D:Histiocytosis

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pChart

Disease Term
Synonyms HISTIOCYTOSES
Documents 149
Hot Single Events 18
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Histiocytosis. They are ordered first by their relevance to Histiocytosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT230437 Binding of PDX1 and HRCT1 1 0.04 2.45 0.43 75.40
2 INT321598 Binding of MLL and TNF 1 0.05 1.07 0.49 5.00
3 INT230438 Binding of PDX1 and HAUS7 1 0.02 2.29 0.35 5.00
4 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
5 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
6 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
7 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
8 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
9 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
10 INT255385 Binding of COL1A2 and DSPP 1 0.40 0.12 0 5.00
11 INT255384 Binding of AKR1C2 and DSG1 1 0.01 1.54 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Histiocytosis. They are ordered first by their pain relevance and then by number of times they were reported in Histiocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT154828 Binding of Lch 2 0.31 3.51 0.06 100.00
2 INT120517 Positive_regulation of Lch 1 0.46 0.8 0.17 100.00
3 INT23257 Regulation of CRP 127 0.62 100.05 21.87 99.66
4 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 96.84
5 INT94628 Gene_expression of CD1D 12 0.75 5.58 2.13 96.84
6 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 95.20
7 INT57699 Positive_regulation of CD1A 11 0.50 8.49 2.93 89.04
8 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 87.60
9 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 87.60
10 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 87.60
11 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 87.16
12 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 85.12
13 INT46359 Positive_regulation of RGD1566134 1 0.66 1.13 0.09 83.76
14 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 83.16
15 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 82.96
16 INT122811 Binding of Ecd 11 0.31 3.01 0.84 82.52
17 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 81.84
18 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 80.32
19 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13 75.00
20 INT39005 Negative_regulation of FBN1 7 0.42 4.97 2.6 75.00
21 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 74.28
22 INT14572 Binding of INS 205 0.48 175.43 13.38 66.48
23 INT16130 Binding of IGF1 67 0.48 27.43 2.95 66.48
24 INT202702 Binding of IGF2BP3 2 0.36 3.82 0.08 66.48
25 INT23030 Positive_regulation of Pth 13 0.61 9.24 0.97 64.88
26 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 63.68
27 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 58.96
28 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 58.40
29 INT22943 Positive_regulation of Positive_regulation of Gpt 23 0.47 16.09 5.55 58.40
30 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 57.64
31 INT35103 Positive_regulation of Positive_regulation of SLC17A5 5 0.12 7.51 1.25 57.64
32 INT131916 Negative_regulation of ALPL 10 0.42 9.33 1.8 51.40
33 INT125804 Localization of Pth 9 0.69 3.93 0.29 50.96
34 INT320983 Negative_regulation of Localization of Pth 2 0.38 1.17 0.09 50.96
35 INT38013 Gene_expression of Casr 30 0.73 6.03 3.09 41.20
36 INT244658 Localization of Lch 1 0.49 1.92 0 32.20
37 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 28.56
38 INT84890 Negative_regulation of PPARD 7 0.59 3.27 3.1 16.32
39 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 16.24
40 INT172557 Negative_regulation of Fdps 6 0.12 2.89 0.39 12.08
41 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 11.76
42 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 11.44
43 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
44 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
