D:Hemangioblastoma

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Disease Term
Synonyms Hemangioblastoma Multiple, HEMANGIOBLASTOMAS, Hemangioblastomas Multiple, Multiple Hemangioblastoma, MULTIPLE HEMANGIOBLASTOMAS
Documents 39
Hot Single Events 18
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hemangioblastoma. They are ordered first by their relevance to Hemangioblastoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT74015 Binding of VHL and XRCC1 1 0.07 3.51 0.09 98.68
2 INT342164 Binding of Csf2 and Nkx2-1 1 0.01 0.52 0.26 73.92
3 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2 73.92
4 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11 58.64
5 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25 5.00
6 INT241120 Binding of Sdhc and Sdhd 1 0.00 1.28 0 5.00
7 INT199581 Braf Negative_regulation of Phosphorylation of tk 1 0.05 0.6 0 5.00
8 INT241119 Binding of Sdhc and Sdhb 1 0.00 1.29 0 5.00
9 INT199576 Raf1 Negative_regulation of Akt1 1 0.00 0.79 0 5.00
10 INT199580 Braf Negative_regulation of Phosphorylation of Mdk 1 0.11 0.6 0 5.00
11 INT199577 Tnk1 Negative_regulation of Akt1 1 0.00 0.79 0 5.00
12 INT251983 XRCC1 Regulation of Binding of MET 1 0.05 0.4 0 5.00
13 INT199582 Braf Negative_regulation of Akt1 1 0.00 0.79 0 5.00
14 INT199579 Tnk1 Negative_regulation of Raf1 1 0.01 0.78 0 5.00
15 INT199578 Tnk1 Negative_regulation of Braf 1 0.01 0.78 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hemangioblastoma. They are ordered first by their pain relevance and then by number of times they were reported in Hemangioblastoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68665 Binding of Vhl 9 0.48 10.3 0.82 99.88
2 INT327824 Positive_regulation of Gene_expression of Aqp1 4 0.67 5.4 1.37 99.20
3 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68 98.84
4 INT121493 Gene_expression of XRCC1 55 0.65 73.43 2.76 98.68
5 INT120519 Localization of XRCC1 15 0.78 17.03 1.51 98.68
6 INT11551 Localization of VHL 12 0.65 22.76 0.68 97.56
7 INT100375 Gene_expression of Vhl 14 0.15 22.3 1.69 97.44
8 INT100376 Positive_regulation of Gene_expression of Vhl 4 0.10 6.47 1.47 97.44
9 INT84798 Gene_expression of Vhl 2 0.48 2.28 0.35 96.24
10 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 95.04
11 INT173080 Positive_regulation of Gene_expression of VHL 3 0.50 9.58 0.1 95.04
12 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 95.04
13 INT74016 Binding of VHL 20 0.48 15.49 0.54 94.28
14 INT241117 Regulation of Gene_expression of Vhl 1 0.06 2.5 0.07 89.88
15 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3 86.88
16 INT73223 Gene_expression of UPF1 78 0.41 31.44 9.94 86.72
17 INT251997 Negative_regulation of Transcription of VHL 1 0.37 1.32 0 84.92
18 INT185287 Transcription of VHL 2 0.60 3.77 0 84.44
19 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 76.60
20 INT75932 Binding of Csf2 45 0.37 33.2 8.01 73.44
21 INT194912 Regulation of Binding of Csf2 3 0.10 3.03 1.41 73.44
22 INT235467 Negative_regulation of Gene_expression of VHL 9 0.43 8.67 0 73.28
23 INT173086 Negative_regulation of VHL 14 0.59 12.54 0.29 70.08
24 INT148702 Positive_regulation of UPF1 29 0.31 12.9 1.91 68.56
25 INT342161 Positive_regulation of Gene_expression of Mapk9 1 0.09 0.63 0.35 68.28
26 INT241118 Negative_regulation of Vhl 3 0.11 4.01 0.08 68.12
27 INT159784 Gene_expression of Mapk9 8 0.61 6.28 1.37 67.72
28 INT319970 Gene_expression of Mapk12 2 0.08 1.47 0.38 67.72
29 INT199571 Binding of Vhl 3 0.23 3.4 0.07 66.92
30 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 66.00
31 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 64.40
32 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66 58.64
33 INT199574 Positive_regulation of Gene_expression of Vhl 1 0.24 1.42 0.12 58.64
34 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 57.20
35 INT118833 Positive_regulation of Gene_expression of Vegfa 11 0.65 8.14 1.7 57.20
36 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 56.56
37 INT109535 Gene_expression of Vegfa 116 0.75 84.61 14.89 56.56
38 INT97973 Positive_regulation of XRCC1 24 0.40 30.95 2.26 51.48
39 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 50.16
40 INT156132 Gene_expression of Aqp9 26 0.49 14.33 3.48 50.08
41 INT169136 Regulation of Csad 3 0.24 2.02 1.75 47.52
42 INT160023 Regulation of Aqp4 9 0.45 8.41 4.19 44.48
43 INT104570 Localization of Aqp1 8 0.77 5.83 3.51 33.16
44 INT109650 Gene_expression of Aqp4 87 0.78 51.52 20.72 29.92
45 INT104569 Gene_expression of Aqp2 23 0.60 16.56 12.23 29.92
46 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 25.08
47 INT106020 Transcription of EPO 8 0.71 9.34 0.6 25.08
48 INT241100 Negative_regulation of Binding of FH 1 0.11 2.76 0.05 21.60
