D:Hemolytic Uremic Syndrome

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Disease Term
Synonyms GASSER S DISEASE, Gasser S Syndrome, Gasser Syndrome, Gassers Syndrome, Haemolytic Uraemia Syndrome, Haemolytic Uraemic Syndrome, Haemolytic Uraemic Syndromes, Haemolytic Uremia Syndrome, Haemolytic Uremic Syndrome, Hemolytic Uremia Syndrome, Hemolytic Uremic Syndromes
Documents 120
Hot Single Events 74
Hot Interactions 16

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hemolytic Uremic Syndrome. They are ordered first by their relevance to Hemolytic Uremic Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT136096 Binding of CFH and CFI 1 0.04 2.28 0.05 100.00
2 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 100.00
3 INT281320 Binding of PLEK and St8sia2 1 0.06 0.38 0 99.56
4 INT281305 Binding of St8sia2 and Tlr4 1 0.02 0.98 0 96.96
5 INT281322 Binding of PLEK and Tlr4 1 0.15 1.41 0 93.24
6 INT281300 Tlr4 Positive_regulation of Gene_expression of tf 1 0.12 2.5 0 90.16
7 INT281304 Binding of St8sia2 and Positive_regulation of Localization of tf 1 0.04 0.32 0 90.16
8 INT281297 Binding of Tlr4 and Positive_regulation of Localization of tf 1 0.08 0.32 0 90.16
9 INT281296 Binding of Tlr4 and Positive_regulation of Localization of F3 1 0.03 0.32 0 90.16
10 INT281316 Binding of St8sia2 and Positive_regulation of Localization of F3 1 0.01 0.32 0 90.16
11 INT281321 STX1A Positive_regulation of Gene_expression of tf 1 0.07 0.96 0 90.00
12 INT96805 Binding of ST8SIA2 and A4GALT 1 0.01 1.31 0.07 87.80
13 INT281310 Stx2 Positive_regulation of Gene_expression of tf 1 0.20 0.89 0 86.84
14 INT279534 Binding of CFH and PTPN11 1 0.02 2.54 0 84.64
15 INT281317 Stx2 Regulation of Gene_expression of tf 1 0.11 1.45 0.03 82.40
16 INT281313 Tlr4 Regulation of Gene_expression of tf 1 0.05 1.45 0.03 82.40
17 INT198593 Binding of CFH and VHL 1 0.02 0.27 0 79.44
18 INT198594 Binding of CFH and MIR1197 1 0.01 0.48 0 75.00
19 INT281307 Binding of Selp and Selplg 1 0.01 0.76 0.17 74.16
20 INT281318 Binding of Selp and Selplg Positive_regulation of Gene_expression of Selplg 1 0.00 0.76 0.17 74.16
21 INT281319 Binding of F7 and tf 1 0.24 1 0.16 62.40
22 INT281302 Binding of Itgam and Fgg 1 0.00 0.62 0.15 55.16
23 INT281315 Binding of Gp1bb and Itgam 1 0.00 0.62 0.15 55.16
24 INT279537 ICAM3 Positive_regulation of C3 1 0.06 0.85 0 54.64
25 INT198595 Binding of CFH and CFHR1 3 0.41 1.36 0.03 50.00
26 INT281301 Stx2 Positive_regulation of Localization of F3 1 0.10 0.19 0.11 14.40
27 INT281311 Tlr4 Positive_regulation of Localization of F3 1 0.04 0.19 0.11 14.40
28 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
29 INT281309 Tlr4 Positive_regulation of Gene_expression of F3 1 0.04 0.15 0.09 5.00
30 INT281312 Stx2 Positive_regulation of Gene_expression of F3 1 0.10 0.15 0.09 5.00
31 INT281303 Binding of Stx2 and Tlr4 1 0.11 0.09 0.06 5.00
32 INT237351 Binding of Mtm1 and Gopc 1 0.19 0.17 0.05 5.00
33 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00
34 INT279536 Binding of C1QC and CRP 1 0.01 0.59 0.04 5.00
35 INT279531 Binding of LPA and MBL2 1 0.02 0.54 0.04 5.00
36 INT245218 Binding of C3 and C5AR1 2 0.29 2.94 0.04 5.00
37 INT279538 Binding of C4B and Positive_regulation of ENPEP 1 0.00 0.48 0.03 5.00
38 INT279593 Binding of C4B and Cfb 1 0.00 1.18 0.03 5.00
39 INT279533 CFH Positive_regulation of C3 1 0.07 1.8 0 5.00
40 INT281314 Positive_regulation of Stx2 Positive_regulation of Gene_expression of Itgam 1 0.08 0.21 0 5.00
41 INT279535 Binding of C1QC and MBL2 1 0.01 2.79 0 5.00
42 INT279530 MBL2 Positive_regulation of Positive_regulation of C3 1 0.26 1.71 0 5.00
43 INT281308 Binding of tf and Tlr4 1 0.06 0 0 5.00
44 INT279539 Binding of CFD and MBL2 1 0.09 0.08 0 5.00
45 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00
46 INT279592 Positive_regulation of Binding of C4B and Cfb 1 0.00 0.74 0 5.00
47 INT279540 Binding of C4B and ENPEP 1 0.00 0.82 0 5.00
48 INT237354 Binding of DNM2 and Bin1 1 0.40 1.22 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hemolytic Uremic Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Hemolytic Uremic Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 100.00
2 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 100.00
