D:Hemoglobinuria

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Disease Term
Synonyms None
Documents 60
Hot Single Events 13
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hemoglobinuria. They are ordered first by their relevance to Hemoglobinuria and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279503 Binding of C1s and C1ra 1 0.03 0.58 0.22 5.00
2 INT279507 Serping1 Negative_regulation of Gene_expression of C3 1 0.03 1.12 0.19 5.00
3 INT279500 Serping1 Negative_regulation of Transcription of C3 1 0.03 1.12 0.19 5.00
4 INT279511 Binding of Serping1 and C1ra 1 0.01 0.3 0.11 5.00
5 INT279502 Binding of C2 and Hc 1 0.01 0.2 0.07 5.00
6 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00
7 INT289293 Binding of CD59 and Cd33 1 0.02 1.06 0 5.00
8 INT279515 Daf2 Negative_regulation of INCENP 1 0.00 0 0 5.00
9 INT289301 Binding of CD59 and Cd24a 1 0.02 1.06 0 5.00
10 INT279501 C3ar1 Positive_regulation of C3 1 0.01 0 0 5.00
11 INT279504 Binding of C1ra and Positive_regulation of C1s 1 0.04 0.33 0 5.00
12 INT289296 Binding of CD59 and C6 1 0.02 0.5 0 5.00
13 INT229983 Binding of CFH and Crp 2 0.14 1.48 0 5.00
14 INT279508 Binding of Arhgap4 and Positive_regulation of C1s 1 0.01 0.33 0 5.00
15 INT279509 Binding of C2 and Abpz 1 0.01 0.21 0 5.00
16 INT279505 Binding of C4b and Abpz 1 0.01 0.21 0 5.00
17 INT289295 Binding of CD59 and Fcgr3 1 0.01 1.06 0 5.00
18 INT289297 Negative_regulation of Binding of CD59 and C6 1 0.02 0.51 0 5.00
19 INT289300 Binding of CD59 and Fut4 1 0.01 1.06 0 5.00
20 INT279510 Binding of C1qa and fc 1 0.01 0.36 0 5.00
21 INT289294 Binding of CD59 and Atp6ap1 1 0.10 0.51 0 5.00
22 INT289299 Binding of CD59 and Cd14 1 0.02 1.06 0 5.00
23 INT279514 Cr1l Negative_regulation of INCENP 1 0.00 0 0 5.00
24 INT289298 Negative_regulation of Binding of CD59 and Atp6ap1 1 0.12 0.51 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hemoglobinuria. They are ordered first by their pain relevance and then by number of times they were reported in Hemoglobinuria. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 99.96
2 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 99.20
3 INT48636 Positive_regulation of Pts 8 0.42 7.14 1.01 99.20
4 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 93.80
5 INT28923 Negative_regulation of Ldha 8 0.58 4.94 3.11 93.80
6 INT138843 Binding of CC2D1A 19 0.33 33.06 1.25 89.68
7 INT35999 Positive_regulation of KCNAB2 6 0.65 5.12 4.31 88.72
8 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 87.84
9 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 86.92
10 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 86.84
11 INT250743 Localization of CC2D1A 12 0.51 20.97 0.51 85.20
12 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 84.00
13 INT32795 Positive_regulation of Hypism 17 0.15 20.16 1.73 83.52
14 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 78.36
15 INT78297 Gene_expression of CD59 31 0.72 24.11 3.18 76.80
16 INT134338 Gene_expression of CD55 23 0.65 13.01 1.38 76.80
17 INT147783 Negative_regulation of Gene_expression of CD48 1 0.38 5.17 0.27 76.80
18 INT147781 Negative_regulation of Gene_expression of CD55 4 0.39 5.48 0.27 76.80
19 INT147782 Gene_expression of CD48 4 0.70 5.39 0.26 76.80
20 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 76.80
21 INT147784 Negative_regulation of CD48 1 0.17 5.15 0.27 75.92
22 INT29777 Negative_regulation of CD59 16 0.42 14.88 1.56 75.12
23 INT134341 Negative_regulation of CD55 12 0.58 10.06 0.95 73.68
24 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 62.80
25 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 62.80
