D:Herpes Simplex Encephalitis

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pChart

Disease Term
Synonyms Acute Necrotizing Encephalitis Herpetic, Encephalitides Herpes Simplex, Encephalitides Herpetic, Encephalitis Herpes, Encephalitis Herpetic, Herpes Encephalitis, Herpes Simplex Encephalitides, Herpes Simplex Meningoencephalitides, HERPES SIMPLEX MENINGOENCEPHALITIS, HERPETIC ACUTE NECROTIZING ENCEPHALITIS, HERPETIC ENCEPHALITIDES
Documents 33
Hot Single Events 21
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Herpes Simplex Encephalitis. They are ordered first by their relevance to Herpes Simplex Encephalitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT313273 Binding of GRIN1 and MAP2 1 0.16 0.79 0.04 89.96
2 INT284689 Binding of Tspo and Map3k12 1 0.00 0.59 0.32 88.40
3 INT352392 Binding of ENOSF1 and Recql4 1 0.02 6.62 0 5.00
4 INT313271 Binding of GRIN1 and GRIN2B 1 0.24 0.06 0 5.00
5 INT313272 Binding of DLG4 and GRIN1 1 0.09 0.06 0 5.00
6 INT306764 Binding of Aes and ZMYND10 1 0.04 0.21 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Herpes Simplex Encephalitis. They are ordered first by their pain relevance and then by number of times they were reported in Herpes Simplex Encephalitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT284683 Binding of Hsd17b6 1 0.03 0.64 0.38 100.00
2 INT284685 Positive_regulation of Binding of Hsd17b6 1 0.05 0.17 0.12 100.00
3 INT281639 Binding of Map3k12 2 0.02 3.05 1.68 99.08
4 INT119016 Negative_regulation of CD19 5 0.37 3.65 0.48 99.00
5 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 98.76
6 INT119015 Negative_regulation of CR2 3 0.27 1.65 0.37 98.52
7 INT119017 Negative_regulation of CD22 4 0.39 2.16 0.21 98.28
8 INT22916 Negative_regulation of CR1 12 0.57 6.31 2.42 98.04
9 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 98.04
10 INT89543 Gene_expression of NEFL 18 0.75 10.6 2.67 98.04
11 INT174844 Binding of Fig4 81 0.41 18.03 12.87 94.24
12 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 94.04
13 INT18088 Binding of Tspo 26 0.48 9.12 10.2 93.32
14 INT66002 Binding of LAMC2 9 0.47 4.5 2.54 93.08
15 INT7841 Gene_expression of Tspo 10 0.75 7.63 4.45 92.32
16 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 87.36
17 INT284684 Negative_regulation of Binding of Map3k12 1 0.01 0.36 0.1 85.28
18 INT155860 Positive_regulation of ENOSF1 5 0.19 3.15 0.95 85.28
19 INT155861 Negative_regulation of ENOSF1 3 0.42 3.29 0.63 85.28
20 INT104731 Positive_regulation of NEFL 13 0.67 9.22 1.37 81.60
21 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 81.28
22 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 79.04
23 INT120665 Binding of TACC2 4 0.07 4.33 0.46 71.80
24 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2 68.96
25 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94 68.96
26 INT44954 Gene_expression of APP 191 0.78 105.86 23.9 68.40
27 INT54565 Binding of SCLC1 12 0.31 20.41 0.81 66.04
28 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 64.36
29 INT58003 Localization of APP 32 0.80 13.75 4.2 57.52
30 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 55.04
31 INT284686 Positive_regulation of Gene_expression of Tspo 1 0.66 2.55 0.9 54.56
32 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 47.44
33 INT100650 Gene_expression of Recql4 2 0.42 1.72 0.28 45.60
34 INT10019 Binding of CD8A 57 0.36 31.49 10.08 43.76
35 INT53196 Binding of Cd4 44 0.47 27.28 5.85 43.44
36 INT25906 Negative_regulation of Cish 6 0.29 5.41 3.17 42.88
37 INT120054 Regulation of Gene_expression of Tspo 2 0.44 0.97 0.59 40.36
38 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 39.92
39 INT161352 Gene_expression of Map3k12 3 0.24 0.59 6.16 39.72
40 INT114524 Binding of GRIN2B 3 0.36 0.44 0.74 35.36
41 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 22.56
42 INT25 Positive_regulation of LAMC2 19 0.67 8.64 7.06 18.04
43 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 17.36
44 INT320680 Regulation of Gene_expression of GNPTAB 2 0.32 2.14 0.09 7.68
45 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 6.80
46 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
47 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
48 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
49 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
50 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
51 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
52 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
53 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
54 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
55 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
56 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
57 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
58 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
59 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
60 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
61 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 5.00
62 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
63 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
64 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
65 INT55583 Localization of IFNA1 135 0.78 85.07 24.13 5.00
66 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 5.00
67 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
68 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
69 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 5.00
70 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
71 INT3545 Positive_regulation of Mtx1 27 0.42 11.97 14.83 5.00
72 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
73 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
74 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18 5.00
75 INT158070 Localization of Aes 23 0.65 19.93 10.9 5.00
76 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
77 INT6065 Localization of GRIN1 15 0.74 3.15 9.81 5.00
78 INT41569 Regulation of APP 32 0.62 17.15 9.4 5.00
79 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
80 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
81 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
82 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
83 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
84 INT48393 Positive_regulation of Localization of CSF2 14 0.60 8.92 6.1 5.00
85 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 5.00
86 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06 5.00
87 INT5561 Negative_regulation of GRIN2D 10 0.50 2.46 4.88 5.00
88 INT70356 Gene_expression of GRIN2D 10 0.74 2.11 4.7 5.00
89 INT146355 Negative_regulation of Aes 15 0.51 7.83 4.25 5.00
90 INT173519 Positive_regulation of Localization of IFNA1 27 0.49 24.48 3.9 5.00
91 INT75685 Regulation of CD86 12 0.58 3.55 2.66 5.00
92 INT82587 Positive_regulation of Gene_expression of GRIN1 8 0.67 3.66 2.18 5.00
93 INT248325 Positive_regulation of Localization of Aes 4 0.26 1.88 2.07 5.00
94 INT70538 Regulation of Localization of CSF2 4 0.54 3.08 1.9 5.00
95 INT147636 Regulation of CD80 3 0.60 1.27 1.73 5.00
96 INT147873 Negative_regulation of Gene_expression of GRIN1 8 0.58 2.3 1.46 5.00
97 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41 5.00
98 INT11984 Gene_expression of IGHA1 9 0.54 6.12 1.35 5.00
99 INT7552 Negative_regulation of IL1RL1 12 0.42 1.68 0.87 5.00
100 INT89544 Phosphorylation of NEFL 2 0.79 1.05 0.86 5.00
101 INT243864 Gene_expression of DLG4 5 0.34 0.22 0.54 5.00
102 INT142958 Positive_regulation of Protein_catabolism of APP 3 0.55 2.04 0.1 5.00
103 INT156437 Binding of DLG4 2 0.35 0.29 0.07 5.00
104 INT149862 Regulation of CD52 2 0.26 2.33 0.07 5.00
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