.67 77.92
93 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 77.44
94 INT65076 Positive_regulation of SLC5A6 1 0.41 3.28 0.4 77.20
95 INT267892 Gene_expression of Prkag2 3 0.62 3.59 0 77.12
96 INT330511 Gene_expression of Bmpr1a 1 0.54 1.9 0 77.12
97 INT193269 Negative_regulation of Brs3 1 0.03 0.26 0.79 76.48
98 INT24472 Positive_regulation of Brs3 5 0.28 1 1.73 76.16
99 INT65075 Positive_regulation of Binding of SLC5A6 1 0.41 1.63 0.22 75.00
100 INT65077 Binding of SLC5A6 1 0.31 1.63 0.22 75.00
101 INT101687 Positive_regulation of AVPR1B 6 0.40 2.95 0.95 75.00
102 INT385 Gene_expression of Agt 182 0.78 63.62 37.91 74.72
103 INT212418 Negative_regulation of Localization of PRKAB1 1 0.27 0.58 0 74.48
104 INT130999 Localization of PRKAB1 5 0.57 4.1 0.35 74.00
105 INT212417 Positive_regulation of Localization of PRKAB1 1 0.32 0.58 0 74.00
106 INT140538 Positive_regulation of Bwk1 2 0.37 0.7 0.28 71.60
107 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 70.84
108 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 70.80
109 INT123419 Binding of NAV1 37 0.48 7.09 26.43 69.80
110 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 69.44
111 INT8624 Positive_regulation of Scn11a 7 0.46 3.56 4.41 68.32
112 INT43009 Gene_expression of Scn7a 45 0.68 7.85 10.29 67.64
113 INT117570 Positive_regulation of Gene_expression of Scn7a 7 0.43 1.4 0.77 67.64
114 INT12924 Negative_regulation of Gene_expression of NA 25 0.30 6.59 6.71 66.96
115 INT200438 Negative_regulation of Gene_expression of SCN5A 6 0.36 1.93 0.71 66.96
116 INT107135 Positive_regulation of KCNJ5 4 0.09 2.78 1.3 66.64
117 INT17028 Positive_regulation of Scn7a 35 0.41 9.83 7.44 65.96
118 INT214005 Gene_expression of Ank2 1 0.78 29.4 1.88 63.00
119 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 62.36
120 INT17029 Regulation of Scn7a 23 0.45 3.89 7.02 62.20
121 INT247021 Binding of GJA1 6 0.47 0.91 0.23 61.20
122 INT284877 Transcription of Scn5a 3 0.72 1.41 0.3 61.08
123 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45 58.80
124 INT123558 Positive_regulation of Gene_expression of Atf3 2 0.70 1.45 0.43 58.80
125 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 58.68
126 INT296806 Positive_regulation of Gene_expression of Scn5a 1 0.50 2.73 0.45 58.56
127 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 58.52
128 INT284882 Positive_regulation of Scn5a 3 0.50 1.73 0.44 58.40
129 INT189002 Binding of MKLN1 2 0.24 0.97 0.38 57.68
130 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49 55.48
131 INT296816 Positive_regulation of Gene_expression of Wbcq1 1 0.03 1.13 0.3 55.44
132 INT296814 Negative_regulation of Gene_expression of Wbcq1 1 0.03 1.13 0.3 55.12
133 INT213993 Negative_regulation of Spnb1 2 0.02 0.37 0.07 54.72
134 INT214010 Binding of Spnb1 2 0.01 0.38 0.07 53.84
135 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 53.56
136 INT296807 Gene_expression of Wbcq1 1 0.04 1.13 0.3 53.52
137 INT226836 Transcription of Scn1b 2 0.50 0.91 0.07 52.96
138 INT284878 Regulation of Scn5a 2 0.27 1.15 0.09 51.80
139 INT157772 Gene_expression of ASF1B 3 0.07 2.78 0.49 49.76
140 INT33431 Localization of Dnahc8 8 0.67 3.49 1.68 49.08
141 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 49.00
142 INT214002 Localization of Slc8a1 1 0.34 1.07 0.04 48.76
143 INT296819 Phosphorylation of Scn5a 1 0.82 0.07 0 48.24
144 INT36040 Localization of Itpr3 21 0.70 4.87 7.77 47.92
145 INT167056 Gene_expression of CALR 29 0.75 20.05 1.25 47.00
