D:Heparin-induced Thrombocytopenia

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Heparin Induced Immune Thrombocytopenia, Induced Thrombocytopenia
Documents 167
Hot Single Events 55
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Heparin-induced Thrombocytopenia. They are ordered first by their relevance to Heparin-induced Thrombocytopenia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT68691 Positive_regulation of Binding of CSF2 and IL3 1 0.49 2.63 0.48 100.00
2 INT11684 Binding of CSF2 and IL3 6 0.36 3.3 0.72 99.82
3 INT187571 Binding of FANCB and Pf4 1 0.00 0.46 0 99.10
4 INT241167 Binding of TNXA and Serpinc1 1 0.00 0.43 0.13 80.96
5 INT240768 Binding of F2 and F13A1 1 0.07 2.25 0.15 33.84
6 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
7 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
8 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
9 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
10 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19 5.00
11 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57 5.00
12 INT298472 LPA Positive_regulation of Gene_expression of CXCL16 1 0.05 0.41 0.32 5.00
13 INT298501 Paf Regulation of Negative_regulation of Alms1 1 0.00 0.63 0.29 5.00
14 INT170128 Binding of ITGAL and ITGB2 2 0.04 1.6 0.28 5.00
15 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28 5.00
16 INT289959 Negative_regulation of Binding of CD28 and CD80 1 0.07 0.24 0.23 5.00
17 INT289953 Binding of CD80 and KLF1 1 0.00 0.21 0.23 5.00
18 INT289955 Binding of APCS and KLF1 1 0.00 0.21 0.23 5.00
19 INT298475 LPA Positive_regulation of Gene_expression of IL8 1 0.07 0.38 0.15 5.00
20 INT298500 Alb Positive_regulation of Paf 1 0.01 0.34 0.15 5.00
21 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
22 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13 5.00
23 INT298476 CD40LG Positive_regulation of HLA-DRB1 1 0.01 0.33 0.12 5.00
24 INT298471 CD40LG Positive_regulation of CD80 1 0.04 0.33 0.12 5.00
25 INT298479 CD40LG Positive_regulation of CD40LG Positive_regulation of HLA-DRB1 1 0.00 0.33 0.12 5.00
26 INT298474 IL4 Positive_regulation of HLA-DRB1 1 0.02 0.33 0.12 5.00
27 INT289958 Binding of IL2 and IL2RB 1 0.02 0.59 0.12 5.00
28 INT298478 IL4 Positive_regulation of CD40LG Positive_regulation of HLA-DRB1 1 0.01 0.33 0.12 5.00
29 INT298473 IL4 Positive_regulation of CD80 1 0.06 0.33 0.12 5.00
30 INT265919 Binding of PLEK and Adp 1 0.01 0.38 0.11 5.00
31 INT298497 CTSC Positive_regulation of F10 Positive_regulation of F2 1 0.00 0.12 0.1 5.00
32 INT279400 GANAB Regulation of ITGAL 1 0.01 0.75 0.09 5.00
33 INT298502 F10 Positive_regulation of F2 1 0.00 0.12 0.09 5.00
34 INT213239 Binding of TNXA and Serpinc1 1 0.00 0.16 0.08 5.00
35 INT289957 Binding of APCS and CD58 1 0.04 0.35 0.08 5.00
36 INT344266 Binding of APOH and CD40LG 1 0.04 0.31 0 5.00
37 INT175246 Binding of F13A1 and SH2B2 1 0.00 2.24 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Heparin-induced Thrombocytopenia. They are ordered first by their pain relevance and then by number of times they were reported in Heparin-induced Thrombocytopenia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131610 Gene_expression of scat 2 0.59 0.98 0 100.00
2 INT87699 Positive_regulation of WAS 16 0.45 5.84 8.03 100.00
3 INT14182 Gene_expression of CPB1 26 0.67 10.06 1.9 99.84
4 INT344283 Negative_regulation of Gene_expression of CPB1 1 0.07 0.61 0.06 99.84
5 INT52965 Negative_regulation of TNXA 18 0.43 8.38 1.9 99.76
6 INT3086 Binding of Pf4 14 0.47 7.1 0.86 99.70
7 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 99.20
8 INT18412 Binding of PLEK 49 0.47 17.82 10.72 99.06
9 INT32394 Regulation of Pf4 12 0.23 6.07 2.85 98.98
10 INT717 Regulation of F2 29 0.61 17.46 6.99 98.92
11 INT11686 Regulation of IL3 15 0.45 8.69 2.54 98.84
12 INT106805 Localization of ACCS 15 0.53 15.22 3.98 98.64
13 INT48909 Localization of DLD 9 0.63 3.37 0.75 98.24
14 INT284514 Regulation of Regulation of PF4 1 0.20 1.19 0.12 98.06
15 INT17694 Regulation of PF4 2 0.44 1.18 0.12 97.88
16 INT118490 Regulation of CNOT4 2 0.02 1.18 0.27 97.88
17 INT12975 Regulation of PLEK 21 0.60 13.62 8.28 97.88
18 INT96132 Gene_expression of F10 10 0.58 6.99 1.24 97.44
19 INT286953 Gene_expression of TNXA 8 0.21 1.74 0.27 97.44
20 INT313643 Negative_regulation of Gene_expression of TNXA 1 0.13 1.01 0.03 97.44
21 INT313644 Negative_regulation of Gene_expression of F10 1 0.34 1.02 0.03 97.44
22 INT35609 Negative_regulation of F10 37 0.57 17.15 4.41 96.68
23 INT18413 Positive_regulation of Binding of PLEK 3 0.49 1.06 0.77 96.56
24 INT19941 Negative_regulation of Pf4 13 0.42 10.35 5.97 95.56
25 INT12035 Regulation of F2 21 0.45 12.66 1.47 95.24
26 INT129967 Binding of Cnot4 3 0.03 2.61 0.75 94.96
27 INT58032 Positive_regulation of Localization of Pf4 3 0.67 1.72 1.46 94.92
28 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96 94.92
29 INT9842 Binding of F2 36 0.47 22.79 4.42 94.80
30 INT14447 Localization of F2 20 0.79 12.77 2.67 94.76
31 INT259024 Regulation of Anxa5 1 0.44 1.25 0 94.72
32 INT200524 Protein_catabolism of ADAMTS13 1 0.40 1.34 0.05 94.56
33 INT41358 Localization of Pf4 11 0.79 6.06 2.89 94.12
