D:Hemangioendothelioma

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Disease Term
Synonyms Hemangioendotheliomas
Documents 55
Hot Single Events 7
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hemangioendothelioma. They are ordered first by their relevance to Hemangioendothelioma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 5.00
2 INT231440 PDGFA Positive_regulation of Gene_expression of HGF 1 0.16 0.83 0.07 5.00
3 INT231434 FN1 Positive_regulation of Gene_expression of PDGFA 1 0.04 0.83 0.07 5.00
4 INT236932 Binding of Rxra and Pprc1 1 0.00 0.45 0.07 5.00
5 INT231436 FN1 Positive_regulation of Gene_expression of VEGFA 1 0.06 0.83 0.07 5.00
6 INT236936 Ppara Positive_regulation of Mapk1 1 0.09 0.64 0.07 5.00
7 INT231442 FN1 Positive_regulation of Gene_expression of HGF 1 0.05 0.83 0.07 5.00
8 INT231441 PDGFA Positive_regulation of Gene_expression of VEGFA 1 0.17 0.83 0.07 5.00
9 INT236938 Binding of Akt1 and SPNS1 1 0.00 0.72 0.06 5.00
10 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03 5.00
11 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03 5.00
12 INT236937 Map2k1 Negative_regulation of Ppara Positive_regulation of Itk 1 0.00 0.31 0 5.00
13 INT236933 Ppara Positive_regulation of Itk 1 0.01 0.31 0 5.00
14 INT236935 Negative_regulation of Ppara Positive_regulation of Itk 1 0.01 0.31 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hemangioendothelioma. They are ordered first by their pain relevance and then by number of times they were reported in Hemangioendothelioma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 91.68
2 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 91.68
3 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 89.20
4 INT27740 Positive_regulation of COX8A 16 0.67 9.66 3.23 88.32
5 INT2920 Regulation of F8 7 0.45 2.9 0.79 84.00
6 INT91152 Regulation of Pecam1 4 0.30 4.14 0.42 84.00
7 INT8385 Gene_expression of F13a1 8 0.76 2.23 1.39 83.68
8 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 77.96
9 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 76.88
10 INT25962 Gene_expression of COX8A 25 0.75 20.04 2.62 75.00
11 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 75.00
12 INT25356 Positive_regulation of S100A12 18 0.69 17.62 3.38 75.00
13 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 72.32
14 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 70.16
15 INT196003 Regulation of Cd34 4 0.30 3.38 0.5 65.92
16 INT196006 Regulation of FLT4 2 0.25 2.24 0.27 65.92
17 INT189852 Localization of H2-Q13 4 0.06 4.1 0.47 65.44
18 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 62.80
19 INT196007 Positive_regulation of FLT4 2 0.56 5.44 0.08 61.76
20 INT134628 Gene_expression of Flt4 9 0.48 7.52 1.94 61.04
21 INT196002 Positive_regulation of Flt4 4 0.22 3.51 0.37 61.04
22 INT90377 Gene_expression of HBA1 26 0.75 7.34 1.51 58.20
23 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 58.20
24 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 58.20
25 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 58.20
26 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 57.04
27 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 56.08
28 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13 56.08
29 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11 51.64
30 INT3046 Gene_expression of LGALS1 20 0.75 12.48 1.11 50.04
31 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 37.76
32 INT10136 Negative_regulation of PLAT 23 0.42 11.18 3.02 37.76
33 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 33.04
34 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 33.04
35 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41 33.04
36 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04 33.04
37 INT122041 Binding of Ppara 308 0.48 189.17 51.48 29.28
38 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 26.80
39 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 26.80
40 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 22.28
41 INT43160 Gene_expression of EOS 3 0.65 5.03 0.81 20.00
42 INT91594 Localization of NOS3 12 0.78 5.39 2.02 19.20
43 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09 19.20
44 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 18.68
45 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84 17.48
46 INT17326 Binding of Plg 14 0.43 11.72 1.94 10.88
47 INT231474 Binding of THBS1 4 0.34 2.04 0.16 10.88
48 INT231471 Binding of PTP4A2P1 1 0.36 1.02 0.03 10.88
49 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 9.12
50 INT236928 Negative_regulation of Araf 1 0.06 1.49 0.5 9.12
51 INT231466 Binding of COL18A1 2 0.25 1.19 0.18 5.28
52 INT231467 Positive_regulation of Binding of COL18A1 1 0.18 1.03 0.03 5.28