26 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 62.08
27 INT1123 Positive_regulation of CD79A 74 0.70 51.96 7.14 62.08
28 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 61.68
29 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 61.68
30 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 61.28
31 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 61.28
32 INT4003 Positive_regulation of Gene_expression of IGHG3 31 0.46 20.38 3.16 61.28
33 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 60.88
34 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 59.44
35 INT48635 Negative_regulation of Pts 15 0.49 15.38 2.43 57.96
36 INT82932 Transcription of AR 14 0.67 5.75 1.34 43.20
37 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 41.04
38 INT29094 Binding of C3 39 0.37 12.65 2.27 38.32
39 INT14690 Localization of CSF2 124 0.80 85.17 27.26 31.76
40 INT21516 Negative_regulation of Positive_regulation of Ldha 13 0.43 4.73 2.53 28.92
41 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 28.44
42 INT262293 Gene_expression of CC2D1A 21 0.40 44.64 1.5 24.72
43 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
44 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
45 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
46 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
47 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
48 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
49 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
50 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
51 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
52 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
53 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
54 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
55 INT2774 Binding of Crp 241 0.48 195.89 44.39 5.00
56 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
57 INT20044 Negative_regulation of Gpi1 50 0.59 29.96 26 5.00
58 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
59 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
60 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
61 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
62 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
63 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
64 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 5.00
65 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
66 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
67 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 5.00
68 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
69 INT37430 Gene_expression of Gpi1 61 0.63 54.63 13.87 5.00
70 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
71 INT24876 Gene_expression of CD34 172 0.78 91.02 12.39 5.00
72 INT192967 Gene_expression of Hp 14 0.43 8.06 11.01 5.00
73 INT167052 Gene_expression of Cr2 43 0.56 25.7 7.76 5.00
74 INT178198 Gene_expression of C3 62 0.78 39.5 7.69 5.00
75 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
76 INT22450 Gene_expression of GPI 31 0.58 18.77 6.71 5.00
77 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 5.00
78 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92 5.00
79 INT64888 Negative_regulation of HBM 52 0.16 34.33 5.45 5.00
80 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
81 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 5.00
82 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4 5.00
83 INT6507 Binding of C5 23 0.48 15.35 3.91 5.00
84 INT179542 Positive_regulation of C3 27 0.52 19.39 3.83 5.00
85 INT69904 Binding of Hc 11 0.35 7.79 3.69 5.00
86 INT135963 Negative_regulation of Hc 19 0.42 12.36 3.63 5.00
