D:Hereditary Spastic Paraplegia

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pChart

Disease Term
Synonyms AUTOSOMAL DOMINANT HEREDITARY SPASTIC PARAPLEGIA, Autosomal Dominant Spastic Paraplegia Hereditary, Autosomal Recessive Hereditary Spastic Paraplegia, Autosomal Recessive Spastic Paraplegia Hereditary, Hereditary Autosomal Dominant Spastic Paraplegia, Hereditary Autosomal Recessive Spastic Paraplegia, Hereditary Motor Sensory Neuropathy With Pyramidal Signs, HEREDITARY SPASTIC PARAPLEGIA AUTOSOMAL DOMINANT, Hereditary Spastic Paraplegia Autosomal Recessive, HEREDITARY SPASTIC PARAPLEGIA X LINKED RECESSIVE, HEREDITARY SPASTIC PARAPLEGIAS
Documents 4
Hot Single Events 4
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hereditary Spastic Paraplegia. They are ordered first by their relevance to Hereditary Spastic Paraplegia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT283542 Binding of SPG19 and Setx 1 0.06 3.69 0 80.44
2 INT283543 Binding of GARS and Setx 1 0.01 3.71 0 80.44
3 INT283533 Binding of GARS and SPG19 1 0.00 1.72 0 74.24
4 INT283544 Binding of GARS and Bscl2 1 0.01 1.74 0 13.00
5 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14 5.00
6 INT283539 Binding of Litaf and Mad2l1bp 1 0.00 0.67 0.11 5.00
7 INT302675 Binding of OPA1 and PLAA 1 0.15 0.73 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hereditary Spastic Paraplegia. They are ordered first by their pain relevance and then by number of times they were reported in Hereditary Spastic Paraplegia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT28817 Binding of TRPV4 6 0.39 3.92 2.59 98.04
2 INT283541 Binding of GARS 1 0.01 3.33 0.04 90.16
3 INT15367 Gene_expression of OPA1 35 0.67 24.9 5.45 86.68
4 INT283536 Binding of Setx 1 0.36 3.69 0 80.44
5 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
6 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12 5.00
7 INT33854 Localization of OPA1 19 0.65 10.55 5.04 5.00
8 INT34870 Positive_regulation of OPA1 18 0.59 10.66 5 5.00
9 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03 5.00
10 INT24883 Regulation of OPA1 14 0.45 9.73 3.44 5.00
11 INT5913 Binding of OPA1 12 0.41 9.33 2.92 5.00
12 INT17094 Negative_regulation of SLC25A4 3 0.41 3.82 1.52 5.00
13 INT74550 Negative_regulation of SUCLA2 5 0.41 3.6 1.24 5.00
14 INT159409 Gene_expression of PLAA 2 0.54 6.14 0.89 5.00
15 INT52460 Localization of SUCLA2 5 0.67 2.5 0.86 5.00
16 INT17246 Negative_regulation of POLG 16 0.56 9.69 0.79 5.00
17 INT19047 Localization of SLC25A4 5 0.73 2.73 0.57 5.00
18 INT251828 Negative_regulation of C10orf2 3 0.37 2.87 0.41 5.00
19 INT284528 Negative_regulation of POLG2 2 0.17 2.19 0.33 5.00
20 INT224340 Localization of TYMP 3 0.62 2.86 0.3 5.00
21 INT155170 Negative_regulation of Localization of SUCLA2 2 0.38 1.26 0.28 5.00
22 INT301935 Gene_expression of UCK2 5 0.13 4.4 0.27 5.00
23 INT283534 Negative_regulation of Ncs1 2 0.25 0.79 0.17 5.00
24 INT194332 Localization of MFN2 2 0.74 1.45 0.15 5.00
25 INT302703 Binding of PLAA 1 0.13 0.87 0.15 5.00
26 INT302683 Negative_regulation of PLAA 1 0.15 0.4 0.13 5.00
27 INT302679 Negative_regulation of Localization of POLG 1 0.39 0.99 0.11 5.00
28 INT302682 Localization of POLG2 1 0.67 1 0.11 5.00
29 INT302693 Localization of C10orf2 1 0.59 1 0.11 5.00
30 INT302695 Negative_regulation of Localization of C10orf2 1 0.33 1 0.11 5.00
31 INT302699 Negative_regulation of Localization of SLC25A4 1 0.38 1.01 0.11 5.00
32 INT302706 Negative_regulation of Localization of POLG2 1 0.38 1 0.11 5.00
33 INT283535 Localization of Bscl2 1 0.72 0 0.1 5.00
34 INT302692 Localization of POLG 1 0.69 0.99 0.1 5.00
35 INT13218 Gene_expression of Litaf 2 0.52 0.8 0.09 5.00
36 INT283537 Binding of Bscl2 1 0.36 0.48 0.09 5.00
37 INT302684 Negative_regulation of RRM2B 1 0.17 0.73 0.08 5.00
38 INT302686 Negative_regulation of Localization of RRM2B 1 0.38 0.73 0.08 5.00
39 INT302690 Negative_regulation of Localization of MPV17 1 0.37 0.67 0.08 5.00
40 INT302698 Negative_regulation of MPV17 1 0.16 0.67 0.08 5.00
41 INT211378 Negative_regulation of TYMP 2 0.56 1.45 0.07 5.00
42 INT302680 Localization of DGUOK 1 0.66 0.65 0.07 5.00
43 INT302681 Negative_regulation of Localization of DGUOK 1 0.38 0.65 0.07 5.00
44 INT302685 Localization of MPV17 1 0.65 0.67 0.07 5.00
45 INT302689 Negative_regulation of TK2 1 0.16 0.65 0.07 5.00
46 INT302691 Negative_regulation of Localization of SUCLG1 1 0.37 0.66 0.07 5.00
47 INT302694 Localization of RRM2B 1 0.66 0.73 0.07 5.00
48 INT302696 Negative_regulation of Localization of TK2 1 0.37 0.65 0.07 5.00
49 INT302697 Negative_regulation of DGUOK 1 0.38 0.65 0.07 5.00
50 INT302700 Localization of TK2 1 0.65 0.65 0.07 5.00
51 INT302702 Negative_regulation of SUCLG1 1 0.16 0.66 0.07 5.00
52 INT302704 Negative_regulation of Localization of TYMP 1 0.35 0.64 0.07 5.00
53 INT302705 Localization of SUCLG1 1 0.65 0.66 0.07 5.00
54 INT283538 Regulation of Gene_expression of Litaf 1 0.24 0.43 0 5.00
55 INT302687 Regulation of PLAA 1 0.19 0.24 0 5.00
56 INT302688 Transcription of OPA1 1 0.68 0.3 0 5.00
57 INT302701 Positive_regulation of PLAA 1 0.18 0 0 5.00
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