34 INT255014 Negative_regulation of Binding of F10 7 0.34 1.81 0.28 93.04
35 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75 92.80
36 INT82845 Binding of F10 25 0.37 7.07 0.81 92.72
37 INT71933 Positive_regulation of Gene_expression of F2 19 0.56 14.24 2.53 92.44
38 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 92.44
39 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 92.24
40 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 92.04
41 INT55733 Negative_regulation of VTN 47 0.58 47.22 5.68 89.60
42 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56 88.36
43 INT69158 Localization of IL4 48 0.71 31.3 11.98 88.24
44 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35 87.60
45 INT14205 Regulation of KLK1 10 0.60 4.38 1.28 86.84
46 INT4047 Binding of F13A1 105 0.43 66.54 11.81 86.80
47 INT39780 Binding of COX8A 2 0.47 1.13 0.27 86.72
48 INT39779 Positive_regulation of Binding of COX8A 1 0.49 0.48 0.2 86.72
49 INT5180 Binding of Serpinc1 27 0.36 13.39 2.47 84.72
50 INT27740 Positive_regulation of COX8A 16 0.67 9.66 3.23 84.48
51 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 83.92
52 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 83.76
53 INT812 Localization of INS 1026 0.81 515.6 145.31 83.52
54 INT242195 Positive_regulation of Negative_regulation of F10 1 0.01 0.34 0.03 83.36
55 INT241166 Binding of TNXA 1 0.01 0.43 0.13 80.96
56 INT21840 Positive_regulation of IL3 20 0.70 14.44 2.86 79.68
57 INT18008 Negative_regulation of IL3 4 0.40 1.5 0.62 78.80
58 INT90307 Positive_regulation of ZNF85 1 0.07 0.39 0.08 77.20
59 INT181870 Localization of THPO 3 0.75 2.7 1.39 76.96
60 INT67283 Binding of Serpinc1 8 0.47 5.02 1.01 76.88
61 INT111820 Positive_regulation of Fdps 10 0.42 10.63 3.01 76.76
62 INT191583 Positive_regulation of Gene_expression of Fdps 2 0.15 1.55 0.44 76.76
63 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52 76.48
64 INT92493 Gene_expression of Fdps 19 0.75 11.28 10.08 76.40
65 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 75.04
66 INT11390 Gene_expression of PF4 5 0.65 3.09 2.07 75.00
67 INT90306 Gene_expression of ZNF85 1 0.11 0.37 0.08 75.00
68 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 75.00
69 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 75.00
70 INT90305 Negative_regulation of ZNF85 1 0.06 0.35 0.07 75.00
71 INT3889 Regulation of Serpinc1 13 0.61 8.6 3.46 66.32
72 INT259040 Phosphorylation of SH2B2 1 0.47 0.85 0.03 63.92
73 INT259029 Regulation of Phosphorylation of SH2B2 1 0.26 0.85 0.03 63.92
74 INT156908 Transcription of THPO 2 0.69 0.15 0 50.00
75 INT69952 Positive_regulation of IK 45 0.32 16.08 14.59 47.08
76 INT142404 Gene_expression of THPO 18 0.77 4.39 0.56 46.24
77 INT306547 Localization of Serpinc1 1 0.05 0.14 0.04 42.64
78 INT306550 Negative_regulation of Localization of Serpinc1 1 0.03 0.15 0.04 42.64
79 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 41.92
80 INT157725 Gene_expression of ACLS 2 0.13 2.89 0.17 41.76
81 INT325346 Negative_regulation of Gene_expression of THPO 1 0.43 0.42 0.05 40.72
82 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 40.48
83 INT161965 Binding of THPO 12 0.48 1.78 0.78 40.08
84 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 34.24
85 INT325348 Regulation of Gene_expression of THPO 1 0.61 0.12 0.07 34.08
86 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 33.60
87 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 32.76
88 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 32.56
89 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 32.56
90 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 32.56
91 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 32.56
92 INT325347 Positive_regulation of Localization of THPO 1 0.50 0.1 0 29.28
93 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 28.36
94 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 28.36
95 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 28.36
96 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 28.36
97 INT17693 Localization of PF4 2 0.68 1.26 1.56 27.92
98 INT298496 Protein_catabolism of PF4 1 0.40 0.47 0.3 26.08
99 INT25602 Positive_regulation of THPO 5 0.69 4.55 0.57 26.00
100 INT52740 Binding of ACLS 5 0.31 3 0.54 25.84
101 INT6849 Localization of IL1B 229 0.81 112.56 69.63 25.52
102 INT12923 Negative_regulation of Atp9a 17 0.35 7.87 3.52 21.76
103 INT46088 Localization of F3 15 0.37 13.7 2.23 20.12
104 INT242196 Positive_regulation of Localization of F3 3 0.09 1.71 0.15 20.12
105 INT44920 Negative_regulation of IK 18 0.41 9.9 7.16 19.28
106 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 17.68
107 INT200523 Regulation of F7 2 0.01 1.82 0.38 16.72
108 INT35584 Binding of ACLY 22 0.35 31.78 7.17 16.56
109 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 16.40
110 INT6481 Binding of TNF 624 0.48 510.2 214.82 15.60
111 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 15.44
112 INT230086 Negative_regulation of Localization of IFN1@ 9 0.57 6.06 1.25 15.44
113 INT193466 Binding of Acta1 5 0.27 2.62 0.23 12.40
114 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 11.04
115 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 11.04