3 INT43931 Binding of CFH 49 0.48 31.85 3.96 100.00
4 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 100.00
5 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 100.00
6 INT56809 Binding of Tlr4 184 0.48 106.02 31.18 100.00
7 INT146898 Positive_regulation of Binding of CFH 3 0.44 2.01 0.17 100.00
8 INT146899 Positive_regulation of Positive_regulation of CFH 2 0.50 1.37 0.17 100.00
9 INT281278 Localization of Hus1 1 0.02 0.59 0 100.00
10 INT198606 Localization of CFH 8 0.65 4.37 0.04 100.00
11 INT281290 Positive_regulation of Hus1 1 0.01 0.95 0 100.00
12 INT281285 Gene_expression of Stx2 1 0.63 5.14 0.38 99.96
13 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 99.92
14 INT136097 Negative_regulation of CD46 1 0.13 1.91 0.09 99.84
15 INT281275 Positive_regulation of Positive_regulation of tf 1 0.27 1.12 0.31 99.84
16 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57 99.76
17 INT250743 Localization of CC2D1A 12 0.51 20.97 0.51 99.74
18 INT23669 Binding of St8sia2 24 0.47 11.37 2.69 99.70
19 INT23226 Positive_regulation of tf 23 0.43 15.55 14.37 99.68
20 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 99.60
21 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 99.60
22 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 99.60
23 INT283060 Positive_regulation of Atp5s 1 0.20 1.81 0 99.60
24 INT119223 Gene_expression of EPHA1 3 0.55 2.59 0.06 99.52
25 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 99.44
26 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6 99.20
27 INT112677 Localization of tf 20 0.48 9.66 1.06 99.12
28 INT129454 Negative_regulation of Adamts13 6 0.30 7.78 0.31 99.12
29 INT23665 Gene_expression of St8sia2 14 0.58 6.74 1.08 99.12
30 INT77853 Positive_regulation of Gene_expression of tf 20 0.31 22.75 5.94 99.08
31 INT262874 Positive_regulation of Gene_expression of ST8SIA2 3 0.11 1.82 0 98.96
32 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 98.88
33 INT23224 Gene_expression of tf 99 0.56 60.22 22.03 98.84
34 INT756 Gene_expression of C3 138 0.75 100.6 19.2 98.78
35 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 98.30
36 INT8546 Positive_regulation of MUC16 99 0.69 74.98 11.26 97.96
37 INT281286 Binding of Stx2 1 0.39 2.02 0.55 97.36
38 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 96.80
39 INT81775 Localization of F3 10 0.61 9.12 0.73 96.36
40 INT70744 Regulation of CFH 12 0.41 7.38 0.8 96.08
41 INT262878 Gene_expression of ST8SIA2 7 0.39 4.7 1.01 95.76
42 INT156579 Localization of Selp 14 0.73 6.53 2.69 94.88
43 INT167637 Negative_regulation of Protein_catabolism of Vwf 1 0.08 3.35 0.19 94.16
44 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 94.16
45 INT167636 Protein_catabolism of Vwf 5 0.52 5.09 0.41 93.36
46 INT9900 Positive_regulation of Vwf 80 0.69 51.85 18.13 93.36
47 INT78498 Regulation of Gene_expression of tf 9 0.32 7.69 1.79 92.84
48 INT281284 Positive_regulation of Binding of St8sia2 1 0.07 1.56 0.04 92.72
49 INT167638 Regulation of Protein_catabolism of Vwf 1 0.05 1.61 0.1 92.40
50 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 92.08
51 INT112676 Positive_regulation of Localization of tf 3 0.31 2.98 0.65 91.52
52 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 91.40
53 INT23932 Negative_regulation of ST8SIA2 4 0.22 1.26 1.73 91.12
54 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 90.40
55 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 89.96
56 INT130392 Positive_regulation of Gene_expression of HP 7 0.69 7.34 1.9 89.96
57 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 89.84
58 INT23351 Positive_regulation of CFI 4 0.29 1.82 0.21 89.84
59 INT262879 Regulation of Gene_expression of ST8SIA2 2 0.10 1.24 0.03 89.68
60 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 88.76
61 INT262295 Regulation of CC2D1A 3 0.27 5.38 0.19 88.24
62 INT10893 Binding of VWF 27 0.47 25.02 2.82 87.36
63 INT18677 Gene_expression of F3 50 0.65 30.86 5.86 87.32
64 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 86.16
65 INT281277 Positive_regulation of Stx2 1 0.41 0.93 0.27 86.16
66 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14 86.16
67 INT281280 Positive_regulation of Positive_regulation of Stx2 1 0.41 0.52 0.06 86.16
