D:Heterotopic Ossification

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Disease Term
Synonyms Ectopic Ossification, OSSIFICATION ECTOPIC, OSSIFICATION PATHOLOGIC, Ossification Pathological, PATHOLOGIC OSSIFICATION, Pathological Ossification
Documents 376
Hot Single Events 130
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Heterotopic Ossification. They are ordered first by their relevance to Heterotopic Ossification and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT107596 Binding of PPA1 and OPLL 1 0.00 1.13 0.77 96.60
2 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09 96.20
3 INT107602 Binding of OPLL and Enpp1 1 0.15 1.12 0.76 95.92
4 INT238036 Binding of ENPP1 and OPLL 1 0.27 0.66 0.12 75.92
5 INT238035 Binding of LEPR and OPLL 1 0.01 0.43 0.03 75.92
6 INT238034 Binding of DMD and SNRNP70 1 0.00 1.18 0.04 69.60
7 INT238033 Binding of COL6A1 and OPLL 1 0.13 0.13 0.03 63.04
8 INT238032 Binding of SNRNP70 and OPLL 1 0.00 0.13 0.03 60.24
9 INT238031 Binding of COL11A2 and OPLL 1 0.10 0.3 0 58.00
10 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0 57.72
11 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0 57.72
12 INT265230 Binding of APC and FKBP1A Regulation of APC 1 0.01 0.41 0 57.72
13 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0 48.00
14 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0 47.72

Single Events

The table below shows the top 200 pain related interactions that have been reported for Heterotopic Ossification. They are ordered first by their pain relevance and then by number of times they were reported in Heterotopic Ossification. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT116529 Binding of HMOX1 10 0.47 15.38 1.04 100.00
2 INT82451 Negative_regulation of HMOX1 18 0.51 13.29 5.74 100.00
3 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 99.98
4 INT153066 Binding of Tsku 1 0.22 1.52 0.1 99.98
5 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 99.84
6 INT6513 Positive_regulation of Gene_expression of BGLAP 24 0.67 11.69 3.96 99.84
7 INT62869 Negative_regulation of REG3A 4 0.57 4.31 0.82 99.72
8 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 99.68
9 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73 99.52
10 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21 99.52
11 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 99.42
12 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 99.42
13 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 99.42
14 INT339669 Regulation of Col2a1 1 0.01 1.02 0.05 99.36
15 INT67988 Positive_regulation of ROM1 7 0.41 1.9 0.7 99.34
16 INT126368 Gene_expression of MSX2 12 0.65 7.2 2.71 99.32
17 INT339672 Positive_regulation of Gene_expression of MSX2 1 0.16 0.98 0.05 99.32
18 INT65265 Positive_regulation of Gene_expression of Col7a1 48 0.69 23.81 6.16 99.22
19 INT165516 Regulation of MSX2 8 0.23 3.41 0.09 99.16
20 INT286993 Localization of CA5P 23 0.63 14.38 0.89 99.12
21 INT286990 Negative_regulation of Localization of CA5P 3 0.36 1.57 0 99.12
22 INT115987 Positive_regulation of SPARC 4 0.44 1.52 0.99 99.08
23 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 99.08
24 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 99.08
25 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 99.02
26 INT200458 Positive_regulation of Tha1 3 0.15 0.78 0.03 98.80
27 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07 98.72
28 INT153067 Positive_regulation of Positive_regulation of Hif1a 10 0.49 11.83 0.47 98.72
29 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8 98.60
30 INT67188 Gene_expression of OPLL 10 0.52 4.58 1.12 98.60
31 INT153065 Regulation of Hif1a 8 0.28 8.57 0.51 98.60
32 INT153064 Positive_regulation of Regulation of Hif1a 1 0.45 1.52 0.1 98.60