49 INT152215 Binding of FH 10 0.41 14.13 0.19 19.84
50 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 16.72
51 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 14.00
52 INT309251 Gene_expression of OGDHL 1 0.01 0.64 0.29 8.40
53 INT68564 Binding of Fap 6 0.32 6.75 0.65 5.16
54 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
55 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 5.00
56 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
57 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 5.00
58 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
59 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
60 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
61 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
62 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
63 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
64 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 5.00
65 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
66 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
67 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
68 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
69 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 5.00
70 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 5.00
71 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1 5.00
72 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 5.00
73 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
74 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18 5.00
75 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
76 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
77 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
78 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
79 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
80 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
81 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35 5.00
82 INT111050 Negative_regulation of Gene_expression of Nav1 23 0.58 5.97 17.06 5.00
83 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 5.00
84 INT98647 Positive_regulation of Mdk 65 0.59 32.93 15.67 5.00
85 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59 5.00
86 INT112207 Binding of Nav1 27 0.47 7.1 15.43 5.00
87 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
88 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
89 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
90 INT12464 Binding of MET 38 0.47 10.3 13.15 5.00
91 INT12156 Positive_regulation of MET 43 0.67 17.75 12.64 5.00
92 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
93 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91 5.00
94 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 5.00
95 INT144430 Gene_expression of Erbb2 137 0.77 103.87 8.66 5.00
96 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 5.00
97 INT165 Regulation of HRH1 12 0.45 1.76 7.57 5.00
98 INT327801 Positive_regulation of Gene_expression of Aqp2 6 0.44 7.67 7.24 5.00
99 INT9397 Regulation of MET 17 0.60 8.36 7.04 5.00
100 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
101 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
102 INT85075 Phosphorylation of Mdk 22 0.61 10.29 5.55 5.00
103 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22 5.00
104 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
105 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94 5.00
106 INT199560 Binding of Braf 4 0.30 8.83 4.8 5.00
107 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
108 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
109 INT144428 Positive_regulation of Gene_expression of Erbb2 41 0.69 41.4 4.13 5.00
110 INT88278 Binding of Kit 33 0.37 24.45 4.13 5.00
111 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71 5.00
112 INT4922 Negative_regulation of MET 19 0.57 13.97 3.7 5.00
113 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 5.00
114 INT86082 Localization of Htr1b 4 0.73 2.77 3.46 5.00
115 INT139807 Gene_expression of Braf 7 0.51 8.78 3.34 5.00
116 INT131748 Binding of Csad 5 0.32 5.23 3.32 5.00
117 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14 5.00
118 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
119 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 5.00
120 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
121 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
122 INT262476 Gene_expression of Aqp8 21 0.34 7.94 2.76 5.00
123 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
124 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
125 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 5.00
126 INT97479 Gene_expression of Tks 11 0.52 3.66 2.44 5.00
127 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 5.00
