D:Hereditary Angioedema

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Disease Term
Synonyms Angioedemas Hereditary, Angioneurotic Edema Hereditary, Angioneurotic Edemas Hereditary, C 1 Esterase Inhibitor Deficiency, C 1 Esterase Inhibitor Deficiency Syndrome, C1 Esterase Inhibitor Deficiency, C1 Inhibitor Deficiency, Complement Esterase Deficiency, EDEMA HEREDITARY ANGIONEUROTIC, EDEMAS HEREDITARY ANGIONEUROTIC, Familial Angio Edema
Documents 190
Hot Single Events 155
Hot Interactions 21

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hereditary Angioedema. They are ordered first by their relevance to Hereditary Angioedema and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT326464 KNG1 Positive_regulation of SERPING1 1 0.19 1.53 0.18 100.00
2 INT232018 Binding of SERPING1 and KNG1 1 0.15 0.81 0.14 100.00
3 INT232013 SERPING1 Negative_regulation of C1S 1 0.24 0.72 0.04 99.36
4 INT232012 SERPING1 Negative_regulation of C1R 1 0.18 0.72 0.04 99.36
5 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23 99.08
6 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23 99.08
7 INT232019 F12 Positive_regulation of TRGC1 1 0.00 0.57 0.09 98.88
8 INT232010 PLG Positive_regulation of TRGC1 1 0.08 0.51 0.09 98.24
9 INT232016 SERPING1 Regulation of C1S 1 0.15 0.57 0 97.88
10 INT332700 Binding of F12 and KNG1 1 0.15 1.05 0.21 96.28
11 INT281041 Binding of MASP2 and Serping1 1 0.00 1.2 0 95.76
12 INT232017 F12 Positive_regulation of PLG 1 0.03 0.52 0.11 95.60
13 INT332699 Binding of KNG1 and TRGC1 1 0.16 3.37 0.75 95.28
14 INT267625 Binding of KNG1 and Klk1 2 0.21 2.23 0.61 95.28
15 INT332707 Binding of TRGC1 and Klk1 1 0.32 1.64 0.36 90.32
16 INT131304 Binding of Serping1 and Sele 1 0.01 1.07 0.15 89.20
17 INT281029 MASP2 Positive_regulation of C4A 1 0.00 0.72 0.1 87.84
18 INT232015 SERPING1 Negative_regulation of F12 2 0.24 1.19 0.12 87.04
19 INT232011 SERPING1 Regulation of Negative_regulation of SERPINE1 1 0.01 0.45 0.07 85.12
20 INT327090 Negative_regulation of F12 Negative_regulation of Gene_expression of KNG1 1 0.00 0.51 0.45 83.92
21 INT281042 Serping1 Regulation of MBL2 1 0.01 0.74 0.11 80.32
22 INT312706 DPP9 Positive_regulation of DPP4 1 0.26 0.54 0.19 77.12
23 INT312708 DPP8 Positive_regulation of DPP4 1 0.24 0.54 0.19 76.64
24 INT58586 IFNG Positive_regulation of Gene_expression of PLG 1 0.41 0.38 0.06 70.40
25 INT332701 Binding of BDKRB1 and BDKRB2 1 0.01 0.5 0.39 69.28
26 INT58588 IFNG Positive_regulation of ARHGAP4 1 0.31 1.22 0.19 57.92
27 INT232009 Positive_regulation of F12 Negative_regulation of Localization of KNG1 1 0.01 0.19 0.05 52.24
28 INT251645 Binding of SERPING1 and CD79A 1 0.10 1.31 0.06 50.00
29 INT327162 Binding of SERPING1 and F12 1 0.05 0.29 0.04 19.36
30 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
31 INT269061 Binding of Il6 and Il6ra 3 0.04 2.59 0.45 5.00
32 INT175330 IL6 Positive_regulation of Gene_expression of CYP19A1 1 0.01 0.97 0.32 5.00
33 INT179566 Binding of C1qa and Ywhaq 1 0.00 0.56 0.26 5.00
34 INT175328 FASLG Positive_regulation of FAS 1 0.01 0.9 0.17 5.00
35 INT312707 Positive_regulation of DPP4 Positive_regulation of Gene_expression of CD86 1 0.20 0.45 0.13 5.00
36 INT269140 Binding of Il6 and Rps7 1 0.02 0.85 0 5.00
37 INT269139 Binding of Csnk2a2 and Sub1 1 0.02 0.68 0 5.00
38 INT269138 Binding of Il6ra and Rps7 1 0.01 0.85 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hereditary Angioedema. They are ordered first by their pain relevance and then by number of times they were reported in Hereditary Angioedema. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17 100.00
2 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75 100.00
3 INT46383 Negative_regulation of TRGC1 42 0.55 44.03 6.2 100.00
4 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75 100.00
5 INT70962 Positive_regulation of SERPING1 33 0.69 27.32 2.14 100.00
6 INT156130 Binding of SERPING1 29 0.42 26.16 2.52 100.00
7 INT156672 Localization of SERPING1 10 0.74 12.15 1.25 100.00
8 INT94026 Regulation of SERPING1 12 0.61 10.28 0.37 100.00
9 INT232021 Positive_regulation of Gene_expression of SERPING1 8 0.49 4.99 0.31 100.00
10 INT144482 Negative_regulation of Gene_expression of SERPING1 8 0.43 6.06 0.89 100.00
11 INT3076 Regulation of KNG1 52 0.60 20.39 27.89 100.00
12 INT40954 Regulation of Serping1 5 0.32 3.71 1.88 100.00
13 INT184641 Regulation of TRGC1 4 0.40 2.84 0.34 100.00
14 INT81371 Binding of Serping1 3 0.37 2.67 0.55 100.00
15 INT326468 Regulation of Negative_regulation of TRGC1 1 0.19 2.8 0.17 100.00
16 INT62060 Positive_regulation of Gene_expression of TRGC1 3 0.61 4.7 0.88 100.00
17 INT46384 Binding of TRGC1 16 0.41 4.87 1.28 100.00
18 INT316318 Phosphorylation of SERPING1 2 0.81 1.7 0.13 100.00
19 INT316315 Negative_regulation of Binding of SERPING1 2 0.37 1.4 0.34 100.00
20 INT3557 Positive_regulation of C1S 10 0.67 8.73 0.54 100.00
21 INT3364 Binding of SGCG 87 0.47 31.93 17.24 100.00
22 INT310196 Localization of Serping1 2 0.39 2.64 0.04 100.00
23 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 100.00
24 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92 99.98
25 INT131301 Binding of Serping1 3 0.28 1.86 0.3 99.98
26 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 99.92
27 INT21647 Negative_regulation of Positive_regulation of KNG1 11 0.43 5.54 5.73 99.92
28 INT62061 Gene_expression of TRGC1 32 0.69 17.43 3.37 99.88
29 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 99.88
30 INT37076 Negative_regulation of Binding of KNG1 3 0.14 1.77 1.32 99.86
31 INT574 Negative_regulation of C1S 9 0.47 11.25 1.41 99.84
32 INT228644 Positive_regulation of Negative_regulation of SERPING1 5 0.46 4.21 0.21 99.84
33 INT281038 Positive_regulation of Negative_regulation of Serping1 1 0.10 2.63 0 99.84
34 INT341046 Negative_regulation of Binding of C1S 1 0.30 1.18 0.08 99.84
35 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 99.70
36 INT80395 Negative_regulation of Vom1r68 7 0.23 1.11 2.76 99.66
37 INT314337 Negative_regulation of Gene_expression of TRGC1 3 0.52 5.24 0.8 99.64
38 INT229968 Binding of C1S 6 0.36 5.87 0.16 99.64
39 INT26551 Positive_regulation of Gene_expression of KNG1 19 0.67 11.05 7.98 99.60
40 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 99.56
41 INT332697 Negative_regulation of Klk1 1 0.42 0.88 0.13 99.38
42 INT316316 Negative_regulation of Binding of F12 1 0.18 1.1 0.12 99.36
43 INT3167 Binding of KNG1 48 0.48 23.26 26.77 99.34
44 INT4585 Gene_expression of Serping1 19 0.46 12.4 2.35 99.28
45 INT64843 Gene_expression of Serping1 19 0.67 8.88 2.72 99.28
46 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 99.22
47 INT151855 Negative_regulation of Negative_regulation of PON1 2 0.38 2.39 0.22 99.22
48 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 99.20
49 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 99.20
