D:Hereditary Neoplastic Syndromes

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Disease Term
Synonyms Cancer Syndrome Hereditary, Cancer Syndromes Hereditary, HEREDITARY CANCER SYNDROME, Hereditary Cancer Syndromes, Hereditary Neoplastic Syndrome, Neoplastic Syndrome Hereditary, Syndrome Hereditary Cancer, Syndrome Hereditary Neoplastic, SYNDROMES HEREDITARY CANCER, SYNDROMES HEREDITARY NEOPLASTIC
Documents 19
Hot Single Events 16
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hereditary Neoplastic Syndromes. They are ordered first by their relevance to Hereditary Neoplastic Syndromes and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT290556 Binding of MLH1 and MSH2 3 0.34 2.74 0 82.72
2 INT258522 Binding of DDR1 and RET 1 0.03 1.05 0.1 43.16
3 INT241119 Binding of Sdhc and Sdhb 1 0.00 1.29 0 38.28
4 INT241120 Binding of Sdhc and Sdhd 1 0.00 1.28 0 37.32
5 INT310188 Binding of Adcyap1r1 and Smad7 1 0.00 0 0 20.32
6 INT310190 Binding of Adcyap1r1 and Smad6 1 0.00 0 0 20.32
7 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24 5.00
8 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23 5.00
9 INT197811 Binding of SMS and SST 1 0.00 0.98 0.21 5.00
10 INT258527 Binding of BRAF and RET 1 0.21 1.49 0.11 5.00
11 INT197808 Binding of MEN1 and NME1 1 0.00 1.81 0 5.00
12 INT197809 Binding of MEN1 and VIM 1 0.04 0.52 0 5.00
13 INT310186 Binding of Gdf2 and Bmpr2 1 0.02 0 0 5.00
14 INT197810 Binding of MEN1 and MUC1 1 0.06 0.47 0 5.00
15 INT258524 IPMK Negative_regulation of KDR 2 0.00 1.98 0 5.00
16 INT310191 Flt3 Positive_regulation of Gene_expression of Id1 1 0.03 0.81 0 5.00
17 INT197816 Binding of MEN1 and NFKB1 1 0.05 0.07 0 5.00
18 INT197813 Binding of AMBP and MEN1 1 0.00 0.51 0 5.00
19 INT197812 Binding of AMBP and RDBP 1 0.00 0.51 0 5.00
20 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 0.19 0.64 0 5.00
21 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0 5.00
22 INT197817 Binding of JUND and MEN1 1 0.18 0.14 0 5.00
23 INT197844 Binding of MEN1 and Nfkb1 1 0.06 0.26 0 5.00
24 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0 5.00
25 INT258526 IPMK Negative_regulation of BRAF 1 0.01 1.11 0 5.00
26 INT310189 Binding of Acvrl1 and Gdf2 1 0.01 0 0 5.00
27 INT197815 Binding of MEN1 and TGFB1 1 0.16 0.13 0 5.00
28 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0 5.00
29 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0 5.00
30 INT258525 IPMK Negative_regulation of DDR1 2 0.00 1.97 0 5.00
31 INT197814 Binding of MEN1 and RELA 1 0.42 0.07 0 5.00
32 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hereditary Neoplastic Syndromes. They are ordered first by their pain relevance and then by number of times they were reported in Hereditary Neoplastic Syndromes. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 98.80
2 INT53487 Gene_expression of TSC1 81 0.58 77.71 7.94 97.64
3 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33 95.28
4 INT258549 Regulation of Positive_regulation of Meta 3 0.44 2.31 0.4 95.28
5 INT64700 Binding of Nf1 14 0.45 15.24 2.29 94.80
6 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 94.56
7 INT68665 Binding of Vhl 9 0.48 10.3 0.82 94.40
8 INT152215 Binding of FH 10 0.41 14.13 0.19 93.76
9 INT8159 Binding of ELL 7 0.36 12.62 0.84 93.24
10 INT258548 Positive_regulation of Meta 10 0.67 5.05 1.42 92.56
11 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 84.20
12 INT56925 Negative_regulation of TSC1 54 0.52 63.39 1.87 84.20
13 INT216011 Regulation of TSC2 2 0.26 3.31 0 82.76
14 INT310171 Phosphorylation of Eng 1 0.24 0.5 0 81.92
15 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2 81.32
16 INT38625 Gene_expression of ELL 8 0.58 12.53 1 80.20
17 INT241104 Gene_expression of FH 7 0.66 20.35 0.31 71.68
18 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 70.92
