D:Hemoglobinopathy

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms CONGENITAL HAEMOGLOBINOPATHIES, Congenital Hemoglobinopathies, Globin Abnormality, Haemoglobin Disease, Haemoglobin Diseases, Haemoglobin Disorder, Haemoglobin Disorders, Haemoglobinopathies, Haemoglobinopathy, Hemoglobin Disease, HEMOGLOBIN DISEASES
Documents 181
Hot Single Events 28
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hemoglobinopathy. They are ordered first by their relevance to Hemoglobinopathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT241853 Binding of SLC40A1 and HAMP 3 0.41 5.35 0.43 5.00
2 INT345421 IFNA1 Positive_regulation of Eif2ak2 2 0.03 1.25 0.3 5.00
3 INT296372 Binding of IDUA and ACD 1 0.03 2.72 0.23 5.00
4 INT230455 FOXG1 Negative_regulation of HBS1L 1 0.02 1.73 0.18 5.00
5 INT213207 Negative_regulation of ASAP2 Negative_regulation of PVR 1 0.01 0.45 0.04 5.00
6 INT290877 Binding of Bcl2a1c and Lepr 1 0.00 0.87 0.04 5.00
7 INT213206 ASAP2 Negative_regulation of PVR 1 0.01 0.44 0.04 5.00
8 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0 5.00
9 INT318132 Binding of ATRX and HBE1 1 0.00 1.47 0 5.00
10 INT290861 MNT Positive_regulation of INS 1 0.03 1.78 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hemoglobinopathy. They are ordered first by their pain relevance and then by number of times they were reported in Hemoglobinopathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT4596 Positive_regulation of SCD 18 0.42 22.59 3.26 100.00
2 INT152037 Regulation of Localization of Csf3 1 0.18 0.74 0.09 99.90
3 INT74442 Binding of ATRX 2 0.41 3.2 0.09 99.30
4 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 99.08
5 INT8772 Positive_regulation of Gene_expression of HBG1 16 0.68 6.93 0.95 99.08
6 INT94827 Gene_expression of HBS1L 24 0.67 26.11 1.61 99.00
7 INT195213 Positive_regulation of Gene_expression of HBS1L 4 0.15 3.5 0.16 99.00
8 INT48444 Localization of Csf3 28 0.72 14.85 2.11 98.92
9 INT23220 Positive_regulation of FOXG1 10 0.43 2.86 3.49 98.40
10 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 98.00
11 INT9110 Binding of PAH 32 0.41 42.1 3.1 97.48
12 INT109654 Positive_regulation of NFE4 1 0.05 0.58 0.16 97.12
13 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 96.92
14 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 96.88
15 INT27519 Positive_regulation of HPFH 1 0.01 0.19 0.1 95.96
16 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 89.56
17 INT51580 Positive_regulation of Positive_regulation of PCA 2 0.41 1.66 0.17 89.56
18 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 88.64
19 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86 88.64
20 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 84.88
21 INT139366 Gene_expression of PROM1 98 0.77 67.84 3.39 83.76
22 INT30610 Localization of PCa 35 0.65 13.91 4.25 83.60
23 INT2919 Negative_regulation of F8 47 0.59 23.48 5.1 82.44
24 INT109655 Binding of TFAM 11 0.08 7.9 2.41 82.24
25 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 82.00
26 INT127460 Positive_regulation of Gene_expression of PAH 5 0.43 4.3 0.5 82.00
27 INT11659 Gene_expression of COL2A1 164 0.78 78.49 22.58 81.44
28 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18 81.32
29 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 79.68
30 INT114247 Gene_expression of Nprl3 2 0.05 1.1 0.46 77.76
31 INT84250 Positive_regulation of IDUA 8 0.56 15.89 0.62 77.12
32 INT296382 Positive_regulation of SLC11A2 3 0.31 1.49 0.08 77.12
33 INT12413 Gene_expression of MPG 11 0.76 3.13 1.94 76.36
34 INT2921 Positive_regulation of F8 53 0.59 41.56 8.56 75.40
35 INT9079 Gene_expression of PPBP 52 0.75 31.2 21.52 75.08
36 INT11390 Gene_expression of PF4 5 0.65 3.09 2.07 75.08
37 INT26660 Gene_expression of HESX1 4 0.63 2.38 0.65 75.00
38 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 74.80
39 INT313869 Gene_expression of Pah 4 0.63 3.1 0.23 74.72
40 INT170743 Negative_regulation of Gene_expression of Scd1 2 0.38 1.57 0 74.56
41 INT26073 Gene_expression of Scd1 17 0.70 9.17 0.47 73.96
42 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 72.72
43 INT170738 Binding of Icam1 23 0.37 25.49 4.09 71.92
44 INT98992 Binding of Vcam1 13 0.34 12.97 1.04 71.92
45 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 71.40
46 INT3765 Positive_regulation of Actvty1 8 0.06 23.53 7.37 70.32
47 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 65.28
48 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 65.28
49 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 64.64
50 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 64.64