87 INT184390 Binding of Arhgap4 13 0.36 3.29 3.35 5.00
88 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 5.00
89 INT116228 Binding of C1qa 26 0.47 15.72 3 5.00
90 INT58756 Binding of GPI 10 0.48 7.17 3 5.00
91 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 5.00
92 INT74508 Gene_expression of Gypa 7 0.75 2.15 2.89 5.00
93 INT184365 Negative_regulation of C3 19 0.43 13.86 2.89 5.00
94 INT155160 Binding of C3 20 0.47 7.77 2.61 5.00
95 INT82966 Transcription of Crp 14 0.70 9.91 2.61 5.00
96 INT182034 Binding of Gpi1 10 0.39 8.76 2.59 5.00
97 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44 5.00
98 INT184378 Binding of Cfb 54 0.20 12.49 2.36 5.00
99 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35 5.00
100 INT133567 Regulation of IL18 11 0.50 9.54 2.31 5.00
101 INT177328 Positive_regulation of CXADR 9 0.48 4.29 2.27 5.00
102 INT9254 Negative_regulation of LDHA 23 0.43 13.3 2.2 5.00
103 INT181015 Gene_expression of C3ar1 12 0.58 8.9 2.18 5.00
104 INT23748 Localization of Ltf 15 0.79 5.43 2.07 5.00
105 INT30531 Gene_expression of C2 15 0.66 5.5 1.99 5.00
106 INT45004 Gene_expression of Cfb 28 0.37 15.06 1.99 5.00
107 INT3179 Positive_regulation of SCT 15 0.50 4.79 1.98 5.00
108 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 5.00
109 INT16385 Regulation of C3 20 0.41 9.98 1.92 5.00
110 INT14184 Positive_regulation of CPB1 23 0.55 14.38 1.73 5.00
111 INT565 Negative_regulation of Cfb 18 0.13 6.77 1.69 5.00
112 INT200835 Gene_expression of Cd59a 5 0.77 9.02 1.64 5.00
113 INT179548 Gene_expression of C4b 17 0.58 9.88 1.62 5.00
114 INT182514 Binding of AGTR1 18 0.47 13.35 1.48 5.00
115 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47 5.00
116 INT147788 Regulation of FUT1 11 0.12 7.72 1.44 5.00
117 INT182035 Positive_regulation of Gene_expression of Gpi1 5 0.36 4.95 1.4 5.00
118 INT273128 Protein_catabolism of Hp 3 0.47 2.2 1.39 5.00
119 INT179539 Positive_regulation of Gene_expression of C3 9 0.70 5.98 1.32 5.00
120 INT57689 Localization of CD59 7 0.78 4.51 1.17 5.00
121 INT118131 Negative_regulation of C1s 10 0.07 2.92 1.15 5.00
122 INT74166 Positive_regulation of C2 10 0.55 2.83 1.05 5.00
123 INT179535 Negative_regulation of C1qa 10 0.57 4.7 1.03 5.00
124 INT37687 Binding of PLAUR 8 0.29 3.61 1.03 5.00
125 INT184352 Positive_regulation of Cr2 6 0.42 2.81 0.96 5.00
126 INT184665 Positive_regulation of C4b 7 0.28 5.84 0.9 5.00
127 INT35292 Negative_regulation of C5 7 0.43 5.3 0.86 5.00
128 INT2608 Localization of GPI 7 0.73 4.53 0.85 5.00
129 INT254143 Negative_regulation of CC2D1A 10 0.35 13.81 0.82 5.00
130 INT21246 Negative_regulation of ATP1A4 3 0.10 3.3 0.79 5.00
131 INT220888 Negative_regulation of Arhgap4 5 0.42 2.19 0.78 5.00
132 INT184341 Negative_regulation of C4b 12 0.50 7.66 0.75 5.00
133 INT200531 Gene_expression of Tnni1 8 0.58 4.68 0.75 5.00
134 INT94442 Gene_expression of Tcf21 2 0.25 2.32 0.72 5.00
135 INT179530 Transcription of C3 4 0.69 2.59 0.7 5.00
136 INT79034 Negative_regulation of GPI 7 0.58 3.94 0.66 5.00
137 INT190229 Gene_expression of Cd55 7 0.64 5 0.64 5.00
138 INT122737 Gene_expression of Daf2 6 0.69 2.11 0.61 5.00
139 INT184367 Protein_catabolism of Hc 4 0.26 2.66 0.6 5.00
140 INT160852 Regulation of CD55 5 0.16 5.28 0.56 5.00
141 INT279499 Negative_regulation of Tnni1 5 0.57 4.35 0.53 5.00
142 INT181965 Negative_regulation of Gene_expression of Gpi1 3 0.07 2.83 0.51 5.00
143 INT149027 Positive_regulation of C1s 8 0.36 4.27 0.51 5.00
144 INT279459 Negative_regulation of Cd59a 3 0.58 5.76 0.5 5.00
145 INT277912 Positive_regulation of Gene_expression of CD59 2 0.19 2.76 0.49 5.00