19 INT208125 Gene_expression of DDR1 10 0.06 8.15 1.03 70.92
20 INT13507 Gene_expression of Erbb2 17 0.77 34.23 7.58 61.60
21 INT85280 Positive_regulation of FH 2 0.45 3.53 0.09 55.56
22 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24 49.12
23 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78 49.12
24 INT310168 Phosphorylation of Tgfbr2 1 0.41 1.5 0 44.52
25 INT23650 Positive_regulation of Sdhb 2 0.17 1.34 0.43 44.24
26 INT192337 Positive_regulation of DDR1 11 0.41 10.34 2.38 42.24
27 INT225812 Localization of EIF3A 1 0.08 1.24 0 37.56
28 INT93503 Positive_regulation of Gene_expression of Erbb2 3 0.69 6.22 0.45 29.92
29 INT183629 Gene_expression of Ctnnd2 14 0.75 11.78 0.48 28.48
30 INT191253 Negative_regulation of DDR1 13 0.25 10.05 1.05 26.96
31 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 20.96
32 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 20.36
33 INT310175 Binding of Adcyap1r1 1 0.02 0 0 20.32
34 INT310173 Binding of Smad6 1 0.05 0 0 18.48
35 INT144020 Positive_regulation of Pdgfrb 30 0.69 24.8 1.92 13.28
36 INT241102 Transcription of FH 2 0.59 2 0.14 6.24
37 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
38 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
39 INT1893 Localization of Gh 1041 0.79 340.23 256.58 5.00
40 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
41 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
42 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
43 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
44 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
45 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
46 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
47 INT8347 Gene_expression of SST 181 0.78 104.59 65.45 5.00
48 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
49 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
50 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
51 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
52 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
53 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 5.00
54 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
55 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
56 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 5.00
57 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
58 INT1578 Negative_regulation of Localization of PRL 52 0.59 20.62 17.18 5.00
59 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
60 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
61 INT2243 Localization of GAST 67 0.81 34.54 16.19 5.00
62 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 5.00
63 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 5.00
64 INT12325 Gene_expression of Plec 47 0.72 11.92 13.35 5.00
65 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
66 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
67 INT109005 Gene_expression of Proc 61 0.75 37.86 8.49 5.00
68 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 5.00
69 INT2093 Gene_expression of GAST 50 0.78 32.32 7.98 5.00
70 INT134624 Gene_expression of Flt1 77 0.66 48.86 7.27 5.00
71 INT9397 Regulation of MET 17 0.60 8.36 7.04 5.00
72 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
73 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
74 INT11154 Binding of EGFR 149 0.48 96.23 6.29 5.00
75 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 5.00
76 INT22825 Regulation of Gtf3a 36 0.25 19.93 5.03 5.00
77 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
78 INT205272 Positive_regulation of Gene_expression of Plec 11 0.43 1.5 4.49 5.00
79 INT141000 Negative_regulation of GSK 24 0.57 9.46 4.4 5.00
80 INT103153 Positive_regulation of Transcription of VEGFA 34 0.69 22.16 4.22 5.00
81 INT40036 Binding of DLL1 10 0.36 2.88 3.95 5.00
82 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76 5.00
83 INT179826 Gene_expression of Il11 29 0.75 11.5 3.75 5.00
84 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7 5.00
85 INT120072 Gene_expression of Smad7 38 0.74 20.87 3.69 5.00
86 INT15930 Positive_regulation of Ptprs 8 0.67 7.02 3.48 5.00
87 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47 5.00
88 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3 5.00
89 INT99687 Negative_regulation of Transcription of VEGFA 17 0.43 10.3 3.25 5.00
90 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15 5.00
91 INT119518 Positive_regulation of Gene_expression of NTRK1 5 0.67 3.47 2.66 5.00
92 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64 5.00
93 INT36923 Binding of Mdk 7 0.35 3.81 2.58 5.00
94 INT281624 Gene_expression of Tag 2 0.58 8 2.4 5.00
95 INT9473 Binding of MUC1 66 0.48 46.77 2.36 5.00
96 INT114327 Positive_regulation of RAF1 26 0.51 20.87 2.32 5.00
97 INT172559 Localization of Proc 16 0.02 21.49 2.08 5.00
98 INT201683 Phosphorylation of GSK 15 0.80 6.6 2.01 5.00
99 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 5.00
100 INT79140 Binding of HCC 36 0.31 46.96 1.87 5.00
101 INT136503 Negative_regulation of KDR 46 0.48 43.1 1.86 5.00
102 INT205266 Regulation of Gene_expression of Plec 3 0.57 1.45 1.74 5.00
103 INT86909 Negative_regulation of MSH2 9 0.41 12.65 1.7 5.00
104 INT100375 Gene_expression of Vhl 14 0.15 22.3 1.69 5.00
105 INT112648 Positive_regulation of Fn1 19 0.49 13.73 1.66 5.00
106 INT107992 Gene_expression of MSH2 39 0.78 37.09 1.6 5.00
107 INT205269 Positive_regulation of Plec 8 0.43 1.78 1.55 5.00
108 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55 5.00
109 INT72138 Gene_expression of Pthlh 18 0.75 17.68 1.49 5.00
110 INT100376 Positive_regulation of Gene_expression of Vhl 4 0.10 6.47 1.47 5.00
111 INT107985 Gene_expression of MLH1 29 0.67 31.31 1.46 5.00
112 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4 5.00
113 INT199550 Negative_regulation of Flt1 18 0.37 12.57 1.37 5.00
114 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 5.00
115 INT95939 Positive_regulation of GSK 19 0.67 10 1.33 5.00
116 INT92383 Gene_expression of KRAS 38 0.65 32.94 1.32 5.00
117 INT90938 Gene_expression of Eng 48 0.72 15.76 1.24 5.00
118 INT164205 Binding of Proc 12 0.36 12.31 1.19 5.00
119 INT96034 Negative_regulation of Proc 11 0.33 10.21 1.18 5.00
120 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17 5.00
121 INT146546 Gene_expression of MSI1 22 0.48 22.91 1.15 5.00
122 INT86908 Negative_regulation of MLH1 7 0.43 6.98 1.12 5.00
123 INT204170 Binding of Mri1 5 0.22 4.45 1.11 5.00
124 INT149838 Binding of TSHB 5 0.14 3.27 1.1 5.00
125 INT35104 Positive_regulation of GC 6 0.11 4.99 1.08 5.00
126 INT156805 Gene_expression of Ebp 6 0.40 6.09 1.07 5.00
127 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 5.00
128 INT55794 Binding of Crlf2 5 0.36 0.68 1.05 5.00
129 INT92139 Binding of MLH1 12 0.42 15.62 1 5.00
130 INT125960 Gene_expression of Ptprs 8 0.78 2.87 0.99 5.00
131 INT86907 Negative_regulation of MSH6 8 0.33 6.76 0.93 5.00
132 INT83461 Binding of RET 8 0.47 9.7 0.87 5.00
133 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87 5.00
134 INT205275 Regulation of Plec 4 0.42 2.93 0.8 5.00
135 INT86910 Negative_regulation of MRC1 6 0.20 6.52 0.8 5.00
136 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78 5.00
137 INT92142 Binding of MSH2 5 0.46 5.64 0.75 5.00
138 INT132521 Gene_expression of BRAF 14 0.65 13.59 0.73 5.00
139 INT2244 Positive_regulation of Localization of GAST 7 0.68 5.28 0.73 5.00
140 INT143953 Regulation of Positive_regulation of MMP2 3 0.44 2.25 0.69 5.00
141 INT197832 Localization of MEN1 1 0.80 11.01 0.63 5.00
142 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61 5.00
143 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59 5.00
144 INT64928 Regulation of LEPRE1 2 0.24 1.26 0.54 5.00
145 INT91209 Binding of VIM 15 0.36 12.02 0.53 5.00
146 INT146545 Negative_regulation of Gene_expression of MSH2 17 0.56 18.87 0.51 5.00
147 INT200851 Binding of Plec 8 0.44 4.77 0.46 5.00
148 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43 5.00
149 INT151400 Binding of JAG1 14 0.37 7.96 0.39 5.00
150 INT143601 Positive_regulation of Erbb2 2 0.46 1.44 0.39 5.00
151 INT229679 Localization of Plec 4 0.65 1.64 0.35 5.00
152 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34 5.00
153 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33 5.00
154 INT33009 Gene_expression of Cdk2ap1 6 0.31 6.69 0.33 5.00
155 INT236623 Positive_regulation of BRAF 3 0.45 2.05 0.32 5.00
156 INT92100 Binding of Smad4 5 0.31 2.23 0.3 5.00
157 INT229681 Negative_regulation of Plec 2 0.39 1.71 0.3 5.00
158 INT229677 Binding of Pan3 1 0.01 1.44 0.21 5.00
159 INT81981 Negative_regulation of Bmpr2 4 0.27 2.88 0.21 5.00
160 INT125773 Transcription of Serpine1 4 0.53 2.35 0.19 5.00
161 INT197842 Gene_expression of PHPT1 1 0.06 5.89 0.16 5.00
162 INT127806 Negative_regulation of ASCL1 6 0.45 5.85 0.16 5.00
163 INT139331 Localization of Vhl 2 0.65 2.34 0.15 5.00
164 INT310174 Positive_regulation of Smad1 9 0.45 2.16 0.14 5.00
165 INT185264 Gene_expression of ASCL1 3 0.50 2.04 0.13 5.00
166 INT181744 Negative_regulation of Gene_expression of MLH1 3 0.05 7.67 0.12 5.00
167 INT241099 Positive_regulation of Gene_expression of FH 3 0.43 5.17 0.11 5.00
168 INT197840 Binding of NME1 2 0.04 1.14 0.11 5.00
169 INT181745 Positive_regulation of MSH2 4 0.48 5.73 0.11 5.00
170 INT241115 Regulation of Vhl 5 0.15 8.36 0.11 5.00
171 INT201962 Transcription of Bmpr2 6 0.37 3.51 0.09 5.00
172 INT258561 Negative_regulation of Negative_regulation of KDR 1 0.11 0.91 0.09 5.00
173 INT241118 Negative_regulation of Vhl 3 0.11 4.01 0.08 5.00
174 INT197827 Regulation of PHPT1 1 0.03 2.54 0.08 5.00
175 INT254332 Negative_regulation of Gene_expression of Bmpr2 3 0.22 2.41 0.07 5.00
176 INT241117 Regulation of Gene_expression of Vhl 1 0.06 2.5 0.07 5.00
177 INT197836 Positive_regulation of Gene_expression of MEN1 1 0.50 3.16 0.07 5.00
178 INT197835 Positive_regulation of Gene_expression of PHPT1 1 0.04 3.17 0.07 5.00
179 INT229678 Regulation of Localization of Plec 1 0.25 0.78 0.07 5.00
180 INT197839 Negative_regulation of PHPT1 1 0.04 2.88 0.06 5.00
181 INT197828 Negative_regulation of MEN1 1 0.43 5.06 0.06 5.00
182 INT224326 Binding of RAF1 3 0.13 3.11 0.05 5.00
183 INT241100 Negative_regulation of Binding of FH 1 0.11 2.76 0.05 5.00
184 INT241114 Transcription of Vhl 1 0.11 2.3 0.05 5.00
185 INT241113 Negative_regulation of Binding of Vhl 1 0.07 3.31 0.03 5.00
186 INT258556 Negative_regulation of BRAF 4 0.42 2.48 0.03 5.00
187 INT107988 Regulation of MRC1 2 0.40 0.56 0 5.00
188 INT310166 Regulation of Acvrl1 1 0.07 0 0 5.00
189 INT310163 Positive_regulation of Positive_regulation of Acvrl1 1 0.08 0 0 5.00
190 INT258550 Negative_regulation of Negative_regulation of Ulbp1 1 0.41 1.23 0 5.00
191 INT310169 Gene_expression of Bmp10 1 0.14 0.48 0 5.00
192 INT281621 Negative_regulation of Negative_regulation of Cdk2ap1 1 0.01 1.37 0 5.00
193 INT197841 Positive_regulation of MEN1 1 0.41 2.38 0 5.00
194 INT241106 Localization of FH 1 0.20 2.1 0 5.00
195 INT281619 Regulation of Cdk2ap1 1 0.01 1 0 5.00
196 INT281623 Negative_regulation of Transcription of Cdk2ap1 1 0.01 1.62 0 5.00
197 INT203465 Negative_regulation of Id1 2 0.06 0.68 0 5.00
198 INT281620 Negative_regulation of Cdk2ap1 1 0.01 2.98 0 5.00
199 INT197843 Regulation of Localization of MEN1 1 0.45 0.24 0 5.00
200 INT197838 Transcription of MEN1 1 0.69 0.13 0 5.00
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