51 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 63.04
52 INT15742 Negative_regulation of EPO 37 0.59 17.44 1.84 63.04
53 INT213214 Positive_regulation of ASAP2 1 0.01 4.59 0.31 62.88
54 INT23040 Regulation of Positive_regulation of F8 1 0.38 0.75 0.07 60.84
55 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 59.92
56 INT66485 Negative_regulation of Binding of Pah 2 0.35 1.27 0.83 59.88
57 INT42485 Binding of Pah 9 0.35 3.42 3.03 59.28
58 INT240787 Positive_regulation of Bcl2a1c 12 0.22 9.79 0.06 57.32
59 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 57.24
60 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 46.80
61 INT206658 Negative_regulation of NAPEPLD 2 0.04 2.18 0.1 46.32
62 INT114862 Gene_expression of BEST1 16 0.65 12.14 1.53 45.84
63 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 45.12
64 INT313864 Negative_regulation of Tdp2 1 0.02 2.14 0.14 45.00
65 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 43.96
66 INT170740 Localization of Scd1 1 0.17 0.99 0 43.28
67 INT170737 Localization of Acsl1 5 0.20 3.51 0.38 42.08
68 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 40.96
69 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 39.56
70 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 39.56
71 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 35.28
72 INT191926 Negative_regulation of Lepr 13 0.48 17.68 0.8 34.80
73 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 34.24
74 INT69485 Regulation of Bcl2a1c 14 0.34 9.99 0.13 31.96
75 INT38989 Gene_expression of IDUA 22 0.78 16.99 1.26 30.80
76 INT69486 Negative_regulation of Bcl2a1c 34 0.10 19.03 0.6 23.40
77 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 22.00
78 INT105131 Gene_expression of KRT122P 8 0.58 9.1 0.7 18.72
79 INT43385 Gene_expression of C6 5 0.58 2.49 0.15 18.72
80 INT6481 Binding of TNF 624 0.48 510.2 214.82 14.96
81 INT22213 Localization of Gpt 52 0.78 34.05 12.94 13.60
82 INT318137 Negative_regulation of PMCH 1 0.02 0.96 0 13.36
83 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 10.88
84 INT94406 Regulation of Slc17a5 10 0.44 3.71 3.77 10.88
85 INT12082 Localization of IL6 365 0.81 241.78 105.78 8.72
86 INT6849 Localization of IL1B 229 0.81 112.56 69.63 8.72
87 INT118575 Positive_regulation of G6PD 9 0.50 3.35 0.18 8.04
88 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
89 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
90 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
91 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
92 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
93 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
94 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
95 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
96 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
97 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
98 INT2893 Localization of Oxt 219 0.80 28.96 79.43 5.00
99 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
100 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
101 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
102 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
103 INT251 Regulation of INS 398 0.62 232.47 55.04 5.00
104 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 5.00
105 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
106 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
107 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
108 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
109 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
110 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
111 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
112 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 5.00
113 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
114 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
115 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
116 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 5.00
117 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 5.00
118 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 5.00
119 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
120 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
121 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
122 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
123 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
124 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 5.00
125 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
126 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 5.00
127 INT36262 Positive_regulation of Tbce 35 0.49 28.79 14.33 5.00
