D:Heart Disease

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Disease Term
Synonyms Cardiac Disease, Cardiac Diseases, CARDIAC DISORDER, CARDIOPATHY, Disease Cardiac, Disease Heart, Disease Syndrome Of Heart, DISEASES CARDIAC, Diseases Heart, DISEASES SYNDROMES OF HEART, Disorder Of Heart
Documents 3896
Hot Single Events 200
Hot Interactions 19

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Heart Disease. They are ordered first by their relevance to Heart Disease and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT310595 Ros1 Positive_regulation of Npr1 1 0.03 0.84 0.16 99.92
2 INT267214 Hspb8 Negative_regulation of Cryab 1 0.32 1.56 0.06 99.88
3 INT203759 Binding of EDN1 and TNF 1 0.16 0.71 0.16 99.28
4 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67 99.00
5 INT88772 Negative_regulation of Binding of AGT and Agtrap 1 0.02 0.89 0.03 98.04
6 INT88773 Positive_regulation of Binding of AGT and Agtrap 1 0.01 0.88 0.05 97.64
7 INT88774 Binding of AGT and Agtrap 2 0.01 2.13 0.03 97.64
8 INT329552 Binding of PPARA and SNRNP70 1 0.01 1.3 0.07 94.80
9 INT325283 Negative_regulation of MCL1 Positive_regulation of Gene_expression of ADIPOQ 1 0.14 1.53 0 88.00
10 INT197496 Binding of Apoe and Lrp1 4 0.22 2.32 0.46 86.56
11 INT308665 Binding of Apoe and Gopc 1 0.02 0.49 0.07 86.56
12 INT199196 Gnat3 Positive_regulation of Aldh2 2 0.26 1.06 0.03 86.20
13 INT308655 Binding of Lrp1 and Gopc 1 0.01 0.49 0.07 85.08
14 INT291967 INA Positive_regulation of NA 1 0.00 0.98 0.14 84.28
15 INT286432 Binding of ANTXR2 and Gtf3a 1 0.00 3.56 0.1 84.00
16 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 82.64
17 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 82.64
18 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29 82.24
19 INT323152 Binding of DBT and ESR1 2 0.02 1.29 0.27 82.04
20 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37 77.20
21 INT68061 Binding of NA and Regulation of INA 1 0.09 0.08 0.46 76.48
22 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82 75.00
23 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77 74.48
24 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76 74.48
25 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39 74.48
26 INT330432 ALDOA Positive_regulation of Binding of Aldh2 1 0.03 0.43 0 73.64
27 INT330423 ALDOA Negative_regulation of Gnat3 Negative_regulation of Aldh2 1 0.01 0.44 0 73.64
28 INT330434 ALDOA Positive_regulation of Aldh2 1 0.03 0.38 0 73.64
29 INT343545 Binding of GLI2 and ROCK1 1 0.07 0.65 0.03 73.20
30 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78 73.04
31 INT330429 Gnat3 Negative_regulation of Gnat3 Negative_regulation of Aldh2 1 0.03 0.44 0 71.56
32 INT330428 Gnat3 Negative_regulation of Aldh2 1 0.11 0.44 0 71.28
33 INT352793 Binding of APOC1 and FGF21 1 0.01 2.76 0 71.20
34 INT332905 Binding of LPL and SNRNP70 1 0.01 1.34 0 68.32
35 INT332943 Binding of SNRNP70 and Adipoq 1 0.00 1.35 0 68.32
36 INT332904 Binding of LEP and SNRNP70 1 0.00 1.34 0 68.32
37 INT348403 FDPS Negative_regulation of FDPS Negative_regulation of Fdps 1 0.03 0.79 0.71 67.92
38 INT310674 Positive_regulation of Binding of ARSB and ELF3 1 0.07 2.46 0.05 67.64
39 INT343544 Negative_regulation of GLI2 Negative_regulation of Gene_expression of PTHLH 1 0.24 0.53 0.03 67.64
40 INT310675 Binding of ARSB and ELF3 1 0.06 2.4 0.05 66.96
41 INT300486 LEP Positive_regulation of ROS1 1 0.15 0.91 0.09 66.36
42 INT267217 Gene_expression of Hspb8 Negative_regulation of Positive_regulation of Casp3 1 0.14 2.8 0.04 66.12
43 INT308666 Binding of Lrp1 and Chol1 1 0.10 0.69 0.09 65.00
44 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0 63.68
45 INT332907 Binding of LPL and SUGT1 1 0.00 1.3 0 63.00
46 INT240625 Binding of CRP and Hdlcl1 1 0.01 2.56 0.19 61.68
47 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78 61.68
48 INT271025 Binding of Car2 and Casq1 1 0.03 0.7 0.03 60.80
