D:Hepatolenticular Degeneration

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Disease Term
Synonyms Cerebral Pseudoscleroses, CEREBRAL PSEUDOSCLEROSIS, Cerebral Pseudosclerosis Disorder, Copper Storage Disease, Degeneration Hepatocerebral, Degeneration Hepatolenticular, DEGENERATION NEUROHEPATIC, Degeneration Progressive Lenticular, Degenerations Hepatocerebral, DEGENERATIONS NEUROHEPATIC, Diseases Hepato Neurologic Wilson
Documents 26
Hot Single Events 21
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hepatolenticular Degeneration. They are ordered first by their relevance to Hepatolenticular Degeneration and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT318920 Binding of XIAP and COMMD1 1 0.12 0.78 0 90.84
2 INT318922 XIAP Regulation of COMMD1 1 0.09 0.37 0 50.00
3 INT318919 Binding of ATP7B and COMMD1 1 0.37 0.76 0 50.00
4 INT259023 CADPS Positive_regulation of Binding of SH2B2 1 0.06 2.05 0.14 5.00
5 INT220289 MARS Regulation of CEBPZ 1 0.02 0.93 0.11 5.00
6 INT220288 MARS Regulation of AFM 1 0.06 1.14 0.08 5.00
7 INT232897 Binding of Rab27a and SAMSN1 1 0.00 0.73 0.08 5.00
8 INT220290 Binding of AFM and MARS 1 0.05 1.09 0.07 5.00
9 INT232902 Binding of YWHAQ and Krt18 1 0.34 0.96 0.07 5.00
10 INT232901 Regulation of Binding of YWHAQ and Krt18 1 0.41 0.96 0.07 5.00
11 INT232900 Binding of ABR and Krt8 1 0.03 0.49 0.03 5.00
12 INT232890 Binding of Rab27a and Gopc 1 0.01 0.3 0 5.00
13 INT232899 Krt18 Negative_regulation of Binding of ABR 1 0.05 0.68 0 5.00
14 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 5.00
15 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0 5.00
16 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00
17 INT232895 Krt18 Positive_regulation of Gene_expression of ABR 1 0.46 0.09 0 5.00
18 INT232898 Binding of KRT1 and Krt8 1 0.27 1.22 0 5.00
19 INT232896 Krt8 Negative_regulation of Binding of ABR 1 0.04 0.68 0 5.00
20 INT232892 Krt18 Positive_regulation of Gene_expression of Krt8 1 0.30 0.09 0 5.00
21 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
22 INT232889 Binding of Krt18 and Krt8 1 0.22 1.09 0 5.00
23 INT232894 Binding of ABR and Rab27a 1 0.08 0.3 0 5.00
24 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hepatolenticular Degeneration. They are ordered first by their pain relevance and then by number of times they were reported in Hepatolenticular Degeneration. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT318928 Positive_regulation of COMMD1 1 0.47 0.87 0 99.60
2 INT102187 Gene_expression of SH2B2 23 0.59 26.54 4.39 99.32
3 INT175260 Negative_regulation of Gene_expression of SH2B2 2 0.25 4.41 0.21 99.32
4 INT318930 Binding of COMMD1 1 0.32 1.06 0 98.50
5 INT318932 Regulation of ATP7B 2 0.40 1.12 0.28 97.58
6 INT113659 Gene_expression of ABR 19 0.65 8.49 1.45 93.80
7 INT110208 Binding of ABR 2 0.35 10.49 0.81 93.80
8 INT318926 Protein_catabolism of XIAP 1 0.19 1.58 0 93.00
9 INT318933 Binding of ATP7B 2 0.37 0.96 0.03 92.12
10 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 89.16
11 INT81664 Positive_regulation of Gene_expression of Pnoc 12 0.68 2.51 9.75 89.16
12 INT64440 Gene_expression of Pnoc 66 0.78 13.61 41.76 89.08
13 INT66532 Positive_regulation of Pnoc 46 0.70 14.99 41.39 88.12
14 INT2383 Positive_regulation of CP 33 0.67 25.41 15.38 88.08
15 INT318925 Negative_regulation of Localization of COMMD1 1 0.37 0.37 0 85.84
16 INT318934 Localization of COMMD1 1 0.75 2 0 84.16
17 INT318927 Positive_regulation of Localization of COMMD1 1 0.44 0.37 0 84.16
18 INT309244 Transcription of HSPA5 1 0.16 2.75 0.36 82.24
19 INT142435 Gene_expression of NES 86 0.78 47.53 4.92 81.12
20 INT260029 Regulation of Gene_expression of NES 1 0.26 0.97 0 81.12
21 INT318931 Localization of ATP7B 1 0.55 0.84 0.09 80.08
