D:Heart Failure

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Disease Term
Synonyms Biventricular Failure, Cardiac Decompensation, CARDIAC FAILURE, Cardiac Function Failed, Cardiac Function Failure, Ccf, Ccf Congestive Cardiac Failure, Chf Congestive Heart Failure, CONGESTIVE HEART DISEASE, Congestive Heart Failure, Congestive Heart Failures
Documents 139
Hot Single Events 84
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Heart Failure. They are ordered first by their relevance to Heart Failure and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT233401 COPD Regulation of HEY1 1 0.07 1.67 0 100.00
2 INT233400 COPD Regulation of CRH 1 0.11 1.67 0 100.00
3 INT208139 Binding of PITX1 and URI1 1 0.01 0.62 0 100.00
4 INT355503 Positive_regulation of SCN10A Positive_regulation of Localization of NPY 1 0.17 1.32 0.22 95.48
5 INT355504 ANGPT2 Positive_regulation of CYBB 1 0.01 0.81 0.18 89.44
6 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37 70.76
7 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 68.40
8 INT316543 GH1 Regulation of Gene_expression of IGF1 1 0.03 1.32 0.09 64.60
9 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 50.00
10 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 5.00
11 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
12 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77 5.00
13 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 5.00
14 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 0.03 1.32 0.37 5.00
15 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37 5.00
16 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34 5.00
17 INT198642 GPI Positive_regulation of TNF 1 0.03 0.98 0.33 5.00
18 INT198640 TNF Positive_regulation of ISYNA1 1 0.04 1.07 0.29 5.00
19 INT198648 VCAM1 Positive_regulation of CADM1 1 0.00 1.1 0.25 5.00
20 INT198644 TNF Positive_regulation of CADM1 1 0.02 1.07 0.24 5.00
21 INT198643 CD36 Positive_regulation of CADM1 1 0.01 1.07 0.24 5.00
22 INT195212 Binding of CCR4 and Hand2 1 0.03 0.46 0.21 5.00
23 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18 5.00
24 INT198638 GPI Positive_regulation of Gene_expression of TNF 1 0.03 1.44 0.15 5.00
25 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13 5.00
26 INT316552 Binding of SST and Sst1 1 0.03 0.53 0.09 5.00
27 INT198639 S100A12 Positive_regulation of TNF 1 0.15 1.49 0.04 5.00
28 INT198646 S100A12 Positive_regulation of IL1B 1 0.01 1.49 0.04 5.00
29 INT231771 Binding of HMOX1 and TNF 2 0.14 1.41 0.04 5.00
30 INT198651 Positive_regulation of S100A12 Positive_regulation of TNF 1 0.15 1.5 0.04 5.00
31 INT213392 Binding of SELPLG and XPO1 1 0.02 0.31 0.04 5.00
32 INT198650 Positive_regulation of S100A12 Positive_regulation of IL1B 1 0.01 1.5 0.04 5.00
33 INT335492 CREM Positive_regulation of Transcription of HMOX1 1 0.00 0.9 0.03 5.00
34 INT344266 Binding of APOH and CD40LG 1 0.04 0.31 0 5.00
35 INT213390 Positive_regulation of Binding of CHKB and SELPLG 1 0.01 0.46 0 5.00
36 INT213391 Positive_regulation of Binding of CHKB and XPO1 1 0.04 0.46 0 5.00
37 INT312379 KIT Positive_regulation of Positive_regulation of Kit 1 0.01 1.37 0 5.00
38 INT213393 Binding of CHKB and SELPLG 1 0.01 0.46 0 5.00
39 INT213394 Binding of CHKB and XPO1 1 0.03 0.46 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Heart Failure. They are ordered first by their pain relevance and then by number of times they were reported in Heart Failure. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5454 Localization of CRH 124 0.79 79.18 41.53 100.00
2 INT121333 Localization of HEY1 11 0.65 18.17 0.72 100.00
3 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 100.00
4 INT208142 Gene_expression of PITX1 3 0.65 9.36 0.73 100.00
5 INT171070 Positive_regulation of Hey2 8 0.05 10.12 1.96 100.00
6 INT219695 Positive_regulation of Gene_expression of COPD 24 0.40 33.04 3.42 100.00
7 INT176618 Gene_expression of HEY1 29 0.59 36 4.37 100.00
8 INT208140 Localization of PITX1 2 0.73 6.18 0.14 100.00
9 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74 100.00
10 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 100.00
11 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89 100.00
12 INT187286 Binding of HEY1 17 0.32 31.21 4.52 100.00
13 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7 100.00
14 INT187288 Positive_regulation of Gene_expression of HEY1 5 0.17 8.42 0.89 100.00
15 INT208141 Positive_regulation of PITX1 1 0.30 1.46 0 100.00
16 INT171073 Regulation of Positive_regulation of Hey2 1 0.03 1.22 0.45 100.00
17 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 100.00
18 INT63534 Binding of CRH 23 0.47 6.84 3.43 100.00
19 INT171074 Gene_expression of Hey2 2 0.44 0.83 0.14 100.00
20 INT115963 Negative_regulation of Gene_expression of CRH 9 0.59 4.53 1.48 100.00
21 INT179688 Negative_regulation of Gene_expression of COPD 13 0.35 16.06 0.97 100.00
22 INT187287 Negative_regulation of Gene_expression of HEY1 2 0.16 2.96 0.45 100.00
23 INT171071 Negative_regulation of Hey2 1 0.03 1.31 0.48 100.00
24 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 100.00
25 INT293961 Binding of PITX1 1 0.31 1.73 0.1 100.00
26 INT184625 Localization of Skap2 4 0.62 0.5 0.03 100.00
27 INT147793 Localization of COPD 70 0.64 89.01 7.3 99.92
28 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 99.92
