D:Hepatotoxicity

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pChart

Disease Term
Synonyms Chemical Driven Liver Damage, Damage To The Liver, Destructive Effect On The Liver, Dysfunction Of The Liver, DYSFUNCTIONAL HEPATIC, Dysfunctional Liver, Dysfunctional Livers, Dysfunctions Of The Hepatic, Dysfunctions Of The Liver, HEPATIC DYSFUNCTION, Hepatic Dysfunctions
Documents 3478
Hot Single Events 200
Hot Interactions 116

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hepatotoxicity. They are ordered first by their relevance to Hepatotoxicity and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT51933 MSMB Negative_regulation of Positive_regulation of Gpt 1 0.18 0.33 0.74 100.00
2 INT153727 Sds Negative_regulation of RYBP Positive_regulation of Slc17a5 1 0.02 0.68 1.01 100.00
3 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81 100.00
4 INT136346 Binding of Aap and Ads1 1 0.09 2.95 1.44 99.96
5 INT339707 TRO Positive_regulation of CYP3A4 1 0.12 0.97 0.04 99.92
6 INT38305 Binding of DACT1 and Gpt 1 0.01 0.43 0.39 99.80
7 INT39971 Ccl4 Positive_regulation of Lpolv 1 0.15 0.32 0.33 99.80
8 INT28187 CYP2B6 Positive_regulation of RYBP 1 0.31 0.35 0.76 99.76
9 INT89723 RYBP Positive_regulation of Fos 1 0.01 0.31 0.08 99.72
10 INT89725 RYBP Positive_regulation of Transcription of Fos 1 0.01 0.31 0.08 99.72
11 INT89726 RYBP Positive_regulation of Jun 1 0.01 0.31 0.08 99.72
12 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 0.01 1.24 0.98 99.56
13 INT347396 RYBP Positive_regulation of Binding of Sdcbp 1 0.00 0.92 1.66 99.48
14 INT118396 Nfe2l2 Positive_regulation of Gene_expression of Cars 1 0.05 0.26 0.47 99.40
15 INT292621 Binding of IL6 and Gpt 1 0.01 3.88 0.24 99.36
16 INT69011 Binding of Cebpb and Nfkb1 1 0.19 0.75 1.04 99.26
17 INT292615 Binding of IL6 and SLC17A5 1 0.01 1.8 0.16 99.20
18 INT10739 IL3 Positive_regulation of CRP 1 0.18 1.14 0.09 99.20
19 INT10740 IL3 Positive_regulation of TNF 1 0.29 1.14 0.09 99.20
20 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95 99.16
21 INT129215 RYBP Positive_regulation of Il10 1 0.01 1.24 0.98 99.16
22 INT38306 Binding of Dpagt1 and DACT1 1 0.01 0.42 0.39 99.04
23 INT324829 ROS1 Positive_regulation of Gene_expression of Ecm1 1 0.00 0.66 0.09 98.80
24 INT227137 Binding of HBS1L and BDNF-AS 1 0.00 1.32 0.08 98.76
25 INT308816 Gpt Positive_regulation of Tnf 1 0.08 0.72 0.24 98.40
26 INT135176 Myst2 Regulation of Gene_expression of Hif1a 1 0.24 0.47 0.47 98.08
27 INT308815 Got1 Positive_regulation of Ldha 1 0.09 0.71 0.24 97.96
28 INT308818 Got1 Positive_regulation of Tnf 1 0.08 0.71 0.24 97.96
29 INT74872 Igh-Dex Positive_regulation of Chd7 1 0.01 0.5 0.89 97.76
30 INT153728 RYBP Positive_regulation of Gpt 3 0.03 2.01 2.36 97.60
31 INT153729 RYBP Positive_regulation of Slc17a5 1 0.02 0.65 0.97 97.60
32 INT308817 Ldha Positive_regulation of Tnf 1 0.06 0.71 0.24 97.60
33 INT206943 Hspa5 Positive_regulation of Atf4 1 0.47 0.62 0 97.60
34 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83 97.36
35 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83 97.36
36 INT97056 Cpz Regulation of Gene_expression of Bcl2l1 1 0.22 0.57 0.83 97.36
37 INT135178 Myst2 Regulation of Hif1a 1 0.24 0.44 0.44 97.20
38 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9 96.84
39 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9 96.84
40 INT12327 Igh-Dex Positive_regulation of Plec 1 0.03 0.73 1.57 96.76
41 INT145055 Pebp1 Negative_regulation of Localization of Nr1i3 1 0.14 0.33 0.14 96.40
42 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77 95.76
