D:Hemangiosarcoma

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Disease Term
Synonyms Angiosarcoma, Angiosarcomas, Hemangiosarcomas
Documents 305
Hot Single Events 95
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hemangiosarcoma. They are ordered first by their relevance to Hemangiosarcoma and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT163492 Binding of TNFRSF8 and KRT7 1 0.26 0.89 0.06 98.58
2 INT287380 Binding of VEGFA and Kdr 12 0.18 11.97 0.34 88.96
3 INT192955 Binding of KIT and VCAM1 1 0.05 0.63 0 79.12
4 INT192956 Binding of CD2 and KIT 1 0.03 0.62 0 78.48
5 INT320786 Binding of Eng and Kdr 1 0.04 1.17 0.04 78.12
6 INT118052 Binding of Pecam1 and Cd34 1 0.22 0.51 0.1 75.00
7 INT296684 Binding of CD99 and Bcl2 1 0.01 1.68 0 61.32
8 INT320887 Binding of TP63 and olt 1 0.01 2.15 0 54.24
9 INT137398 Binding of CD99 and Vim 2 0.02 2.36 0.09 13.16
10 INT296670 Binding of Bcl2 and Vim 1 0.00 1.31 0 13.16
11 INT320888 Binding of olt and HCC 1 0.00 1.62 0.06 5.84
12 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 5.00
13 INT320794 Binding of VEGFA and Flt4 4 0.08 3.04 0.27 5.00
14 INT192333 PDGFA Positive_regulation of Gene_expression of FN1 2 0.11 1.26 0.18 5.00
15 INT320789 NRP2 Positive_regulation of Binding of Flt1 and Kdr 1 0.00 0.68 0.08 5.00
16 INT320785 Binding of Flt1 and Kdr 1 0.15 0.67 0.08 5.00
17 INT320788 VEGFA Positive_regulation of Binding of Flt1 and Kdr 1 0.15 0.68 0.08 5.00
18 INT231440 PDGFA Positive_regulation of Gene_expression of HGF 1 0.16 0.83 0.07 5.00
19 INT231434 FN1 Positive_regulation of Gene_expression of PDGFA 1 0.04 0.83 0.07 5.00
20 INT236932 Binding of Rxra and Pprc1 1 0.00 0.45 0.07 5.00
21 INT231436 FN1 Positive_regulation of Gene_expression of VEGFA 1 0.06 0.83 0.07 5.00
22 INT236936 Ppara Positive_regulation of Mapk1 1 0.09 0.64 0.07 5.00
23 INT231442 FN1 Positive_regulation of Gene_expression of HGF 1 0.05 0.83 0.07 5.00
24 INT231441 PDGFA Positive_regulation of Gene_expression of VEGFA 1 0.17 0.83 0.07 5.00
25 INT236938 Binding of Akt1 and SPNS1 1 0.00 0.72 0.06 5.00
26 INT320795 Flt1 Negative_regulation of VEGFA 1 0.29 0.29 0.06 5.00
27 INT302632 Rac1 Positive_regulation of Gene_expression of Rhog 1 0.37 0.21 0.05 5.00
28 INT256418 PPARA Positive_regulation of NR1H4 1 0.01 1.17 0.04 5.00
29 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03 5.00
30 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03 5.00
31 INT302640 Rac1 Regulation of Gene_expression of VEGFA 1 0.03 0 0 5.00
32 INT302641 Rac1 Regulation of TIE1 1 0.25 0.47 0 5.00
33 INT236937 Map2k1 Negative_regulation of Ppara Positive_regulation of Itk 1 0.00 0.31 0 5.00
34 INT302634 Rac1 Regulation of Gene_expression of Kdr 1 0.36 0 0 5.00
35 INT302633 Rac1 Regulation of Cdc42ep2 1 0.01 0 0 5.00
36 INT242102 Nkx2-1 Regulation of Gene_expression of Ttf1 1 0.00 1.55 0 5.00
37 INT236933 Ppara Positive_regulation of Itk 1 0.01 0.31 0 5.00
38 INT236935 Negative_regulation of Ppara Positive_regulation of Itk 1 0.01 0.31 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hemangiosarcoma. They are ordered first by their pain relevance and then by number of times they were reported in Hemangiosarcoma. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT16205 Localization of ras 25 0.73 18.99 1.85 100.00
2 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 99.84
3 INT347696 Negative_regulation of ZBTB16 1 0.06 1.21 0 99.84
4 INT356395 Gene_expression of Ascc1 1 0.02 1.72 0 99.70
5 INT249057 Gene_expression of FGF14 1 0.33 3.44 0.04 99.60
6 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 99.52
7 INT82685 Gene_expression of Pecam1 36 0.76 27.95 9.01 99.52
8 INT82684 Positive_regulation of Pecam1 27 0.49 25.67 11.47 99.52
9 INT67379 Positive_regulation of Cd34 38 0.58 26.18 3.28 99.52
10 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 99.52
11 INT9899 Gene_expression of Vwf 91 0.74 45.06 9.13 99.52
12 INT91152 Regulation of Pecam1 4 0.30 4.14 0.42 99.50