49 INT271027 Binding of RYR1 and Car2 1 0.03 0.46 0 60.80
50 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38 60.72
51 INT343546 Negative_regulation of ROCK1 Negative_regulation of Gene_expression of PTHLH 1 0.16 3.28 0.03 60.48
52 INT279510 Binding of C1qa and fc 1 0.01 0.36 0 59.76
53 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28 59.04
54 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58 58.28
55 INT325028 TNF Negative_regulation of Ptgs1 1 0.00 1.79 0.23 58.12
56 INT325008 TNF Negative_regulation of Gene_expression of NOSTRIN 1 0.00 1.78 0.23 58.12
57 INT325007 TNF Negative_regulation of NOSTRIN 1 0.00 1.78 0.23 58.12
58 INT178334 Binding of Pon1 and Chdh 1 0.11 11.45 0.66 56.72
59 INT283980 Binding of IL12A and IL23A 2 0.24 1.33 0.57 55.64
60 INT279504 Binding of C1ra and Positive_regulation of C1s 1 0.04 0.33 0 55.32
61 INT279508 Binding of Arhgap4 and Positive_regulation of C1s 1 0.01 0.33 0 55.32
62 INT329369 Jun Regulation of Gene_expression of Il12a 1 0.00 1.48 0.27 52.96
63 INT279505 Binding of C4b and Abpz 1 0.01 0.21 0 51.56
64 INT279509 Binding of C2 and Abpz 1 0.01 0.21 0 51.28
65 INT259703 Binding of MYBPC3 and HELT 1 0.04 1.64 0 50.72
66 INT325285 COMP Positive_regulation of UBR5 1 0.00 2.9 0 50.44
67 INT291641 Binding of DST and ESRRG 1 0.16 1.8 0.28 50.00
68 INT291642 Binding of DST and GGT1 1 0.00 1.4 0.19 50.00
69 INT291644 Binding of DST and ESR1 1 0.05 0.84 0.14 50.00
70 INT291643 Binding of DST and INS 1 0.07 0.38 0 50.00
71 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93 48.72
72 INT239839 IL18 Positive_regulation of TNF 1 0.11 1.08 0.09 47.48
73 INT348398 LPA Positive_regulation of Pik3cb 1 0.04 0.88 1.14 45.84
74 INT348400 LPA Positive_regulation of Trib3 1 0.00 0.87 1.14 45.84
75 INT297215 Gene_expression of Ppp3ca Positive_regulation of Ppp3r1 1 0.36 0.22 0 45.04
76 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03 43.20
77 INT300197 Binding of APOA1 and C1S 1 0.39 3.56 0 43.20
78 INT297212 Gene_expression of Ppp3ca Positive_regulation of Nfatc1 1 0.38 0.22 0 42.80
79 INT279501 C3ar1 Positive_regulation of C3 1 0.01 0 0 41.16
80 INT325284 Binding of COMP and MCL1 1 0.01 1.69 0 39.84
81 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37 37.52
82 INT311470 Binding of Crp and Il1 1 0.00 2.44 0.63 37.04
83 INT311466 Binding of Acsl1 and Il1 1 0.00 2.46 0.63 37.04
84 INT207375 Negative_regulation of CPOX Negative_regulation of Gene_expression of Chol1 1 0.10 0.37 0.17 35.84
85 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 35.64
86 INT247656 Binding of Tnnc1 and Gdf15 1 0.02 0.94 0.16 35.40
87 INT94411 Positive_regulation of ADRB3 Negative_regulation of Gene_expression of TNF 1 0.19 0.15 0.09 35.16
88 INT280949 Binding of Fst and Inhbe 3 0.01 2.51 1.15 31.92
89 INT295572 Binding of Fst and Mstn 1 0.13 0.38 0 31.92
90 INT311467 Binding of Crp and Acsl1 1 0.00 2.31 0.61 31.24
91 INT295578 Binding of Mstn and Gprasp1 1 0.23 0.19 0 28.56
92 INT295575 Binding of Mstn and Wfikkn2 1 0.02 0.19 0 28.56
93 INT308658 Binding of Apoa2 and Apoe 1 0.17 0.15 0.03 26.32
94 INT61954 IFNA1 Positive_regulation of Nos2 1 0.05 0.46 0.38 25.00
95 INT273291 Atp2a2 Regulation of Car2 1 0.10 0.31 0 24.76
96 INT273286 Tlx2 Regulation of Car2 1 0.06 0.31 0 24.28
97 INT305270 Lep Negative_regulation of Localization of Car2 1 0.16 1.28 0 24.12
98 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41 23.76
99 INT178336 Binding of SUGT1 and Chdh 1 0.00 0.98 0.17 23.76
100 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07 23.60
101 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86 22.72
102 INT190824 Binding of Cl and Bcl2 1 0.02 1.4 0.05 21.84
103 INT319483 Binding of LCT and HSR 1 0.11 0.23 0 21.28
104 INT194407 Binding of CALCA and MTCP1NB 1 0.01 0 0.51 19.20
105 INT194396 CALCA Positive_regulation of Binding of CALCA and MTCP1NB 1 0.01 0 0.51 19.20
106 INT265950 Clas4 Negative_regulation of Gene_expression of AGT 1 0.02 0.62 0 17.52
107 INT279502 Binding of C2 and Hc 1 0.01 0.2 0.07 15.04
108 INT267216 Binding of Cryab and Hspb8 1 0.36 9.29 0 14.80
109 INT267215 Binding of Cryab and Hspb1 1 0.25 7.19 0 14.40
110 INT155009 IL23A Positive_regulation of Gene_expression of IL17A 2 0.17 0.62 0.39 12.96
111 INT325313 IL23A Positive_regulation of Gene_expression of IL22 1 0.20 0.48 0.23 12.96
112 INT341775 DBT Regulation of Binding of ESR1 1 0.02 0.1 0.11 11.88
113 INT286444 PCSK9 Positive_regulation of Apob 1 0.02 0.49 0 11.64
114 INT310612 OTOR Positive_regulation of F13A1 1 0.05 0.36 0.06 10.96
115 INT184889 Binding of ALOX5 and MCRS1 1 0.06 1.34 0.07 6.56
116 INT343353 Binding of HSD11B1 and Egfl7 1 0.03 0.97 0 6.48
117 INT271026 Binding of Car2 and Dnahc8 1 0.00 0.44 0 6.24
118 INT182813 EEF1A2 Negative_regulation of ITGAL 1 0.10 1.53 0.51 6.04
119 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64 5.08
120 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18 5.00
121 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
122 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
123 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
124 INT166590 Binding of RAMP1 and DCLK3 2 0.37 0.39 4.8 5.00
125 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
126 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81 5.00
127 INT182635 Binding of CCR5 and CCL5 2 0.09 4.19 3 5.00
128 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91 5.00
129 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84 5.00
130 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
131 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
132 INT240131 Binding of Crp and Nppb 7 0.07 11.53 2.12 5.00
133 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87 5.00
134 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68 5.00
135 INT288731 Binding of Got1 and Gpt 1 0.23 1.25 1.61 5.00
136 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 5.00
137 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5 5.00
138 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41 5.00
139 INT194408 Regulation of Binding of CALCA and DCLK3 1 0.15 0 1.29 5.00
140 INT348380 Binding of Fdps and Lpar5 1 0.07 1.45 1.25 5.00
141 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18 5.00
142 INT194403 Negative_regulation of Binding of CALCA and DCLK3 1 0.22 0 1.18 5.00
143 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04 5.00
144 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
145 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98 5.00
146 INT278292 Binding of CRP and ESR1 6 0.09 10.92 0.96 5.00
147 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95 5.00
148 INT243044 Mmp8 Regulation of Mmp9 1 0.05 1.45 0.91 5.00
149 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85 5.00
150 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84 5.00
151 INT287494 CRP Positive_regulation of Gene_expression of CCL2 2 0.30 2.33 0.83 5.00
152 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82 5.00
153 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77 5.00
154 INT170127 Binding of ITGAL and PECAM1 2 0.01 2.71 0.75 5.00
155 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 0.01 0.16 0.73 5.00
156 INT194402 Binding of IGKV1D-8 and DCLK3 1 0.06 0 0.7 5.00
157 INT165583 Binding of Bdnf and Ngf 3 0.33 0.81 0.69 5.00
158 INT348396 Binding of LPAR5 and Fdps 1 0.07 0.81 0.69 5.00
159 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 5.00
160 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 0.12 1.72 0.68 5.00
161 INT313993 Ros1 Positive_regulation of Nfkb1 1 0.05 1.61 0.68 5.00
162 INT194410 Binding of CALCA and LZTS1 1 0.06 0 0.67 5.00
163 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 5.00
164 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 5.00
165 INT348381 Fdps Positive_regulation of Lpar5 1 0.07 0.75 0.64 5.00
166 INT348399 Fdps Positive_regulation of LPAR5 1 0.08 0.75 0.64 5.00
167 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
168 INT174860 VEGFA Positive_regulation of Localization of CCL2 1 0.21 1.68 0.63 5.00
169 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62 5.00
170 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62 5.00
171 INT182819 Binding of CD63 and PECAM1 1 0.00 1.63 0.61 5.00
172 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61 5.00
173 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61 5.00
174 INT177899 Crp Positive_regulation of Positive_regulation of Crp 1 0.01 1.69 0.6 5.00
175 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6 5.00
176 INT352496 AVP Regulation of Gene_expression of CRS 1 0.27 2.47 0.59 5.00
177 INT316831 CCL5 Positive_regulation of Gene_expression of MMP2 1 0.02 0.51 0.59 5.00
178 INT185358 Binding of MCS and PCS 7 0.22 3.34 0.57 5.00
179 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57 5.00
180 INT273244 Binding of VCF and Del(7)Tyr<c-23DVT>-p 1 0.00 2.94 0.55 5.00
181 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54 5.00
182 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 5.00
183 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53 5.00
184 INT356351 Binding of CALM1 and TNC 1 0.02 0 0.52 5.00
185 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 0.02 2.42 0.51 5.00
186 INT106744 Binding of CRP and EGFL7 2 0.07 2.35 0.51 5.00
187 INT349636 IL17A Positive_regulation of Gene_expression of IL4 1 0.06 1.28 0.5 5.00
188 INT229095 Binding of IL1R1 and Il1r1 1 0.00 0.64 0.5 5.00
189 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 5.00
190 INT27730 Binding of ALB and Shbg 2 0.01 0.44 0.5 5.00
191 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49 5.00
192 INT288729 Positive_regulation of Binding of Got1 and Gpt 1 0.25 0.61 0.49 5.00
193 INT292873 Binding of Fas and Fasl 5 0.26 15.74 0.49 5.00
194 INT320451 ECT Positive_regulation of Gene_expression of BDNF 1 0.05 1.21 0.49 5.00
195 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 5.00
196 INT348402 LPA Positive_regulation of Gene_expression of Ptgs2 1 0.01 0.62 0.48 5.00
197 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48 5.00
198 INT355672 Il6 Negative_regulation of Transcription of TNF 1 0.05 0.98 0.46 5.00
199 INT262815 Gene_expression of Serpinf1 Negative_regulation of Gene_expression of Gfap 1 0.39 2.73 0.44 5.00
200 INT194405 DCLK3 Positive_regulation of Gene_expression of RAMP1 1 0.16 0.09 0.43 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Heart Disease. They are ordered first by their pain relevance and then by number of times they were reported in Heart Disease. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT101027 Binding of DST 20 0.41 10.9 1.17 100.00
2 INT50080 Binding of APOE 38 0.45 29.61 2.67 100.00
3 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 100.00
4 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 100.00
5 INT9660 Regulation of TNF 363 0.62 312.94 139.99 100.00
6 INT152982 Negative_regulation of ACCS 14 0.37 9.63 1.3 100.00
7 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 100.00
8 INT56223 Positive_regulation of MPO 35 0.70 43 8.2 100.00
9 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 100.00
10 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 99.96
11 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 99.96
12 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 99.96
13 INT52047 Gene_expression of APOE 50 0.78 34.75 3.52 99.92
14 INT96772 Positive_regulation of Gene_expression of APOE 5 0.66 5.44 0.14 99.92
15 INT190611 Gene_expression of Cnn1 13 0.56 5.87 0.75 99.92
16 INT134821 Gene_expression of Gja3 8 0.77 7.45 4.44 99.84
17 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 99.84
18 INT257685 Regulation of Gene_expression of Gja3 1 0.61 2.86 0.91 99.84
19 INT24983 Binding of MPO 18 0.42 17.56 3.29 99.80
20 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 99.76
21 INT50878 Positive_regulation of Positive_regulation of TNNI3 7 0.50 5.57 0.97 99.76
22 INT61946 Positive_regulation of HGF 57 0.69 38.93 11.99 99.68
23 INT39948 Binding of FLNA 45 0.42 58.05 4.27 99.66
24 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 99.64
25 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19 99.62
26 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18 99.54
27 INT120433 Regulation of TRPM8 11 0.62 8.56 3.78 99.48
28 INT189130 Regulation of AIS 11 0.39 7.64 0.99 99.44
29 INT273613 Negative_regulation of PVR 7 0.17 5.06 1.26 99.36
30 INT78380 Binding of Trim67 1 0.22 0.27 0.09 99.36
31 INT267892 Gene_expression of Prkag2 3 0.62 3.59 0 99.36
32 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 99.32
33 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 99.32
34 INT172390 Negative_regulation of Gene_expression of Cacna1c 2 0.17 2.33 0.11 99.28
35 INT68589 Gene_expression of Cacna1c 14 0.58 6.36 0.69 99.28
36 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 99.28
37 INT61951 Regulation of Negative_regulation of Nos2 5 0.58 3.08 1.39 99.28
38 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 99.24
39 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 99.20
40 INT188239 Binding of LMNA 20 0.47 6.58 0.18 99.20
41 INT32165 Binding of CALM1 92 0.48 24.19 29.57 99.18
42 INT111461 Positive_regulation of hb 30 0.38 21.08 2.1 99.16
43 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.16
44 INT2774 Binding of Crp 241 0.48 195.89 44.39 99.16
45 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 99.16
46 INT60209 Transcription of RYR1 3 0.69 3.06 0.16 99.16
47 INT73938 Gene_expression of Cd36 20 0.76 12.27 1.35 99.12
48 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 99.12
49 INT199178 Positive_regulation of Negative_regulation of Aldh2 2 0.50 0.98 0.18 99.10
50 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 99.04
51 INT255140 Regulation of Protein_catabolism of IGHD1-7 1 0.05 0.82 0 99.04
52 INT352373 Regulation of Mir21 1 0.04 0.45 0 99.00
53 INT9256 Gene_expression of SELPLG 30 0.75 16.44 3.66 98.96
54 INT158864 Negative_regulation of Aldh2 25 0.58 10.92 3.81 98.82
55 INT257683 Negative_regulation of Gene_expression of Gja3 1 0.58 2.63 2.78 98.80
56 INT127016 Regulation of Grk4 3 0.60 2.59 1 98.80
57 INT261228 Binding of Impact 1 0.06 2.16 0.5 98.80
58 INT102698 Binding of ACCS 54 0.42 66.73 9.06 98.78
59 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 98.76
60 INT236648 Binding of Hrt1 4 0.07 5.07 0.51 98.68
61 INT136403 Negative_regulation of DCC 1 0.01 0.87 0.14 98.68
62 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 98.64
63 INT352803 Positive_regulation of FGF21 1 0.66 18.41 0.14 98.64
64 INT122653 Positive_regulation of Gene_expression of CD4 48 0.68 22.5 5.96 98.62
65 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 98.60
66 INT57954 Negative_regulation of Anxa3 4 0.11 4.51 0.89 98.60
67 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 98.58
68 INT61952 Negative_regulation of Transcription of Nos2 17 0.54 5.1 3.34 98.58
69 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 98.52
70 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 98.52
71 INT121336 Positive_regulation of HTT 10 0.45 10.88 0.59 98.48
72 INT145279 Regulation of hb 19 0.34 16.58 2.41 98.44
73 INT272057 Phosphorylation of COPD 2 0.54 4.15 0.22 98.44
74 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9 98.34
75 INT240839 Negative_regulation of Negative_regulation of Ros1 4 0.12 2.42 0.45 98.32
76 INT183753 Regulation of HBM 24 0.39 13.13 1.79 98.28
77 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 98.28
78 INT110040 Binding of Nppb 9 0.18 8.91 0.19 98.28
79 INT175455 Gene_expression of Hspb8 54 0.76 59.87 3.9 98.24
80 INT191925 Positive_regulation of Gene_expression of Hspb8 18 0.68 26.99 0.83 98.24
81 INT174589 Negative_regulation of GLG1 37 0.58 32.41 5.44 98.24