33 INT34592 Positive_regulation of Gene_expression of ALPP 51 0.67 20.62 5.68 98.54
34 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 98.54
35 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28 98.32
36 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28 98.32
37 INT339673 Regulation of Gene_expression of RUNX2 2 0.41 1.78 0.4 98.16
38 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 98.04
39 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 98.04
40 INT220211 Gene_expression of RUNX2 7 0.71 7.31 2 97.88
41 INT220203 Positive_regulation of Gene_expression of RUNX2 3 0.63 3.4 0.97 97.88
42 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 97.76
43 INT339670 Positive_regulation of Acvr1 1 0.24 0.47 0 97.68
44 INT265241 Regulation of FGFR1OP 1 0.33 0.88 0.05 97.68
45 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35 97.60
46 INT286992 Negative_regulation of CA5P 3 0.49 1.55 0 97.44
47 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01 97.20
48 INT107601 Positive_regulation of OPLL 2 0.25 1.66 0.72 97.20
49 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 97.08
50 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51 96.64
51 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 96.64
52 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 96.64
53 INT129304 Gene_expression of CA5P 8 0.57 4.52 0.57 96.36
54 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 96.24
55 INT280947 Gene_expression of Acvr1 3 0.40 2.73 0.26 95.76
56 INT339671 Positive_regulation of Gene_expression of Acvr1 1 0.36 1.67 0 95.76
57 INT339666 Positive_regulation of Gene_expression of Fgfr1op 1 0.07 0.88 0 95.48
58 INT112650 Positive_regulation of Col1a1 3 0.30 5.96 1.3 95.40
59 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 95.36
60 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44 95.32
61 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 95.32
62 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 95.32
63 INT84945 Transcription of BMP2 5 0.61 1.8 0.36 95.08
64 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11 95.08
65 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05 94.72
66 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59 94.72
67 INT321889 Negative_regulation of Dkk1 2 0.38 5.7 1.42 94.64
68 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 94.44
69 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 94.44
70 INT155833 Gene_expression of Cma1 9 0.58 15.28 2.04 94.20
71 INT134967 Gene_expression of Ecm1 66 0.29 38.4 7.16 94.08
72 INT267187 Negative_regulation of Grem1 2 0.19 2.16 0.04 94.04
73 INT339665 Gene_expression of Fgfr1op 1 0.09 0.87 0 93.88
74 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 93.76
75 INT59357 Gene_expression of Fosb 36 0.78 7.81 9.68 93.76
76 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06 93.76
77 INT242153 Negative_regulation of Wnt2 19 0.49 11.87 1.37 93.76
78 INT92678 Positive_regulation of Ecm1 30 0.09 28.41 3.68 93.52
79 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24 93.08
80 INT114702 Gene_expression of Fgf1 34 0.74 17.39 2.96 92.64
81 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 92.64
82 INT133874 Negative_regulation of Gene_expression of Fgf1 2 0.24 2.82 0.36 92.64
83 INT233856 Regulation of SFTPC 4 0.60 2.25 0.19 92.28
84 INT52212 Gene_expression of Bmp6 6 0.64 2.38 1.27 92.16
85 INT123185 Positive_regulation of Gene_expression of Bmp6 2 0.24 1.28 0.38 92.16
86 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31 92.16
87 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3 92.16
88 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 90.88
89 INT153063 Positive_regulation of Tsku 1 0.26 1.44 0.08 90.56