68 INT20650 Positive_regulation of F2 26 0.69 15.49 5.08 85.92
69 INT116867 Positive_regulation of Gene_expression of CFH 11 0.67 11.42 0.3 83.84
70 INT198598 Transcription of CFH 3 0.69 3.21 0.05 83.84
71 INT198603 Positive_regulation of Transcription of CFH 2 0.50 2 0 83.84
72 INT213381 Gene_expression of STX1A 5 0.65 3.41 0.71 81.52
73 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 80.28
74 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 80.28
75 INT241305 Binding of PTPN11 9 0.46 6.08 0.1 78.16
76 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 77.52
77 INT281282 Negative_regulation of Stx2 1 0.34 0.34 0 77.52
78 INT283239 Negative_regulation of Localization of CC2D1A 1 0.29 10.4 0.41 76.80
79 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 76.48
80 INT198607 Regulation of Gene_expression of CFH 2 0.27 2.16 0 75.00
81 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 75.00
82 INT98995 Binding of Selplg 3 0.36 2.59 0.38 74.16
83 INT101314 Gene_expression of Selplg 10 0.75 5.63 1.71 71.36
84 INT196322 Binding of F2 18 0.15 7.74 0.83 71.04
85 INT18412 Binding of PLEK 49 0.47 17.82 10.72 70.96
86 INT17081 Binding of Ttpa 7 0.27 2.12 0.34 70.92
87 INT78499 Binding of tf 8 0.22 2.64 0.55 69.28
88 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 67.44
89 INT279579 Transcription of C4A 1 0.11 0.93 0 62.60
90 INT279588 Negative_regulation of Transcription of C4A 1 0.07 0.93 0 62.60
91 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 61.92
92 INT254143 Negative_regulation of CC2D1A 10 0.35 13.81 0.82 59.52
93 INT137203 Positive_regulation of Emr1 3 0.45 2.34 0.24 59.12
94 INT9254 Negative_regulation of LDHA 23 0.43 13.3 2.2 58.60
95 INT15173 Positive_regulation of Gene_expression of Itgam 59 0.49 21.89 5.43 56.68
96 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 56.24
97 INT194049 Positive_regulation of Binding of CRP 3 0.48 4.48 0.24 54.24
98 INT279587 Positive_regulation of Binding of ICAM3 1 0.07 0.85 0 54.24
99 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11 52.48
100 INT100861 Binding of CRP 179 0.48 175.2 26.45 52.28
101 INT279569 Binding of ICAM3 1 0.06 0.78 0 52.28
102 INT661 Gene_expression of REN 100 0.78 48.21 11.36 52.08
103 INT17905 Binding of Fgg 9 0.05 4.79 1.68 50.04
104 INT17598 Positive_regulation of CFHR1 11 0.50 2.6 2.38 50.00
105 INT17596 Gene_expression of CFHR1 24 0.67 3.07 1.61 50.00
106 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 50.00
107 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 50.00
108 INT17597 Positive_regulation of Gene_expression of CFHR1 3 0.50 0 0.85 50.00
109 INT45722 Negative_regulation of CFHR1 6 0.56 1.43 0.78 50.00
110 INT198600 Negative_regulation of Gene_expression of CFH 4 0.41 3.25 0.12 50.00
111 INT179307 Regulation of GNAS 7 0.01 1.93 0.05 50.00
112 INT198599 Transcription of CFHR1 1 0.69 0.14 0 50.00
113 INT198602 Positive_regulation of Positive_regulation of CFHR1 1 0.50 0.23 0 50.00
114 INT198601 Positive_regulation of MIR1197 1 0.01 0 0 50.00
115 INT198608 Positive_regulation of Transcription of CFHR1 1 0.50 0.14 0 50.00
116 INT198605 Gene_expression of CFHR3 1 0.63 0 0 50.00
117 INT198609 Positive_regulation of Gene_expression of CFHR3 1 0.47 0 0 50.00
118 INT262293 Gene_expression of CC2D1A 21 0.40 44.64 1.5 49.52
119 INT246070 Gene_expression of GPX2 3 0.65 1.79 0.15 49.12
120 INT29402 Gene_expression of Src 16 0.74 4.57 2.29 46.80
121 INT100222 Binding of Src 9 0.26 5.41 5.37 46.08
122 INT262876 Localization of ST8SIA2 2 0.16 1.41 1.39 42.96
123 INT35584 Binding of ACLY 22 0.35 31.78 7.17 42.00
124 INT33393 Positive_regulation of Gene_expression of PLEK 9 0.67 7.35 1.65 41.32
125 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 41.00
126 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 37.36
127 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 34.96
128 INT228975 Gene_expression of SERPINA2 1 0.31 1.61 0 34.40
129 INT104031 Regulation of ENPEP 18 0.33 13.48 1.69 34.00
130 INT283232 Negative_regulation of Localization of KCNAB2 1 0.01 0.95 0.26 32.52
131 INT283235 Localization of KCNAB2 1 0.02 0.94 0.26 32.12
132 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 30.32