146 INT81965 Gene_expression of F5 16 0.65 13.29 0.48 5.00
147 INT149861 Gene_expression of CD52 14 0.75 9.35 0.47 5.00
148 INT68701 Positive_regulation of C4bp 7 0.67 3.02 0.46 5.00
149 INT207081 Binding of Plaur 6 0.31 5.99 0.41 5.00
150 INT283239 Negative_regulation of Localization of CC2D1A 1 0.29 10.4 0.41 5.00
151 INT220894 Positive_regulation of C3ar1 4 0.09 3.75 0.41 5.00
152 INT153705 Gene_expression of CLDN3 5 0.58 4.07 0.37 5.00
153 INT179532 Protein_catabolism of C3 5 0.26 1.61 0.34 5.00
154 INT262297 Negative_regulation of Gene_expression of CC2D1A 2 0.25 2.95 0.31 5.00
155 INT131301 Binding of Serping1 3 0.28 1.86 0.3 5.00
156 INT102114 Negative_regulation of Chkb 6 0.39 2.05 0.28 5.00
157 INT263705 Binding of C1ra 2 0.36 0.62 0.26 5.00
158 INT283235 Localization of KCNAB2 1 0.02 0.94 0.26 5.00
159 INT283232 Negative_regulation of Localization of KCNAB2 1 0.01 0.95 0.26 5.00
160 INT279445 Binding of C7 2 0.23 0.85 0.25 5.00
161 INT279440 Binding of C6 2 0.22 0.85 0.25 5.00
162 INT210391 Negative_regulation of FUT1 5 0.20 5.51 0.23 5.00
163 INT236354 Negative_regulation of Negative_regulation of C3 2 0.25 2.19 0.21 5.00
164 INT279464 Regulation of Chkb 2 0.20 1.48 0.21 5.00
165 INT244789 Positive_regulation of Cdca3 2 0.04 1.41 0.2 5.00
166 INT262295 Regulation of CC2D1A 3 0.27 5.38 0.19 5.00
167 INT279456 Binding of Ly76 1 0.02 1.26 0.18 5.00
168 INT180525 Regulation of LCN2 4 0.54 4.37 0.18 5.00
169 INT279443 Binding of Cd59a 1 0.14 0.92 0.17 5.00
170 INT220895 Negative_regulation of Binding of C3 3 0.28 0.95 0.16 5.00
171 INT244793 Gene_expression of Cdca3 2 0.12 1.38 0.16 5.00
172 INT283236 Regulation of ATN1 1 0.09 1.67 0.14 5.00
173 INT229956 Binding of CD59 4 0.23 1.35 0.13 5.00
174 INT178221 Negative_regulation of Gene_expression of HBG1 3 0.33 2.43 0.13 5.00
175 INT279448 Binding of Cdca3 1 0.05 0.32 0.12 5.00
176 INT277914 Positive_regulation of Negative_regulation of CD59 1 0.11 1.01 0.12 5.00
177 INT279439 Binding of C1s 2 0.11 0.39 0.11 5.00
178 INT165978 Localization of CD55 5 0.60 1.78 0.1 5.00
179 INT279457 Negative_regulation of Daf2 1 0.14 3.17 0.09 5.00
180 INT262294 Positive_regulation of Gene_expression of CC2D1A 2 0.30 2.74 0.09 5.00
181 INT208515 Regulation of Gene_expression of Gpi1 2 0.11 2.51 0.09 5.00
182 INT279438 Negative_regulation of Localization of Ltf 1 0.09 0.35 0.08 5.00
183 INT283234 Positive_regulation of Protein_catabolism of CC2D1A 1 0.30 1.77 0.07 5.00
184 INT283238 Negative_regulation of Negative_regulation of CC2D1A 1 0.25 2.4 0.05 5.00
185 INT283237 Protein_catabolism of CC2D1A 1 0.52 1.7 0.05 5.00
186 INT283240 Regulation of Binding of CC2D1A 1 0.31 2.21 0.05 5.00
187 INT283233 Regulation of Regulation of EDNRA 1 0.04 2.22 0.05 5.00
188 INT198606 Localization of CFH 8 0.65 4.37 0.04 5.00
189 INT220896 Protein_catabolism of C4b 2 0.66 0.26 0.04 5.00
190 INT279460 Positive_regulation of Gene_expression of C2 1 0.10 0.14 0.04 5.00
191 INT279470 Positive_regulation of Gene_expression of Cdca3 1 0.05 1.33 0.04 5.00
192 INT279452 Negative_regulation of Negative_regulation of Serping1 1 0.06 0.3 0.03 5.00
193 INT160252 Gene_expression of C1s 5 0.21 1.49 0.03 5.00
194 INT218465 Regulation of Binding of Cfb 2 0.05 0 0 5.00
195 INT277909 Negative_regulation of Gene_expression of PIGA 1 0.41 1.17 0 5.00
196 INT66823 Positive_regulation of PIGA 2 0.49 2.83 0 5.00
197 INT289270 Positive_regulation of Gene_expression of Cd55 1 0.24 0.6 0 5.00
198 INT279450 Protein_catabolism of C2 1 0.20 0 0 5.00
199 INT259001 Localization of Cd55 2 0.35 1.1 0 5.00
200 INT174983 Regulation of HTN3 1 0.00 0.63 0 5.00
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