53 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
54 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
55 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
56 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
57 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
58 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
59 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
60 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 5.00
61 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 5.00
62 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
63 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
64 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 5.00
65 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
66 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 5.00
67 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
68 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29 5.00
69 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98 5.00
70 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
71 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
72 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 5.00
73 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
74 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
75 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18 5.00
76 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
77 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
78 INT122039 Positive_regulation of Gene_expression of Ppara 144 0.68 113.55 28.55 5.00
79 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
80 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 5.00
81 INT37296 Binding of Esr1 117 0.43 62.51 27.33 5.00
82 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 5.00
83 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
84 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
85 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
86 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
87 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
88 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
89 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
90 INT50814 Positive_regulation of Mmp2 72 0.68 51.37 20.42 5.00
91 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
92 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 5.00
93 INT14737 Gene_expression of FN1 117 0.78 78.74 18.99 5.00
94 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
95 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 5.00
96 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31 5.00
97 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 5.00
98 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59 5.00
99 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
100 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
101 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4 5.00
102 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
103 INT122037 Regulation of Ppara 93 0.62 56.28 12.89 5.00
104 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
105 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39 5.00
106 INT194462 Localization of Ppara 94 0.78 68.33 12.09 5.00
107 INT1762 Negative_regulation of PTGER2 64 0.43 28.21 11.27 5.00
108 INT151168 Gene_expression of Pten 60 0.78 35.63 10.54 5.00
109 INT173159 Localization of PPARA 96 0.74 64.55 10.26 5.00
110 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
111 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
112 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 5.00
113 INT209866 Regulation of Gene_expression of CD36 27 0.60 10.04 8.42 5.00
114 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 5.00
115 INT87650 Positive_regulation of EPHB2 49 0.67 22.77 8.25 5.00
116 INT108336 Phosphorylation of EPHB2 41 0.80 22.25 8.21 5.00
117 INT171367 Phosphorylation of Map2k1 31 0.58 32.87 8 5.00
118 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 5.00
119 INT181817 Negative_regulation of Gene_expression of Ppara 58 0.58 43.24 7.67 5.00
120 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59 5.00
121 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 5.00
122 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37 5.00
123 INT95117 Gene_expression of PDGFA 71 0.71 51.17 6.9 5.00
124 INT138799 Regulation of Gene_expression of Ppara 40 0.60 29.42 6.89 5.00
125 INT35486 Regulation of PTGER2 39 0.36 19.03 6.75 5.00
126 INT194479 Phosphorylation of Ppara 47 0.81 30.36 6.6 5.00
127 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61 5.00
128 INT91147 Positive_regulation of Positive_regulation of Ppara 30 0.69 19.31 5.56 5.00
129 INT122038 Transcription of Ppara 35 0.71 20.5 5.12 5.00
130 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01 5.00
131 INT105393 Positive_regulation of Localization of VEGFA 66 0.70 45.45 4.9 5.00
132 INT181186 Binding of Rxra 78 0.35 14.93 4.87 5.00
133 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62 5.00
134 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44 5.00
135 INT197171 Negative_regulation of Binding of Ppara 15 0.43 11.51 4.41 5.00
136 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 5.00
137 INT158416 Localization of Mapk1 19 0.67 5.32 4.18 5.00
138 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97 5.00
139 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9 5.00
140 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 5.00
141 INT113924 Binding of Mapk1 27 0.38 8.64 3.84 5.00
142 INT124655 Negative_regulation of PECAM1 13 0.23 10.32 3.78 5.00
143 INT26282 Negative_regulation of ELN 9 0.51 6.37 3.76 5.00
144 INT26702 Transcription of CD36 17 0.70 3.56 3.49 5.00
145 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 5.00
146 INT62957 Positive_regulation of CXCL5 13 0.50 8.53 3.28 5.00
147 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27 5.00
148 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14 5.00
149 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 5.00
150 INT134470 Positive_regulation of Map2k1 74 0.49 46.07 3.02 5.00
151 INT103607 Binding of Sp1 7 0.42 1.26 2.92 5.00
152 INT108338 Positive_regulation of Phosphorylation of EPHB2 13 0.67 5.42 2.92 5.00
153 INT132575 Binding of NR1H4 57 0.20 22.06 2.82 5.00
154 INT99895 Positive_regulation of Mmp14 10 0.58 6.64 2.72 5.00
155 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 5.00
156 INT24672 Localization of FGF2 27 0.71 14.59 2.48 5.00
157 INT215379 Positive_regulation of Binding of Ppara 15 0.66 8.04 2.36 5.00
158 INT198662 Positive_regulation of CD36 14 0.68 7.73 2.36 5.00
159 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 5.00
160 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13 5.00
161 INT26706 Positive_regulation of Transcription of CD36 8 0.68 3.32 2.12 5.00
162 INT173851 Localization of FN1 20 0.76 13.95 1.97 5.00
163 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9 5.00
164 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 5.00
165 INT211984 Regulation of Binding of Ppara 11 0.45 9.55 1.87 5.00
166 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85 5.00
167 INT16205 Localization of ras 25 0.73 18.99 1.85 5.00
168 INT173177 Positive_regulation of Localization of PPARA 21 0.49 12.61 1.74 5.00
169 INT146943 Gene_expression of Src 13 0.49 6.65 1.65 5.00
170 INT169461 Regulation of Gene_expression of Mapk1 7 0.44 1.64 1.61 5.00
171 INT173198 Regulation of Binding of PPARA 17 0.43 9.58 1.47 5.00
172 INT76477 Positive_regulation of CD99 14 0.50 14.77 1.42 5.00
173 INT173162 Phosphorylation of PPARA 22 0.80 11.09 1.38 5.00
174 INT115948 Regulation of Gene_expression of MMRN1 7 0.26 10.37 1.33 5.00
175 INT81400 Binding of RARA 25 0.36 12.93 1.27 5.00
176 INT132577 Binding of RXRB 12 0.30 6.58 1.25 5.00
177 INT197167 Positive_regulation of Localization of Ppara 18 0.67 9.51 1.21 5.00
178 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 5.00
179 INT227548 Negative_regulation of Localization of Ppara 7 0.38 4.1 1.17 5.00
180 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13 5.00
181 INT183046 Transcription of INS 25 0.70 11.14 1.13 5.00
182 INT102249 Binding of HIF1A 39 0.36 30.47 1.04 5.00
183 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 5.00
184 INT138287 Gene_expression of Map2k1 69 0.65 46.14 1.02 5.00
185 INT236927 Positive_regulation of Ptk2b 9 0.67 3.41 0.94 5.00
186 INT199345 Gene_expression of Lyve1 11 0.50 8.44 0.89 5.00
187 INT199563 Negative_regulation of Abl1 38 0.46 21.5 0.87 5.00
188 INT96188 Binding of Cd34 11 0.31 10.4 0.82 5.00
189 INT265800 Localization of NRP1 14 0.75 3.66 0.69 5.00
190 INT171042 Negative_regulation of Protein_catabolism of MMRN1 2 0.05 1.55 0.65 5.00
191 INT76315 Gene_expression of Myog 15 0.41 6.79 0.6 5.00
192 INT44080 Positive_regulation of HBA1 7 0.25 2.23 0.6 5.00
193 INT114879 Gene_expression of Cdk2 5 0.55 2.33 0.6 5.00
194 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59 5.00
195 INT236915 Binding of Map2k1 2 0.15 1.51 0.49 5.00
196 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45 5.00
197 INT154565 Regulation of Positive_regulation of PIK3CD 2 0.09 1.59 0.45 5.00
198 INT213272 Negative_regulation of Phosphorylation of INS 7 0.40 9.13 0.44 5.00
199 INT190362 Negative_regulation of Transcription of PPARA 5 0.42 3.19 0.42 5.00
200 INT104143 Transcription of EWSR1 7 0.67 8.1 0.42 5.00
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