D:Hepatic Encephalopathy

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Disease Term
Synonyms Coma Hepatic, Coma Hepaticum, COMAS HEPATIC, Encephalopathies Hepatic, Encephalopathies Hepatocerebral, Encephalopathies Portal Systemic, Encephalopathies Portosystemic, ENCEPHALOPATHY HEPATIC, Encephalopathy Hepatocerebral, Encephalopathy Portal Systemic, Encephalopathy Portosystemic
Documents 292
Hot Single Events 107
Hot Interactions 4

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hepatic Encephalopathy. They are ordered first by their relevance to Hepatic Encephalopathy and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT52632 Binding of TSPO and CCK 1 0.15 0.53 0.37 94.28
2 INT220288 MARS Regulation of AFM 1 0.06 1.14 0.08 93.76
3 INT220289 MARS Regulation of CEBPZ 1 0.02 0.93 0.11 93.56
4 INT251702 Fig4 Regulation of Positive_regulation of Ache 1 0.07 0.42 0 87.72
5 INT251704 Ache Regulation of Gene_expression of Acot1 1 0.08 1.68 0.87 78.48
6 INT43543 SH3RF3 Negative_regulation of DNAH8 1 0.03 0.27 0.14 75.00
7 INT251706 Chat Regulation of Gene_expression of Acot1 1 0.06 1.64 0.85 72.96
8 INT251708 Chat Regulation of Acot1 1 0.03 1.64 0.84 72.96
9 INT220290 Binding of AFM and MARS 1 0.05 1.09 0.07 71.12
10 INT319963 Binding of IGFALS and Vcan 1 0.03 2.99 0.13 68.84
11 INT244709 Binding of Ldha and Gpt 1 0.01 1.32 0 52.56
12 INT186502 Binding of AMELX and HLA-A 1 0.00 0.71 0 44.60
13 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08 37.92
14 INT301649 Irs1 Negative_regulation of Transcription of G6pc 1 0.05 0.65 0.08 37.92
15 INT301641 Irs2 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08 37.52
16 INT301628 Irs2 Negative_regulation of Transcription of G6pc 1 0.04 0.65 0.08 37.52
17 INT301619 Positive_regulation of Irs1 Positive_regulation of Gene_expression of Srebf1 1 0.10 0.67 0.08 32.84
18 INT301646 Srebf1 Negative_regulation of Gene_expression of Irs2 1 0.08 0.62 0.08 30.12
19 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08 12.88
20 INT301659 Gene_expression of Mapk8 Positive_regulation of Positive_regulation of Srebf1 1 0.33 0.8 0.08 12.88
21 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59 5.00
22 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24 5.00
23 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71 5.00
24 INT349585 Aap Positive_regulation of Etf1 1 0.00 1.68 1.94 5.00
25 INT349588 Aap Positive_regulation of Gene_expression of Ros1 1 0.06 0.73 1.85 5.00
26 INT349587 Binding of Aap and Csf2 1 0.04 0.41 1.18 5.00
27 INT349586 Aap Regulation of Gene_expression of Ros1 1 0.03 0.56 1.17 5.00
28 INT349590 Aap Positive_regulation of Cytl1 1 0.13 1.31 1.15 5.00
29 INT349576 Binding of Ugt2b and Sult1a1 1 0.00 0.45 1.03 5.00
30 INT349592 GTF2H5 Negative_regulation of Cyp2c22 1 0.00 0.64 0.98 5.00
31 INT261783 Bdnf Regulation of Gene_expression of Slc12a5 1 0.09 0 0.87 5.00
32 INT186672 IL8 Positive_regulation of Transcription of PTH 1 0.01 1.83 0.85 5.00
33 INT261786 Bdnf Negative_regulation of Slc12a5 1 0.14 0.05 0.85 5.00
34 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77 5.00
35 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 5.00
36 INT186674 Binding of BGLAP and CYP27A1 1 0.01 1.91 0.71 5.00
37 INT261782 Bdnf Positive_regulation of Gene_expression of Slc12a5 1 0.18 0 0.44 5.00
38 INT186673 IL8 Positive_regulation of Positive_regulation of PTH 1 0.01 0.92 0.42 5.00
39 INT261790 SHC1 Positive_regulation of Slc12a5 1 0.02 0.06 0.41 5.00
40 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39 5.00
41 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38 5.00