22 INT68970 Positive_regulation of Pnoc 33 0.67 9.29 19.08 79.56
23 INT199222 Gene_expression of SAMSN1 14 0.57 18.97 1.61 77.20
24 INT90899 Gene_expression of Rab27a 49 0.78 26.71 0.74 76.48
25 INT649 Positive_regulation of Afp 10 0.55 6.5 0.62 74.80
26 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 74.04
27 INT35584 Binding of ACLY 22 0.35 31.78 7.17 73.44
28 INT232877 Negative_regulation of Binding of ABR 1 0.06 1.88 0.14 68.72
29 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 66.36
30 INT127432 Gene_expression of Nup62 20 0.71 11.01 0.71 66.36
31 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 65.68
32 INT232850 Phosphorylation of Krt8 7 0.52 3.8 0.05 59.84
33 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 47.28
34 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 46.48
35 INT78281 Gene_expression of Krt7 28 0.70 26.77 0.97 44.88
36 INT77670 Positive_regulation of ACLY 24 0.49 21.68 3.12 42.56
37 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 40.56
38 INT199308 Gene_expression of Krt8 37 0.75 23.17 1.06 39.48
39 INT209501 Gene_expression of CADPS 15 0.65 20.7 2.22 33.24
40 INT236277 Positive_regulation of Gene_expression of CADPS 5 0.42 9.17 1.29 33.24
41 INT259031 Negative_regulation of Gene_expression of CADPS 1 0.07 3.04 0.35 33.24
42 INT232840 Positive_regulation of Gene_expression of Krt8 1 0.44 4.51 0.42 31.80
43 INT232821 Positive_regulation of Gene_expression of Krt18 11 0.50 4.38 0.31 31.80
44 INT232848 Negative_regulation of Gene_expression of Krt18 5 0.36 2.3 0.08 30.96
45 INT232822 Negative_regulation of Gene_expression of Krt8 5 0.36 2.3 0.08 30.96
46 INT232826 Gene_expression of Krt18 26 0.68 14.24 0.48 29.88
47 INT232841 Gene_expression of Scap 11 0.02 8.68 0.7 29.72
48 INT232829 Positive_regulation of Scap 6 0.02 2.97 0.11 27.80
49 INT217463 Positive_regulation of Nup62 5 0.39 1.79 0.17 27.40
50 INT232830 Positive_regulation of Protein_catabolism of Nup62 3 0.39 0.75 0.15 27.40
51 INT232834 Protein_catabolism of Nup62 3 0.56 0.8 0.07 26.52
52 INT232885 Positive_regulation of Binding of ABR 1 0.07 0.5 0.07 24.32
53 INT175262 Binding of SH2B2 18 0.36 22.85 3.18 19.84
54 INT259032 Binding of PEX1 2 0.01 4.67 0.15 19.68
55 INT259036 Transcription of SH2B2 2 0.55 7.01 1.46 12.24
56 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
57 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
58 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
59 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
60 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
61 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
62 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
63 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
64 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
65 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
66 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
67 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
68 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
69 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
70 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
71 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
72 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
73 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
74 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
75 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
76 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
77 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 5.00
78 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
79 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
80 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
