D:Heat Stroke

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Disease Term
Synonyms Heat Cramps, Heat Exhaustion, Heat Strokes, Heatstroke, Heatstrokes, Siriasis, Stroke Heat, Strokes Heat, SUNSTROKE, THERMIC FEVER
Documents 86
Hot Single Events 36
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Heat Stroke. They are ordered first by their relevance to Heat Stroke and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT198653 TNF Positive_regulation of MIF 1 0.15 3.81 1.55 5.00
2 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
3 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 0.03 1.32 0.37 5.00
4 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34 5.00
5 INT198642 GPI Positive_regulation of TNF 1 0.03 0.98 0.33 5.00
6 INT198640 TNF Positive_regulation of ISYNA1 1 0.04 1.07 0.29 5.00
7 INT198648 VCAM1 Positive_regulation of CADM1 1 0.00 1.1 0.25 5.00
8 INT198644 TNF Positive_regulation of CADM1 1 0.02 1.07 0.24 5.00
9 INT198643 CD36 Positive_regulation of CADM1 1 0.01 1.07 0.24 5.00
10 INT207783 Binding of MRC1 and Ap3d1 1 0.00 2.54 0.22 5.00
11 INT337697 FGF2 Regulation of VEGFA 1 0.03 0.51 0.18 5.00
12 INT201212 FGF2 Regulation of FGFR1 2 0.09 1.01 0.18 5.00
13 INT337698 VEGFA Regulation of FGFR1 1 0.09 0.51 0.18 5.00
14 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18 5.00
15 INT207784 Ap3d1 Regulation of CACNA1S 1 0.05 0.97 0.16 5.00
16 INT198638 GPI Positive_regulation of Gene_expression of TNF 1 0.03 1.44 0.15 5.00
17 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13 5.00
18 INT207785 Binding of RYR1 and Ap3d1 1 0.06 3.24 0.13 5.00
19 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12 5.00
20 INT198639 S100A12 Positive_regulation of TNF 1 0.15 1.49 0.04 5.00
21 INT198646 S100A12 Positive_regulation of IL1B 1 0.01 1.49 0.04 5.00
22 INT198651 Positive_regulation of S100A12 Positive_regulation of TNF 1 0.15 1.5 0.04 5.00
23 INT198650 Positive_regulation of S100A12 Positive_regulation of IL1B 1 0.01 1.5 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Heat Stroke. They are ordered first by their pain relevance and then by number of times they were reported in Heat Stroke. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35 99.98
2 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 99.82
3 INT54619 Negative_regulation of Positive_regulation of Il1a 6 0.42 5.68 3.12 99.52
4 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24 99.40
5 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.20
6 INT7000 Positive_regulation of Htr2a 42 0.67 9.48 18.7 99.08
7 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54 98.90
8 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 98.84
9 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 98.84
10 INT2532 Negative_regulation of Cebpz 98 0.00 53.06 28.57 98.74
11 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 98.70
12 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 98.68
13 INT11747 Positive_regulation of IL2RA 22 0.67 16.55 6.95 98.60
14 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 98.56
15 INT35711 Positive_regulation of Sdcbp 110 0.60 50.45 22.11 98.44
16 INT58435 Gene_expression of Hspa1a 19 0.78 15.35 4.45 98.20
17 INT79721 Positive_regulation of Gene_expression of Hspa1a 13 0.69 10.69 1.17 98.20
18 INT151421 Negative_regulation of Positive_regulation of Sdcbp 11 0.30 6.61 3.32 97.98
19 INT35122 Negative_regulation of Sdcbp 43 0.51 22.01 4.34 97.66
20 INT207777 Binding of Ap3d1 1 0.07 14.51 1.91 97.00
21 INT207778 Positive_regulation of Binding of Ap3d1 1 0.06 1.26 0.52 97.00
22 INT2531 Positive_regulation of Cebpz 166 0.00 43.08 38.86 96.80
23 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58 96.32
24 INT58338 Negative_regulation of Localization of Il1a 8 0.25 3.13 5.18 96.08
25 INT5966 Localization of Il1a 50 0.78 22.91 26.54 96.08
26 INT35121 Negative_regulation of Gene_expression of Sdcbp 6 0.43 2.4 1.83 95.84
27 INT35120 Gene_expression of Sdcbp 68 0.67 21.33 13.96 95.84
28 INT24712 Positive_regulation of Ap3d1 18 0.54 8.58 2.71 95.72
29 INT8841 Positive_regulation of ICT1 3 0.34 2.27 0.17 89.08
30 INT316 Regulation of Cebpz 105 0.00 27.21 35.41 88.64
31 INT7134 Localization of KNG1 127 0.79 65.73 67.97 88.04
32 INT98609 Negative_regulation of PYGM 11 0.43 6.21 0.6 87.92
33 INT106972 Gene_expression of MAP2 36 0.75 9.72 3.87 86.84
34 INT186995 Gene_expression of RBFOX3 17 0.30 2.31 1.3 86.84
35 INT4651 Gene_expression of Cebpz 39 0.00 20.19 8.5 83.32
36 INT36777 Gene_expression of CTD 12 0.41 11.47 1.42 83.04
37 INT55305 Regulation of RYR1 14 0.45 5.27 1.33 72.96
38 INT15648 Positive_regulation of RYR1 30 0.67 12.03 3.26 69.88
39 INT2442 Localization of Mb 38 0.80 24.74 6.33 68.80
40 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 63.20
41 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 63.20
