D:Heartburn

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pChart

Disease Term
Synonyms Brash, BURNING REFLUX, Heartburn Symptom, Pyroses, Pyrosis
Documents 84
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Heartburn. They are ordered first by their relevance to Heartburn and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT202620 Binding of Ppara and Rxra 15 0.09 2.63 1.11 5.00
2 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73 5.00
3 INT307215 Negative_regulation of Prkca Negative_regulation of Ppara 1 0.09 0.21 0.3 5.00
4 INT307207 Ppara Positive_regulation of Apoa2 1 0.10 0.94 0.25 5.00
5 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23 5.00
6 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12 5.00
7 INT307217 Fas Positive_regulation of Agpat2 1 0.06 0.27 0.07 5.00
8 INT307218 Binding of Rxra and D0Nrs1 1 0.00 0.1 0.05 5.00
9 INT307209 Fas Positive_regulation of Fasn 1 0.05 0.13 0.03 5.00
10 INT307214 Hnf4a Regulation of Ppara 1 0.18 0.35 0 5.00
11 INT307213 Srebf1 Regulation of Gene_expression of Fasn 1 0.05 0.06 0 5.00
12 INT307219 Mlxipl Regulation of Srebf1 1 0.07 0.12 0 5.00
13 INT307210 Ide Positive_regulation of Ppara 1 0.02 0.18 0 5.00
14 INT307216 Ppara Regulation of Srebf1 1 0.22 0.12 0 5.00
15 INT307208 Binding of Ppara and Nrip1 1 0.34 0.31 0 5.00
16 INT307212 Ide Regulation of Lep 1 0.00 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Heartburn. They are ordered first by their pain relevance and then by number of times they were reported in Heartburn. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 99.12
2 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39 97.20
3 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 96.70
4 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 96.40
5 INT18773 Localization of ALB 117 0.80 69.18 13.8 96.16
6 INT3530 Regulation of BCHE 18 0.60 5.47 4.12 96.08
7 INT3529 Regulation of GOT1 6 0.52 2.4 1.01 94.40
8 INT62848 Negative_regulation of GER 8 0.57 3.89 0.93 93.40
9 INT39664 Regulation of Ggt6 4 0.26 2.97 1.13 92.08
10 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 77.04
11 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 76.68
12 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 75.60
13 INT122041 Binding of Ppara 308 0.48 189.17 51.48 69.92
14 INT194462 Localization of Ppara 94 0.78 68.33 12.09 39.20
15 INT159058 Negative_regulation of Omd 3 0.37 2.93 1.6 26.04
16 INT155036 Localization of NT5E 6 0.73 4.1 1.35 15.44
17 INT200372 Positive_regulation of Omd 3 0.33 2.23 0.57 10.72
18 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
19 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
20 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
21 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 5.00
22 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 5.00
23 INT4853 Regulation of Hrh2 42 0.45 22.34 16.65 5.00
24 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
25 INT7475 Positive_regulation of Hdl1 138 0.67 175.81 15.05 5.00
26 INT93482 Localization of Rela 56 0.78 24.52 14.82 5.00
27 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 5.00
28 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
29 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 5.00
30 INT138799 Regulation of Gene_expression of Ppara 40 0.60 29.42 6.89 5.00
31 INT194479 Phosphorylation of Ppara 47 0.81 30.36 6.6 5.00
32 INT50712 Gene_expression of Comt 13 0.68 6.33 6.23 5.00
33 INT91147 Positive_regulation of Positive_regulation of Ppara 30 0.69 19.31 5.56 5.00
34 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2 5.00
35 INT122038 Transcription of Ppara 35 0.71 20.5 5.12 5.00
36 INT181186 Binding of Rxra 78 0.35 14.93 4.87 5.00
37 INT106524 Phosphorylation of Jun 23 0.80 15.35 4.78 5.00
38 INT2871 Positive_regulation of Comt 9 0.50 2.8 4.78 5.00
39 INT169492 Gene_expression of Mirlet7a-1 27 0.67 14.85 4.73 5.00
40 INT97903 Negative_regulation of FGFR1 16 0.17 5.6 4.57 5.00
41 INT93483 Negative_regulation of Localization of Rela 11 0.57 5.1 4.19 5.00
42 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
43 INT169495 Negative_regulation of Mirlet7a-1 10 0.58 4 3.53 5.00
44 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
45 INT102034 Positive_regulation of Ppard 10 0.69 3.97 3.17 5.00
46 INT128983 Protein_catabolism of Comt 5 0.87 0.22 2.6 5.00
47 INT190081 Gene_expression of Abca1 21 0.65 18.18 2.45 5.00
48 INT215378 Protein_catabolism of Ppara 12 0.86 5.12 2.14 5.00
49 INT57115 Negative_regulation of NT5E 8 0.57 4.35 2.03 5.00
