D:Hip Osteoarthritis

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pChart

Disease Term
Synonyms Coxarthroses, COXARTHROSIS, Hip Osteoarthritides, OSTEOARTHRITIDES HIP
Documents 419
Hot Single Events 20
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hip Osteoarthritis. They are ordered first by their relevance to Hip Osteoarthritis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT171250 Binding of BMI1 and OAP 1 0.13 1.02 0.22 100.00
2 INT354790 MMP3 Negative_regulation of Gene_expression of OSM 1 0.00 0.27 0.31 50.00
3 INT250976 Binding of FMOD and IL8 1 0.08 1.26 0.91 5.00
4 INT250975 Binding of FMOD and CSAD 1 0.01 0.86 0.41 5.00
5 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4 5.00
6 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
7 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
8 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hip Osteoarthritis. They are ordered first by their pain relevance and then by number of times they were reported in Hip Osteoarthritis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT18639 Positive_regulation of OAP 16 0.69 10.49 4.57 100.00
2 INT18636 Negative_regulation of OAP 9 0.37 5.05 2.13 100.00
3 INT171254 Binding of OAP 7 0.39 8.04 3.42 100.00
4 INT2250 Binding of REG3A 3 0.47 3.58 1.33 100.00
5 INT12951 Negative_regulation of Cat 126 0.57 64.39 20.61 100.00
6 INT49437 Gene_expression of OAP 25 0.54 20.12 7.34 100.00
7 INT88103 Regulation of CCAL1 1 0.00 0.1 0.18 100.00
8 INT171253 Positive_regulation of BMI1 23 0.53 39.41 11.23 99.54
9 INT111766 Regulation of Chst11 2 0.41 0.32 0.19 99.38
10 INT32624 Regulation of LBP 15 0.60 11.48 8.71 98.36
11 INT9246 Positive_regulation of Cat 113 0.70 52.73 18.04 96.68
12 INT165228 Binding of BMI1 13 0.47 25.36 7.97 96.48
13 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 95.08
14 INT84377 Positive_regulation of Acp1 2 0.31 1.11 1.08 94.74
15 INT171251 Regulation of BMI1 8 0.20 10.46 2.01 94.40
16 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 94.28
17 INT9664 Binding of LBP 127 0.48 94.9 63.42 93.28
18 INT81934 Gene_expression of Il4i1 4 0.22 1.91 0.65 89.36
19 INT64862 Negative_regulation of Negative_regulation of PTGS2 3 0.36 0.76 1.09 86.84
20 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 83.92
21 INT250978 Binding of FMOD 4 0.16 12.32 8.75 79.28
22 INT88101 Positive_regulation of T(15E;16B1)60Dn 1 0.00 0.23 0 78.72
23 INT88100 Positive_regulation of Tg(EGFR)0Jlj 1 0.05 0.23 0 78.72
24 INT41881 Gene_expression of Acp1 2 0.09 0.65 0.74 75.00
25 INT97909 Binding of COMP 13 0.37 5.98 1.22 74.72
26 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 74.04
27 INT3364 Binding of SGCG 87 0.47 31.93 17.24 70.56
28 INT250982 Positive_regulation of FMOD 7 0.24 8.65 6.09 69.68
29 INT101839 Gene_expression of Hr 4 0.31 3.62 0.26 66.48
30 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29 63.64
31 INT150384 Binding of RCT 10 0.25 3.1 2.05 60.24
32 INT171252 Gene_expression of BMI1 21 0.70 26.98 4.11 59.52
33 INT197512 Gene_expression of ABCA4 19 0.75 7.08 0.57 58.24
34 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 57.28
35 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 50.00
36 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 50.00
37 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 50.00
38 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18 50.00
39 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 50.00
40 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 50.00
41 INT81695 Gene_expression of OSM 14 0.75 7.29 3.58 50.00
42 INT323909 Positive_regulation of Gene_expression of OSM 2 0.29 0.67 0.61 50.00
43 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
44 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 5.00
45 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 5.00
46 INT2649 Regulation of Calca 433 0.62 146.05 330.95 5.00
47 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
48 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
49 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
50 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 5.00
51 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
52 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 5.00
53 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 5.00
54 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
55 INT109910 Gene_expression of CCL16 104 0.74 76.1 43.97 5.00
56 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
57 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94 5.00
58 INT3167 Binding of KNG1 48 0.48 23.26 26.77 5.00
59 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12 5.00
60 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
61 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 5.00