116 INT39457 Positive_regulation of SOAT1 32 0.67 22.8 8.28 9.84
117 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 7.68
118 INT325345 Positive_regulation of Gene_expression of THPO 1 0.50 0.09 0 7.04
119 INT75869 Gene_expression of Acsl1 24 0.45 27.76 3.66 5.72
120 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
121 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
122 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
123 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
124 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
125 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
126 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
127 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
128 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
129 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
130 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
131 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 5.00
132 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
133 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
134 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
135 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 5.00
136 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
137 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 5.00
138 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 5.00
139 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
140 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
141 INT2429 Negative_regulation of Mpo 128 0.59 93.76 39.57 5.00
142 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
143 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
144 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
145 INT103094 Binding of PPARA 308 0.47 177.26 34.75 5.00
146 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
147 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
148 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
149 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
150 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
151 INT9650 Gene_expression of LPA 141 0.75 104.57 29 5.00
152 INT2609 Localization of ELANE 111 0.81 50.22 26.63 5.00
153 INT5650 Gene_expression of Mpo 117 0.77 80.27 26.42 5.00
154 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6 5.00
155 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
156 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 5.00
157 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
158 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
159 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 5.00
160 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
161 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61 5.00
162 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
163 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
164 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
165 INT1060 Negative_regulation of Pla2g1b 50 0.57 22.91 18.12 5.00
166 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 5.00
167 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
168 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
169 INT100139 Positive_regulation of Gene_expression of PPARA 160 0.63 97.78 14.53 5.00
170 INT22276 Gene_expression of TBXA2R 65 0.77 23.22 14.21 5.00
171 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
172 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
173 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
174 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 5.00
175 INT132178 Binding of CD80 41 0.47 15.55 12.98 5.00
176 INT8232 Gene_expression of Paf 21 0.67 22.18 12.8 5.00
177 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
178 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
179 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47 5.00
180 INT55687 Localization of TIMP1 47 0.74 30.24 12.31 5.00
181 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
182 INT73829 Positive_regulation of Gene_expression of VCAM1 41 0.61 35.96 11.92 5.00
183 INT2415 Binding of MAOA 26 0.47 13.26 11.86 5.00
184 INT49142 Gene_expression of SELP 94 0.75 54.61 11.64 5.00
185 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 5.00
186 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
187 INT13303 Positive_regulation of PTAFR 40 0.69 16.27 11.56 5.00
188 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
189 INT150540 Binding of TLR2 50 0.45 35.86 10.43 5.00
190 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14 5.00
191 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
192 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
193 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 5.00
194 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 5.00
195 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 5.00
196 INT15449 Positive_regulation of Plat 32 0.69 12.76 9.71 5.00
197 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
198 INT47390 Negative_regulation of Paf 18 0.58 14.81 9.66 5.00
199 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5 5.00
200 INT62829 Positive_regulation of VCAM1 39 0.70 38.42 9.15 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox