D:Hiatal Hernia

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Disease Term
Synonyms Bergmann S Disease, BERGMANN S SYNDROME, Diaphragmatic Hernia, DIAPHRAGMATIC HERNIAS, DIAPHRAGMATIC HIATUS HERNIA, ESOPHAGEAL HERNIA, Esophageal Hernia Sliding, Esophageal Hernias, Esophageal Hernias Sliding, Esophageal Hiatal Hernia, Esophageal Hiatal Hernias
Documents 540
Hot Single Events 30
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hiatal Hernia. They are ordered first by their relevance to Hiatal Hernia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT175596 Binding of ACAT1 and HGF 1 0.01 1.58 0.18 67.04
2 INT347563 Abat Positive_regulation of Gopc 1 0.04 0.2 0.43 5.00
3 INT347562 Abat Positive_regulation of Mki67 1 0.03 0 0.3 5.00
4 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26 5.00
5 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 0.01 0.71 0.25 5.00
6 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25 5.00
7 INT296372 Binding of IDUA and ACD 1 0.03 2.72 0.23 5.00
8 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2 5.00
9 INT311399 Binding of Celf1 and Uts2r 1 0.08 0.26 0.12 5.00
10 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 5.00
11 INT272517 Binding of Ccnd1 and Celf1 3 0.08 0.07 0 5.00
12 INT311390 Mbnl1 Positive_regulation of Celf1 1 0.26 0.48 0 5.00
13 INT311387 Binding of Celf1 and Mbnl1 1 0.20 0.25 0 5.00
14 INT311405 CCND3 Regulation of Celf1 1 0.41 0.14 0 5.00
15 INT294065 ANGPT2 Positive_regulation of VEGFA 1 0.02 0.1 0 5.00
16 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0 5.00
17 INT311389 Positive_regulation of Binding of Celf1 and Eif2s2 1 0.17 0.59 0 5.00
18 INT311381 Phosphorylation of Akt1 Regulation of Celf1 1 0.10 0.14 0 5.00
19 INT294066 ANGPT1 Positive_regulation of VEGFA 1 0.01 0.1 0 5.00
20 INT311379 Celf1 Negative_regulation of Mbnl1 1 0.24 0.26 0 5.00
21 INT311384 Binding of Cnbp and Eef2 1 0.07 0.15 0 5.00
22 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0 5.00
23 INT311385 Gopc Regulation of Celf1 1 0.04 0.14 0 5.00
24 INT272516 Binding of Celf1 and Tpt1 2 0.05 0.07 0 5.00
25 INT311380 Positive_regulation of Celf1 Negative_regulation of Mbnl1 1 0.26 0.26 0 5.00
26 INT311393 Binding of Eef2 and Rps17 1 0.02 0.15 0 5.00
27 INT311392 Binding of Cnbp and Pabpc1 1 0.04 0.14 0 5.00
28 INT311397 Binding of Celf1 and Gopc 1 0.04 0.09 0 5.00
29 INT311378 Binding of Cnbp and Rps17 1 0.06 0.14 0 5.00
30 INT311375 Phosphorylation of Prkca Positive_regulation of Celf1 1 0.04 0.1 0 5.00
31 INT311402 Binding of Celf1 and Eif2s2 Positive_regulation of Phosphorylation of Celf1 1 0.11 0.22 0 5.00
32 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
33 INT311394 Binding of Celf1 and Eif2s2 1 0.12 1.67 0 5.00
34 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0 5.00
35 INT311391 Binding of Celf1 and Dmpk 1 0.34 0.09 0 5.00
36 INT311395 Binding of Esr1 and 20S 1 0.04 0.11 0 5.00
37 INT311383 Mbnl1 Regulation of Insr 1 0.00 0.24 0 5.00
38 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0 5.00
39 INT311376 Binding of Ccnd3 and Celf1 1 0.06 0.07 0 5.00
40 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0 5.00
41 INT311386 Celf1 Regulation of Insr 1 0.00 0.24 0 5.00
42 INT311388 Mbnl1 Positive_regulation of Binding of Celf1 1 0.26 0.13 0 5.00
43 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 5.00
44 INT311377 Binding of Eef2 and Pabpc1 1 0.01 0.15 0 5.00
45 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0 5.00
46 INT311396 Akt1 Regulation of Celf1 1 0.04 0.14 0 5.00
47 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0 5.00
48 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0 5.00
49 INT223734 Binding of VEGFA and Nos2 1 0.01 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hiatal Hernia. They are ordered first by their pain relevance and then by number of times they were reported in Hiatal Hernia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 100.00
2 INT122557 Localization of Chdh 6 0.74 4.44 2.6 100.00
3 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 100.00
4 INT137347 Regulation of Gene_expression of Chdh 3 0.44 3.01 0.62 100.00
5 INT66646 Regulation of Chdh 13 0.44 16.24 8.84 100.00
6 INT36428 Binding of Chdh 42 0.47 48.04 26.54 100.00
7 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 99.80
8 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64 99.62
9 INT24989 Positive_regulation of Cfp 125 0.61 29.55 64.9 99.50
10 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 99.36
11 INT68592 Negative_regulation of asa 8 0.37 3.75 2.1 99.32
12 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 99.24
13 INT3496 Negative_regulation of HPRT1 7 0.58 25.05 1.92 99.20
14 INT92260 Binding of Nlrp3 14 0.46 8.94 2.13 98.64
15 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 97.48
16 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2 96.52
17 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48 96.52
18 INT32835 Negative_regulation of Pde3a 5 0.10 3.65 0.82 96.08
19 INT5781 Gene_expression of Edn1 190 0.78 99.1 46 95.96
20 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 91.84
21 INT251238 Gene_expression of Lvs 35 0.32 29.41 1.59 91.48
22 INT20612 Positive_regulation of Asap1 36 0.68 24.35 6.06 90.20
23 INT75778 Regulation of GER 8 0.61 4.18 0.32 90.08
24 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 88.16
25 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 87.92