29 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 99.88
30 INT70970 Binding of COPD 144 0.42 180.34 18.29 99.84
31 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 99.84
32 INT142491 Positive_regulation of Positive_regulation of SCN10A 6 0.61 3.48 0.35 99.84
33 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 99.68
34 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 99.04
35 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 98.76
36 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21 98.70
37 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 98.40
38 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 98.36
39 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 98.32
40 INT159472 Localization of NPPB 32 0.79 33.67 3.59 98.32
41 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84 98.20
42 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 98.16
43 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.00
44 INT52348 Positive_regulation of CHM 7 0.44 4.18 0.25 97.84
45 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 97.68
46 INT29231 Regulation of Dbp 44 0.53 10.08 4.47 97.64
47 INT9083 Gene_expression of Nppb 74 0.78 70.96 12.19 97.36
48 INT9655 Regulation of Il6 98 0.62 70.92 31.95 97.20
49 INT116527 Positive_regulation of Gene_expression of HMOX1 29 0.70 25.79 4.87 97.06
50 INT165681 Positive_regulation of Transcription of HMOX1 2 0.69 4.29 0.53 97.06
51 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 96.82
52 INT165680 Transcription of HMOX1 7 0.71 11.2 1.41 96.82
53 INT131877 Negative_regulation of Nps 12 0.39 8.19 3.56 96.44
54 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 96.24
55 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 96.12
56 INT240681 Positive_regulation of AVPR2 3 0.41 0.87 0.29 95.28
57 INT252 Localization of GH1 529 0.80 227.4 122.05 95.16
58 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24 94.56
59 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 94.04
60 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 94.00
61 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 93.12
62 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 93.00
63 INT72182 Gene_expression of Mcpt1 167 0.75 123.7 52.15 92.80
64 INT24366 Positive_regulation of Localization of NPY 4 0.50 4.01 3.79 92.80
65 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92 92.64
66 INT11243 Localization of NPY 33 0.78 11.18 19.24 92.24
67 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 91.84
68 INT112969 Negative_regulation of Mcpt1 30 0.45 20.17 10.11 91.32
69 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 90.40
70 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 90.40
71 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 90.40
72 INT210088 Regulation of Life1 3 0.00 1.15 0.07 89.96
73 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52 89.48
74 INT35609 Negative_regulation of F10 37 0.57 17.15 4.41 89.04
75 INT18008 Negative_regulation of IL3 4 0.40 1.5 0.62 88.76
76 INT214 Localization of AVP 370 0.81 208.51 91.09 88.56
77 INT171072 Negative_regulation of Fcr 2 0.07 1.71 0.31 85.16
78 INT45159 Regulation of Nppb 16 0.54 13.57 4.46 84.64
79 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 83.52
80 INT94784 Binding of ROS1 113 0.40 71.57 10.26 82.72
81 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 82.24
82 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 82.24
83 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 81.88
84 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 81.12
85 INT16919 Gene_expression of IL36RN 48 0.48 32.78 13.83 79.92
86 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 78.80
87 INT344283 Negative_regulation of Gene_expression of CPB1 1 0.07 0.61 0.06 78.44
88 INT14182 Gene_expression of CPB1 26 0.67 10.06 1.9 77.52
89 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 77.40
90 INT661 Gene_expression of REN 100 0.78 48.21 11.36 76.72
91 INT72717 Gene_expression of Nppc 8 0.51 6.25 0.39 75.64
92 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29 75.36
93 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 73.68
94 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 73.68
95 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 73.12
96 INT55114 Gene_expression of CRS 42 0.58 26.86 4.69 69.40
97 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 68.96
98 INT685 Regulation of AVP 124 0.62 34.9 39.91 68.08
99 INT4047 Binding of F13A1 105 0.43 66.54 11.81 63.28
100 INT9842 Binding of F2 36 0.47 22.79 4.42 63.28
101 INT71794 Binding of SERPINC1 17 0.39 10.5 2.64 61.96
102 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 59.36
103 INT237862 Positive_regulation of Gene_expression of Nps 8 0.43 3.82 1.52 59.36
104 INT93789 Gene_expression of Tnnc1 28 0.76 17.3 1.99 58.52
105 INT1893 Localization of Gh 1041 0.79 340.23 256.58 57.76
106 INT155889 Binding of Nps 22 0.42 9.79 2.6 56.04
107 INT38330 Binding of Adh1 4 0.41 3.98 0.3 52.16
108 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 50.00
109 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 50.00
110 INT45272 Regulation of Nps 15 0.39 8.08 2.69 50.00
111 INT84264 Regulation of NPPB 22 0.61 21.18 1.94 50.00
112 INT23921 Negative_regulation of NPPB 13 0.58 16.19 0.9 50.00
113 INT237866 Positive_regulation of Positive_regulation of Nps 5 0.48 2.67 0.69 50.00