13 INT2920 Regulation of F8 7 0.45 2.9 0.79 99.50
14 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 99.20
15 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 99.08
16 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 99.08
17 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 99.08
18 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 99.02
19 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 98.92
20 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 98.82
21 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 98.76
22 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13 98.68
23 INT25962 Gene_expression of COX8A 25 0.75 20.04 2.62 98.60
24 INT73091 Binding of TNFRSF8 21 0.44 6.64 0.93 98.58
25 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 98.46
26 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 98.46
27 INT10889 Gene_expression of F8 60 0.78 41.36 5.06 98.20
28 INT15796 Regulation of IL2 66 0.61 25.43 20.62 98.18
29 INT199567 Binding of Kdr 18 0.47 13.81 1.34 97.92
30 INT103154 Gene_expression of FLT1 138 0.76 58.5 7.41 97.70
31 INT265800 Localization of NRP1 14 0.75 3.66 0.69 97.56
32 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 97.48
33 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 97.36
34 INT4991 Positive_regulation of Vim 74 0.69 69.84 8.33 97.36
35 INT163493 Localization of ACPP 2 0.41 1.8 0.11 96.92
36 INT11887 Localization of MUC16 16 0.80 10.66 1.26 96.92
37 INT26434 Localization of MME 17 0.81 8.67 2.3 96.92
38 INT4342 Localization of ALPP 27 0.69 15.19 5.32 96.92
39 INT204924 Negative_regulation of Clta 1 0.01 1.37 0 96.84
40 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 96.72
41 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 95.88
42 INT96188 Binding of Cd34 11 0.31 10.4 0.82 95.32
43 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 95.04
44 INT88278 Binding of Kit 33 0.37 24.45 4.13 95.00
45 INT194801 Binding of MAPK1 7 0.29 1.9 0.23 94.80
46 INT154565 Regulation of Positive_regulation of PIK3CD 2 0.09 1.59 0.45 94.76
47 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37 94.76
48 INT320099 Protein_catabolism of STS 1 0.68 1.84 0 94.36
49 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 93.96
50 INT85085 Positive_regulation of KIT 36 0.53 30.08 2.17 93.76
51 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 93.52
52 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 93.36
53 INT84881 Positive_regulation of Gene_expression of Pecam1 5 0.46 5.79 2.35 93.24
54 INT173851 Localization of FN1 20 0.76 13.95 1.97 93.20
55 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 93.12
56 INT89116 Regulation of Positive_regulation of VEGFA 8 0.43 6.62 1.5 93.12
57 INT245880 Positive_regulation of Positive_regulation of FIGF 1 0.05 1.61 0.06 93.12
58 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 93.04
59 INT86023 Transcription of PPARA 60 0.66 25.8 5.7 93.04
60 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 92.64
61 INT347698 Regulation of OSMR 1 0.03 0.86 0.03 92.64
62 INT90377 Gene_expression of HBA1 26 0.75 7.34 1.51 92.24
63 INT125244 Gene_expression of Ril2 4 0.30 1.9 0.87 91.84
64 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 91.76
65 INT245878 Binding of FLI1 2 0.11 2.57 0.1 91.72
66 INT245879 Binding of IGLV3-1 2 0.36 1.6 0.04 91.72
67 INT245877 Binding of HBA1 2 0.11 2.59 0.04 91.72
68 INT347697 Gene_expression of ZBTB16 1 0.07 0.94 0 91.52
69 INT249059 Binding of FGF14 1 0.20 2.3 0.13 91.20
70 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 91.12
71 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 90.84
72 INT347699 Regulation of ROR1 1 0.00 0.85 0.03 90.80
73 INT64743 Positive_regulation of olt 19 0.40 16.46 3.86 90.56
74 INT112110 Positive_regulation of FIGF 3 0.18 5.28 0.37 90.40
75 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 90.20
76 INT195206 Binding of BCC1 15 0.41 21.3 0.62 89.56