26 INT123564 Negative_regulation of Rock2 13 0.59 9.61 3.58 87.08
27 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 85.84
28 INT49706 Positive_regulation of TNNT2 22 0.69 12.65 1.56 82.76
29 INT45365 Negative_regulation of Cfp 68 0.57 25.44 32.11 82.64
30 INT53194 Negative_regulation of Positive_regulation of Cfp 10 0.45 4.87 4.78 82.64
31 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28 79.80
32 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 78.24
33 INT151449 Negative_regulation of Gene_expression of Kit 18 0.45 12.05 2.23 78.24
34 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 77.68
35 INT122196 Gene_expression of TAL1 5 0.47 2.07 0.63 75.92
36 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 75.28
37 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 74.56
38 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 73.44
39 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 72.32
40 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 72.32
41 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 72.32
42 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 71.92
43 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 70.76
44 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 64.56
45 INT68187 Gene_expression of TNNT2 21 0.67 10.22 1.64 55.72
46 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 55.04
47 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 50.00
48 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 47.88
49 INT73723 Gene_expression of Tff3 11 0.77 1.37 3.36 47.44
50 INT73724 Binding of Tff3 2 0.08 0.29 0.08 46.88
51 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 45.20
52 INT200595 Regulation of Gene_expression of TNNT2 1 0.24 0.95 0.08 45.00
53 INT49302 Localization of TNNT2 6 0.78 3.1 0.34 41.60
54 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 41.28
55 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 30.64
56 INT279349 Localization of IDUA 7 0.76 4.97 0.07 30.36
57 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 29.76
58 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 27.20
59 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 27.20
60 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 27.20
61 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28 25.60
62 INT171364 Localization of Pdgfrb 6 0.37 4.98 0.68 24.76
63 INT70884 Localization of Pdgfb 8 0.35 6.22 0.42 24.76
64 INT70220 Localization of Dse 3 0.65 1.84 0.41 20.88
65 INT61202 Gene_expression of Dse 11 0.58 5.53 2.16 15.64
66 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 15.20
67 INT6133 Negative_regulation of Serpinc1 56 0.58 42.8 8.35 15.04
68 INT152787 Positive_regulation of epf 4 0.26 0.86 1.42 7.52
69 INT323977 Phosphorylation of PTGFRN 1 0.01 0.81 0.22 6.56
70 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
71 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
72 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
73 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
74 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
75 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
76 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
77 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
78 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
79 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
80 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
81 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
82 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
83 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
84 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
85 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
86 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
87 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
88 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 5.00
89 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 5.00
90 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
91 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
92 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
93 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
94 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
95 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
96 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
97 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
98 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
99 INT2212 Binding of Abat 89 0.48 18.36 63.99 5.00
100 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 5.00
101 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
102 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
103 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 5.00
104 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 5.00
105 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67 5.00
106 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
107 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
108 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
109 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89 5.00
110 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
111 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
112 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71 5.00
113 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
114 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04 5.00
115 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
116 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
117 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
118 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
119 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
120 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 5.00
121 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
122 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28 5.00
123 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
124 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
125 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
126 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
127 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
128 INT7035 Regulation of CGA 87 0.45 29.04 28.45 5.00
129 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 5.00
130 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
131 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
132 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
133 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
134 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 5.00
135 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
136 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
137 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65 5.00
138 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
139 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
140 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
141 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 5.00
142 INT28642 Gene_expression of CXCR2 60 0.78 38.69 18.11 5.00
143 INT61949 Regulation of Nos2 74 0.58 34.08 16.7 5.00
144 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
145 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 5.00
146 INT20611 Gene_expression of Asap1 55 0.65 23.71 14.62 5.00
147 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 5.00
148 INT3174 Negative_regulation of Ptger2 43 0.38 20.95 13.43 5.00
149 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82 5.00
150 INT116528 Gene_expression of HMOX1 106 0.78 86.13 12.8 5.00
151 INT8548 Gene_expression of HP 86 0.77 47.62 11.94 5.00
152 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
153 INT66606 Gene_expression of CXCR1 34 0.75 27.79 11.36 5.00
154 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
155 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 5.00
156 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
157 INT51530 Negative_regulation of Adk 11 0.56 3.83 9.07 5.00
158 INT25381 Localization of Csf2 62 0.76 47.48 9.03 5.00
159 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
160 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 5.00
161 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
162 INT197 Gene_expression of Hrh2 24 0.63 12.35 8.37 5.00
163 INT61599 Positive_regulation of CYP2C9 43 0.69 11.1 8.33 5.00
164 INT113987 Localization of IK 29 0.23 16.73 8.25 5.00
165 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47 5.00
166 INT15872 Positive_regulation of EPO 74 0.70 45.35 6.67 5.00
167 INT25022 Binding of PAEP 66 0.42 22.83 6.59 5.00
168 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 5.00
169 INT8803 Gene_expression of IL3 32 0.78 21.06 6.01 5.00
170 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 5.00
171 INT86111 Positive_regulation of Positive_regulation of VEGFA 38 0.69 33.81 5.78 5.00
172 INT69153 Positive_regulation of Gene_expression of IL5 22 0.32 23.59 5.7 5.00
173 INT53684 Negative_regulation of Gene_expression of ITGAM 23 0.59 14.36 5.66 5.00
174 INT131944 Gene_expression of Mki67 30 0.53 6.58 5.63 5.00
175 INT56299 Transcription of IL4 15 0.64 10.2 5.44 5.00
176 INT19541 Gene_expression of Ptgir 22 0.65 15.42 5.39 5.00
177 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2 5.00
178 INT90848 Localization of F2rl1 23 0.80 3.15 5.2 5.00
179 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 5.00
180 INT146488 Gene_expression of Slc12a2 16 0.73 4.63 5.11 5.00
181 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89 5.00
182 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 5.00
183 INT7346 Localization of Hrh2 15 0.69 5.78 4.79 5.00
184 INT99690 Negative_regulation of Positive_regulation of VEGFA 30 0.58 14.56 4.79 5.00
185 INT18011 Positive_regulation of HP 60 0.50 31.88 4.75 5.00
186 INT82354 Positive_regulation of PECAM1 25 0.34 22.93 4.69 5.00
187 INT87322 Binding of ITGAL 23 0.47 15.73 4.68 5.00
188 INT87632 Positive_regulation of Gene_expression of PECAM1 32 0.45 29.47 4.66 5.00
189 INT26787 Localization of Uchl1 10 0.60 5.9 4.48 5.00
190 INT73503 Positive_regulation of Gene_expression of IL13 16 0.37 14.6 4.23 5.00
191 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18 5.00
192 INT75136 Binding of Akt1 27 0.27 8.81 4.15 5.00
193 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 5.00
194 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91 5.00
195 INT172677 Gene_expression of SHE 65 0.59 25.86 3.85 5.00
196 INT54886 Negative_regulation of ANGPT2 25 0.42 9.33 3.79 5.00
197 INT146946 Gene_expression of Lyn 16 0.76 8.9 3.75 5.00
198 INT18881 Binding of Asap1 7 0.41 4.28 3.66 5.00
199 INT40712 Gene_expression of EPX 9 0.78 5.93 3.6 5.00
200 INT130295 Gene_expression of Abcg2 21 0.75 9.75 3.42 5.00
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