146 INT232067 Gene_expression of RNPC3 6 0.65 0.95 0.2 46.40
147 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 45.96
148 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 45.60
149 INT105762 Positive_regulation of Pvr 6 0.40 2.13 0.65 45.36
150 INT214007 Negative_regulation of Ank2 1 0.43 2.63 0.14 44.16
151 INT42250 Binding of Scn7a 7 0.33 0.51 1.48 43.92
152 INT214533 Regulation of Pvr 2 0.31 0.97 0.06 42.00
153 INT22491 Binding of Atrn 23 0.30 4.51 7.79 41.92
154 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 41.48
155 INT284880 Binding of Eomes 1 0.03 0 0 40.44
156 INT213997 Negative_regulation of Gene_expression of Ank2 1 0.43 5.06 0.22 37.96
157 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 37.84
158 INT22493 Localization of Atrn 6 0.60 0 0.86 37.56
159 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 36.88
160 INT202527 Negative_regulation of Gene_expression of DRGX 5 0.07 1.53 2.54 36.88
161 INT6791 Binding of NA 55 0.46 5.36 17.59 36.40
162 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 35.44
163 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 35.28
164 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 31.92
165 INT235553 Gene_expression of Gvh 8 0.48 4.95 1.68 30.52
166 INT122106 Localization of Cdh2 3 0.69 0.95 1 29.28
167 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 28.76
168 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 28.44
169 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89 28.08
170 INT6481 Binding of TNF 624 0.48 510.2 214.82 27.72
171 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11 26.68
172 INT32660 Regulation of Hps1 8 0.16 2.3 1.21 24.68
173 INT284870 Regulation of Scn3b 1 0.45 0.45 0.34 20.64
174 INT193612 Transcription of SART1 2 0.58 1.56 0.03 18.56
175 INT147366 Gene_expression of Hist1h1t 15 0.44 9.84 6.67 17.96
176 INT45342 Binding of AVSD1 6 0.31 7.23 0.27 17.20
177 INT178291 Gene_expression of Hps1 26 0.67 8.2 2.52 15.72
178 INT268032 Regulation of Kcnj5 23 0.27 3.66 3.51 14.32
179 INT124300 Negative_regulation of Sod2 17 0.45 12.54 0.9 13.28
180 INT350856 Localization of Hist1h1t 1 0.34 0.35 0.03 13.28
181 INT87571 Negative_regulation of KCNQ1 6 0.41 1.69 1.51 11.48
182 INT296811 Gene_expression of Gja4 1 0.24 0.19 0.19 11.16
183 INT118666 Negative_regulation of AVPR1B 7 0.43 2.88 0.59 8.64
184 INT194105 Localization of MKLN1 1 0.37 0.37 0.18 8.52
185 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28 8.48
186 INT151387 Gene_expression of Cav3 14 0.78 4 5.31 8.48
187 INT169659 Positive_regulation of Gene_expression of Cav3 5 0.70 1.44 2.33 8.48
188 INT129360 Positive_regulation of Gene_expression of Scn11a 2 0.10 0.49 1.01 8.48
189 INT77610 Gene_expression of Cacna1h 6 0.65 0.47 0.8 8.48
190 INT296813 Positive_regulation of Gene_expression of Cacna1h 1 0.06 0.19 0.17 8.48
191 INT202526 Positive_regulation of ADAM18 1 0.01 1.77 8.31 7.48
192 INT5536 Regulation of NA 74 0.59 16.61 15.36 6.08
193 INT101906 Negative_regulation of AVL9 2 0.32 2.1 0.68 5.68
194 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
195 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
196 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
197 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
198 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
199 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
200 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
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