128 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 5.00
129 INT98376 Gene_expression of tk 27 0.51 21.9 2.23 5.00
130 INT141721 Binding of Aqp1 5 0.37 1.77 2.15 5.00
131 INT157927 Gene_expression of Scn1a 5 0.64 6.55 2.02 5.00
132 INT57272 Negative_regulation of Gene_expression of FN1 16 0.43 11.42 1.93 5.00
133 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82 5.00
134 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
135 INT131572 Negative_regulation of Phosphorylation of Mdk 4 0.15 1.67 1.71 5.00
136 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
137 INT98648 Negative_regulation of Positive_regulation of Mdk 5 0.50 3.03 1.56 5.00
138 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 5.00
139 INT199550 Negative_regulation of Flt1 18 0.37 12.57 1.37 5.00
140 INT220177 Binding of Apc 21 0.37 15.34 1.37 5.00
141 INT199567 Binding of Kdr 18 0.47 13.81 1.34 5.00
142 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
143 INT35742 Positive_regulation of tk 8 0.43 5.53 1.33 5.00
144 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 5.00
145 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3 5.00
146 INT74018 Binding of XRCC1 19 0.31 24.78 1.24 5.00
147 INT68565 Gene_expression of Fap 14 0.57 24.39 1.14 5.00
148 INT24297 Regulation of CYP21A2 3 0.05 1.29 1.09 5.00
149 INT74020 Negative_regulation of XRCC1 16 0.35 17.18 1.06 5.00
150 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87 5.00
151 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 5.00
152 INT131286 Binding of Egfr 26 0.44 13.58 0.78 5.00
153 INT50687 Gene_expression of Aldoc 6 0.78 0.17 0.78 5.00
154 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75 5.00
155 INT259042 Gene_expression of D18Tlj1e 1 0.06 1.85 0.74 5.00
156 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 5.00
157 INT97478 Positive_regulation of Tks 1 0.46 1.42 0.71 5.00
158 INT91172 Positive_regulation of Gene_expression of Pdgfrb 4 0.38 2.83 0.68 5.00
159 INT178489 Negative_regulation of Kdr 31 0.42 25.65 0.66 5.00
160 INT199570 Negative_regulation of Tks 7 0.26 4.41 0.59 5.00
161 INT309253 Negative_regulation of Transcription of LMOD1 1 0.03 0.2 0.57 5.00
162 INT259041 Binding of D18Tlj1e 1 0.03 1.98 0.57 5.00
163 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 5.00
164 INT199556 Binding of Tks 3 0.19 1.59 0.51 5.00
165 INT144024 Negative_regulation of Phosphorylation of Pdgfrb 6 0.42 3.48 0.51 5.00
166 INT199553 Gene_expression of Bcr 25 0.76 13.83 0.48 5.00
167 INT23650 Positive_regulation of Sdhb 2 0.17 1.34 0.43 5.00
168 INT309242 Localization of Nat1 1 0.01 0.17 0.42 5.00
169 INT156121 Phosphorylation of Tnk1 2 0.03 0.3 0.37 5.00
170 INT199559 Binding of Erbb2 5 0.36 4.23 0.36 5.00
171 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 5.00
172 INT130999 Localization of PRKAB1 5 0.57 4.1 0.35 5.00
173 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 5.00
174 INT225667 Transcription of Apc 3 0.52 3.73 0.32 5.00
175 INT199566 Positive_regulation of Gene_expression of tk 4 0.39 3.06 0.31 5.00
176 INT241104 Gene_expression of FH 7 0.66 20.35 0.31 5.00
177 INT309249 Regulation of OGDHL 1 0.01 0.6 0.3 5.00
178 INT199557 Positive_regulation of Gene_expression of Bcr 6 0.68 4.21 0.3 5.00
179 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 5.00
180 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28 5.00
181 INT127654 Positive_regulation of Gene_expression of XRCC1 11 0.38 13.7 0.26 5.00
182 INT199569 Negative_regulation of Braf 4 0.36 3.73 0.23 5.00
183 INT99176 Positive_regulation of Fap 4 0.13 7.5 0.22 5.00
184 INT193015 Positive_regulation of Gene_expression of EPAS1 6 0.32 8.77 0.21 5.00
185 INT199561 Positive_regulation of Gene_expression of Abl1 8 0.36 4.77 0.16 5.00
186 INT199555 Negative_regulation of Flt3 5 0.33 3.64 0.16 5.00
187 INT74017 Regulation of VHL 4 0.43 7.59 0.16 5.00
188 INT139331 Localization of Vhl 2 0.65 2.34 0.15 5.00
189 INT241102 Transcription of FH 2 0.59 2 0.14 5.00
190 INT184749 Gene_expression of Car9 9 0.31 9.45 0.14 5.00
191 INT11552 Positive_regulation of Localization of VHL 2 0.44 2.12 0.13 5.00
192 INT241099 Positive_regulation of Gene_expression of FH 3 0.43 5.17 0.11 5.00
193 INT104566 Negative_regulation of Aqp2 3 0.44 1.23 0.11 5.00
194 INT241115 Regulation of Vhl 5 0.15 8.36 0.11 5.00
195 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1 5.00
196 INT85280 Positive_regulation of FH 2 0.45 3.53 0.09 5.00
197 INT199549 Phosphorylation of tk 1 0.16 0.9 0.08 5.00
198 INT224327 Negative_regulation of EPAS1 5 0.09 4.29 0.08 5.00
199 INT140494 Negative_regulation of Fap 3 0.37 2.3 0.08 5.00
200 INT199572 Positive_regulation of Positive_regulation of tk 1 0.10 0.6 0.08 5.00
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