133 INT194546 Positive_regulation of Gene_expression of Dbp 9 0.28 2.93 0.36 29.64
134 INT8773 Gene_expression of HBG1 58 0.76 37.6 4.59 29.44
135 INT178221 Negative_regulation of Gene_expression of HBG1 3 0.33 2.43 0.13 29.44
136 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01 28.80
137 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 28.64
138 INT2442 Localization of Mb 38 0.80 24.74 6.33 23.92
139 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 23.56
140 INT279582 Positive_regulation of C1QC 3 0.02 2.62 0 23.12
141 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 22.24
142 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 21.48
143 INT185412 Negative_regulation of CFD 5 0.27 3.49 0.2 15.76
144 INT279586 Negative_regulation of Gene_expression of CFD 3 0.20 3.99 0.16 15.76
145 INT170854 Gene_expression of CFD 26 0.68 39.77 4.74 14.48
146 INT259036 Transcription of SH2B2 2 0.55 7.01 1.46 14.12
147 INT262297 Negative_regulation of Gene_expression of CC2D1A 2 0.25 2.95 0.31 13.72
148 INT117998 Positive_regulation of Gene_expression of Src 4 0.36 1.45 0.51 11.92
149 INT259032 Binding of PEX1 2 0.01 4.67 0.15 10.88
150 INT283240 Regulation of Binding of CC2D1A 1 0.31 2.21 0.05 10.84
151 INT138843 Binding of CC2D1A 19 0.33 33.06 1.25 10.36
152 INT126030 Regulation of CFD 4 0.21 3.92 0.83 6.72
153 INT279571 Regulation of Gene_expression of CFD 2 0.21 2.86 0.31 6.72
154 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
155 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
156 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
157 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
158 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
159 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
160 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
161 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
162 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
163 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 5.00
164 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
165 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
166 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
167 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
168 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 5.00
169 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
170 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
171 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
172 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
173 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
174 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
175 INT50039 Positive_regulation of Il4 48 0.55 34.8 23.34 5.00
176 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
177 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
178 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
179 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
180 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 5.00
181 INT75434 Gene_expression of Il13 27 0.52 26.19 15.4 5.00
182 INT2383 Positive_regulation of CP 33 0.67 25.41 15.38 5.00
183 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 5.00
184 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
185 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
186 INT9649 Positive_regulation of LPA 105 0.69 74.75 13.89 5.00
187 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
188 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 5.00
189 INT17584 Regulation of tf 12 0.50 4.69 10.39 5.00
190 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 5.00
191 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
192 INT25834 Positive_regulation of Dbp 59 0.68 24.34 9.32 5.00
193 INT32581 Positive_regulation of C4B 9 0.45 11.17 9.05 5.00
194 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 5.00
195 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35 5.00
196 INT32579 Binding of C4B 14 0.36 14.99 7.79 5.00
197 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
198 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
199 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 5.00
200 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
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