114 INT157226 Positive_regulation of Gene_expression of Tnnc1 11 0.49 6.21 0.57 50.00
115 INT296884 Negative_regulation of Negative_regulation of NPPB 1 0.01 1.37 0 50.00
116 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 44.68
117 INT443 Localization of POMC 1020 0.81 284.52 443.17 44.28
118 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 42.08
119 INT272228 Localization of TGFBR1 1 0.34 0.74 0 36.92
120 INT272225 Localization of Tgfbr2 1 0.29 0.74 0 36.92
121 INT9256 Gene_expression of SELPLG 30 0.75 16.44 3.66 36.64
122 INT124651 Gene_expression of XPO1 2 0.30 0.64 0 36.64
123 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 31.04
124 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 24.96
125 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 24.96
126 INT188634 Positive_regulation of Sig 6 0.41 8.76 0.04 22.20
127 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 9.60
128 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 6.68
129 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
130 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
131 INT162 Regulation of Prl 794 0.62 165.01 322.24 5.00
132 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
133 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
134 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
135 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
136 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
137 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
138 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
139 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
140 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
141 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
142 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
143 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
144 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
145 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
146 INT5617 Localization of Nppa 266 0.81 83.51 83.89 5.00
147 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
148 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
149 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
150 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
151 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
152 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
153 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
154 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
155 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
156 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
157 INT921 Regulation of GH1 172 0.60 52.88 51.04 5.00
158 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
159 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
160 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 5.00
161 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
162 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
163 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
164 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
165 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
166 INT916 Regulation of Localization of PRL 92 0.62 22.98 38.13 5.00
167 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
168 INT5620 Positive_regulation of Localization of Nppa 105 0.70 30.23 36.45 5.00
169 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
170 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
171 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
172 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 5.00
173 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
174 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
175 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
176 INT121663 Gene_expression of CXCR3 76 0.77 50.96 30.62 5.00
177 INT7412 Positive_regulation of SST 71 0.70 24.44 29.48 5.00
178 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
179 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
180 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
181 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
182 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 5.00
183 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
184 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
185 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
186 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
187 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
188 INT182217 Gene_expression of CCR9 8 0.75 44.81 18.15 5.00
189 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
190 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
191 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 5.00
192 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
193 INT75908 Regulation of LEP 77 0.60 60.16 15.19 5.00
194 INT22276 Gene_expression of TBXA2R 65 0.77 23.22 14.21 5.00
195 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
196 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
197 INT14764 Negative_regulation of Localization of Nppa 28 0.59 11.29 12.82 5.00
198 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78 5.00
199 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
200 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 5.00
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