42 INT170090 Gene_expression of ICT1 6 0.07 3.96 0.37 59.76
43 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 58.68
44 INT2393 Positive_regulation of Mb 174 0.69 93.59 26.79 50.00
45 INT2792 Gene_expression of Mb 91 0.76 41.56 10.25 50.00
46 INT23954 Negative_regulation of Mb 24 0.49 11.27 2.55 50.00
47 INT11365 Positive_regulation of Localization of Mb 5 0.38 3.78 1.54 50.00
48 INT38573 Positive_regulation of Gene_expression of Mb 10 0.46 2.11 0.54 50.00
49 INT40857 Positive_regulation of MAOA 6 0.49 2.51 1.71 42.96
50 INT103095 Binding of ISYNA1 10 0.28 6.17 2.03 38.84
51 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 36.04
52 INT207779 Localization of Ap3d1 1 0.11 3.16 0.14 29.52
53 INT50595 Positive_regulation of HRASLS 16 0.49 9.65 4.24 28.44
54 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91 10.44
55 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
56 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
57 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
58 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
59 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
60 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
61 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
62 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
63 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
64 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
65 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
66 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
67 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
68 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
69 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
70 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 5.00
71 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
72 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 5.00
73 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
74 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
75 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
76 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 5.00
77 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
78 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
79 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
80 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
81 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
82 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
83 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
84 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
85 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 5.00
86 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
87 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
88 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
89 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
90 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
91 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 5.00
92 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 5.00
93 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 5.00
94 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
95 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
96 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
97 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
98 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3 5.00
99 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 5.00
100 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
101 INT7675 Gene_expression of ENG 146 0.77 45.35 34.6 5.00
102 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89 5.00
103 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
104 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
105 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 5.00
106 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
107 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
108 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 5.00
109 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
110 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
111 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
112 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 5.00
113 INT15470 Regulation of CPP 42 0.48 26.1 18.25 5.00
114 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
115 INT111416 Positive_regulation of Trpm8 65 0.70 14.62 17.13 5.00
116 INT38056 Localization of Crp 71 0.78 53.14 17.03 5.00
117 INT20216 Localization of NGF 40 0.80 18.16 16.61 5.00
118 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 5.00
119 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 5.00
120 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
121 INT111488 Gene_expression of HAS1 56 0.77 32.6 15.29 5.00
122 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14 5.00
123 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
124 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 5.00
125 INT174838 Localization of INCENP 80 0.64 19.05 12.89 5.00
126 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 5.00
127 INT2385 Gene_expression of MIF 57 0.68 40.74 12.78 5.00
128 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 5.00
129 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
130 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
131 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
132 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
133 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
134 INT111223 Positive_regulation of HMOX1 47 0.70 39.14 10.92 5.00
135 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
136 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4 5.00
137 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 5.00
138 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
139 INT67101 Gene_expression of DST 47 0.54 25.92 9.59 5.00
140 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
141 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
142 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
143 INT860 Regulation of ALB 48 0.60 25.11 8.95 5.00
144 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 5.00
145 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 5.00
146 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
147 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41 5.00
148 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 5.00
149 INT38644 Positive_regulation of DST 30 0.53 12.48 6.59 5.00
150 INT28122 Gene_expression of MSC 111 0.58 26.83 6.57 5.00
151 INT142082 Positive_regulation of IDO1 17 0.60 9.46 6.33 5.00
152 INT121370 Positive_regulation of MIF 22 0.70 17.79 6.08 5.00
153 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 5.00
154 INT32458 Gene_expression of VWF 57 0.78 28.97 5.56 5.00
155 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 5.00
156 INT62525 Positive_regulation of SELE 38 0.70 46 5.25 5.00
157 INT83442 Negative_regulation of MIF 18 0.57 9.51 5.12 5.00
158 INT59555 Binding of RYR1 39 0.42 8.65 4.92 5.00
159 INT191343 Gene_expression of IDO1 23 0.55 11.3 4.81 5.00
160 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72 5.00
161 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 5.00
162 INT24910 Negative_regulation of Enpp3 20 0.57 8.23 4.67 5.00
163 INT21855 Gene_expression of Ap3d1 4 0.32 12.21 4.66 5.00
164 INT9842 Binding of F2 36 0.47 22.79 4.42 5.00
165 INT35744 Binding of MAOB 13 0.46 7.52 4.26 5.00
166 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 5.00
167 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 5.00
168 INT184288 Localization of HMGB1 20 0.61 14.5 3.84 5.00
169 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
170 INT9256 Gene_expression of SELPLG 30 0.75 16.44 3.66 5.00
171 INT102076 Regulation of DST 15 0.22 10 3.5 5.00
172 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 5.00
173 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38 5.00
174 INT117476 Negative_regulation of Gene_expression of Mpo 10 0.43 8.25 3.33 5.00
175 INT9549 Regulation of CHKB 25 0.47 13.61 3.2 5.00
176 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11 5.00
177 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06 5.00
178 INT21853 Regulation of Ap3d1 3 0.10 1.4 2.95 5.00
179 INT163290 Binding of MIF 9 0.31 7.57 2.8 5.00
180 INT41874 Positive_regulation of GPI 9 0.49 9.97 2.79 5.00
181 INT181267 Gene_expression of USE1 12 0.32 7.6 2.7 5.00
182 INT142908 Localization of FGFR1 18 0.38 11.46 2.57 5.00
183 INT71933 Positive_regulation of Gene_expression of F2 19 0.56 14.24 2.53 5.00
184 INT39560 Positive_regulation of F10 25 0.67 10.67 2.5 5.00
185 INT24672 Localization of FGF2 27 0.71 14.59 2.48 5.00
186 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48 5.00
187 INT198662 Positive_regulation of CD36 14 0.68 7.73 2.36 5.00
188 INT4210 Gene_expression of MB 24 0.78 11.74 2.32 5.00
189 INT47543 Positive_regulation of Chrm3 11 0.38 5.23 2.17 5.00
190 INT170469 Gene_expression of THY1 66 0.65 11.9 2.15 5.00
191 INT6508 Gene_expression of RYR1 34 0.77 11.11 2.04 5.00
192 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 5.00
193 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92 5.00
194 INT16385 Regulation of C3 20 0.41 9.98 1.92 5.00
195 INT130775 Regulation of FASLG 4 0.30 5.8 1.82 5.00
196 INT98580 Positive_regulation of CADM1 11 0.49 10.16 1.78 5.00
197 INT11713 Localization of RYR1 22 0.76 10.42 1.64 5.00
198 INT198663 Positive_regulation of HMGB1 14 0.52 11.41 1.58 5.00
199 INT21852 Regulation of Gene_expression of Ap3d1 2 0.18 1.34 1.54 5.00
200 INT112540 Negative_regulation of Hmgb1 2 0.26 1.98 1.51 5.00
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