D:Hereditary Spastic Paraplegia

Disease Term Synonyms AUTOSOMAL DOMINANT HEREDITARY SPASTIC PARAPLEGIA, Autosomal Dominant Spastic Paraplegia Hereditary, Autosomal Recessive Hereditary Spastic Paraplegia, Autosomal Recessive Spastic Paraplegia Hereditary, Hereditary Autosomal Dominant Spastic Paraplegia, Hereditary Autosomal Recessive Spastic Paraplegia, Hereditary Motor Sensory Neuropathy With Pyramidal Signs, HEREDITARY SPASTIC PARAPLEGIA AUTOSOMAL DOMINANT, Hereditary Spastic Paraplegia Autosomal Recessive, HEREDITARY SPASTIC PARAPLEGIA X LINKED RECESSIVE, HEREDITARY SPASTIC PARAPLEGIAS Documents 4 Hot Single Events 4 Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hereditary Spastic Paraplegia. They are ordered first by their relevance to Hereditary Spastic Paraplegia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT283542	Binding of SPG19 and Setx	1	0.06	3.69	0	80.44
2	INT283543	Binding of GARS and Setx	1	0.01	3.71	0	80.44
3	INT283533	Binding of GARS and SPG19	1	0.00	1.72	0	74.24
4	INT283544	Binding of GARS and Bscl2	1	0.01	1.74	0	13.00
5	INT302676	Binding of OPA1 and MFN2	1	0.46	1.12	0.14	5.00
6	INT283539	Binding of Litaf and Mad2l1bp	1	0.00	0.67	0.11	5.00
7	INT302675	Binding of OPA1 and PLAA	1	0.15	0.73	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hereditary Spastic Paraplegia. They are ordered first by their pain relevance and then by number of times they were reported in Hereditary Spastic Paraplegia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT28817	Binding of TRPV4	6	0.39	3.92	2.59	98.04
2	INT283541	Binding of GARS	1	0.01	3.33	0.04	90.16
3	INT15367	Gene_expression of OPA1	35	0.67	24.9	5.45	86.68
4	INT283536	Binding of Setx	1	0.36	3.69	0	80.44
5	INT169926	Positive_regulation of Gopc	416	0.46	157.8	58.67	5.00
6	INT17041	Gene_expression of PER1	24	0.66	5.31	7.12	5.00
7	INT33854	Localization of OPA1	19	0.65	10.55	5.04	5.00
8	INT34870	Positive_regulation of OPA1	18	0.59	10.66	5	5.00
9	INT32933	Gene_expression of GNAS	57	0.32	10.58	4.03	5.00
10	INT24883	Regulation of OPA1	14	0.45	9.73	3.44	5.00
11	INT5913	Binding of OPA1	12	0.41	9.33	2.92	5.00
12	INT17094	Negative_regulation of SLC25A4	3	0.41	3.82	1.52	5.00
13	INT74550	Negative_regulation of SUCLA2	5	0.41	3.6	1.24	5.00
14	INT159409	Gene_expression of PLAA	2	0.54	6.14	0.89	5.00
15	INT52460	Localization of SUCLA2	5	0.67	2.5	0.86	5.00
16	INT17246	Negative_regulation of POLG	16	0.56	9.69	0.79	5.00
17	INT19047	Localization of SLC25A4	5	0.73	2.73	0.57	5.00
18	INT251828	Negative_regulation of C10orf2	3	0.37	2.87	0.41	5.00
19	INT284528	Negative_regulation of POLG2	2	0.17	2.19	0.33	5.00
20	INT224340	Localization of TYMP	3	0.62	2.86	0.3	5.00
21	INT155170	Negative_regulation of Localization of SUCLA2	2	0.38	1.26	0.28	5.00
22	INT301935	Gene_expression of UCK2	5	0.13	4.4	0.27	5.00
23	INT283534	Negative_regulation of Ncs1	2	0.25	0.79	0.17	5.00
24	INT194332	Localization of MFN2	2	0.74	1.45	0.15	5.00
25	INT302703	Binding of PLAA	1	0.13	0.87	0.15	5.00
26	INT302683	Negative_regulation of PLAA	1	0.15	0.4	0.13	5.00
27	INT302679	Negative_regulation of Localization of POLG	1	0.39	0.99	0.11	5.00
28	INT302682	Localization of POLG2	1	0.67	1	0.11	5.00
29	INT302693	Localization of C10orf2	1	0.59	1	0.11	5.00
30	INT302695	Negative_regulation of Localization of C10orf2	1	0.33	1	0.11	5.00
31	INT302699	Negative_regulation of Localization of SLC25A4	1	0.38	1.01	0.11	5.00
32	INT302706	Negative_regulation of Localization of POLG2	1	0.38	1	0.11	5.00
33	INT283535	Localization of Bscl2	1	0.72	0	0.1	5.00
34	INT302692	Localization of POLG	1	0.69	0.99	0.1	5.00
35	INT13218	Gene_expression of Litaf	2	0.52	0.8	0.09	5.00
36	INT283537	Binding of Bscl2	1	0.36	0.48	0.09	5.00
37	INT302684	Negative_regulation of RRM2B	1	0.17	0.73	0.08	5.00
38	INT302686	Negative_regulation of Localization of RRM2B	1	0.38	0.73	0.08	5.00
39	INT302690	Negative_regulation of Localization of MPV17	1	0.37	0.67	0.08	5.00
40	INT302698	Negative_regulation of MPV17	1	0.16	0.67	0.08	5.00
41	INT211378	Negative_regulation of TYMP	2	0.56	1.45	0.07	5.00
42	INT302680	Localization of DGUOK	1	0.66	0.65	0.07	5.00
43	INT302681	Negative_regulation of Localization of DGUOK	1	0.38	0.65	0.07	5.00
44	INT302685	Localization of MPV17	1	0.65	0.67	0.07	5.00
45	INT302689	Negative_regulation of TK2	1	0.16	0.65	0.07	5.00
46	INT302691	Negative_regulation of Localization of SUCLG1	1	0.37	0.66	0.07	5.00
47	INT302694	Localization of RRM2B	1	0.66	0.73	0.07	5.00
48	INT302696	Negative_regulation of Localization of TK2	1	0.37	0.65	0.07	5.00
49	INT302697	Negative_regulation of DGUOK	1	0.38	0.65	0.07	5.00
50	INT302700	Localization of TK2	1	0.65	0.65	0.07	5.00
51	INT302702	Negative_regulation of SUCLG1	1	0.16	0.66	0.07	5.00
52	INT302704	Negative_regulation of Localization of TYMP	1	0.35	0.64	0.07	5.00
53	INT302705	Localization of SUCLG1	1	0.65	0.66	0.07	5.00
54	INT283538	Regulation of Gene_expression of Litaf	1	0.24	0.43	0	5.00
55	INT302687	Regulation of PLAA	1	0.19	0.24	0	5.00
56	INT302688	Transcription of OPA1	1	0.68	0.3	0	5.00
57	INT302701	Positive_regulation of PLAA	1	0.18	0	0	5.00