43 INT38512 Binding of Cyp2c22 and Atp6v1c2 1 0.00 0.17 0.73 95.48
44 INT128684 Binding of TGM1 and RETNLB 1 0.00 2.46 0.72 95.48
45 INT38161 Binding of Caf and Ack 1 0.21 0.52 2.23 95.40
46 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64 95.28
47 INT49585 Binding of Glul and Selenbp2 1 0.20 0.19 0.76 95.24
48 INT288729 Positive_regulation of Binding of Got1 and Gpt 1 0.25 0.61 0.49 95.04
49 INT154337 Ppa1 Regulation of Aap 1 0.15 0.45 0.07 94.88
50 INT61360 Regulation of TNF Positive_regulation of NFKB1 2 0.21 1.34 0.14 94.64
51 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6 93.96
52 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6 93.96
53 INT288731 Binding of Got1 and Gpt 1 0.23 1.25 1.61 93.92
54 INT331599 Tlr9 Positive_regulation of Gene_expression of Il6 1 0.03 1.8 0.73 93.56
55 INT22920 Negative_regulation of Ccl4 Positive_regulation of Gpt 1 0.00 0.24 0.39 93.56
56 INT125567 Ncoa6 Positive_regulation of Casr 1 0.52 0.46 0.3 93.48
57 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89 93.32
58 INT22921 Ccl4 Positive_regulation of Gpt 1 0.00 0.24 0.39 93.16
59 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 0.00 1.04 0.95 92.80
60 INT129214 RYBP Positive_regulation of Gene_expression of Il4 1 0.01 1.04 0.94 91.84
61 INT330598 Binding of Il6 and Fig4 1 0.11 1.78 0.4 91.76
62 INT278610 CDCA2 Negative_regulation of NR1H4 1 0.01 0.62 0.13 91.76
63 INT343857 Binding of ABCC8 and LY96 1 0.02 0.96 0.34 91.68
64 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9 91.60
65 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05 91.04
66 INT69949 Car2 Positive_regulation of MTAP 1 0.02 0.41 0.18 90.28
67 INT262210 Negative_regulation of Nr1i2 Negative_regulation of Positive_regulation of Cyp3a11 1 0.31 0.4 0.2 90.16
68 INT310311 Tlr4 Positive_regulation of Gpt 1 0.05 1.15 0.12 89.60
69 INT96501 Il11 Regulation of Gene_expression of NOS2 1 0.00 1.04 0.8 89.48
70 INT129213 RYBP Positive_regulation of Gene_expression of Il10 1 0.01 1.04 0.94 89.20
71 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 0.01 1.04 0.94 89.20
72 INT75039 Slc6a14 Positive_regulation of Gene_expression of Mgst1 1 0.01 0.17 0.17 88.96
73 INT75030 Slc6a14 Positive_regulation of Gene_expression of Ephx1 1 0.01 0.17 0.17 88.96
74 INT75036 Slc6a14 Negative_regulation of Cyp11b1 1 0.00 0.17 0.17 88.96
75 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29 88.72
76 INT347369 RYBP Positive_regulation of GSR 1 0.01 0.43 0.51 87.88
77 INT347395 RYBP Positive_regulation of Gsr 1 0.01 0.43 0.5 87.88
78 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73 87.88
79 INT355153 Gpt Positive_regulation of Positive_regulation of Ldha 1 0.02 1.33 0.3 87.56
80 INT355152 Gpt Positive_regulation of Gene_expression of Ldha 1 0.02 1.26 0.29 87.56
81 INT153696 Binding of GSTM1 and Gstt1 1 0.06 0.71 0.08 87.44
82 INT312573 AMBP Negative_regulation of IL6 1 0.11 1.41 0.32 87.40
83 INT312571 AMBP Negative_regulation of Positive_regulation of IL6 1 0.11 1.41 0.32 87.40
84 INT284461 Gtf3a Positive_regulation of Gene_expression of IFN1@ 1 0.01 0.56 0.57 87.20
85 INT134427 Alb Regulation of GGT1 1 0.05 0.7 0.35 86.76
86 INT120191 Ccl4 Positive_regulation of Pdlim3 1 0.51 0.24 0.25 86.52
87 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38 86.52
88 INT323395 Binding of BCHE and SERPINH1 1 0.02 0.74 0.03 85.92
89 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11 85.72
90 INT228563 Grhpr Regulation of Negative_regulation of Coq10a 1 0.00 0.71 0 85.04
91 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24 84.80
92 INT112870 Aap Positive_regulation of Gene_expression of Ccnd1 1 0.24 0.34 0.63 84.56
93 INT225607 Ncoa6 Regulation of Gene_expression of Casr 1 0.15 0.68 0.17 84.56
94 INT225501 Plcl1 Regulation of Gene_expression of Casr 1 0.04 0.67 0.16 84.32
95 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 84.12
96 INT343834 Binding of CD14 and IRF6 1 0.02 2.08 0.9 84.12
97 INT343859 Binding of IRF6 and TBCE 1 0.01 1.1 0.51 84.12
98 INT343860 Binding of CD14 and TBCE 1 0.03 1.1 0.51 84.12
99 INT89724 RYBP Positive_regulation of Gclc 1 0.01 0.21 0.07 84.12
100 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 84.12
101 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 84.12
102 INT301640 Positive_regulation of Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.03 0.25 0 84.08
103 INT145058 Nr1i3 Regulation of Transcription of Ppara 1 0.28 0.23 0.13 83.88
104 INT203852 Binding of Eif2ak2 and Lna1 1 0.03 0.65 0.1 83.36
105 INT47719 Gpr143 Regulation of Grhpr 1 0.00 0.08 0.08 83.16
106 INT11651 Nlrp1a Negative_regulation of Gpt 1 0.12 0.24 0.47 82.76
107 INT329847 PPARA Regulation of Gene_expression of CREB3L3 1 0.17 0.84 0.13 82.56
108 INT108105 Mir1893 Negative_regulation of Gene_expression of Ros1 1 0.01 0.17 0 82.44
109 INT330048 G6pd Positive_regulation of Gene_expression of Ros1 1 0.03 0.61 0 82.20
110 INT330060 GSR Positive_regulation of Gene_expression of Ros1 1 0.00 0.61 0 82.20
111 INT312794 Hdl1 Regulation of Pon1 1 0.02 1.63 0.15 82.04
112 INT249959 Cpa1 Regulation of NOS1 1 0.00 0.08 0.04 81.84
113 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1 81.80
114 INT121944 Nr1i2 Positive_regulation of Gene_expression of Cyp3a11 1 0.78 0.43 0.49 80.52
115 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86 80.48
116 INT125569 In(4)1Dn-p Negative_regulation of Positive_regulation of Casr 1 0.01 0.39 0.25 80.40
117 INT223283 Binding of CYP2C9 and VKORC1 1 0.31 0.16 0 79.36
118 INT121382 Casr Positive_regulation of Abcc3 1 0.32 0.25 0.19 79.16
119 INT121381 Casr Positive_regulation of Positive_regulation of Abcc3 1 0.30 0.25 0.19 79.16
120 INT121380 Casr Positive_regulation of Positive_regulation of Cyp3a11 1 0.15 0.25 0.18 79.16
121 INT343856 Binding of S100A9 and ABCC8 1 0.04 0.9 0.28 78.80
122 INT203848 Binding of Pten and Lna1 1 0.06 0.4 0.2 77.88
123 INT203850 Binding of Tradd and Lna1 1 0.10 0.4 0.2 77.88
124 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59 77.80
125 INT88689 Binding of HBE1 and Gpt 1 0.00 0.71 0 77.76
126 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09 76.84
127 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7 76.80
128 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08 76.56
129 INT57746 Il1 Regulation of Gene_expression of Ltc4s 1 0.36 0.33 0.88 75.00
130 INT168427 RYBP Positive_regulation of Nfkb1 1 0.01 0.53 0.38 75.00
131 INT168426 RYBP Regulation of Nos2 1 0.01 0.4 0.36 75.00
132 INT168424 Ptger2 Regulation of Binding of Nos2 1 0.22 0.52 0.36 75.00
133 INT168423 Ptger2 Regulation of Nos2 1 0.13 0.52 0.36 75.00
134 INT100823 Cyp2e1 Positive_regulation of Ros1 1 0.35 1.22 0.22 75.00
135 INT130356 Adcy10 Negative_regulation of Positive_regulation of Crp 1 0.13 0.23 0.71 75.00
136 INT63588 Aap Positive_regulation of Positive_regulation of Got1 1 0.31 0.6 0.79 75.00
137 INT96955 Glul Positive_regulation of Positive_regulation of Ugcg 1 0.07 0.14 0.14 75.00
138 INT156749 Gpt Positive_regulation of Gene_expression of Gpt2 1 0.50 0.22 0.1 75.00
139 INT156750 Gpt Positive_regulation of Gpt 1 0.27 0.22 0.1 75.00
140 INT156751 Gpt2 Positive_regulation of Gpt 1 0.12 0.21 0.1 75.00
141 INT63589 Binding of Got1 and Gpt 1 0.36 0.56 0.74 75.00
142 INT130357 Adcy10 Regulation of Fgg 1 0.03 0.2 0.66 75.00
143 INT130354 Adcy10 Regulation of Serpine1 1 0.17 0.2 0.66 75.00
144 INT130353 spc Regulation of Fgg 1 0.02 0.2 0.66 75.00
145 INT130355 spc Regulation of Serpine1 1 0.14 0.2 0.66 75.00
146 INT150863 Grtp1 Negative_regulation of Gpt 1 0.09 0.58 0.71 75.00
147 INT31776 Positive_regulation of Gclc Positive_regulation of G6pd 1 0.29 0.19 0.75 75.00
148 INT168026 Positive_regulation of HBG2 Regulation of Gpt 1 0.01 0.15 0.89 75.00
149 INT168019 Ldha Regulation of Gpt 1 0.01 0.15 0.88 75.00
150 INT168018 Positive_regulation of Ldha Regulation of Gpt 1 0.01 0.15 0.88 75.00
151 INT168025 HBG2 Regulation of Gpt 1 0.01 0.15 0.88 75.00
152 INT151008 Gpt Positive_regulation of Gene_expression of alp 1 0.08 0.07 0.83 75.00
153 INT168425 Ptger2 Negative_regulation of RYBP Positive_regulation of Nfkb1 1 0.01 0.27 0.19 75.00
154 INT56278 Binding of CYP2B6 and TACC2 1 0.40 0.32 0.06 75.00
155 INT203853 Eif2ak3 Positive_regulation of Eif2ak1 1 0.05 0.63 0 74.52
156 INT125551 Binding of FGFR1 and Cyp2e1 1 0.02 0.07 0.13 74.48
157 INT168010 Asap1 Positive_regulation of HBG2 1 0.01 3.03 1.82 74.32
158 INT136368 RYBP Regulation of Localization of Ifng 1 0.00 0.4 0.28 73.60
159 INT184140 Socs2 Negative_regulation of Gh Positive_regulation of Stat5b 1 0.10 1.33 0.1 73.12
160 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92 73.12
161 INT184133 Binding of Gh and Socs2 1 0.10 0.66 0.05 73.12
162 INT125549 Binding of CYP2B6 and FGFR1 1 0.00 0.07 0.13 72.96
163 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21 72.92
164 INT184102 Cish Negative_regulation of Thpo 1 0.14 0.62 0.07 72.80
165 INT125568 Binding of Casr and Ncoa6 3 0.50 1.13 0.46 72.72
166 INT225494 Binding of Casr and Asc2 1 0.03 0.63 0.07 72.72
167 INT343569 Negative_regulation of Synm Positive_regulation of Gpt 1 0.01 0.96 0.29 72.16
168 INT343571 Synm Positive_regulation of ALPP 1 0.01 1.28 0.28 72.16
169 INT343570 Synm Positive_regulation of Gpt 1 0.01 1.28 0.28 72.16
170 INT343573 Synm Positive_regulation of SLC17A5 1 0.17 1.28 0.28 72.16
171 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 71.28
172 INT184097 Cish Negative_regulation of Il3 1 0.10 0.62 0.07 71.28
173 INT343912 Fgg Positive_regulation of Gene_expression of IL6 1 0.00 0.83 0.35 70.96
174 INT184139 Gh Positive_regulation of Gh Positive_regulation of Stat5b 1 0.06 1.31 0.1 70.80
175 INT184089 Gh Positive_regulation of Stat5b 1 0.13 1.3 0.1 70.80
176 INT23585 Binding of KRIT1 and CCR1 1 0.40 0.97 0.19 70.56
177 INT330053 Binding of Ros1 and Mapk8 1 0.02 0.88 0.24 70.32
178 INT23586 Binding of CALCR and KRIT1 1 0.40 0.97 0.19 70.24
179 INT76866 Negative_regulation of Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2 70.16
180 INT108732 Gene_expression of Gstp1 Positive_regulation of Gene_expression of Mgst1 1 0.44 0.58 0.41 69.92
181 INT76865 Lmo4 Positive_regulation of Sds 1 0.02 0.38 0.2 69.84
182 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71 69.36
183 INT349590 Aap Positive_regulation of Cytl1 1 0.13 1.31 1.15 69.36
184 INT324828 ELANE Positive_regulation of Localization of Ecm1 1 0.00 0.61 0.09 68.08
185 INT112869 Aap Positive_regulation of Gpt 2 0.26 0.75 0.6 67.36
186 INT214380 Binding of IL1A and PRTN3 1 0.00 0.94 0.18 67.20
187 INT136367 RYBP Negative_regulation of Positive_regulation of Il10 1 0.00 0.37 0.26 66.56
188 INT232896 Krt8 Negative_regulation of Binding of ABR 1 0.04 0.68 0 65.92
189 INT234599 Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44 65.80
190 INT234600 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44 65.80
191 INT249961 Gatm Regulation of NOS1 1 0.00 0.07 0.03 65.52
192 INT232899 Krt18 Negative_regulation of Binding of ABR 1 0.05 0.68 0 65.48
193 INT120236 Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28 64.08
194 INT120237 Positive_regulation of Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28 64.08
195 INT136364 Cpz Positive_regulation of Localization of Tnf 1 0.29 0.36 0.25 64.04
196 INT255019 Myo7a Positive_regulation of F10 1 0.00 0.06 0 63.88
197 INT228333 Binding of IFNA1 and IRF9 2 0.04 0.53 0.09 63.72
198 INT255020 TF Positive_regulation of Binding of Gtf3a 1 0.00 0.06 0 63.64
199 INT255012 TF Positive_regulation of F10 1 0.06 0.06 0 63.64
200 INT220524 Ppara Negative_regulation of Positive_regulation of Gdf15 1 0.01 0.56 0.17 63.28

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hepatotoxicity. They are ordered first by their pain relevance and then by number of times they were reported in Hepatotoxicity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 100.00
2 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 100.00
3 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 100.00
4 INT18883 Negative_regulation of RYBP 53 0.56 21.14 57.52 100.00
5 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 100.00
6 INT3920 Localization of Ldha 241 0.81 83.08 58.72 100.00
7 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 100.00
8 INT22213 Localization of Gpt 52 0.78 34.05 12.94 100.00
9 INT53746 Regulation of Cyp2e1 11 0.62 3.82 9.52 100.00
10 INT12189 Localization of Gpt 8 0.73 3.63 3.92 100.00
11 INT3919 Localization of Got1 10 0.71 2.95 3.28 100.00
12 INT50646 Transcription of Glul 12 0.38 3.59 4.07 100.00
13 INT129901 Gene_expression of Nr1i2 60 0.73 22.44 6.04 100.00
14 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 100.00
15 INT39908 Gene_expression of Cyp27b1 16 0.69 4.8 2.83 100.00
16 INT47348 Binding of Ccl4 8 0.37 3.24 1.08 100.00
17 INT46443 Regulation of Positive_regulation of Gpt 1 0.27 0.52 0.3 100.00
18 INT240559 Positive_regulation of RHOF 1 0.06 1.06 0 100.00
19 INT91232 Regulation of Positive_regulation of Hmox1 5 0.45 2.43 1.55 100.00
20 INT153946 Localization of Slc17a5 8 0.66 4.83 2.93 100.00
21 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24 100.00
22 INT59198 Regulation of Ccnd1 11 0.47 6.54 0.9 100.00
23 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 100.00
24 INT6487 Positive_regulation of Positive_regulation of Tnf 21 0.56 16.06 5.64 100.00
25 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 100.00
26 INT52747 Negative_regulation of Positive_regulation of alp 3 0.30 1.54 0.97 100.00
27 INT89812 Negative_regulation of Gene_expression of Il1a 1 0.24 0.58 0.66 100.00
28 INT143238 Positive_regulation of HAVCR1 3 0.67 2.66 0.67 100.00
29 INT45880 Negative_regulation of Positive_regulation of Sord 1 0.43 0.26 0.32 100.00
30 INT48258 Positive_regulation of Positive_regulation of CYP3A5 1 0.49 0.71 0.6 100.00
31 INT203831 Binding of Lna1 1 0.15 0.93 0.35 100.00
32 INT20201 Positive_regulation of Fgf12 8 0.43 15.13 0.98 100.00
33 INT108327 Negative_regulation of Gene_expression of Ccnd1 18 0.38 14.36 1.31 100.00
34 INT114876 Negative_regulation of Gene_expression of Cdk4 3 0.38 2.3 0.7 100.00
35 INT114872 Negative_regulation of Gene_expression of Cdk2 2 0.35 1.21 0.6 100.00
36 INT71190 Regulation of Gene_expression of Cyp27b1 1 0.13 0.17 0.39 100.00
37 INT71191 Regulation of Positive_regulation of Cyp27b1 1 0.13 0.17 0.39 100.00
38 INT48141 Binding of Csf3 18 0.39 9.93 1.71 100.00
39 INT227332 Phosphorylation of Csf3 2 0.43 2.01 0.31 100.00
40 INT332453 Positive_regulation of Phosphorylation of Csf3 1 0.27 0.43 0.04 100.00
41 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 99.98
42 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46 99.98
43 INT14883 Regulation of Car3 8 0.58 5.57 2.75 99.98
44 INT157280 Binding of Gm7100 1 0.01 0.1 0 99.98
45 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 99.96
46 INT22967 Positive_regulation of RYBP 94 0.56 37.04 85.92 99.96
47 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 99.96
48 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 99.96
49 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 99.96
50 INT18884 Regulation of RYBP 25 0.38 11.43 23.2 99.96
51 INT39699 Negative_regulation of Positive_regulation of RYBP 11 0.41 3.73 10.42 99.96
52 INT130754 Gene_expression of Cast 21 0.78 11.6 2.08 99.96
53 INT104502 Gene_expression of Abcc2 26 0.78 8.37 9.65 99.96
54 INT38856 Positive_regulation of Ccl4 24 0.69 9.55 1.62 99.96
55 INT130755 Positive_regulation of Gene_expression of Cast 4 0.70 4.3 1.18 99.96
56 INT18526 Positive_regulation of Aap 19 0.56 12.28 14.57 99.96
57 INT65880 Gene_expression of CYP2C8 25 0.77 9.49 1.92 99.96
58 INT44466 Gene_expression of Ugt2b7 7 0.75 1.32 2 99.96
59 INT55342 Negative_regulation of Gene_expression of Ros1 49 0.37 31.62 8.93 99.96
60 INT14853 Negative_regulation of Tac1 80 0.59 30.87 45.06 99.96
61 INT24154 Negative_regulation of Regulation of NA 2 0.04 0.98 0.39 99.96
62 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 99.96
63 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 99.96
64 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72 99.92
65 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49 99.92
66 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39 99.92
67 INT2480 Negative_regulation of Got1 43 0.51 14.47 16.09 99.92
68 INT11180 Binding of RYBP 52 0.46 13.86 42.53 99.92
69 INT114311 Negative_regulation of Gene_expression of Gpt 33 0.38 17.83 4.94 99.92
70 INT43486 Positive_regulation of Ifng 52 0.69 32.71 24.77 99.92
71 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75 99.92
72 INT97912 Gene_expression of Sod3 25 0.78 22.44 3.28 99.92
73 INT142461 Positive_regulation of Positive_regulation of Stat1 7 0.54 5.06 1.94 99.92
74 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09 99.92
75 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29 99.92
76 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 99.92
77 INT140818 Positive_regulation of Positive_regulation of Ifng 2 0.47 4.2 2.06 99.92
78 INT49313 Positive_regulation of Gene_expression of Apoa1 3 0.68 9.55 2.01 99.92
79 INT8579 Gene_expression of Apoa1 13 0.76 35.89 7.21 99.92
80 INT130078 Regulation of Gene_expression of Cyp1a1 1 0.14 0.25 0.64 99.92
81 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 99.92
82 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 99.92
83 INT121942 Binding of Nr1i2 2 0.45 15.69 3.66 99.92
84 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 99.90
85 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10 99.90
86 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 99.90
87 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 99.90
88 INT39900 Positive_regulation of Gene_expression of Ldha 36 0.50 20.35 5.22 99.90
89 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09 99.90
90 INT327507 Negative_regulation of Localization of CYLD 1 0.05 0.58 0 99.90
91 INT125561 Negative_regulation of Gene_expression of Casr 1 0.55 0.48 0.27 99.90
92 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 99.90
93 INT39678 Negative_regulation of Regulation of Atrn 1 0.17 0.34 0.25 99.88
94 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 99.84
95 INT3970 Positive_regulation of Sord 9 0.70 4.29 3.93 99.84
96 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 99.84
97 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 99.84
98 INT19271 Binding of Aap 6 0.30 0.88 5.27 99.84
99 INT95616 Gene_expression of Thpo 48 0.78 21.51 5.88 99.84
100 INT19947 Negative_regulation of B3GAT2 10 0.57 4.2 7.95 99.84
101 INT80696 Positive_regulation of Thpo 16 0.70 13.75 4.49 99.84
102 INT108724 Positive_regulation of Gene_expression of Thpo 9 0.70 8.12 1.9 99.84
103 INT49862 Negative_regulation of Positive_regulation of Gpt 8 0.41 3.49 2.6 99.82
104 INT222845 Gene_expression of Chuk 27 0.52 25.15 2.67 99.82
105 INT26337 Negative_regulation of Hmmr 6 0.30 1.11 4.01 99.82
106 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 99.80
107 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 99.80
108 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 99.80
109 INT38303 Binding of Gpt 21 0.47 15.84 3.43 99.80
110 INT12595 Positive_regulation of LPO 14 0.70 4.92 3.47 99.80
111 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 99.80
112 INT53393 Positive_regulation of Cyp3a62 25 0.70 7.56 17.69 99.76
113 INT206698 Regulation of HBS1L 4 0.09 3.06 0 99.76
114 INT38814 Positive_regulation of Aspt1 9 0.63 6.89 3.06 99.76
115 INT102882 Positive_regulation of Positive_regulation of Aspt1 1 0.03 0.17 0.36 99.76
116 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.74
117 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 99.74
118 INT42410 Positive_regulation of Cyb5d2 13 0.31 6.75 0.54 99.74
119 INT288083 Positive_regulation of Gene_expression of Cyb5d2 1 0.10 0.75 0 99.74
120 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37 99.72
121 INT16287 Positive_regulation of NOVA2 25 0.49 6.62 3.01 99.72
122 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 99.70
123 INT138922 Positive_regulation of Stat1 57 0.69 28.35 7.2 99.70
124 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 99.70
125 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 99.68
126 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 99.68
127 INT130300 Gene_expression of Abcc3 14 0.70 5.34 4.96 99.68
128 INT147159 Regulation of Gene_expression of Abcc3 4 0.55 2.96 2.97 99.68
129 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 99.68
130 INT123813 Positive_regulation of Parp1 74 0.70 65.36 8.56 99.68
131 INT83794 Positive_regulation of Gene_expression of Bcl2l1 26 0.69 16.89 4.28 99.68
132 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22 99.68
133 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 99.66
134 INT1242 Negative_regulation of Slc17a5 14 0.42 4.06 5.78 99.66
135 INT29845 Positive_regulation of Sds 11 0.62 3.69 6.63 99.66
136 INT35895 Positive_regulation of Sord 8 0.69 3.25 4.45 99.64
137 INT52088 Binding of Cyp2e1 8 0.48 2.5 4.43 99.64
138 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39 99.64
139 INT142923 Binding of Cyp3a11 1 0.36 0.38 0.76 99.64
140 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 99.64
141 INT98836 Transcription of Bax 6 0.69 5.04 1.96 99.64
142 INT20274 Regulation of Aap 9 0.45 5.55 7.27 99.64
143 INT76860 Gene_expression of HSPG2 32 0.65 37.14 9.06 99.64
144 INT287126 Negative_regulation of Negative_regulation of Comt 1 0.37 0.78 0.25 99.64
145 INT22919 Negative_regulation of Gpt 18 0.55 6.84 7.4 99.62
146 INT5408 Localization of Alb 30 0.73 12.1 3.84 99.62
147 INT130079 Gene_expression of Cyp1a1 1 0.23 0.25 0.64 99.62
148 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 99.60
149 INT135016 Positive_regulation of Gene_expression of Slc17a5 7 0.55 4.33 3.74 99.60
150 INT137679 Localization of Gfm1 18 0.08 9.58 3.24 99.60
151 INT23035 Regulation of Il1a 6 0.60 5.69 4.25 99.60
152 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 99.60
153 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 99.60
154 INT1278 Negative_regulation of Ldha 93 0.59 37.66 19.36 99.58
155 INT4419 Gene_expression of GOT1 20 0.65 22.53 2.53 99.58
156 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33 99.58
157 INT132903 Gene_expression of Cd34 65 0.72 33.95 2.2 99.58
158 INT130301 Positive_regulation of Gene_expression of Abcc3 2 0.63 0.52 1 99.58
159 INT50580 Binding of PPIG 39 0.36 11.17 12.34 99.58
160 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 99.56
161 INT203814 Gene_expression of Lna1 8 0.65 6.48 1.95 99.56
162 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45 99.54
163 INT81796 Binding of AGRP 62 0.36 37.19 5.3 99.54
164 INT207421 Positive_regulation of Gene_expression of GPT 9 0.49 5.62 0.83 99.54
165 INT14152 Gene_expression of Slc17a5 46 0.61 20.01 15.9 99.52
166 INT79780 Gene_expression of Cyp4a3 14 0.56 5.19 1.12 99.52
167 INT144843 Regulation of Gmcl1 5 0.37 2.76 1.15 99.52
168 INT210488 Phosphorylation of CFH 1 0.04 0.48 0.05 99.52
169 INT78460 Negative_regulation of Positive_regulation of Mgst1 1 0.43 0.39 0.47 99.52
170 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 99.52
171 INT212591 Phosphorylation of AGRP 2 0.30 3.02 0.03 99.52
172 INT8798 Positive_regulation of Csrp1 61 0.69 63.86 14.14 99.52
173 INT14111 Positive_regulation of Cyp2c22 41 0.67 7.24 17.88 99.50
174 INT3892 Positive_regulation of XDH 8 0.67 8.57 1.5 99.50
175 INT5536 Regulation of NA 74 0.59 16.61 15.36 99.50
176 INT87778 Positive_regulation of Gene_expression of Gja1 6 0.69 1.46 2.14 99.50
177 INT83797 Gene_expression of Bcl2l1 124 0.77 94.55 22.39 99.48
178 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 99.48
179 INT64818 Regulation of Binding of Jun 3 0.33 1.06 1.17 99.48
180 INT197750 Binding of RHOF 2 0.34 1.41 0 99.48
181 INT35636 Gene_expression of Sord 6 0.78 2.31 1.35 99.48
182 INT125356 Negative_regulation of Negative_regulation of Cat 4 0.42 2.66 1.06 99.48
183 INT69009 Regulation of Binding of Nfkb1 9 0.27 9.86 2.58 99.48
184 INT307240 Localization of CYLD 3 0.72 3.09 0.1 99.48
185 INT3287 Gene_expression of Gpt 50 0.75 23.69 8.57 99.46
186 INT120189 Gene_expression of Pdlim3 3 0.75 0.52 0.54 99.46
187 INT39679 Regulation of Atrn 8 0.11 1.29 2.22 99.46
188 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 99.44
189 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72 99.44
190 INT92865 Gene_expression of Ambp 3 0.65 0.97 0.3 99.44
191 INT425 Localization of PRL 455 0.81 189.64 144.8 99.44
192 INT86245 Positive_regulation of Bcl2l1 15 0.46 12.67 3.11 99.44
193 INT37490 Negative_regulation of Cyp1b1 3 0.30 1.57 0.68 99.44
194 INT14110 Positive_regulation of Positive_regulation of Cyp2c22 6 0.67 1.45 3.45 99.44
195 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 99.44
196 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 99.44
197 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 99.40
198 INT19109 Positive_regulation of CYP3A5 7 0.67 1.48 1.51 99.40
199 INT2367 Binding of Sct 34 0.42 8.46 8.62 99.40
200 INT96952 Gene_expression of Gclc 7 0.38 2.08 0.28 99.38
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