81 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
82 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
83 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
84 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
85 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
86 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
87 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
88 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
89 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
90 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51 5.00
91 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
92 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 5.00
93 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
94 INT26585 Gene_expression of Vim 117 0.77 39.97 6 5.00
95 INT75800 Gene_expression of Cyp2a5 12 0.77 5.15 5.37 5.00
96 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
97 INT8959 Binding of Gnb5 17 0.40 31.38 5.1 5.00
98 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
99 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
100 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 5.00
101 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 5.00
102 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
103 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 5.00
104 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 5.00
105 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73 5.00
106 INT89966 Negative_regulation of Fas 26 0.58 24.83 3.5 5.00
107 INT87517 Gene_expression of LDLR 73 0.69 37.35 3.32 5.00
108 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
109 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 5.00
110 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
111 INT111263 Gene_expression of Gnb5 8 0.75 8.51 3 5.00
112 INT61791 Positive_regulation of SH2B2 9 0.50 8.36 2.99 5.00
113 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
114 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 5.00
115 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63 5.00
116 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
117 INT18848 Localization of LMOD1 5 0.69 1 2.49 5.00
118 INT232842 Gene_expression of Tnfaip8 15 0.66 5.81 2.34 5.00
119 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26 5.00
120 INT11183 Negative_regulation of SH2B2 4 0.34 6.99 2.12 5.00
121 INT95580 Positive_regulation of Afm 5 0.21 5.51 2.04 5.00
122 INT40215 Negative_regulation of Fech 9 0.57 8.39 1.85 5.00
123 INT122895 Transcription of DIO2 3 0.52 0.91 1.73 5.00
124 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 5.00
125 INT144380 Gene_expression of SYNE1 12 0.58 6.99 1.55 5.00
126 INT12035 Regulation of F2 21 0.45 12.66 1.47 5.00
127 INT181868 Localization of ACLY 5 0.62 6.36 1.4 5.00
128 INT31403 Positive_regulation of AFM 3 0.29 5.57 1.38 5.00
129 INT3404 Binding of BCAR1 10 0.33 7.97 1.33 5.00
130 INT202193 Gene_expression of Krt19 4 0.45 5.02 1.17 5.00
131 INT209503 Positive_regulation of CADPS 3 0.42 7 1.11 5.00
132 INT183820 Regulation of BCAR1 4 0.39 3.27 1.06 5.00
133 INT17554 Regulation of ABR 6 0.54 2.21 0.98 5.00
134 INT68186 Gene_expression of GOT2 11 0.65 6.01 0.91 5.00
135 INT11198 Negative_regulation of Gclc 3 0.59 0.49 0.87 5.00
136 INT102842 Binding of YWHAQ 6 0.47 3.48 0.86 5.00
137 INT218315 Gene_expression of RBP4 25 0.76 18.19 0.85 5.00
138 INT207421 Positive_regulation of Gene_expression of GPT 9 0.49 5.62 0.83 5.00
139 INT50687 Gene_expression of Aldoc 6 0.78 0.17 0.78 5.00
140 INT117120 Gene_expression of Krt14 20 0.75 6.53 0.77 5.00
141 INT151525 Gene_expression of Olfr148 7 0.67 8.5 0.74 5.00
142 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71 5.00
143 INT309253 Negative_regulation of Transcription of LMOD1 1 0.03 0.2 0.57 5.00
144 INT163221 Protein_catabolism of Krt18 2 0.81 2.18 0.56 5.00
145 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 5.00
146 INT52740 Binding of ACLS 5 0.31 3 0.54 5.00
147 INT232886 Regulation of Gene_expression of ABR 3 0.06 1.42 0.45 5.00
148 INT309242 Localization of Nat1 1 0.01 0.17 0.42 5.00
149 INT173912 Negative_regulation of LRP2 5 0.57 6.22 0.42 5.00
150 INT232825 Positive_regulation of Krt8 1 0.44 6.83 0.42 5.00
151 INT259035 Localization of SH2B2 3 0.43 1.77 0.42 5.00
152 INT111822 Binding of Krt8 6 0.34 4.61 0.39 5.00
153 INT56433 Negative_regulation of Cl 3 0.13 1.87 0.35 5.00
154 INT220295 Gene_expression of MARS 6 0.47 4.74 0.35 5.00
155 INT131674 Negative_regulation of HEXB 3 0.10 3.78 0.32 5.00
156 INT202195 Negative_regulation of Krt19 2 0.32 2.28 0.3 5.00
157 INT309249 Regulation of OGDHL 1 0.01 0.6 0.3 5.00
158 INT309251 Gene_expression of OGDHL 1 0.01 0.64 0.29 5.00
159 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 5.00
160 INT232828 Regulation of Krt18 1 0.50 2.2 0.26 5.00
161 INT220292 Binding of AFM 3 0.10 1.15 0.25 5.00
162 INT184995 Binding of HGS 4 0.26 3.1 0.25 5.00
163 INT232844 Localization of Krt19 1 0.42 2.63 0.24 5.00
164 INT232845 Positive_regulation of Krt18 1 0.41 4.5 0.24 5.00
165 INT17009 Regulation of CADPS 2 0.08 1.97 0.24 5.00
166 INT199221 Binding of SAMSN1 2 0.29 2.36 0.24 5.00
167 INT172442 Binding of Rab27a 3 0.37 1.5 0.21 5.00
168 INT232831 Binding of Krt18 7 0.39 4.61 0.21 5.00
169 INT232824 Regulation of Krt8 1 0.29 1.64 0.21 5.00
170 INT164753 Negative_regulation of Clcn5 2 0.58 5.13 0.2 5.00
171 INT220296 Negative_regulation of MARS 3 0.29 1.43 0.2 5.00
172 INT285702 Negative_regulation of Tpmt 2 0.28 1.4 0.19 5.00
173 INT233570 Gene_expression of Rbp4 4 0.66 3.4 0.17 5.00
174 INT157725 Gene_expression of ACLS 2 0.13 2.89 0.17 5.00
175 INT219484 Positive_regulation of MARS 5 0.46 2.79 0.17 5.00
176 INT232887 Binding of MBTPS2 2 0.23 0.99 0.16 5.00
177 INT259033 Gene_expression of LCA5L 1 0.01 2.71 0.16 5.00
178 INT340373 Negative_regulation of Rbp4 1 0.17 1.96 0.16 5.00
179 INT232880 Phosphorylation of ABR 1 0.79 0.76 0.13 5.00
180 INT232875 Negative_regulation of Phosphorylation of ABR 1 0.41 0.76 0.13 5.00
181 INT259037 Negative_regulation of Binding of ACLY 1 0.07 1.54 0.13 5.00
182 INT220293 Regulation of MARS 8 0.31 7.79 0.11 5.00
183 INT217454 Positive_regulation of Gene_expression of Nup62 2 0.39 1.56 0.11 5.00
184 INT25530 Positive_regulation of ABR 3 0.33 0.34 0.1 5.00
185 INT259038 Negative_regulation of Positive_regulation of SH2B2 1 0.25 1.83 0.09 5.00
186 INT259039 Positive_regulation of Binding of ACLY 1 0.09 1.85 0.09 5.00
187 INT232839 Phosphorylation of Krt18 1 0.67 1.78 0.09 5.00
188 INT259030 Negative_regulation of Gene_expression of ACLY 1 0.07 1.95 0.08 5.00
189 INT232883 Regulation of Binding of YWHAQ 1 0.26 0.95 0.07 5.00
190 INT221377 Localization of Krt18 4 0.61 1.82 0.07 5.00
191 INT261026 Localization of Gclc 3 0.36 0.88 0.06 5.00
192 INT261017 Regulation of Gclc 2 0.22 0.88 0.06 5.00
193 INT309245 Binding of SETX 1 0.08 1.98 0.06 5.00
194 INT183819 Negative_regulation of Positive_regulation of BCAR1 1 0.38 2.04 0.05 5.00
195 INT220291 Binding of MARS 1 0.25 0.75 0.05 5.00
196 INT183818 Positive_regulation of MKKS 1 0.01 1.82 0.05 5.00
197 INT220294 Positive_regulation of Gene_expression of MARS 3 0.35 2.45 0.05 5.00
198 INT232833 Positive_regulation of Gene_expression of Cyp2a5 2 0.38 0.79 0.04 5.00
199 INT340358 Negative_regulation of Positive_regulation of Cl 1 0.13 0.79 0.04 5.00
200 INT309246 Localization of ATXN2 1 0.10 1.45 0.03 5.00
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