42 INT261788 Bdnf Regulation of Slc12a5 1 0.10 0.07 0.38 5.00
43 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38 5.00
44 INT301665 CYP2C9 Regulation of Binding of Ppara 1 0.26 1.79 0.34 5.00
45 INT301666 Binding of CYP4F2 and Ltb4r1 1 0.02 0.57 0.28 5.00
46 INT301668 Ltb4r1 Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27 5.00
47 INT301671 Ltc4s Positive_regulation of Gene_expression of IL8 1 0.00 0.9 0.27 5.00
48 INT301670 Binding of CYP4F2 and Cyp4f18 1 0.02 1.04 0.27 5.00
49 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25 5.00
50 INT260743 Mapk14 Regulation of Gene_expression of Il10 1 0.04 0.99 0.24 5.00
51 INT261787 Positive_regulation of Bdnf Positive_regulation of Fig4 1 0.02 0.77 0.2 5.00
52 INT261784 Positive_regulation of Bdnf Positive_regulation of Slc12a5 1 0.15 0.77 0.2 5.00
53 INT301083 Binding of BCS1L and MYH7 1 0.36 1.53 0.19 5.00
54 INT301615 Binding of Cyp2e1 and Samsn1 1 0.02 2.42 0.18 5.00
55 INT301638 Ppara Regulation of Slc27a2 1 0.30 0.29 0.14 5.00
56 INT261789 PDGFA Positive_regulation of Slc12a5 1 0.07 0.15 0.12 5.00
57 INT182886 Ros1 Positive_regulation of Mapk8 3 0.09 2.3 0.12 5.00
58 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
59 INT301637 Positive_regulation of Ros1 Positive_regulation of Phosphorylation of Ins1 1 0.00 0.91 0.1 5.00
60 INT240903 Mapk8 Positive_regulation of Ros1 2 0.09 1.01 0.1 5.00
61 INT301660 Ppara Regulation of Gene_expression of CYP4A11 1 0.24 0.65 0.09 5.00
62 INT301663 Ppara Regulation of CYP4A11 1 0.14 0.65 0.09 5.00
63 INT251712 Fig4 Regulation of Ache 1 0.02 0.23 0.08 5.00
64 INT301613 Binding of Fabp4 and Cd36 1 0.05 0.38 0.08 5.00
65 INT301645 Binding of Alb and Slc27a1 1 0.02 0.38 0.08 5.00
66 INT301651 Binding of Alb and Fabp4 1 0.01 0.38 0.08 5.00
67 INT251710 Fig4 Regulation of Chat 1 0.03 0.23 0.08 5.00
68 INT251705 Fig4 Regulation of Localization of Chat 1 0.05 0.23 0.08 5.00
69 INT251703 Fig4 Regulation of Localization of Ache 1 0.07 0.23 0.08 5.00
70 INT301614 Binding of Slc27a1 and Cd36 1 0.09 0.38 0.08 5.00
71 INT301656 Ins1 Positive_regulation of Srebf1 1 0.02 0.73 0.07 5.00
72 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00
73 INT301623 Ins1 Positive_regulation of Slc27a2 1 0.01 0.37 0.07 5.00
74 INT301632 Binding of Dbi and Fabp1 1 0.13 0.49 0.07 5.00
75 INT301658 Ins1 Positive_regulation of Slc27a4 1 0.01 0.37 0.07 5.00
76 INT212440 STAT3 Regulation of Phosphorylation of SOAT1 1 0.11 1.42 0.05 5.00
77 INT301496 PPA1 Negative_regulation of CYP4F3 1 0.01 0.69 0.05 5.00
78 INT301497 UBXN11 Negative_regulation of CYP4F3 1 0.37 0.69 0.05 5.00
79 INT301653 Mlxipl Positive_regulation of Gene_expression of Scd1 1 0.08 0.5 0.05 5.00
80 INT212442 HGF Positive_regulation of MET 2 0.21 1.25 0.04 5.00
81 INT301627 Binding of Fabp1 and Ppara 1 0.21 0.49 0.04 5.00
82 INT301661 Binding of CYP2B6 and Ros1 1 0.02 0.64 0.04 5.00
83 INT296893 Nps Negative_regulation of Gene_expression of REN 1 0.00 1.05 0.04 5.00
84 INT301647 Negative_regulation of Mapk8 Positive_regulation of Irs1 1 0.08 0.83 0.04 5.00
85 INT301626 Mapk8 Positive_regulation of Irs1 1 0.09 0.83 0.04 5.00
86 INT301643 Binding of Dbi and fa 1 0.05 0.45 0.03 5.00
87 INT301667 Tlr4 Positive_regulation of Gene_expression of CYBB 1 0.01 0.84 0.03 5.00
88 INT301662 Binding of Tlr4 and Positive_regulation of Gene_expression of CYBB 1 0.01 0.84 0.03 5.00
89 INT251701 Bche Regulation of Gene_expression of Acot1 1 0.03 0.25 0.03 5.00
90 INT301622 Binding of Fabp4 and fa 1 0.01 0.45 0.03 5.00
91 INT301633 Binding of Ros1 and Cyb5 1 0.00 0.41 0 5.00
92 INT301640 Positive_regulation of Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.03 0.25 0 5.00
93 INT301635 Ppara Positive_regulation of Gene_expression of Fabp1 1 0.26 0.29 0 5.00
94 INT301657 Binding of Dbi and Ppara 1 0.26 0.23 0 5.00
95 INT301644 Fabp4 Positive_regulation of fa 1 0.01 0 0 5.00
96 INT301629 Ins1 Positive_regulation of Mlxipl 1 0.00 0.36 0 5.00
97 INT301636 Slc27a1 Positive_regulation of Fabp4 1 0.01 0 0 5.00
98 INT301621 Ppara Positive_regulation of Gene_expression of Mttp 1 0.22 0.59 0 5.00
99 INT301669 PPA1 Positive_regulation of Ppara 1 0.02 0.14 0 5.00
100 INT301082 Binding of BCS1L and TARM1 1 0.17 1.21 0 5.00
101 INT301650 Ins1 Positive_regulation of Dbi 1 0.02 0.23 0 5.00
102 INT301620 Positive_regulation of Binding of Ros1 and Scd1 1 0.03 0.41 0 5.00
103 INT301652 Binding of Ros1 and Scd1 1 0.02 0.41 0 5.00
104 INT301624 Slc27a1 Positive_regulation of fa 1 0.03 0 0 5.00
105 INT301664 UBXN11 Positive_regulation of Negative_regulation of Cpt1a 1 0.27 0.37 0 5.00
106 INT301634 Positive_regulation of Binding of Ros1 and Cyb5 1 0.00 0.41 0 5.00
107 INT301639 Positive_regulation of Mlxipl Positive_regulation of Gene_expression of Pklr 1 0.03 0.52 0 5.00
108 INT301654 Binding of Slc27a2 and Slc27a5 1 0.15 0.18 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hepatic Encephalopathy. They are ordered first by their pain relevance and then by number of times they were reported in Hepatic Encephalopathy. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT220294 Positive_regulation of Gene_expression of MARS 3 0.35 2.45 0.05 100.00
2 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 99.96
3 INT7909 Positive_regulation of Positive_regulation of Got1 8 0.49 6.44 3.06 99.96
4 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 99.90
5 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 99.72
6 INT4735 Gene_expression of Acot1 80 0.71 13.22 26.68 99.66
7 INT61644 Gene_expression of Gc 16 0.70 11.35 1.95 99.64
8 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 99.60
9 INT6073 Negative_regulation of Localization of Penk 63 0.59 8.67 53.95 99.52
10 INT22542 Regulation of ITPA 2 0.44 0.45 0.35 99.40
11 INT220292 Binding of AFM 3 0.10 1.15 0.25 99.40
12 INT61645 Negative_regulation of Gc 15 0.51 10.44 2.71 99.32
13 INT220295 Gene_expression of MARS 6 0.47 4.74 0.35 99.28
14 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 99.24
15 INT17563 Negative_regulation of Hya 1 0.19 0.46 0.11 99.24
16 INT292 Localization of Penk 876 0.81 88.44 669.14 99.20
17 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 99.16
18 INT231596 Positive_regulation of GLIPR2 1 0.09 1.75 0.05 99.16
19 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 99.12
20 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 98.82
21 INT1429 Gene_expression of PDYN 308 0.78 61.33 175.65 98.80
22 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 98.76
23 INT17274 Gene_expression of Got1 11 0.58 3.98 2 98.74
24 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 98.42
25 INT182667 Binding of DLAT 11 0.31 40.75 2.8 98.40
26 INT3074 Negative_regulation of Chkb 29 0.57 14 12.04 98.20
27 INT192423 Positive_regulation of TARM1 5 0.34 10.77 0.51 98.08
28 INT1079 Positive_regulation of Ache 104 0.70 23.52 30.28 97.96
29 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89 97.76
30 INT19072 Regulation of Gene_expression of Ache 14 0.62 2.74 5.29 97.76
31 INT46357 Regulation of Gene_expression of Acot1 4 0.45 1.1 0.26 97.76
32 INT220291 Binding of MARS 1 0.25 0.75 0.05 97.72
33 INT250645 Gene_expression of Samsn1 6 0.33 9.95 0.86 97.60
34 INT152174 Negative_regulation of Samsn1 5 0.14 6.46 2.1 97.60