45 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
46 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
47 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
48 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
49 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
50 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
51 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 5.00
52 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
53 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
54 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
55 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
56 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
57 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
58 INT14690 Localization of CSF2 124 0.80 85.17 27.26 5.00
59 INT17739 Gene_expression of S100B 226 0.78 132.7 26.4 5.00
60 INT250 Regulation of GHRH 65 0.61 17.46 23.19 5.00
61 INT14731 Positive_regulation of TGFB1 78 0.67 52.57 22.23 5.00
62 INT14733 Positive_regulation of Gene_expression of TGFB1 71 0.69 49.89 22.2 5.00
63 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 5.00
64 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
65 INT12081 Localization of TGFB1 64 0.81 35.4 17.47 5.00
66 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 5.00
67 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 5.00
68 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
69 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 5.00
70 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
71 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 5.00
72 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 5.00
73 INT4047 Binding of F13A1 105 0.43 66.54 11.81 5.00
74 INT94454 Gene_expression of CD68 73 0.72 63.94 10.43 5.00
75 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
76 INT149138 Binding of PDX1 27 0.37 32.62 9.33 5.00
77 INT132586 Negative_regulation of Hand2 40 0.30 26.58 9.28 5.00
78 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 5.00
79 INT27551 Gene_expression of SERPINH1 45 0.62 42.87 9.04 5.00
80 INT19185 Negative_regulation of Cd4 80 0.51 61.32 8.51 5.00
81 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
82 INT38672 Binding of KRT20 69 0.39 48.01 6.31 5.00
83 INT3550 Negative_regulation of GLA 52 0.59 33.93 5.26 5.00
84 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 5.00
85 INT120073 Positive_regulation of Itk 34 0.44 23.45 5.09 5.00
86 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 5.00
87 INT121954 Binding of Mthfr 17 0.44 13.47 4.66 5.00
88 INT89103 Regulation of Gene_expression of TGFB1 15 0.56 8.11 4.37 5.00
89 INT149332 Gene_expression of CD163 19 0.75 13.63 3.65 5.00
90 INT84891 Gene_expression of PPARD 10 0.78 6.8 3.64 5.00
91 INT12083 Regulation of TGFB1 22 0.53 15.4 3.6 5.00
92 INT78284 Positive_regulation of PTPRC 40 0.49 27.17 3.45 5.00
93 INT133214 Regulation of PDX1 9 0.34 10.26 3.36 5.00
94 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 5.00
95 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
96 INT171058 Negative_regulation of PDX1 5 0.32 9.31 2.72 5.00
97 INT24895 Positive_regulation of LYZ 25 0.70 17.92 2.64 5.00
98 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 5.00
99 INT27217 Negative_regulation of LYZ 6 0.42 3.1 2.26 5.00
100 INT83896 Gene_expression of CD1A 19 0.68 15.58 2.1 5.00
101 INT158442 Gene_expression of Nkx2-1 21 0.59 8.47 1.99 5.00
102 INT57339 Negative_regulation of HLA-DRA 17 0.49 7.67 1.96 5.00
103 INT171059 Localization of PDX1 8 0.56 6.7 1.9 5.00
104 INT133269 Positive_regulation of PDX1 10 0.54 9.77 1.9 5.00
105 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83 5.00
106 INT90377 Gene_expression of HBA1 26 0.75 7.34 1.51 5.00
107 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46 5.00
108 INT140647 Gene_expression of DSG1 45 0.75 27.95 1.33 5.00
109 INT183065 Positive_regulation of Gene_expression of PDX1 7 0.54 6.58 1.29 5.00