50 INT211984 Regulation of Binding of Ppara 11 0.45 9.55 1.87 5.00
51 INT447 Localization of Comt 4 0.75 0.76 1.8 5.00
52 INT169491 Negative_regulation of Gene_expression of Mirlet7a-1 11 0.37 6.22 1.54 5.00
53 INT187411 Gene_expression of Cd320 23 0.75 12.1 1.39 5.00
54 INT190880 Binding of Ncor2 11 0.27 2.24 1.34 5.00
55 INT122040 Positive_regulation of Transcription of Ppara 9 0.50 3.97 1.33 5.00
56 INT197167 Positive_regulation of Localization of Ppara 18 0.67 9.51 1.21 5.00
57 INT227548 Negative_regulation of Localization of Ppara 7 0.38 4.1 1.17 5.00
58 INT169496 Localization of Mirlet7a-1 3 0.65 0.42 1.15 5.00
59 INT129425 Negative_regulation of Ldlr 22 0.42 17.15 0.97 5.00
60 INT211557 Gene_expression of Scarb1 30 0.75 5.03 0.94 5.00
61 INT236104 Positive_regulation of Negative_regulation of Ppara 6 0.59 6.91 0.91 5.00
62 INT287128 Protein_catabolism of NT5E 2 0.11 0.64 0.76 5.00
63 INT164082 Protein_catabolism of Omd 2 0.76 0.89 0.69 5.00
64 INT175945 Gene_expression of Acox1 7 0.65 2.77 0.68 5.00
65 INT287127 Gene_expression of Omd 6 0.39 1.63 0.67 5.00
66 INT187407 Negative_regulation of Gene_expression of Cd320 7 0.57 5.05 0.67 5.00
67 INT307186 Negative_regulation of Phosphorylation of Jun 4 0.10 2.91 0.61 5.00
68 INT111198 Gene_expression of Fasn 8 0.55 2.54 0.52 5.00
69 INT287125 Negative_regulation of Gene_expression of Omd 2 0.02 0.47 0.51 5.00
70 INT235512 Transcription of Lpl 10 0.42 2.76 0.49 5.00
71 INT203949 Regulation of Srebf1 8 0.38 3.19 0.48 5.00
72 INT100822 Localization of Fas 8 0.74 6.13 0.48 5.00
73 INT26073 Gene_expression of Scd1 17 0.70 9.17 0.47 5.00
74 INT251661 Phosphorylation of NT5E 2 0.21 1.59 0.46 5.00
75 INT170208 Negative_regulation of Lpl 15 0.49 6.07 0.45 5.00
76 INT28059 Positive_regulation of Apol7b 7 0.03 8.19 0.44 5.00
77 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39 5.00
78 INT194468 Positive_regulation of Phosphorylation of Ppara 4 0.46 2.11 0.38 5.00
79 INT200249 Binding of Ahrr 4 0.01 0.2 0.38 5.00
80 INT287129 Regulation of NT5E 3 0.12 1.02 0.32 5.00
81 INT253540 Positive_regulation of Transcription of Lpl 3 0.29 1.43 0.3 5.00
82 INT18933 Binding of GER 11 0.37 11.56 0.3 5.00
83 INT287124 Negative_regulation of Protein_catabolism of Comt 1 0.38 0.22 0.29 5.00
84 INT287126 Negative_regulation of Negative_regulation of Comt 1 0.37 0.78 0.25 5.00
85 INT307183 Positive_regulation of Gene_expression of Scarb1 1 0.07 0.93 0.22 5.00
86 INT105327 Positive_regulation of Ncoa2 3 0.06 1.85 0.21 5.00
87 INT118482 Negative_regulation of Fasn 3 0.31 0.83 0.21 5.00
88 INT301561 Negative_regulation of Acox1 4 0.30 2.13 0.2 5.00
89 INT187412 Negative_regulation of Cd320 5 0.42 3.09 0.18 5.00
90 INT262100 Gene_expression of Ncor2 3 0.42 0.31 0.12 5.00
91 INT107960 Positive_regulation of Ncoa1 3 0.37 1.59 0.08 5.00
92 INT225369 Gene_expression of nr 7 0.17 1.97 0.07 5.00
93 INT307190 Gene_expression of Agpat2 1 0.20 0.27 0.07 5.00
94 INT233912 Localization of Ncoa1 4 0.73 0.53 0.05 5.00
95 INT236137 Positive_regulation of Localization of Ncoa1 3 0.10 0.34 0.05 5.00
96 INT307185 Negative_regulation of Ncoa3 1 0.42 0.22 0 5.00
97 INT307197 Negative_regulation of Med1 1 0.30 0.7 0 5.00
98 INT307193 Positive_regulation of Gene_expression of Acox2 1 0.32 0.2 0 5.00
99 INT307188 Transcription of Med1 1 0.48 0.7 0 5.00
100 INT225442 Localization of Ncoa3 1 0.42 1.02 0 5.00
101 INT307205 Regulation of Binding of Ncor2 1 0.28 0.1 0 5.00
102 INT307203 Transcription of Scd1 2 0.32 1.11 0 5.00
103 INT307195 Positive_regulation of Mybbp1a 1 0.09 0.24 0 5.00
104 INT307187 Negative_regulation of Ncoa1 1 0.08 0.11 0 5.00
105 INT307180 Positive_regulation of Localization of Ncoa2 1 0.06 0.28 0 5.00
106 INT225400 Positive_regulation of Gene_expression of Med1 2 0.35 0.82 0 5.00
107 INT243074 Positive_regulation of Ncoa3 3 0.27 0.62 0 5.00
108 INT307182 Gene_expression of Nrip1 3 0.58 1.06 0 5.00
109 INT307179 Positive_regulation of Localization of Ncoa3 1 0.08 0.28 0 5.00
110 INT307200 Negative_regulation of Nrip1 2 0.41 1.72 0 5.00
111 INT307191 Protein_catabolism of Cat 1 0.10 0.19 0 5.00
112 INT307181 Localization of Ncoa2 1 0.10 0.28 0 5.00
113 INT307184 Positive_regulation of Transcription of Scd1 1 0.28 0 0 5.00
114 INT236694 Gene_expression of Acox2 2 0.53 0.42 0 5.00
115 INT307189 Localization of Med1 3 0.53 0.32 0 5.00
116 INT261756 Gene_expression of Dr1 2 0.26 0.34 0 5.00
117 INT225358 Negative_regulation of Gene_expression of Med1 2 0.30 1.16 0 5.00
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