128 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
129 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
130 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
131 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
132 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
133 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
134 INT55597 Negative_regulation of Gpx1 59 0.55 28.3 8.83 5.00
135 INT28521 Gene_expression of HBG2 56 0.77 16.62 8.64 5.00
136 INT4046 Positive_regulation of HBG2 42 0.69 13.66 8.51 5.00
137 INT113987 Localization of IK 29 0.23 16.73 8.25 5.00
138 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 5.00
139 INT3915 Gene_expression of SCD 25 0.57 13.94 6 5.00
140 INT139329 Phosphorylation of IFNA1 24 0.79 16.19 5.95 5.00
141 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 5.00
142 INT114311 Negative_regulation of Gene_expression of Gpt 33 0.38 17.83 4.94 5.00
143 INT11064 Positive_regulation of NPR1 24 0.49 14.63 4.78 5.00
144 INT8786 Negative_regulation of ALDH7A1 27 0.52 12.81 4.76 5.00
145 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 5.00
146 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
147 INT87632 Positive_regulation of Gene_expression of PECAM1 32 0.45 29.47 4.66 5.00
148 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
149 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 5.00
150 INT61680 Positive_regulation of PVR 23 0.60 23.27 3.86 5.00
151 INT22431 Negative_regulation of HBG2 20 0.58 6.6 3.33 5.00
152 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31 5.00
153 INT45503 Binding of EPO 42 0.48 24.85 2.88 5.00
154 INT156522 Gene_expression of NAPEPLD 11 0.75 4.25 2.87 5.00
155 INT8112 Regulation of EPO 38 0.58 22.04 2.76 5.00
156 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7 5.00
157 INT2021 Binding of HBG2 13 0.36 4.2 2.65 5.00
158 INT16964 Binding of IFNG 27 0.48 14.31 2.45 5.00
159 INT23219 Regulation of FOXG1 8 0.22 1.32 2.34 5.00
160 INT142626 Negative_regulation of Localization of ALB 9 0.55 6.63 2.24 5.00
161 INT9188 Localization of HBG1 12 0.75 8.14 2.24 5.00
162 INT14 Regulation of LDHA 22 0.57 15.26 2.14 5.00
163 INT108422 Binding of Pde5a 11 0.36 3.07 2.07 5.00
164 INT191534 Negative_regulation of EGFL7 10 0.06 7.52 1.98 5.00
165 INT84264 Regulation of NPPB 22 0.61 21.18 1.94 5.00
166 INT47062 Gene_expression of ANTXR1 10 0.66 4.63 1.93 5.00
167 INT45167 Positive_regulation of ASAP1 32 0.60 17.09 1.84 5.00
168 INT197166 Gene_expression of Cyp4a10 27 0.75 15.63 1.81 5.00
169 INT133885 Binding of SCN2A 7 0.47 1.27 1.54 5.00
170 INT55479 Localization of Epo 13 0.81 6.1 1.53 5.00
171 INT121335 Localization of SCD 10 0.68 6.81 1.51 5.00
172 INT93350 Binding of Lepr 17 0.05 27.21 1.5 5.00
173 INT27762 Positive_regulation of Gene_expression of EPO 18 0.70 17.67 1.45 5.00
174 INT140858 Negative_regulation of SUGT1 9 0.05 8.41 1.4 5.00
175 INT197174 Positive_regulation of Gene_expression of Cyp4a10 17 0.67 8.65 1.4 5.00
176 INT38990 Negative_regulation of IDUA 12 0.59 5.04 1.33 5.00
177 INT199004 Gene_expression of ARMC9 43 0.58 17.72 1.32 5.00
178 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31 5.00
179 INT152982 Negative_regulation of ACCS 14 0.37 9.63 1.3 5.00
180 INT95116 Negative_regulation of PDGFA 24 0.57 19.56 1.29 5.00
181 INT132453 Binding of TF 31 0.36 12.98 1.22 5.00
182 INT41893 Negative_regulation of HBS1L 16 0.23 8.98 1.19 5.00
183 INT17802 Transcription of Edn1 6 0.24 6.31 1.18 5.00
184 INT110400 Negative_regulation of Pde1b 21 0.50 0.58 1.14 5.00
185 INT36451 Gene_expression of G6PD 26 0.75 7.2 1.09 5.00
186 INT28929 Negative_regulation of PVR 22 0.57 16.64 1.07 5.00
187 INT79928 Positive_regulation of Localization of ALB 10 0.60 8.96 1.05 5.00
188 INT197721 Positive_regulation of ARMC9 36 0.35 20.08 1.03 5.00
189 INT9243 Gene_expression of FOXG1 14 0.53 7.52 1.02 5.00
190 INT129971 Regulation of PVR 5 0.60 3.96 0.97 5.00
191 INT296385 Binding of IDUA 12 0.39 20.73 0.93 5.00
192 INT87240 Gene_expression of Aggf1 14 0.11 8.41 0.93 5.00
193 INT4681 Localization of RAPGEF5 12 0.68 8.69 0.93 5.00
194 INT178209 Negative_regulation of Binding of IFNA1 7 0.39 4.8 0.89 5.00
195 INT24815 Binding of LDHA 9 0.36 6.73 0.89 5.00
196 INT49846 Localization of HBS1L 4 0.24 1.31 0.86 5.00
197 INT170742 Positive_regulation of Acsl1 6 0.44 6.98 0.86 5.00
198 INT50453 Regulation of Gene_expression of HBG2 6 0.45 1.6 0.86 5.00
199 INT4103 Regulation of G6PD 6 0.60 0.78 0.82 5.00
200 INT114504 Positive_regulation of Scd1 10 0.48 3.77 0.8 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox