D:Hepatic Insufficiency

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Disease Term
Synonyms INSUFFICIENCY HEPATIC, Insufficiency Liver, LIVER INSUFFICIENCY
Documents 201
Hot Single Events 46
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hepatic Insufficiency. They are ordered first by their relevance to Hepatic Insufficiency and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT339675 CSF2 Positive_regulation of Localization of FUT1 1 0.01 0.42 0 77.36
2 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22 76.88
3 INT262335 Binding of Sv2a and Bri3 1 0.01 0.71 0.08 76.88
4 INT145491 PROC Positive_regulation of Cpox 1 0.00 1.08 0.58 74.72
5 INT300192 Gene_expression of APOA1 Positive_regulation of HSD11B1 1 0.16 1.08 0.08 36.48
6 INT300193 Binding of APOA1 and INSL4 1 0.01 2.17 0.18 31.28
7 INT262354 TRIP10 Negative_regulation of Cyp4a3 1 0.00 0.8 0.26 27.00
8 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26 27.00
9 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 27.00
10 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 27.00
11 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26 5.00
12 INT262336 Binding of Abat and Tmem132a 1 0.00 1.39 1.14 5.00
13 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98 5.00
14 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 5.00
15 INT353128 Negative_regulation of Binding of TAC1 and B3GAT1 1 0.29 1.95 0.33 5.00
16 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22 5.00
17 INT273024 Binding of FXYD1 and RLS 1 0.04 1.24 0.21 5.00
18 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
19 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
20 INT252646 Binding of C6orf25 and SYT16 1 0.00 0.51 0.17 5.00
21 INT240768 Binding of F2 and F13A1 1 0.07 2.25 0.15 5.00
22 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 0.01 0.72 0.11 5.00
23 INT242203 GLP1R Regulation of GCG 1 0.04 0.64 0.1 5.00
24 INT242204 DPP4 Positive_regulation of Gene_expression of GLP1R 1 0.03 0.66 0.1 5.00
25 INT247439 Binding of APOA1 and HSD11B1 3 0.32 5.01 0.03 5.00
26 INT300191 Binding of C1S and HSD11B1 1 0.13 1.75 0 5.00
27 INT316101 Binding of HIST1H4PS1 and ANGPTL5 1 0.01 0.28 0 5.00
28 INT300195 Binding of C1S and CHDH 1 0.23 2.51 0 5.00
29 INT308314 Binding of CD34 and Pfpl 1 0.03 0.57 0 5.00
30 INT327101 Binding of AREG and EGF 1 0.05 0.35 0 5.00
31 INT339676 CSF2 Positive_regulation of HGF 1 0.08 0.46 0 5.00
32 INT300194 HSD11B1 Negative_regulation of CHDH 1 0.08 2.19 0 5.00
33 INT327100 Binding of BTC and EGF 1 0.04 0.35 0 5.00
34 INT255041 DPP4 Positive_regulation of GIP 1 0.49 0.32 0 5.00
35 INT300199 PCSK9 Regulation of Gene_expression of LDLR 1 0.13 0.88 0 5.00
36 INT255043 DPP4 Positive_regulation of GLP1R 1 0.35 0.32 0 5.00
37 INT327099 Binding of EGF and EREG 1 0.05 0.35 0 5.00
38 INT300197 Binding of APOA1 and C1S 1 0.39 3.56 0 5.00
39 INT300196 Binding of HSD11B1 and CHDH 1 0.07 4.01 0 5.00
40 INT348644 Binding of DPP4 and GLP1R 1 0.16 0.5 0 5.00
41 INT300198 Positive_regulation of Binding of C1S and CHDH 1 0.31 1.63 0 5.00
42 INT255042 Negative_regulation of DPP4 Positive_regulation of GLP1R 1 0.33 0.34 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hepatic Insufficiency. They are ordered first by their pain relevance and then by number of times they were reported in Hepatic Insufficiency. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 100.00
2 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 99.88
3 INT262350 Negative_regulation of Localization of Bri3 1 0.02 0.64 0.07 99.28
4 INT345424 Phosphorylation of PAH 1 0.05 1.55 0.11 98.96
5 INT262342 Localization of Bri3 1 0.04 0.64 0.07 98.84
6 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 98.60
7 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 98.28
8 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 98.28
9 INT76427 Regulation of Negative_regulation of Cpox 17 0.31 6.75 7.93 98.20
10 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 97.68
11 INT47662 Localization of CHKB 34 0.81 22.63 5.14 97.68
12 INT130015 Positive_regulation of Localization of CHKB 3 0.48 1.72 0.39 97.68
13 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 96.84
14 INT200523 Regulation of F7 2 0.01 1.82 0.38 95.56
15 INT117031 Binding of Samsn1 6 0.21 6.82 0.76 95.48
16 INT262348 Gene_expression of Lgsn 12 0.58 12.64 2.08 94.88
17 INT3824 Negative_regulation of PTH 40 0.59 28.58 3.39 94.52
18 INT87819 Localization of CD34 21 0.81 7.69 0.47 94.36
19 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 93.44
20 INT308672 Gene_expression of Ghitm 1 0.05 0.82 0.05 93.40
21 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 92.84
22 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 91.60
23 INT234 Binding of Alb 151 0.48 52.34 32.97 91.20
24 INT12334 Positive_regulation of CYP3A 34 0.70 6.77 7.85 90.64
25 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 89.72
26 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 88.76
27 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 88.56
28 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 86.52
29 INT14572 Binding of INS 205 0.48 175.43 13.38 86.16
30 INT12131 Gene_expression of POR 17 0.77 9.42 2.17 85.64
31 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 85.56
32 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 85.12
33 INT635 Negative_regulation of MAOB 51 0.59 24.5 12.66 84.64
34 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81 84.48
35 INT94532 Regulation of MT2A 5 0.36 4.25 0.98 84.48
36 INT269274 Regulation of MTNR1A 3 0.60 1.47 0.05 84.48
37 INT165400 Positive_regulation of TST 13 0.68 4.25 0.35 84.48
38 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 84.32
39 INT111607 Gene_expression of CDH1 103 0.75 90.45 7.77 84.32
40 INT85084 Gene_expression of KRT19 66 0.73 42.56 1.82 84.32
41 INT129695 Binding of Sv2a 6 0.47 4.96 2.51 83.80
42 INT339687 Positive_regulation of ARHGEF1 1 0.03 0.44 0 83.04
43 INT339689 Positive_regulation of Positive_regulation of ARHGEF1 1 0.03 0.44 0 83.04
44 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51 81.60
45 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 81.56
46 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 81.12
47 INT19181 Gene_expression of Bche 35 0.68 16.93 1.52 79.56
48 INT34585 Negative_regulation of Positive_regulation of HSD11B1 31 0.57 43.54 2.47 78.80
49 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 78.28
50 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 78.20
51 INT49759 Negative_regulation of CETP 43 0.58 52 2.68 78.00
52 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2 77.60
53 INT105921 Localization of FUT1 13 0.23 3.92 1.39 77.36
54 INT273647 Positive_regulation of Localization of FUT1 3 0.09 0.65 0.09 77.36
55 INT91913 Regulation of GRIN3B 16 0.61 11.48 14.44 77.12
56 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72 76.88
57 INT52113 Gene_expression of CETP 25 0.69 25.71 0.99 75.72
58 INT86370 Regulation of CDH1 10 0.54 13.89 0.7 75.28
59 INT79140 Binding of HCC 36 0.31 46.96 1.87 75.08
60 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 74.96
61 INT316105 Binding of HIST1H4PS1 2 0.03 1.76 0.23 74.64
62 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 74.12
63 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 74.12
64 INT262347 Binding of Bri3 1 0.02 0.7 0.08 73.52
65 INT139237 Negative_regulation of Gene_expression of CDH1 23 0.57 24.31 1.28 71.08
66 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 70.84
67 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28 70.84
68 INT111603 Positive_regulation of Gene_expression of CDH1 14 0.49 11.17 1.72 70.40
69 INT12598 Binding of DBP 20 0.48 13.11 3.62 70.16
70 INT66191 Gene_expression of DBP 42 0.66 22.25 3.18 70.16
71 INT70854 Regulation of Localization of PTH 2 0.27 1.13 0.14 69.80
72 INT2544 Localization of PTH 39 0.81 30.55 2.22 69.36
73 INT59302 Positive_regulation of POR 19 0.49 15.18 1.95 69.12
74 INT91431 Positive_regulation of Gene_expression of CD44 18 0.69 9.25 1.12 68.64
75 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 68.00
76 INT66819 Binding of CYP2C9 41 0.48 8.23 8.76 68.00
77 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 67.36
78 INT263191 Gene_expression of Pde1a 7 0.21 0.33 0 66.80
79 INT80892 Negative_regulation of Hmox2 10 0.55 4.76 3.64 61.68
80 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29 61.40
81 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 61.28
82 INT5361 Positive_regulation of CPM 4 0.60 1.61 0.09 61.04
83 INT107779 Negative_regulation of F7 3 0.30 2.99 0.66 59.92
84 INT18084 Negative_regulation of Pde11a 6 0.41 0.6 2.5 58.24
85 INT70970 Binding of COPD 144 0.42 180.34 18.29 56.48
86 INT67606 Localization of POR 3 0.68 1.22 0.06 55.00
87 INT692 Negative_regulation of SST 72 0.59 28.68 34.52 54.88
88 INT261273 Negative_regulation of Pde6a 5 0.02 1.11 0.28 53.92
89 INT254045 Gene_expression of TRIP10 4 0.29 3.04 1.67 52.20
90 INT6573 Regulation of Negative_regulation of Ptgs1 19 0.45 6.16 8.71 50.72
91 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 50.32
92 INT10284 Binding of ORM1 16 0.48 0.98 7.73 47.84
93 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 47.84
94 INT44135 Regulation of Binding of ORM1 1 0.58 0.3 0 47.84
95 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 46.40
96 INT546 Binding of ALB 311 0.48 85.98 60.14 45.44
97 INT31134 Regulation of Binding of ALB 13 0.62 2.51 2.37 45.44
98 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 45.40
99 INT262344 Negative_regulation of Lgsn 4 0.37 3.6 0.67 44.40
100 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 44.16
101 INT212170 Localization of CDIPT 4 0.41 1.55 0.13 43.88
102 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 42.48
103 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 42.48
104 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 42.44
105 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 41.84
106 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 41.28
107 INT273064 Positive_regulation of Positive_regulation of MAOB 1 0.46 0.12 0.05 40.88
108 INT20239 Regulation of APOA1 10 0.60 10.98 0.51 40.20
109 INT53998 Positive_regulation of MAOB 8 0.61 1.22 2 40.04
110 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 39.76
111 INT284514 Regulation of Regulation of PF4 1 0.20 1.19 0.12 39.20
112 INT17694 Regulation of PF4 2 0.44 1.18 0.12 39.20
113 INT21712 Positive_regulation of APOA1 32 0.67 21.64 2.64 38.80
114 INT41986 Positive_regulation of Gene_expression of HSD11B1 26 0.49 32.84 1.52 38.80
115 INT72672 Positive_regulation of Gene_expression of APOA1 4 0.67 3.81 0.89 38.80
116 INT118490 Regulation of CNOT4 2 0.02 1.18 0.27 38.80
117 INT124623 Binding of GDF15 4 0.35 2.06 1.09 38.52
118 INT72676 Gene_expression of APOA1 34 0.75 34.15 1.67 38.36
119 INT12975 Regulation of PLEK 21 0.60 13.62 8.28 38.08
120 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 36.00
121 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 35.76
122 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 35.60
123 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 34.64
124 INT201196 Negative_regulation of Gene_expression of PAH 2 0.30 3.11 0.19 34.64
125 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 33.96
126 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 33.84
127 INT2910 Regulation of Abat 169 0.62 36.95 153.53 30.08
128 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 29.72
129 INT5113 Binding of MROS 4 0.31 2.52 0.17 29.36
130 INT4498 Gene_expression of F2 83 0.65 57.4 10.8 29.00
131 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 27.72
132 INT425 Localization of PRL 455 0.81 189.64 144.8 27.32
133 INT262339 Positive_regulation of TRIP10 2 0.26 2.07 2.5 27.00
134 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 26.32
135 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 25.08
136 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 25.00
137 INT308671 Positive_regulation of Ghitm 1 0.03 0.37 0.03 25.00
138 INT193312 Localization of DSPP 8 0.74 1.88 0.18 24.52
139 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 24.08
140 INT122448 Regulation of Gene_expression of ABCB1 13 0.62 3.67 3.5 24.08
141 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 24.00
142 INT67604 Gene_expression of SERPINC1 14 0.67 11.47 1.72 23.16
143 INT102731 Regulation of ABCB1 29 0.62 5.36 11.67 22.08
144 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 21.08
145 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 20.72
146 INT76751 Negative_regulation of Protein_catabolism of F13A1 7 0.13 5.16 0.79 20.64
147 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 20.28
148 INT3881 Positive_regulation of Protein_catabolism of F13A1 21 0.41 20 3.28 20.28
149 INT39518 Negative_regulation of HBN1 66 0.09 37.54 2.58 19.96
150 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 19.92
151 INT300227 Positive_regulation of Binding of ABCA1 1 0.41 1.85 0.19 18.40
152 INT300220 Positive_regulation of Binding of ABCG1 1 0.34 1.96 0.19 18.40
153 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41 17.68
154 INT209319 Gene_expression of VKORC1 1 0.01 1.95 0 17.60
155 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75 16.84
156 INT28130 Positive_regulation of ABCA1 18 0.61 7.08 3.22 16.52
157 INT300231 Positive_regulation of Gene_expression of ABCG1 1 0.32 0.97 0.09 16.52
158 INT300228 Positive_regulation of ABCG1 1 0.32 0.97 0.09 16.52
159 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 16.20
160 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 16.12
161 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 16.12
162 INT300223 Gene_expression of ABCG1 3 0.58 1.26 0.29 16.12
163 INT300237 Binding of ABCG1 1 0.25 0.97 0.09 16.12
164 INT175738 Regulation of ARNTL 4 0.28 0.29 0 15.28
165 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 14.28
166 INT262340 Binding of TRIP10 6 0.36 1.45 0.96 11.92
167 INT14690 Localization of CSF2 124 0.80 85.17 27.26 11.16
168 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 8.12
169 INT288858 Gene_expression of HCAR2 2 0.66 2.41 0.17 7.76
170 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73 5.04
171 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
172 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
173 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
174 INT1045 Localization of LH 1211 0.81 87.04 456.25 5.00
175 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
176 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
177 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
178 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
179 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
180 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
181 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 5.00
182 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 5.00
183 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
184 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
185 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
186 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
187 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 5.00
188 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
189 INT90 Localization of Gast 400 0.81 137.67 113 5.00
190 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
191 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
192 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
193 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 5.00
194 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 5.00
195 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
196 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
197 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
198 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 5.00
199 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 5.00
200 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
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