35 INT133354 Regulation of Chkb 9 0.60 4.35 3.15 97.52
36 INT11945 Regulation of Chat 38 0.62 7.75 14.97 97.44
37 INT276 Regulation of Ache 83 0.62 16.75 25.99 97.40
38 INT63505 Negative_regulation of F2 18 0.57 7.4 2.2 97.30
39 INT196321 Negative_regulation of Gene_expression of F2 2 0.17 1.48 0.04 97.30
40 INT50444 Negative_regulation of Gene_expression of Alb 11 0.39 7.63 1.06 97.30
41 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 97.28
42 INT19023 Localization of B2m 6 0.75 5.15 0.46 97.28
43 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 96.86
44 INT22839 Gene_expression of F2 31 0.74 15.53 5.56 96.70
45 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15 96.44
46 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 95.64
47 INT39945 Binding of Dlat 27 0.32 14.95 3.88 95.60
48 INT28783 Positive_regulation of Gc 13 0.52 7.89 1.76 95.36
49 INT179744 Negative_regulation of SLC1A2 16 0.45 12.32 6.14 95.16
50 INT7995 Positive_regulation of Lta 28 0.66 14.98 9.8 94.52
51 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18 94.36
52 INT6335 Binding of TSPO 39 0.44 10.88 7.66 94.28
53 INT97646 Binding of Gc 6 0.36 3.56 1.32 94.12
54 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 94.00
55 INT88995 Positive_regulation of GSTA2 7 0.49 3.05 1.26 93.24
56 INT153906 Positive_regulation of Localization of GSTA2 1 0.68 1.76 0.17 93.24
57 INT141799 Transcription of Got1 2 0.35 1.41 0.43 92.92
58 INT72053 Localization of GSTA2 15 0.78 6.12 2.78 92.68
59 INT63222 Negative_regulation of MGAM 8 0.43 4.33 0.37 92.56
60 INT15109 Gene_expression of H6PD 9 0.65 7.21 0.93 92.44
61 INT27346 Regulation of ANIB1 5 0.03 3.47 1.47 92.32
62 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 92.08
63 INT121788 Localization of BCS1L 11 0.73 10.16 1.14 91.76
64 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 91.72
65 INT162336 Negative_regulation of Ckb 1 0.12 0.55 0.43 91.72
66 INT20201 Positive_regulation of Fgf12 8 0.43 15.13 0.98 91.68
67 INT6437 Binding of YY1 154 0.47 26.3 90.46 91.60
68 INT119271 Positive_regulation of BCS1L 13 0.50 7.56 0.39 91.36
69 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 91.20
70 INT83734 Negative_regulation of RLS 24 0.50 35.75 5.66 91.16
71 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 90.88
72 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 90.64
73 INT1827 Gene_expression of Aap 11 0.67 9.37 12.66 90.32
74 INT47386 Negative_regulation of CHAT 5 0.29 1.63 2.61 90.24
75 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 90.20
76 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 90.00
77 INT133744 Gene_expression of Vcan 27 0.74 10.64 2.85 89.64
78 INT141382 Negative_regulation of ASS1 2 0.57 1.07 0 89.36
79 INT158148 Positive_regulation of Gene_expression of Gc 2 0.36 1.89 0.23 89.32
80 INT251700 Positive_regulation of Protein_catabolism of Ache 1 0.46 0.44 0.14 88.00
81 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 87.96
82 INT20059 Protein_catabolism of Ache 15 0.98 3.73 4.87 87.72
83 INT31403 Positive_regulation of AFM 3 0.29 5.57 1.38 87.64
84 INT28009 Positive_regulation of Gene_expression of Ache 15 0.70 5.46 3.26 87.60
85 INT54331 Positive_regulation of Glul 8 0.67 3.55 2.74 87.04
86 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 86.72
87 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 86.72
88 INT27345 Positive_regulation of ANIB1 9 0.07 9.81 3.46 86.24
89 INT220296 Negative_regulation of MARS 3 0.29 1.43 0.2 86.00
90 INT5499 Transcription of Avp 52 0.72 7.98 19.87 85.72
91 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 84.84
92 INT14973 Regulation of Gene_expression of AFP 3 0.44 4.16 0.69 84.84
93 INT152506 Negative_regulation of Gene_expression of Gc 2 0.33 2.29 0.41 84.80
94 INT100262 Positive_regulation of Positive_regulation of Cyp2e1 7 0.50 2.39 4.31 84.56
95 INT349572 Positive_regulation of Positive_regulation of Cytl1 1 0.49 0.69 0.67 84.56
96 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49 84.08
97 INT204277 Positive_regulation of Cytl1 3 0.67 2.56 1.64 84.08
98 INT17566 Gene_expression of Hya 1 0.24 0.49 0.13 83.68
99 INT219484 Positive_regulation of MARS 5 0.46 2.79 0.17 83.44
100 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 82.56
101 INT5361 Positive_regulation of CPM 4 0.60 1.61 0.09 82.00
102 INT103260 Positive_regulation of Nps 35 0.48 23.8 5.67 81.84
103 INT237866 Positive_regulation of Positive_regulation of Nps 5 0.48 2.67 0.69 81.84
104 INT43544 Binding of SH3RF3 1 0.11 0.77 0.37 81.68
105 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24 81.08
106 INT57188 Regulation of Gene_expression of Chat 4 0.45 1.89 1.12 81.08
107 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 80.16
108 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95 78.76
109 INT84964 Gene_expression of MAOB 14 0.61 2.8 0.89 78.76
110 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 78.64
111 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3 78.64
112 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 78.40
113 INT53447 Negative_regulation of DLD 17 0.54 12.9 2.48 77.84
114 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 77.76
115 INT214 Localization of AVP 370 0.81 208.51 91.09 77.68
116 INT201308 Binding of Vcan 5 0.34 1.05 0.24 77.68
117 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 77.60
118 INT133353 Negative_regulation of Negative_regulation of Chkb 2 0.42 1.31 2.41 76.96
119 INT546 Binding of ALB 311 0.48 85.98 60.14 76.88
120 INT169591 Gene_expression of FAT1 23 0.67 10.73 0.77 76.80
121 INT316105 Binding of HIST1H4PS1 2 0.03 1.76 0.23 76.80
122 INT251699 Negative_regulation of Negative_regulation of G4 1 0.23 0.88 0.06 76.16
123 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 76.12
124 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 76.08
125 INT354483 Gene_expression of Evl 1 0.49 1.92 0.1 75.76
126 INT1756 Negative_regulation of DNAH8 105 0.59 42.73 20.24 75.00
127 INT84965 Gene_expression of MAOA 15 0.75 6.9 6.06 75.00
128 INT28617 Negative_regulation of ITPA 7 0.45 1.27 1.65 75.00
129 INT43545 Positive_regulation of Negative_regulation of DNAH8 2 0.14 0.9 0.18 75.00
130 INT141380 Negative_regulation of Slc25a13 2 0.25 1.79 0.29 74.20
131 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 74.12
132 INT60826 Negative_regulation of Positive_regulation of Ache 3 0.50 0.68 0.73 74.12
133 INT156287 Negative_regulation of G4 7 0.41 1.35 0.08 73.88
134 INT2386 Gene_expression of Pgr 112 0.78 45.46 22.19 73.64
135 INT9660 Regulation of TNF 363 0.62 312.94 139.99 73.52
136 INT9210 Regulation of IL6 166 0.62 125.61 49.95 73.52
137 INT23257 Regulation of CRP 127 0.62 100.05 21.87 73.52
138 INT122500 Protein_catabolism of Slco1c1 17 0.52 16.7 1.7 73.00
139 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 72.92
140 INT202981 Positive_regulation of Binding of MCRS1 3 0.18 4.05 1.02 72.92
141 INT175554 Binding of MCRS1 21 0.23 25.2 8.59 72.52
142 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 72.40
143 INT251695 Negative_regulation of Gene_expression of G4 1 0.23 0.32 0.03 71.64
144 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 71.28
145 INT237862 Positive_regulation of Gene_expression of Nps 8 0.43 3.82 1.52 71.28
146 INT205868 Gene_expression of G4 4 0.42 1.1 0.03 70.92
147 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 70.36
148 INT34809 Gene_expression of Ec 36 0.15 15.7 3.24 70.24
149 INT22907 Positive_regulation of Ggt1 33 0.67 17.82 5.28 69.92
150 INT86410 Localization of PDK1 1 0.05 0.65 0.44 69.60
151 INT220293 Regulation of MARS 8 0.31 7.79 0.11 68.72
152 INT141381 Gene_expression of SLC25A13 2 0.27 1.77 0.29 68.08
153 INT39469 Negative_regulation of Alb 21 0.41 13.33 2.68 68.08
154 INT240924 Transcription of Pck1 7 0.66 3.6 0.37 67.68
155 INT301526 Transcription of G6pc 1 0.23 1.97 0.21 67.68
156 INT46 Localization of Ren 233 0.81 46.15 62.44 67.48
157 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 67.28
158 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 67.04
159 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 66.72
160 INT8743 Positive_regulation of Gcg 19 0.65 10.63 4.43 66.64
161 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06 66.20
162 INT184995 Binding of HGS 4 0.26 3.1 0.25 66.04
163 INT51801 Gene_expression of Gabrd 64 0.72 19.17 22.61 65.72
164 INT158149 Negative_regulation of Regulation of Alb 2 0.15 1.24 0.16 64.88
165 INT615 Regulation of Alb 66 0.62 33.43 15.33 64.40
166 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 64.40
167 INT19071 Localization of Ache 66 0.81 5.1 16.27 64.36
168 INT15308 Localization of Chat 29 0.81 2.35 8.47 64.36
169 INT2570 Negative_regulation of Gene_expression of Ache 13 0.43 2.88 2.18 64.36
170 INT32052 Positive_regulation of Negative_regulation of Acot1 2 0.24 0.73 0.41 63.20
171 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44 63.20
172 INT308149 Gene_expression of Slc22a5 1 0.63 2.77 0.25 62.40
173 INT308141 Positive_regulation of Gene_expression of Slc22a5 1 0.56 0.44 0 62.40
174 INT39444 Negative_regulation of Positive_regulation of F2 7 0.59 5.82 1.42 61.76
175 INT105287 Positive_regulation of Slco1c1 24 0.34 15.41 6.81 61.28
176 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75 60.64
177 INT22943 Positive_regulation of Positive_regulation of Gpt 23 0.47 16.09 5.55 59.92
178 INT97212 Regulation of Positive_regulation of Gpt 4 0.43 3.95 1.47 59.92
179 INT21255 Binding of Slco1c1 9 0.33 5.11 2.45 56.88
180 INT22213 Localization of Gpt 52 0.78 34.05 12.94 55.20
181 INT3920 Localization of Ldha 241 0.81 83.08 58.72 54.64
182 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 54.64
183 INT22069 Positive_regulation of Localization of Ache 9 0.70 0.61 2.9 54.48
184 INT187505 Positive_regulation of Localization of Fig4 16 0.24 1.21 3.17 51.44
185 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 50.52
186 INT201307 Negative_regulation of Vcan 4 0.41 1.71 0.43 50.00
187 INT319962 Gene_expression of Line 1 0.01 0 0 50.00
188 INT171820 Localization of Fig4 144 0.65 27.38 20.88 49.00
189 INT296641 Binding of Polr2f 2 0.10 1.09 0.21 48.24
190 INT182144 Negative_regulation of Protein_catabolism of Slco1c1 1 0.29 1.23 0 47.28
191 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 46.80
192 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55 45.92
193 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 44.00
194 INT80656 Regulation of SLC17A5 15 0.26 6.89 3.19 43.52
195 INT723 Regulation of Gc 1 0.20 0.57 0.54 42.88
196 INT301540 Positive_regulation of Dnlz 1 0.01 0.65 0.07 42.80
197 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 42.16
198 INT41728 Gene_expression of CHAT 65 0.75 42.19 12.73 39.60
199 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 39.56
200 INT246828 Binding of Irs1 9 0.37 2.68 0.42 38.12
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