D:Hepatorenal Syndrome

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Disease Term
Synonyms Syndrome Hepatorenal
Documents 67
Hot Single Events 24
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hepatorenal Syndrome. They are ordered first by their relevance to Hepatorenal Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT327112 HCCS Positive_regulation of Gene_expression of SLCO1B3 1 0.03 0.65 0.19 5.00
2 INT350363 Gatm Negative_regulation of NOS1 1 0.00 0.31 0.17 5.00
3 INT220289 MARS Regulation of CEBPZ 1 0.02 0.93 0.11 5.00
4 INT220288 MARS Regulation of AFM 1 0.06 1.14 0.08 5.00
5 INT220290 Binding of AFM and MARS 1 0.05 1.09 0.07 5.00
6 INT283226 Binding of ACE and CC2D1A 1 0.11 2.37 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hepatorenal Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Hepatorenal Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT207899 Binding of Hgs 2 0.47 1.96 0.35 100.00
2 INT184995 Binding of HGS 4 0.26 3.1 0.25 100.00
3 INT207901 Regulation of Hgs 3 0.26 1.17 0.12 100.00
4 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 98.60
5 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8 98.28
6 INT546 Binding of ALB 311 0.48 85.98 60.14 95.88
7 INT654 Localization of REN 250 0.81 75.12 47.86 95.72
8 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 95.72
9 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 95.68
10 INT214 Localization of AVP 370 0.81 208.51 91.09 92.32
11 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 92.32
12 INT17803 Regulation of Edn1 14 0.54 4.75 4.71 90.20
13 INT20348 Negative_regulation of Tbxa2r 47 0.59 19.88 7.68 89.96
14 INT2271 Gene_expression of F2 51 0.76 30.21 7.97 89.12
15 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 88.88
16 INT685 Regulation of AVP 124 0.62 34.9 39.91 87.92
17 INT31738 Negative_regulation of Regulation of AVP 3 0.37 1.36 0.4 87.92
18 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 87.80
19 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 85.84
20 INT17802 Transcription of Edn1 6 0.24 6.31 1.18 85.84
21 INT5458 Negative_regulation of Tbxa2r 31 0.54 10.58 8.89 84.60
22 INT2733 Negative_regulation of Tbxas1 33 0.57 12.12 6.97 83.60
23 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 83.00
24 INT44817 Negative_regulation of Gene_expression of Shbg 9 0.34 9.84 1.11 83.00
25 INT9660 Regulation of TNF 363 0.62 312.94 139.99 80.00
26 INT9210 Regulation of IL6 166 0.62 125.61 49.95 80.00
27 INT23257 Regulation of CRP 127 0.62 100.05 21.87 80.00
28 INT7561 Positive_regulation of gr 70 0.57 31.92 20.22 75.88
29 INT55091 Positive_regulation of Mgst1 35 0.69 10.77 6.88 75.88
30 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 75.00
31 INT9908 Negative_regulation of IAPP 29 0.57 19.37 2.12 75.00
32 INT46 Localization of Ren 233 0.81 46.15 62.44 74.64
33 INT53201 Negative_regulation of gr 35 0.50 17.76 10.62 74.60
34 INT31599 Negative_regulation of Mgst1 14 0.59 5.35 1.72 74.60
35 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3 71.28
36 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 70.72
37 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 69.48
38 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 69.00
39 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 67.52
40 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38 62.88
41 INT220294 Positive_regulation of Gene_expression of MARS 3 0.35 2.45 0.05 61.80
42 INT220295 Gene_expression of MARS 6 0.47 4.74 0.35 56.60
43 INT10517 Localization of Plat 16 0.47 8.44 3.11 56.40
44 INT220291 Binding of MARS 1 0.25 0.75 0.05 55.76
45 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 55.36
46 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 54.04
47 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 54.04
48 INT7153 Positive_regulation of Regulation of Edn1 2 0.35 1.97 0.57 54.04
49 INT4636 Positive_regulation of Regulation of Agt 4 0.50 1.3 0.3 54.04
50 INT1158 Regulation of Agt 106 0.61 29.4 30.29 53.12
51 INT5806 Regulation of Edn1 63 0.62 23.46 13.88 53.12
52 INT101105 Positive_regulation of FUT1 62 0.30 55.96 9.28 50.40
53 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 50.00
54 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 50.00
55 INT661 Gene_expression of REN 100 0.78 48.21 11.36 50.00
56 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81 50.00
57 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 50.00
58 INT19537 Negative_regulation of Binding of ALB 6 0.43 3.32 2.26 50.00
59 INT60749 Localization of IAPP 17 0.78 12.57 1.69 50.00
60 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43 50.00
61 INT116248 Positive_regulation of Localization of IAPP 2 0.49 0.28 0.62 50.00
62 INT231888 Negative_regulation of Positive_regulation of IAPP 2 0.42 2.43 0.23 50.00
63 INT231889 Regulation of Positive_regulation of IAPP 1 0.26 0.55 0 50.00
64 INT262293 Gene_expression of CC2D1A 21 0.40 44.64 1.5 48.08
65 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 47.48
66 INT19584 Negative_regulation of Ptafr 3 0.56 1.82 0.61 44.08
67 INT220296 Negative_regulation of MARS 3 0.29 1.43 0.2 42.36
68 INT250645 Gene_expression of Samsn1 6 0.33 9.95 0.86 41.68
69 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 34.72
70 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 34.72
71 INT18773 Localization of ALB 117 0.80 69.18 13.8 33.84
72 INT162249 Gene_expression of Hist1h2aa 8 0.12 6.46 4.35 33.20
73 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 33.00
74 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 32.64
75 INT319472 Phosphorylation of Abcd1 1 0.02 3.12 0.31 31.28
76 INT63505 Negative_regulation of F2 18 0.57 7.4 2.2 28.52
77 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 25.76
78 INT153329 Gene_expression of Cm9 6 0.67 4.35 0.95 25.76
79 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 25.00
80 INT234 Binding of Alb 151 0.48 52.34 32.97 25.00
81 INT35143 Negative_regulation of ANGPTL5 28 0.54 18.59 3.14 24.20
82 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 20.24
83 INT16359 Positive_regulation of Gene_expression of AGT 30 0.49 28.27 6.14 20.24
84 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 19.20
85 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 18.96
86 INT220292 Binding of AFM 3 0.10 1.15 0.25 18.16
87 INT10173 Binding of Tnf 45 0.48 35.6 14.32 17.88
88 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 7.76
89 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
90 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
91 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
92 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
93 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
94 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
95 INT1308 Localization of Pomc 457 0.81 66.83 217.5 5.00
96 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
97 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
98 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 5.00
99 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
100 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
101 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
102 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 5.00
103 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
104 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 5.00
105 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
106 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
107 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 5.00
108 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
109 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
110 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 5.00
111 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14 5.00
112 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 5.00
113 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 5.00
114 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
115 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
116 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
117 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49 5.00
118 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
119 INT13995 Gene_expression of gr 96 0.74 48.21 26.54 5.00
120 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 5.00
121 INT74377 Regulation of Cnr1 38 0.59 16.93 24.77 5.00
122 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 5.00
123 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
124 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
125 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
126 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 5.00
127 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54 5.00
128 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
129 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
130 INT82531 Positive_regulation of Gene_expression of Gal 41 0.69 28.67 18.04 5.00
131 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 5.00
132 INT83198 Positive_regulation of Nos3 78 0.64 35.69 17.71 5.00
133 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 5.00
134 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 5.00
135 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
136 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
137 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
138 INT14572 Binding of INS 205 0.48 175.43 13.38 5.00
139 INT28458 Localization of Slc6a3 31 0.76 2.33 12.49 5.00
140 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 5.00
141 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
142 INT113317 Regulation of Cnr2 17 0.52 10.27 10.68 5.00
143 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04 5.00
144 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 5.00
145 INT6499 Localization of Ntrk2 44 0.79 11.78 8.75 5.00
146 INT48908 Transcription of NOS1 27 0.55 13.46 8.39 5.00
147 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11 5.00
148 INT83006 Gene_expression of AGTR1 59 0.75 54.46 7.27 5.00
149 INT43721 Gene_expression of Vegfa 49 0.77 36.18 6.63 5.00
150 INT39516 Gene_expression of Alb 81 0.75 30.08 6.59 5.00
151 INT31598 Gene_expression of Mgst1 41 0.78 6.44 6.3 5.00
152 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 5.00
153 INT22839 Gene_expression of F2 31 0.74 15.53 5.56 5.00
154 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36 5.00
155 INT124605 Gene_expression of Ifih1 16 0.57 7.36 5.33 5.00
156 INT201130 Localization of AES 31 0.63 25.45 5.12 5.00
157 INT9863 Negative_regulation of Ifih1 17 0.20 10.58 5.07 5.00
158 INT105923 Binding of FUT1 34 0.14 17.81 4.79 5.00
159 INT37661 Negative_regulation of SERPINC1 48 0.59 38.6 4.77 5.00
160 INT14470 Gene_expression of HCC 83 0.67 110.55 4.61 5.00
161 INT8743 Positive_regulation of Gcg 19 0.65 10.63 4.43 5.00
162 INT76581 Regulation of Negative_regulation of NOS1 14 0.45 7.49 4.4 5.00
163 INT39945 Binding of Dlat 27 0.32 14.95 3.88 5.00
164 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 5.00
165 INT19211 Binding of Shbg 35 0.48 16.29 3.31 5.00
166 INT109095 Binding of Drd4 7 0.40 3.6 3.18 5.00
167 INT9110 Binding of PAH 32 0.41 42.1 3.1 5.00
168 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07 5.00
169 INT146758 Gene_expression of LCN2 45 0.78 38.29 2.97 5.00
170 INT54331 Positive_regulation of Glul 8 0.67 3.55 2.74 5.00
171 INT39469 Negative_regulation of Alb 21 0.41 13.33 2.68 5.00
172 INT129695 Binding of Sv2a 6 0.47 4.96 2.51 5.00
173 INT200217 Localization of PAH 10 0.36 15.51 2.46 5.00
174 INT72782 Positive_regulation of HCC 41 0.40 63.74 2.46 5.00
175 INT70242 Localization of HCC 18 0.66 23.95 2.35 5.00
176 INT133567 Regulation of IL18 11 0.50 9.54 2.31 5.00
177 INT152174 Negative_regulation of Samsn1 5 0.14 6.46 2.1 5.00
178 INT17274 Gene_expression of Got1 11 0.58 3.98 2 5.00
179 INT138844 Positive_regulation of CC2D1A 25 0.41 41.36 1.92 5.00
180 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92 5.00
181 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 5.00
182 INT79140 Binding of HCC 36 0.31 46.96 1.87 5.00
183 INT447 Localization of Comt 4 0.75 0.76 1.8 5.00
184 INT89167 Positive_regulation of Gene_expression of Mgst1 11 0.69 2.09 1.53 5.00
185 INT12429 Negative_regulation of Spdya 5 0.20 1.07 1.49 5.00
186 INT182514 Binding of AGTR1 18 0.47 13.35 1.48 5.00
187 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47 5.00
188 INT147788 Regulation of FUT1 11 0.12 7.72 1.44 5.00
189 INT60571 Positive_regulation of Gsta4 8 0.45 3.76 1.44 5.00
190 INT31403 Positive_regulation of AFM 3 0.29 5.57 1.38 5.00
191 INT138843 Binding of CC2D1A 19 0.33 33.06 1.25 5.00
192 INT47839 Localization of Slc6a4 4 0.79 0.96 1.14 5.00
193 INT11934 Regulation of Sv2a 4 0.44 1.72 1.1 5.00
194 INT108997 Localization of Htt 28 0.77 3.76 1.07 5.00
195 INT50444 Negative_regulation of Gene_expression of Alb 11 0.39 7.63 1.06 5.00
196 INT6588 Negative_regulation of Nmt1 3 0.09 0.53 1.04 5.00
197 INT20201 Positive_regulation of Fgf12 8 0.43 15.13 0.98 5.00
198 INT132667 Regulation of Transcription of NOS1 1 0.30 2.58 0.95 5.00
199 INT47055 Gene_expression of RBP1 8 0.75 7.85 0.86 5.00
200 INT175106 Gene_expression of LCN1 6 0.75 4.59 0.83 5.00
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