90 INT153062 Positive_regulation of Negative_regulation of Col7a1 1 0.07 1.44 0.08 90.56
91 INT53704 Negative_regulation of Col7a1 42 0.35 22.4 6.88 90.32
92 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 89.44
93 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93 89.44
94 INT81982 Gene_expression of Bmpr2 36 0.60 14.58 1.55 89.44
95 INT339668 Negative_regulation of Gene_expression of Acvr1 1 0.22 0.74 0 89.32
96 INT75975 Gene_expression of Grem1 3 0.59 2.22 0.18 89.16
97 INT81453 Positive_regulation of Gene_expression of JUN 18 0.50 9.39 3.23 89.08
98 INT286994 Regulation of Positive_regulation of CA5P 1 0.38 0.65 0 88.92
99 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 88.72
100 INT60197 Gene_expression of JUN 90 0.78 42.32 14.61 88.72
101 INT69648 Positive_regulation of CA5P 10 0.58 6.41 1.57 88.36
102 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86 88.08
103 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25 88.08
104 INT168919 Regulation of Regulation of Ihh 1 0.40 0.43 0.07 88.08
105 INT265238 Positive_regulation of FGFR1OP 1 0.26 0.76 0.04 87.92
106 INT140984 Regulation of Ihh 5 0.54 2.81 0.56 87.68
107 INT286991 Positive_regulation of Positive_regulation of CA5P 1 0.48 0.58 0 87.60
108 INT252961 Localization of Fgf1 3 0.27 5.91 0.35 86.64
109 INT110599 Gene_expression of Bglap 49 0.74 41.23 6.97 85.36
110 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 85.12
111 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 84.64
112 INT36770 Positive_regulation of Localization of Pth 14 0.70 10.42 0.46 84.64
113 INT39500 Positive_regulation of Positive_regulation of Pth 14 0.48 9.75 1.28 84.64
114 INT188047 Positive_regulation of Wnt2 51 0.58 31.41 2.94 84.56
115 INT238040 Transcription of OPLL 1 0.34 0.14 0 84.48
116 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 84.20
117 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 83.80
118 INT39900 Positive_regulation of Gene_expression of Ldha 36 0.50 20.35 5.22 83.48
119 INT17963 Gene_expression of Ldha 11 0.75 6.53 2.48 83.48
120 INT282122 Positive_regulation of Gene_expression of Ldha 3 0.11 1.58 0.1 83.48
121 INT4097 Localization of Pth 66 0.81 47.17 4.36 83.24
122 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 83.12
123 INT140033 Positive_regulation of Gene_expression of Col1a1 6 0.14 3.68 1.2 83.08
124 INT294824 Positive_regulation of Gene_expression of Sparc 10 0.69 7.64 0.81 83.08
125 INT319129 Regulation of Regulation of Fgfr1op 1 0.14 0.97 0.13 82.72
126 INT179788 Gene_expression of Sparc 42 0.77 19.96 2.57 82.44
127 INT319130 Regulation of Fgfr1op 1 0.14 0.96 0.13 81.84
128 INT126513 Gene_expression of Col1a1 23 0.75 10.92 2.18 81.80
129 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 80.12
130 INT339667 Localization of Bmp4 1 0.38 0.27 0 80.08
131 INT62870 Binding of ZNRF1 3 0.14 2.68 0.98 79.84
132 INT238043 Regulation of Positive_regulation of OPLL 1 0.22 0.33 0 79.24
133 INT107597 Binding of Enpp1 5 0.37 3.35 2.23 79.20
134 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 78.96
135 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0 78.40
136 INT85808 Localization of BMP2 7 0.77 1.94 0.51 78.24
137 INT332262 Positive_regulation of Gene_expression of Cma1 1 0.41 4.94 0.38 78.16
138 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11 77.60
139 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 77.56
140 INT193777 Negative_regulation of Fgf1 6 0.13 4.26 0.12 77.40
141 INT155832 Negative_regulation of Cma1 2 0.33 2.02 0.3 77.40
142 INT157589 Binding of Tdrd6 1 0.40 1.12 0.15 76.72
143 INT238046 Negative_regulation of Gene_expression of OPLL 1 0.21 0.35 0 75.52
144 INT9242 Negative_regulation of FOXG1 13 0.40 1.43 2.86 75.00