82 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 98.24
83 INT94388 Gene_expression of GDF15 124 0.77 79.48 31.42 98.20
84 INT45238 Gene_expression of Hfe 3 0.71 2.16 0.21 98.20
85 INT239896 Positive_regulation of Gene_expression of Hfe 1 0.13 0.65 0 98.20
86 INT246520 Positive_regulation of Positive_regulation of Tnnc1 1 0.49 2.54 0.33 98.16
87 INT86250 Regulation of WDTC1 11 0.31 4.2 1.64 98.12
88 INT2947 Regulation of TFPI 10 0.44 5.81 4.86 98.12
89 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 98.08
90 INT21869 Negative_regulation of Otc 16 0.58 8.43 3.67 98.08
91 INT61953 Transcription of Nos2 101 0.72 46.64 25.49 98.00
92 INT78182 Positive_regulation of ACCS 43 0.43 46.39 6.78 98.00
93 INT2824 Positive_regulation of HTN1 10 0.40 10.41 1.4 98.00
94 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 97.96
95 INT61947 Positive_regulation of Regulation of HGF 2 0.46 1.35 0.48 97.88
96 INT38033 Regulation of HGF 26 0.45 14.96 3.81 97.88
97 INT11121 Positive_regulation of NPPA 64 0.70 34.09 11.96 97.84
98 INT300236 Regulation of Positive_regulation of LPAL1 1 0.00 1.82 0 97.84
99 INT300219 Positive_regulation of LPAL1 1 0.01 1.81 0 97.84
100 INT73611 Negative_regulation of SCD 15 0.37 26.67 3.71 97.76
101 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 97.68
102 INT85683 Regulation of Gpbar1 16 0.60 3.3 5.5 97.62
103 INT73939 Negative_regulation of Cd36 7 0.57 6.3 0.95 97.60
104 INT77490 Positive_regulation of Tnnc1 85 0.68 43.54 9.07 97.60
105 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 97.60
106 INT214735 Gene_expression of IGHD1-7 5 0.57 3.28 0.14 97.60
107 INT28176 Localization of Cp 17 0.73 14.3 4.86 97.60
108 INT214731 Positive_regulation of Gene_expression of IGHD1-7 2 0.39 1.34 0.08 97.60
109 INT255137 Protein_catabolism of IGHD1-7 1 0.09 0.81 0 97.60
110 INT185691 Positive_regulation of WDTC1 24 0.48 12.57 6.49 97.56
111 INT84979 Regulation of CHDH 22 0.38 22.34 0.78 97.52
112 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14 97.50
113 INT60151 Positive_regulation of Positive_regulation of HSD11B1 4 0.45 3.54 0.49 97.50
114 INT139678 Positive_regulation of Hspb8 23 0.68 23.94 1.85 97.44
115 INT171997 Gene_expression of ERAL1 5 0.25 4.97 1.67 97.44
116 INT205908 Positive_regulation of Hsd17b10 3 0.35 2.74 0.33 97.40
117 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 97.36
118 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 97.36
119 INT142741 Gene_expression of Atp6v1e1 28 0.31 9.41 2.34 97.36
120 INT129105 Gene_expression of Mstn 95 0.76 29.96 0.32 97.28
121 INT129106 Negative_regulation of Mstn 102 0.57 30.57 0.49 97.28
122 INT192760 Gene_expression of Mrvi1 2 0.26 1.05 0.2 97.28
123 INT2162 Regulation of Comt 13 0.60 2.9 5.18 97.20
124 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 97.20
125 INT36287 Binding of CD4 96 0.47 58.93 11.88 97.16
126 INT257688 Negative_regulation of Gja3 1 0.58 1.15 0.5 97.08
127 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 97.04
128 INT214 Localization of AVP 370 0.81 208.51 91.09 97.04
129 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 96.92
130 INT257689 Negative_regulation of Gja1 1 0.37 0.58 0.05 96.84
131 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 96.80
132 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 96.72
133 INT185685 Positive_regulation of Gene_expression of WDTC1 1 0.35 4.37 3.26 96.68
134 INT104551 Gene_expression of Il18 156 0.76 115.51 36.95 96.68
135 INT104550 Positive_regulation of Il18 67 0.70 55.14 17.48 96.68
136 INT141014 Positive_regulation of Gene_expression of Il18 46 0.68 47.63 13.3 96.68
137 INT49104 Positive_regulation of Gene_expression of Vcam1 30 0.69 36.52 7.64 96.68
138 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 96.68
139 INT267204 Regulation of Positive_regulation of Hspb8 1 0.60 2.73 0.07 96.68
140 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 96.64
141 INT170284 Gene_expression of Arsb 9 0.65 9.12 0.63 96.64