62 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
63 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
64 INT28216 Gene_expression of HRAS 173 0.75 93.97 20.78 5.00
65 INT47689 Positive_regulation of Ntrk2 44 0.68 16.84 19.59 5.00
66 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
67 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 5.00
68 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
69 INT63361 Gene_expression of CD44 126 0.77 71.58 12.96 5.00
70 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 5.00
71 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57 5.00
72 INT238920 Positive_regulation of SLC9A3R2 44 0.50 27.86 10.51 5.00
73 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 5.00
74 INT35269 Localization of SGCG 38 0.78 14.68 9.01 5.00
75 INT10171 Binding of Gtf3a 33 0.36 19.84 5.1 5.00
76 INT10138 Negative_regulation of Gene_expression of KNG1 13 0.57 9.57 4.9 5.00
77 INT125478 Localization of HHIP 32 0.80 3.43 4.68 5.00
78 INT250981 Gene_expression of FMOD 2 0.20 7.3 4.47 5.00
79 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37 5.00
80 INT9456 Gene_expression of Anpep 9 0.78 1.69 4.26 5.00
81 INT20981 Binding of HRAS 42 0.48 24.49 4.23 5.00
82 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 5.00
83 INT80175 Positive_regulation of Gene_expression of HRAS 24 0.67 14.69 3.97 5.00
84 INT169475 Localization of HRAS 14 0.73 9.02 3.9 5.00
85 INT30238 Positive_regulation of Anpep 14 0.66 2.77 3.38 5.00
86 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 5.00
87 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 5.00
88 INT14872 Gene_expression of TGFB3 15 0.55 12.45 2.96 5.00
89 INT109917 Positive_regulation of Gene_expression of CCL16 17 0.66 11.87 2.94 5.00
90 INT62683 Negative_regulation of HRAS 19 0.57 7.93 2.65 5.00
91 INT178888 Gene_expression of CHDH 41 0.65 38.66 2.51 5.00
92 INT4686 Gene_expression of Cys1 32 0.66 36.24 2.49 5.00
93 INT250980 Negative_regulation of FMOD 2 0.14 2.67 2.31 5.00
94 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 5.00
95 INT250983 Regulation of Gene_expression of FMOD 2 0.09 2.62 2.18 5.00
96 INT197681 Binding of CHDH 40 0.48 33.72 2.13 5.00
97 INT49250 Regulation of Atp6v0d2 5 0.08 1.54 2.04 5.00
98 INT51570 Regulation of Anpep 6 0.43 1.7 2 5.00
99 INT216848 Gene_expression of TCIRG1 8 0.52 2.59 1.95 5.00
100 INT76993 Regulation of HRAS 8 0.60 7.81 1.95 5.00
101 INT12835 Negative_regulation of Positive_regulation of CRH 6 0.42 3.15 1.76 5.00
102 INT91430 Positive_regulation of CD44 25 0.69 15.43 1.76 5.00
103 INT184206 Protein_catabolism of HRAS 22 0.66 7.86 1.46 5.00
104 INT37076 Negative_regulation of Binding of KNG1 3 0.14 1.77 1.32 5.00
105 INT118196 Gene_expression of ROM1 18 0.66 4.81 1.19 5.00
106 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15 5.00
107 INT124069 Localization of Ntrk1 9 0.59 3.32 1.13 5.00
108 INT286596 Positive_regulation of Positive_regulation of SLC9A3R2 2 0.50 3.37 1.07 5.00
109 INT165387 Regulation of ROM1 6 0.37 0.87 1.06 5.00
110 INT286597 Localization of SLC9A3R2 3 0.54 6.71 1.05 5.00
111 INT105922 Gene_expression of SLC9A3R2 6 0.48 2.09 1.04 5.00
112 INT269485 Positive_regulation of Gene_expression of HHIP 9 0.41 1.08 0.92 5.00
113 INT114664 Binding of BMP2 12 0.37 6.54 0.91 5.00
114 INT84979 Regulation of CHDH 22 0.38 22.34 0.78 5.00
115 INT177716 Gene_expression of GALNT3 7 0.53 6.91 0.75 5.00
116 INT156926 Protein_catabolism of Vsig2 5 0.57 2.01 0.64 5.00
117 INT259408 Gene_expression of Atp6v0d2 5 0.09 2.01 0.54 5.00
118 INT105677 Binding of Vegfa 7 0.37 5.22 0.51 5.00
119 INT90090 Gene_expression of ADO 4 0.58 1.41 0.42 5.00
120 INT265490 Localization of CSPG4 3 0.20 1.5 0.33 5.00
121 INT265480 Negative_regulation of CSPG4 5 0.32 2.37 0.31 5.00
122 INT244625 Negative_regulation of Localization of Ntrk1 1 0.04 0.56 0.28 5.00
123 INT286598 Regulation of SLC9A3R2 6 0.19 0.88 0.22 5.00
124 INT280460 Positive_regulation of Localization of Ntrk1 2 0.11 0.32 0.21 5.00
125 INT219724 Protein_catabolism of CHDH 3 0.37 2.25 0.21 5.00
126 INT348918 Negative_regulation of Negative_regulation of CSPG4 1 0.06 0.59 0.2 5.00
127 INT348917 Negative_regulation of Protein_catabolism of HRAS 1 0.02 0.57 0.2 5.00
128 INT246630 Positive_regulation of Positive_regulation of CD44 1 0.51 0.34 0.18 5.00
129 INT81940 Regulation of TGFB3 3 0.14 0.45 0.1 5.00
130 INT233399 Binding of ABCA4 9 0.46 9.49 0.07 5.00
131 INT316570 Binding of BMP7 3 0.37 0.95 0.07 5.00
132 INT264147 Gene_expression of CLCN7 1 0.35 0.73 0 5.00
133 INT197513 Transcription of ABCA4 2 0.43 0.86 0 5.00
134 INT247976 Negative_regulation of Alm 2 0.04 0.66 0 5.00
135 INT264145 Gene_expression of BSND 1 0.04 1.25 0 5.00
136 INT264146 Gene_expression of MYO7A 1 0.05 1.36 0 5.00
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