145 INT93911 Regulation of COX5A 11 0.60 4.94 4.05 74.96
146 INT99444 Positive_regulation of Proc 15 0.45 9.18 1.75 74.04
147 INT238041 Binding of OPLL 7 0.27 2.95 0.54 74.00
148 INT16814 Negative_regulation of COX5A 74 0.57 33.72 28.63 73.92
149 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3 73.60
150 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 73.28
151 INT238048 Positive_regulation of Gene_expression of OPLL 1 0.25 0.07 0.11 72.72
152 INT62570 Binding of Pth 48 0.48 26.45 4.85 71.88
153 INT332257 Localization of Cma1 1 0.36 1.06 0.04 71.68
154 INT144618 Gene_expression of COL11A2 4 0.65 2.57 0.05 70.84
155 INT171998 Binding of DMD 58 0.47 38.13 3.35 69.32
156 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 68.68
157 INT332259 Positive_regulation of Positive_regulation of Fgf1 1 0.18 2.33 0.23 67.64
158 INT114704 Positive_regulation of Fgf1 13 0.50 8.89 0.89 67.08
159 INT332258 Positive_regulation of Localization of Fgf1 1 0.18 2.32 0.23 67.08
160 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 66.76
161 INT168916 Positive_regulation of Gene_expression of Ndst1 1 0.50 0.35 0.08 66.68
162 INT168917 Gene_expression of Ndst1 1 0.68 0.35 0.08 66.68
163 INT76636 Gene_expression of MOS 10 0.58 11.36 0.59 66.28
164 INT319132 Binding of Fgfr1op 1 0.11 0.72 0 66.24
165 INT302312 Localization of Bmpr2 4 0.46 0.47 0 65.60
166 INT194462 Localization of Ppara 94 0.78 68.33 12.09 65.60
167 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24 65.28
168 INT49488 Gene_expression of mMCP-7 37 0.75 26.11 7.68 64.80
169 INT265244 Positive_regulation of Phosphorylation of MLLT10 1 0.13 0.55 0.03 64.20
170 INT265242 Positive_regulation of Binding of MLLT10 1 0.13 0.55 0.03 64.20
171 INT265235 Positive_regulation of MLLT10 1 0.12 0.55 0.03 64.20
172 INT38056 Localization of Crp 71 0.78 53.14 17.03 63.76
173 INT114664 Binding of BMP2 12 0.37 6.54 0.91 63.72
174 INT265236 Binding of MLLT10 1 0.10 0.54 0.03 63.64
175 INT265245 Phosphorylation of MLLT10 1 0.22 0.54 0.03 63.64
176 INT19395 Negative_regulation of Localization of Pth 11 0.58 10.16 0.55 62.88
177 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 62.84
178 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 61.92
179 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 59.56
180 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85 59.56
181 INT57062 Regulation of APC 24 0.58 14.3 0.7 57.72
182 INT168918 Negative_regulation of Ndst1 1 0.43 0.43 0.17 57.28
183 INT238050 Negative_regulation of OPLL 1 0.21 0.99 0.21 56.52
184 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 52.80
185 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 50.00
186 INT45234 Binding of Ldha 20 0.37 9.8 8.18 50.00
187 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 50.00
188 INT137609 Localization of Vegfa 22 0.78 14.67 3.01 50.00
189 INT137607 Positive_regulation of Localization of Vegfa 7 0.49 3.72 1.18 50.00
190 INT181026 Positive_regulation of Cma1 3 0.40 2.76 0.43 50.00
191 INT332263 Negative_regulation of Positive_regulation of Cma1 1 0.25 0.9 0.21 50.00
192 INT332260 Negative_regulation of Gene_expression of Cma1 1 0.25 0.9 0.21 50.00
193 INT73972 Gene_expression of Bmpr1a 4 0.78 1.95 0.55 49.56
194 INT174297 Positive_regulation of MOS 6 0.51 3.26 0.42 46.08
195 INT225689 Gene_expression of SMS 10 0.65 5.66 0.03 45.12
196 INT316570 Binding of BMP7 3 0.37 0.95 0.07 43.36
197 INT265249 Positive_regulation of ACVR1 1 0.50 0.97 0 42.20
198 INT265243 Binding of FGFR1OP 1 0.20 0.74 0 42.16
199 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 39.56
200 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 38.68
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