77 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 89.48
78 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28 89.24
79 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 88.20
80 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03 87.76
81 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87 87.76
82 INT28084 Positive_regulation of VIM 49 0.67 35.12 5.15 87.40
83 INT21681 Positive_regulation of CD34 54 0.66 33.95 4.14 87.40
84 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 87.40
85 INT193822 Regulation of Gene_expression of Sts 1 0.03 1.04 0 86.32
86 INT347444 Gene_expression of KRTAP5-2 1 0.16 1.4 0.09 85.92
87 INT162478 Gene_expression of KRT6B 2 0.75 1.39 0.08 85.92
88 INT14301 Binding of CSF2 82 0.48 67.95 8.98 84.80
89 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 83.80
90 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 83.64
91 INT192962 Positive_regulation of Transcription of KIT 1 0.46 2.74 0 83.32
92 INT192957 Transcription of KIT 5 0.69 2.19 0.23 83.12
93 INT47311 Gene_expression of Sts 12 0.58 11.02 0.44 82.56
94 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 82.12
95 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 81.72
96 INT249060 Localization of FGF14 1 0.37 2.67 0.03 79.44
97 INT249058 Positive_regulation of FGF14 1 0.23 2.67 0.03 79.44
98 INT29441 Negative_regulation of Gene_expression of Cea 6 0.20 5.97 0.55 79.32
99 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 79.08
100 INT95652 Gene_expression of Krt20 54 0.61 53.69 3.31 79.00
101 INT90940 Binding of Eng 5 0.35 1.92 0.13 78.96
102 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 78.72
103 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 78.64
104 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 78.40
105 INT83212 Positive_regulation of Gene_expression of Mki67 21 0.55 17.53 0.39 78.40
106 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 78.24
107 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 77.44
108 INT152681 Gene_expression of PDPN 29 0.65 23.06 0.18 76.72
109 INT10890 Binding of F8 11 0.36 7.27 1.15 76.04
110 INT44872 Localization of Sts 5 0.64 5.2 0.2 75.96
111 INT103094 Binding of PPARA 308 0.47 177.26 34.75 75.20
112 INT91151 Regulation of Flt4 1 0.06 1.96 0.15 75.00
113 INT90670 Positive_regulation of KRT1 10 0.44 6.25 1.16 75.00
114 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16 75.00
115 INT27740 Positive_regulation of COX8A 16 0.67 9.66 3.23 75.00
116 INT8385 Gene_expression of F13a1 8 0.76 2.23 1.39 75.00
117 INT22329 Gene_expression of Ptprc 36 0.66 15.84 1.59 74.72
118 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 74.32
119 INT278117 Negative_regulation of TP63 5 0.32 3.38 1.13 73.80
120 INT70019 Binding of BCL2 25 0.47 17.55 0.79 73.76
121 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 71.52
122 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 70.28
123 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 67.92
124 INT147464 Binding of Ptprc 13 0.36 15.18 0.98 67.60
125 INT129783 Positive_regulation of Gene_expression of KIT 16 0.50 18.12 0.58 67.20
126 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 67.08
127 INT193156 Gene_expression of CRAMP1L 17 0.42 10.96 0.18 66.80
128 INT88070 Binding of Ema 7 0.18 7.39 0.31 65.12
129 INT257453 Positive_regulation of USE1 12 0.20 6.7 0.94 64.64
130 INT131931 Binding of KRT7 13 0.36 19.24 0.5 64.48
131 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 64.16
132 INT58563 Negative_regulation of S100B 13 0.51 11.75 1.77 63.92
133 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 61.84
134 INT68269 Gene_expression of CD99 49 0.77 47.38 3.86 61.84
135 INT186998 Negative_regulation of Gene_expression of KIT 20 0.43 16.77 0.46 60.96
136 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 59.36
137 INT192960 Regulation of Gene_expression of KIT 3 0.45 4.16 0 58.96
138 INT83531 Gene_expression of KITLG 54 0.65 26 7.07 58.36
139 INT180036 Positive_regulation of D7Cwr3P 2 0.03 4.58 0.54 57.84
140 INT163489 Binding of CDH1 13 0.19 8.63 0.35 57.68
141 INT146191 Gene_expression of Rhoa 32 0.67 17.63 2.92 56.44
142 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 56.44
143 INT197290 Gene_expression of Cdc42 9 0.35 2.52 0.15 56.44
144 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 55.40
145 INT155036 Localization of NT5E 6 0.73 4.1 1.35 55.36
146 INT146197 Positive_regulation of Rhoa 60 0.68 34.12 12.02 53.56
147 INT146194 Negative_regulation of Rhoa 21 0.42 11.05 3.22 53.56
148 INT161682 Positive_regulation of Cdc42 8 0.53 4.55 0.9 53.32
149 INT254795 Negative_regulation of Cdc42 2 0.12 1.53 0 53.32
150 INT67174 Negative_regulation of Rac1 22 0.56 10.72 0.99 52.92
151 INT228103 Positive_regulation of Rac1 25 0.67 18.92 0.57 52.92
152 INT221083 Localization of CES2 2 0.80 1.48 0.03 51.76
153 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 51.16
154 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11 50.64
155 INT210673 Gene_expression of Gpx4 2 0.48 3.54 0.09 47.44
156 INT99290 Positive_regulation of STS 16 0.43 6.96 0.75 47.08
157 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48 44.56
158 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 44.56
159 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41 44.56
160 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04 44.56
161 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 39.12
162 INT10136 Negative_regulation of PLAT 23 0.42 11.18 3.02 39.12
163 INT349621 Positive_regulation of Gpx4 1 0.36 2.26 0 37.84
164 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 37.76
165 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 33.80
166 INT105782 Positive_regulation of Krt20 9 0.20 9.62 0.53 33.52
167 INT115982 Positive_regulation of KRT7 18 0.50 19.81 1.14 32.80
168 INT12844 Binding of TP63 15 0.47 10.57 3.38 32.68
169 INT91594 Localization of NOS3 12 0.78 5.39 2.02 30.72
170 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09 30.72
171 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 29.96
172 INT200855 Positive_regulation of Kdr 14 0.45 11.14 0.77 28.88
173 INT122041 Binding of Ppara 308 0.48 189.17 51.48 28.28
174 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 28.16
175 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 28.16
176 INT175002 Positive_regulation of Mki67 10 0.31 5.7 0.26 26.96
177 INT119605 Positive_regulation of Anxa5 2 0.67 2.3 0.16 25.00
178 INT128376 Binding of KIT 26 0.48 14.24 0.47 20.84
179 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 17.68
180 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84 16.48
181 INT264629 Localization of Rac1 8 0.72 5.7 0.79 14.88
182 INT16012 Binding of Rac1 17 0.37 6.9 0.53 14.88
183 INT302630 Localization of Tg(Tek-cre)12Flv 1 0.31 0.47 0.05 14.68
184 INT17326 Binding of Plg 14 0.43 11.72 1.94 12.24
185 INT231474 Binding of THBS1 4 0.34 2.04 0.16 12.24
186 INT231471 Binding of PTP4A2P1 1 0.36 1.02 0.03 12.24
187 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 12.08
188 INT70437 Negative_regulation of Mdk 115 0.57 41.03 35.72 10.48
189 INT236928 Negative_regulation of Araf 1 0.06 1.49 0.5 10.48
190 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 10.00
191 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 9.20
192 INT147796 Gene_expression of Ccndbp1 5 0.05 3.9 0.4 8.56
193 INT231466 Binding of COL18A1 2 0.25 1.19 0.18 6.64
194 INT231467 Positive_regulation of Binding of COL18A1 1 0.18 1.03 0.03 6.64
195 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 5.84
196 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
197 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
198 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
199 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 5.00
200 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
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