D:Heart Injuries

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Disease Term
Synonyms Cardiac Rupture Traumatic, Cardiac Ruptures Traumatic, Heart Injury, Heart Rupture Traumatic, Heart Ruptures Traumatic, Injuries Heart, Injury Heart, Rupture Traumatic Cardiac, Rupture Traumatic Heart, Ruptures Traumatic Cardiac, Ruptures Traumatic Heart
Documents 24
Hot Single Events 20
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Heart Injuries. They are ordered first by their relevance to Heart Injuries and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 0.02 2.42 0.51 5.00
2 INT271350 MPO Positive_regulation of TIMP1 1 0.05 1.66 0.29 5.00
3 INT89612 Binding of FABP3 and MB 3 0.34 1.49 0.22 5.00
4 INT271345 Negative_regulation of PIGF Negative_regulation of FLT1 1 0.02 1.17 0.13 5.00
5 INT271343 Binding of CRP and PAPPA 1 0.20 0.86 0.1 5.00
6 INT271349 ACCS Positive_regulation of PAPPA 1 0.06 0.87 0.09 5.00
7 INT271347 Negative_regulation of Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
8 INT271354 MPO Regulation of Gene_expression of CRP 1 0.16 1.74 0.08 5.00
9 INT271346 Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
10 INT271351 MPO Positive_regulation of CRP 1 0.07 1.69 0.08 5.00
11 INT271355 PGF Positive_regulation of PIGF 1 0.01 0.99 0.06 5.00
12 INT106823 Binding of MBP and PAPPA 2 0.17 3.89 0.05 5.00
13 INT271328 FABP3 Positive_regulation of Binding of FABP3 and MB 1 0.00 0.81 0.03 5.00
14 INT340502 Agtr1a Negative_regulation of Phosphorylation of Jak2 1 0.12 2.32 0 5.00
15 INT340504 Agtr1a Negative_regulation of Phosphorylation of Pik3cb 1 0.06 1.16 0 5.00
16 INT271348 Binding of CHKB and MB 1 0.01 1.01 0 5.00
17 INT191258 Binding of LRPAP1 and GOPC 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Heart Injuries. They are ordered first by their pain relevance and then by number of times they were reported in Heart Injuries. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 98.76
2 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 98.72
3 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 98.72
4 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 98.72
5 INT149755 Transcription of P2rx3 13 0.60 8.28 2.11 98.64
6 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24 98.64
7 INT68187 Gene_expression of TNNT2 21 0.67 10.22 1.64 98.44
8 INT149753 Negative_regulation of Transcription of P2rx3 3 0.38 2.59 0.52 97.48
9 INT96803 Negative_regulation of Gene_expression of P2rx3 6 0.51 3.65 2.49 97.48
10 INT127630 Regulation of Slc9a1 3 0.42 0.79 0.22 95.92
11 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 94.00
12 INT5619 Positive_regulation of Gene_expression of Nppa 21 0.70 11.95 4.41 94.00
13 INT60552 Localization of TNNI3 56 0.79 20.05 1.44 93.16
14 INT49302 Localization of TNNT2 6 0.78 3.1 0.34 93.16
15 INT100188 Positive_regulation of Gene_expression of P2rx3 8 0.49 5.96 3.26 92.92
16 INT149754 Positive_regulation of Transcription of P2rx3 5 0.44 3 0.59 92.92
17 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15 86.16
18 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 85.52
19 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 81.92
20 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 80.80
21 INT58302 Regulation of Mpo 13 0.62 11.14 3.04 78.80
22 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 76.32
23 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 76.32
24 INT139180 Regulation of Positive_regulation of Fas 2 0.43 2.19 0.69 76.32
25 INT347940 Regulation of Positive_regulation of Fasl 1 0.30 1.95 0.13 76.32
26 INT135411 Gene_expression of Il23a 76 0.72 72.87 26.15 73.04
27 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24 65.20
28 INT141275 Negative_regulation of Gene_expression of Hand1 18 0.34 15.83 5.05 65.20
29 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 64.76
30 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 64.76
31 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 64.76
32 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 64.76
33 INT79835 Regulation of Il10 28 0.61 21.22 11.29 62.16
34 INT296054 Positive_regulation of Il22 13 0.33 17.97 4.06 61.84
35 INT3703 Negative_regulation of Grhpr 38 0.50 11.43 9.2 61.12
36 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 61.04
37 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 60.56
38 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 56.16
39 INT77490 Positive_regulation of Tnnc1 85 0.68 43.54 9.07 49.12
40 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 41.84
41 INT10166 Localization of Tnf 237 0.81 153.95 88.64 24.96
42 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 20.72
43 INT46713 Binding of TNNC1 10 0.35 6.35 2.28 16.72
44 INT190027 Regulation of Apaf1 2 0.16 2.59 0.04 16.40
45 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16 11.52
46 INT227406 Regulation of Bcl2l10 2 0.03 2.99 0.13 11.52
47 INT64538 Binding of TNNI3 17 0.48 11.65 1.83 6.48
48 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
49 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 5.00
50 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
51 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
52 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
53 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
54 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
55 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
56 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 5.00
57 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44 5.00
58 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
59 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 5.00
60 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 5.00
61 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
62 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
63 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
64 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 5.00
65 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 5.00
66 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
67 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
68 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
69 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
70 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
71 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
72 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
73 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
74 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 5.00
75 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
76 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
77 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
78 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 5.00
79 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
80 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 5.00
81 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
82 INT97596 Localization of S100a8 94 0.78 90.69 40.41 5.00
83 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
84 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
85 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
86 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
87 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 5.00
88 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
89 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
90 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
91 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07 5.00
92 INT234 Binding of Alb 151 0.48 52.34 32.97 5.00
93 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
94 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
95 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
96 INT35406 Localization of Tnf 94 0.81 64.63 31.65 5.00
97 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 5.00
98 INT1158 Regulation of Agt 106 0.61 29.4 30.29 5.00
99 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
100 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 5.00
101 INT16428 Positive_regulation of Gtf3a 135 0.20 106.44 26.67 5.00
102 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
103 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
104 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
105 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
106 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 5.00
107 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
108 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
109 INT7678 Localization of Alb 142 0.81 80.93 22.49 5.00
110 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 5.00
111 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
112 INT74682 Positive_regulation of Mmp2 72 0.69 40.46 21.73 5.00
113 INT78057 Localization of Tlr4 140 0.77 67.75 21.72 5.00
114 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 5.00
115 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 5.00
116 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62 5.00
117 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
118 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 5.00
119 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
120 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
121 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 5.00
122 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 5.00
123 INT10169 Positive_regulation of Localization of Tnf 44 0.70 27.71 16.75 5.00
124 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 5.00
125 INT74545 Negative_regulation of Gene_expression of Prkcg 22 0.42 7.77 16.26 5.00
126 INT6110 Negative_regulation of Gene_expression of Ins1 83 0.56 60.59 16.07 5.00
127 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
128 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
129 INT615 Regulation of Alb 66 0.62 33.43 15.33 5.00
130 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 5.00
131 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 5.00
132 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91 5.00
133 INT5904 Localization of MPO 62 0.81 36.37 14.64 5.00
134 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
135 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15 5.00
136 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
137 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
138 INT35120 Gene_expression of Sdcbp 68 0.67 21.33 13.96 5.00
139 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 5.00
140 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 5.00
141 INT22213 Localization of Gpt 52 0.78 34.05 12.94 5.00
142 INT27268 Localization of Gtf3a 71 0.21 56.93 12.51 5.00
143 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21 5.00
144 INT93620 Positive_regulation of Gene_expression of Fasl 51 0.66 59.45 12.04 5.00
145 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 5.00
146 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 5.00
147 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
148 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 5.00
149 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
150 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 5.00
151 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 5.00
152 INT160563 Localization of Il17a 34 0.74 26.53 10.24 5.00
153 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 5.00
154 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
155 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
156 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
157 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 5.00
158 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 5.00
159 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36 5.00
160 INT56223 Positive_regulation of MPO 35 0.70 43 8.2 5.00
161 INT17996 Binding of Crp 40 0.37 31.4 7.8 5.00
162 INT38971 Positive_regulation of Gene_expression of Gtf3a 27 0.60 18.25 7.77 5.00
163 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 5.00
164 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46 5.00
165 INT48626 Positive_regulation of Csf3 33 0.66 29.79 7.34 5.00
166 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
167 INT3098 Positive_regulation of Epo 46 0.70 28.27 7 5.00
168 INT16722 Negative_regulation of MPO 25 0.59 18.55 6.99 5.00
169 INT112986 Positive_regulation of S100b 19 0.70 17.61 6.86 5.00
170 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 5.00
171 INT78182 Positive_regulation of ACCS 43 0.43 46.39 6.78 5.00
172 INT24907 Gene_expression of PAPPA 42 0.75 28.32 6.63 5.00
173 INT91721 Binding of IL18 21 0.48 21.17 6.56 5.00
174 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 5.00
175 INT86805 Localization of HGF 49 0.71 28.48 6.35 5.00
176 INT934 Regulation of Gtf3a 25 0.35 11.35 6.34 5.00
177 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 5.00
178 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 5.00
179 INT115947 Regulation of Il17a 17 0.37 14.26 5.97 5.00
180 INT8916 Regulation of Igf1 45 0.60 13.06 5.81 5.00
181 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53 5.00
182 INT47662 Localization of CHKB 34 0.81 22.63 5.14 5.00
183 INT95631 Positive_regulation of Gene_expression of MMP8 16 0.50 13.75 5.12 5.00
184 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 5.00
185 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 5.00
186 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 5.00
187 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
188 INT45159 Regulation of Nppb 16 0.54 13.57 4.46 5.00
189 INT88182 Gene_expression of Atp2a2 40 0.78 22.91 4.26 5.00
190 INT81628 Positive_regulation of Gene_expression of Fas 32 0.67 38.13 4.23 5.00
191 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15 5.00
192 INT99608 Transcription of MMP9 18 0.65 9.67 4.11 5.00
193 INT116643 Phosphorylation of Pik3cb 12 0.80 4.73 3.87 5.00
194 INT117614 Positive_regulation of PAPPA 18 0.67 11.9 3.76 5.00
195 INT159472 Localization of NPPB 32 0.79 33.67 3.59 5.00
196 INT216985 Gene_expression of Ccl17 10 0.64 8.74 3.56 5.00
197 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
198 INT32517 Positive_regulation of LRPAP1 13 0.49 7.4 3.44 5.00
199 INT3919 Localization of Got1 10 0.71 2.95 3.28 5.00
200 INT226178 Gene_expression of thd 14 0.23 8.29 2.92 5.00
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