50 INT3821 Negative_regulation of C1s 13 0.42 7.89 2.08 99.16
51 INT153156 Negative_regulation of KLKB1 5 0.48 7.88 1.6 99.12
52 INT11488 Negative_regulation of KLK1 15 0.57 9.92 3.06 99.04
53 INT608 Negative_regulation of KNG1 98 0.43 72.36 31.23 99.04
54 INT14205 Regulation of KLK1 10 0.60 4.38 1.28 99.00
55 INT82402 Negative_regulation of Negative_regulation of TRGC1 3 0.50 2.32 0.09 99.00
56 INT4586 Negative_regulation of Gene_expression of Serping1 3 0.30 2.12 0.28 98.98
57 INT23350 Negative_regulation of CFI 9 0.05 3.48 0.78 98.96
58 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49 98.92
59 INT77164 Binding of F12 8 0.47 2.66 1.48 98.88
60 INT82404 Negative_regulation of SAA4 3 0.09 3.03 0.38 98.84
61 INT314336 Positive_regulation of Negative_regulation of TRGC1 2 0.41 2.23 0.21 98.76
62 INT14204 Protein_catabolism of KNG1 41 0.96 20.94 11.47 98.64
63 INT232025 Regulation of Gene_expression of SERPING1 3 0.56 1.75 0.15 98.62
64 INT11481 Positive_regulation of F12 11 0.58 5.53 1.8 98.44
65 INT10129 Gene_expression of F12 4 0.65 3.4 0.37 98.36
66 INT82403 Negative_regulation of Gene_expression of SAA4 1 0.06 0.94 0.09 98.16
67 INT82401 Gene_expression of SAA4 1 0.09 0.94 0.09 98.16
68 INT35141 Regulation of PLG 6 0.44 2.64 0.85 98.04
69 INT49217 Positive_regulation of Positive_regulation of KNG1 7 0.41 3.64 4.18 97.88
70 INT90699 Regulation of F12 4 0.45 2.7 0.67 97.84
71 INT116362 Positive_regulation of C4A 17 0.69 11.53 1.03 97.76
72 INT74260 Positive_regulation of Serping1 5 0.64 6.05 0.8 97.72
73 INT327091 Negative_regulation of SPINT1 1 0.01 0.96 0.25 97.56
74 INT221932 Gene_expression of F12 4 0.66 2.61 0.5 97.48
75 INT232026 Positive_regulation of Gene_expression of F12 1 0.03 0.58 0.11 97.48
76 INT7134 Localization of KNG1 127 0.79 65.73 67.97 97.36
77 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 97.36
78 INT23620 Negative_regulation of C4A 24 0.57 15.1 2.23 97.32
79 INT23621 Regulation of C4A 10 0.44 5.07 0.84 97.32
80 INT61223 Positive_regulation of Negative_regulation of ACE 6 0.49 5.92 1.37 97.28
81 INT326469 Positive_regulation of Negative_regulation of AGTR2 1 0.09 2.96 0.16 97.28
82 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 97.12
83 INT162357 Protein_catabolism of KCNMA1 3 0.77 1.19 1.18 97.00
84 INT162362 Positive_regulation of Protein_catabolism of KCNMA1 1 0.05 0.61 0.6 97.00
85 INT341047 Negative_regulation of Negative_regulation of C1S 1 0.31 1.17 0.08 96.88
86 INT571 Negative_regulation of C2 9 0.43 3.93 1.54 96.84
87 INT12240 Negative_regulation of PRSS1 46 0.57 29.5 10.77 96.80
88 INT20664 Binding of ACE 60 0.48 35.27 9.16 96.68
89 INT157366 Positive_regulation of Positive_regulation of KCNMA1 2 0.05 2.43 1.74 96.56
90 INT45147 Gene_expression of C2 21 0.58 6.18 3.98 96.52
91 INT128609 Gene_expression of C1S 18 0.75 17.36 0.98 96.28
92 INT174519 Gene_expression of C1R 4 0.35 0.51 0.29 96.28
93 INT232023 Positive_regulation of Gene_expression of C1S 1 0.27 0.16 0.07 96.28
94 INT232022 Positive_regulation of Gene_expression of C1R 1 0.20 0.16 0.07 96.28
95 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82 96.20
96 INT279576 Positive_regulation of MBL2 4 0.38 4.1 0 96.16
97 INT46045 Negative_regulation of Gene_expression of C3 5 0.30 3.15 0.45 96.08
98 INT66720 Negative_regulation of BDKRB2 5 0.57 1.92 3.11 96.00
99 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9 95.96
100 INT316317 Negative_regulation of Gene_expression of KLK1 1 0.41 1.04 0.12 95.96
101 INT756 Gene_expression of C3 138 0.75 100.6 19.2 95.76
102 INT58589 Regulation of F12 3 0.39 1.9 0.16 95.68
103 INT58594 Regulation of ARHGAP4 1 0.21 0.65 0.1 95.68
104 INT11496 Negative_regulation of F12 6 0.59 3.41 1.27 95.64
105 INT26451 Gene_expression of KLK1 14 0.75 5.79 1.66 95.40
106 INT64842 Negative_regulation of Gene_expression of Serping1 2 0.35 0.56 0.36 95.24
107 INT209345 Negative_regulation of AGTR2 5 0.17 4.83 0.2 95.20
108 INT23251 Positive_regulation of KLKB1 10 0.67 2.98 1.59 95.12
109 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55 94.76
110 INT11480 Positive_regulation of Localization of KNG1 15 0.30 6.39 5.5 94.52
111 INT46382 Negative_regulation of Negative_regulation of C4A 1 0.32 0.98 0.06 94.40
112 INT279572 Gene_expression of MBL2 27 0.64 20.88 1.51 94.28
113 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 93.84
114 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 93.80
115 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 93.80
116 INT12104 Positive_regulation of PLG 45 0.68 28.94 4.81 93.48
117 INT46201 Gene_expression of KLKB1 21 0.53 3.01 2.87 93.00
118 INT302888 Positive_regulation of HIST1H4PS1 3 0.05 1.52 0.32 92.96
119 INT6967 Regulation of KCNMA1 28 0.61 3.37 4.3 92.76
120 INT162355 Regulation of Protein_catabolism of KCNMA1 1 0.05 0.59 0.59 92.76
121 INT36795 Localization of KLKB1 3 0.78 1.05 0.27 92.12
122 INT281033 Regulation of MBL2 6 0.34 4.96 0.52 91.80
123 INT281035 Regulation of MASP2 1 0.03 0.22 0.04 91.80
124 INT78429 Positive_regulation of TRGC1 11 0.44 4.6 2.1 91.32
125 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51 91.28
126 INT21962 Localization of KLK1 15 0.78 3.54 1.61 91.16
127 INT201955 Regulation of DPP4 18 0.45 11.91 1.18 90.84
128 INT326636 Positive_regulation of Gene_expression of Serping1 1 0.23 0.54 0 90.48
129 INT247102 Binding of MBL2 16 0.38 14.18 1.54 90.08
130 INT281034 Binding of MASP2 1 0.02 0.34 0 90.08
131 INT195 Gene_expression of C4a 16 0.48 15.55 6.1 89.48
132 INT316319 Negative_regulation of C1R 1 0.38 0.64 0.04 89.08
133 INT281032 Gene_expression of MASP2 2 0.48 0.67 0.03 89.08
134 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94 88.72
135 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76 88.12
136 INT39819 Localization of C4A 4 0.62 3.1 0.72 87.84
137 INT281031 Localization of MASP2 1 0.04 0.72 0.1 87.60
138 INT3822 Negative_regulation of Negative_regulation of C1s 3 0.20 1.25 0.69 87.04
139 INT88375 Negative_regulation of Localization of KNG1 4 0.39 1.12 1.91 87.00
140 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 86.16
141 INT30531 Gene_expression of C2 15 0.66 5.5 1.99 86.00
142 INT162361 Positive_regulation of Gene_expression of KCNMA1 6 0.46 2.44 1.25 84.40
143 INT35146 Negative_regulation of PLG 27 0.57 17.63 1.98 83.80
144 INT10136 Negative_regulation of PLAT 23 0.42 11.18 3.02 83.80
145 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 83.80
146 INT53251 Positive_regulation of Gene_expression of Kng1 2 0.60 0.71 0.58 83.52
147 INT326261 Positive_regulation of Gene_expression of Klk1 1 0.49 0.71 0.23 83.52
148 INT37864 Regulation of Negative_regulation of Serping1 1 0.10 0.69 0.09 83.20
149 INT19944 Negative_regulation of IFNG 39 0.58 22.35 10.91 83.20
150 INT53252 Gene_expression of Kng1 7 0.67 2.18 1.27 83.12
151 INT35242 Negative_regulation of MBL2 17 0.48 12.53 1.73 82.84
152 INT326260 Gene_expression of Klk1 1 0.65 0.7 0.23 82.56
153 INT27465 Positive_regulation of F12 21 0.70 8.09 3.06 81.88
154 INT77162 Regulation of Binding of F12 2 0.33 0.52 0.28 81.76
155 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 81.44
156 INT26453 Binding of KLK1 2 0.47 0.84 0.28 79.76
157 INT232024 Protein_catabolism of KLK1 2 0.64 1.21 0.28 79.76
158 INT265802 Regulation of KLKB1 9 0.04 1.01 0.64 78.24
159 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 78.08
160 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 77.32
161 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 77.32
162 INT16385 Regulation of C3 20 0.41 9.98 1.92 77.28
163 INT125725 Regulation of C1QC 1 0.06 0.83 0.18 77.28
164 INT125724 Negative_regulation of C1QC 1 0.10 0.82 0.18 76.40
165 INT326466 Regulation of Gene_expression of F12 1 0.03 0.6 0 75.84
166 INT326467 Regulation of Gene_expression of F12 1 0.44 0.6 0 75.44
167 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 75.00
168 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35 75.00
169 INT36793 Binding of KLKB1 3 0.40 0.51 0.42 75.00
170 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 74.00
171 INT145530 Negative_regulation of Positive_regulation of KLK1 2 0.42 1.02 0.57 73.84
172 INT11493 Positive_regulation of KLK1 21 0.67 9.22 5 73.84
173 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 72.56
174 INT328286 Positive_regulation of C1orf38 1 0.01 2.93 0.33 71.16
175 INT162359 Gene_expression of KRT32 4 0.18 1.94 1.62 69.44
176 INT4561 Gene_expression of PLG 32 0.75 17.59 6.21 69.16
177 INT35144 Negative_regulation of Gene_expression of PLG 3 0.29 0.98 0.06 69.16
178 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 68.88
179 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 68.80
180 INT58468 Negative_regulation of Gene_expression of IL1A 10 0.58 9.39 5.57 68.80
181 INT76229 Binding of BDKRB1 5 0.33 1.46 3.66 68.52
182 INT69310 Negative_regulation of IL1A 10 0.43 7.83 5.05 67.20
183 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 66.48
184 INT20156 Positive_regulation of Negative_regulation of Serpine1 4 0.49 2.89 0.97 66.24
185 INT46340 Positive_regulation of Negative_regulation of Plg 2 0.15 1.71 0.54 66.24
186 INT162358 Positive_regulation of Gene_expression of KRT32 1 0.12 0.57 0.57 66.16
187 INT85854 Binding of SALL1 5 0.36 1.4 0.41 65.84
188 INT50014 Negative_regulation of ARHGAP4 2 0.27 1.59 0.32 65.56
189 INT58593 Regulation of Negative_regulation of ARHGAP4 1 0.21 0.53 0.07 65.56
190 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 65.20
191 INT58591 Negative_regulation of Positive_regulation of PLG 4 0.42 2.46 0.51 63.56
192 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93 62.96
193 INT10610 Negative_regulation of Plg 22 0.40 11.81 6.74 62.96
194 INT58592 Negative_regulation of Protein_catabolism of IFNG 1 0.40 0.51 0.07 62.64
195 INT58590 Protein_catabolism of IFNG 2 0.84 0.75 0.1 61.52
196 INT24064 Positive_regulation of F12 7 0.60 2.74 1.38 58.56
197 INT18773 Localization of ALB 117 0.80 69.18 13.8 55.60
198 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52 54.44
199 INT311965 Positive_regulation of Gene_expression of Serping1 2 0.16 1.33 0.24 52.36
200 INT19134 Gene_expression of TPSAB1 16 0.66 11.61 2.48 52.12
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