142 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 96.64
143 INT305242 Binding of Obsty1 1 0.07 9.33 0.17 96.56
144 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 96.50
145 INT32572 Gene_expression of Hctq1 4 0.38 1.49 0.87 96.48
146 INT21938 Positive_regulation of Atp7b 26 0.10 11.33 7.1 96.40
147 INT101414 Gene_expression of Phc1 27 0.60 9.55 7.58 96.40
148 INT32188 Regulation of Atp7b 7 0.04 3.01 0.81 96.40
149 INT32189 Positive_regulation of Regulation of Atp7b 1 0.04 0.69 0.08 96.40
150 INT34143 Regulation of IMPA1 14 0.44 4.83 0.58 96.28
151 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 96.24
152 INT86184 Negative_regulation of Acsl1 10 0.34 20.45 2.23 96.20
153 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 96.08
154 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 96.08
155 INT9664 Binding of LBP 127 0.48 94.9 63.42 95.92
156 INT21246 Negative_regulation of ATP1A4 3 0.10 3.3 0.79 95.92
157 INT77383 Gene_expression of Tnni3 8 0.65 4.14 1.55 95.88
158 INT227632 Gene_expression of Foxn1 1 0.13 1.36 0 95.84
159 INT145195 Positive_regulation of Irak3 4 0.15 3.65 2.12 95.80
160 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 95.76
161 INT939 Gene_expression of PAEP 86 0.77 31.02 8.59 95.76
162 INT92330 Gene_expression of WDTC1 22 0.47 13.12 5.15 95.72
163 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 95.72
164 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74 95.72
165 INT56216 Positive_regulation of Tnnt3 10 0.67 6.72 1.81 95.64
166 INT56215 Positive_regulation of Positive_regulation of Tnnt3 2 0.45 1.26 0.47 95.64
167 INT62570 Binding of Pth 48 0.48 26.45 4.85 95.60
168 INT4199 Binding of Agt 76 0.48 21.06 12.66 95.60
169 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06 95.60
170 INT182830 Negative_regulation of Protein_catabolism of APP 2 0.35 2.09 0.03 95.60
171 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 95.52
172 INT334396 Negative_regulation of Csde1 1 0.06 0.63 0.09 95.52
173 INT626 Localization of CALCA 289 0.81 125.39 221.15 95.44
174 INT329319 Positive_regulation of Transcription of Ece1 1 0.08 2.64 0.48 95.40
175 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 95.40
176 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 95.36
177 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 95.36
178 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94 95.36
179 INT89580 Negative_regulation of STAR 16 0.35 14.88 0.2 95.36
180 INT120226 Positive_regulation of Cxadr 4 0.44 2.54 0.48 95.20
181 INT113845 Protein_catabolism of PARP1 54 0.88 43.86 8.77 95.16
182 INT10992 Gene_expression of PARP1 32 0.76 22.22 3.74 95.16
183 INT11673 Positive_regulation of ECT 43 0.59 13.93 11.25 95.12
184 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1 95.00
185 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 94.96
186 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 94.96
187 INT97900 Negative_regulation of Gene_expression of FGF2 9 0.57 8.37 1.48 94.96
188 INT230676 Gene_expression of 4930579C15Rik 13 0.34 5.61 0.49 94.92
189 INT13510 Gene_expression of ERBB2 530 0.78 405.68 16.79 94.88
190 INT15376 Positive_regulation of Gene_expression of ERBB2 215 0.70 168.54 5.23 94.88
191 INT235660 Gene_expression of EPHA2 27 0.75 23.46 0.4 94.88
192 INT235655 Positive_regulation of Gene_expression of EPHA2 14 0.67 13.48 0.35 94.88
193 INT279213 Positive_regulation of Binding of ERBB2 2 0.46 2.29 0 94.88
194 INT9547 Regulation of TNNI3 25 0.56 14.22 2.22 94.80
195 INT17913 Regulation of HSD11B1 87 0.60 93.23 6.04 94.80
196 INT9549 Regulation of CHKB 25 0.47 13.61 3.2 94.80
197 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 94.80
198 INT9551 Regulation of AK1 2 0.03 1.38 1.03 94.80
199 INT142006 Positive_regulation of COL18A1 2 0.41 3.01 0.53 94.76
200 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64 94.72
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