110 INT120075 Gene_expression of Itk 11 0.43 6.39 1.27 5.00
111 INT37253 Negative_regulation of PTPRC 12 0.37 6.13 1.26 5.00
112 INT211198 Localization of SERPINH1 2 0.66 4.33 1.25 5.00
113 INT28788 Regulation of LYZ 5 0.42 1.8 1.24 5.00
114 INT183933 Binding of CD68 8 0.31 8.74 1.06 5.00
115 INT67097 Gene_expression of MIB1 20 0.75 21.06 1.03 5.00
116 INT230440 Gene_expression of HAUS7 1 0.04 4.13 1.02 5.00
117 INT15040 Gene_expression of NKX2-1 8 0.65 3.95 1.02 5.00
118 INT89128 Binding of DSPP 7 0.32 2.24 0.98 5.00
119 INT51066 Binding of S100B 24 0.48 13.5 0.97 5.00
120 INT199345 Gene_expression of Lyve1 11 0.50 8.44 0.89 5.00
121 INT62002 Regulation of Cd68 6 0.35 7.89 0.86 5.00
122 INT84892 Negative_regulation of Gene_expression of PPARD 2 0.43 1.85 0.83 5.00
123 INT169706 Positive_regulation of Gene_expression of Itk 2 0.32 2.08 0.81 5.00
124 INT51281 Gene_expression of Cyp2c29 4 0.54 0.96 0.74 5.00
125 INT234950 Binding of DSG1 29 0.36 23.67 0.69 5.00
126 INT114909 Negative_regulation of Localization of TGFB1 5 0.36 1.37 0.66 5.00
127 INT174239 Gene_expression of CYP2C18 5 0.65 2.25 0.63 5.00
128 INT44080 Positive_regulation of HBA1 7 0.25 2.23 0.6 5.00
129 INT60334 Gene_expression of ITGAV 6 0.26 3.15 0.51 5.00
130 INT248322 Negative_regulation of CD68 4 0.34 4.2 0.44 5.00
131 INT234962 Positive_regulation of Gene_expression of DSG1 5 0.48 5.41 0.37 5.00
132 INT202424 Gene_expression of HRCT1 3 0.07 3.47 0.36 5.00
133 INT139075 Negative_regulation of Cyp2j6 1 0.24 0.28 0.34 5.00
134 INT186450 Negative_regulation of SFTPB 17 0.58 10.94 0.31 5.00
135 INT230442 Binding of HAUS7 1 0.02 2.2 0.3 5.00
136 INT317746 Positive_regulation of Gene_expression of FCER2 2 0.01 4.09 0.3 5.00
137 INT16180 Regulation of DSPP 6 0.53 4.63 0.28 5.00
138 INT44599 Gene_expression of CNOT4 4 0.40 3.09 0.25 5.00
139 INT167751 Gene_expression of DSPP 15 0.77 8.56 0.24 5.00
140 INT275892 Positive_regulation of Gene_expression of HBA1 7 0.67 2.4 0.24 5.00
141 INT299545 Positive_regulation of Binding of TGFB1 2 0.06 1.08 0.22 5.00
142 INT202701 Regulation of CNO 1 0.27 1.26 0.21 5.00
143 INT285743 Regulation of CD68 2 0.33 1.82 0.2 5.00
144 INT239883 Transcription of SFTPC 3 0.69 1.11 0.18 5.00
145 INT193312 Localization of DSPP 8 0.74 1.88 0.18 5.00
146 INT192842 Binding of Hspa5 3 0.33 1.48 0.16 5.00
147 INT231230 Localization of SFTPC 2 0.68 2.06 0.16 5.00
148 INT244657 Regulation of Lch 3 0.40 6.63 0.13 5.00
149 INT230441 Positive_regulation of HRCT1 1 0.05 0.74 0.12 5.00
150 INT146139 Gene_expression of ETV4 11 0.12 8.43 0.11 5.00
151 INT331623 Negative_regulation of Binding of TGFB1 1 0.02 1.02 0.08 5.00
152 INT331613 Regulation of Positive_regulation of Itk 1 0.02 0.87 0.06 5.00
153 INT256649 Negative_regulation of Cyp2b19 1 0.13 0.17 0.06 5.00
154 INT256653 Negative_regulation of Cyp2d11 1 0.01 0.2 0.06 5.00
155 INT208648 Positive_regulation of NCBP2 1 0.10 1.39 0.05 5.00
156 INT331615 Binding of Igbp1 1 0.00 0.95 0.05 5.00
157 INT256650 Gene_expression of Cyp2b19 1 0.24 0.27 0.03 5.00
158 INT256652 Transcription of Cyp2b19 1 0.17 0.32 0.03 5.00
159 INT191542 Binding of ABCA3 1 0.22 1.61 0.03 5.00
160 INT256654 Transcription of CYP2C18 1 0.44 0.32 0.03 5.00
161 INT278221 Regulation of Lipo1 1 0.02 1.32 0 5.00
162 INT255387 Phosphorylation of DSPP 1 0.71 0 0 5.00
163 INT256651 Regulation of Cyp2c29 1 0.19 0.09 0 5.00
164 INT298953 Positive_regulation of Gene_expression of Lyve1 1 0.03 0.77 0 5.00
165 INT331624 Transcription of SFTPB 1 0.03 0.48 0 5.00
166 INT234940 Regulation of DSG1 2 0.21 2.29 0 5.00
167 INT278220 Gene_expression of Lipo1 1 0.03 1.23 0 5.00
168 INT167750 Positive_regulation of Gene_expression of DSPP 2 0.50 3.13 0 5.00
169 INT234937 Localization of DSG1 5 0.66 4.14 0 5.00
170 INT234943 Phosphorylation of DSG1 2 0.48 1.81 0 5.00
171 INT331625 Negative_regulation of ABCA3 1 0.27 0.38 0 5.00
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