D:Histoplasma Infection

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Disease Term
Synonyms AFRICAN HISTOPLASMOSIS, DISSEMINATED HISTOPLASMOSIS, HISTOPLASMA CAPSULATUM, Histoplasma Infections, Histoplasmoses, HISTOPLASMOSIS, North American Histoplasmosis
Documents 169
Hot Single Events 14
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Histoplasma Infection. They are ordered first by their relevance to Histoplasma Infection and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT172081 TNF Regulation of IFNA1 1 0.03 1.13 0.5 14.08
2 INT172083 TNF Regulation of Regulation of IFNA1 1 0.03 0.91 0.22 14.08
3 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
4 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
5 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
6 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
7 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 5.00
8 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19 5.00
9 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
10 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91 5.00
11 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 5.00
12 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 5.00
13 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07 5.00
14 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9 5.00
15 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9 5.00
16 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74 5.00
17 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73 5.00
18 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57 5.00
19 INT172082 TNF Regulation of SFTPA1 1 0.05 0.85 0.5 5.00
20 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 5.00
21 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 5.00
22 INT239474 Binding of ACR and Ifx 1 0.02 0.36 0.45 5.00
23 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44 5.00
24 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43 5.00
25 INT211115 Positive_regulation of Binding of LTBR and TNF 1 0.01 0.31 0.39 5.00
26 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35 5.00
27 INT170128 Binding of ITGAL and ITGB2 2 0.04 1.6 0.28 5.00
28 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28 5.00
29 INT185092 CRP Positive_regulation of ESR1 1 0.06 2.83 0.28 5.00
30 INT277705 SMAP2 Regulation of TNF 1 0.01 1.23 0.25 5.00
31 INT289959 Negative_regulation of Binding of CD28 and CD80 1 0.07 0.24 0.23 5.00
32 INT289953 Binding of CD80 and KLF1 1 0.00 0.21 0.23 5.00
33 INT289955 Binding of APCS and KLF1 1 0.00 0.21 0.23 5.00
34 INT277995 TNF Positive_regulation of Gene_expression of Tnfrsf1a 1 0.03 1.48 0.22 5.00
35 INT277996 TNF Positive_regulation of Tnfrsf1a 1 0.03 1.48 0.22 5.00
36 INT306714 IL23A Positive_regulation of TNF 1 0.29 0.5 0.21 5.00
37 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21 5.00
38 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2 5.00
39 INT306747 IL23A Positive_regulation of Il17a 1 0.05 0.51 0.16 5.00
40 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13 5.00
41 INT174820 IL6 Positive_regulation of VEGFA 1 0.20 3.32 0.12 5.00
42 INT174821 VEGFA Positive_regulation of Gene_expression of IL6 1 0.20 3.13 0.12 5.00
43 INT289958 Binding of IL2 and IL2RB 1 0.02 0.59 0.12 5.00
44 INT289957 Binding of APCS and CD58 1 0.04 0.35 0.08 5.00
45 INT353105 Binding of Aes and Rgs9bp 1 0.01 0.35 0.05 5.00
46 INT353104 Binding of amd and Gtf3a 1 0.01 1.53 0.03 5.00
47 INT203978 Binding of Srebf1 and Scap 1 0.01 0.26 0 5.00
48 INT353106 Binding of amd and C3 1 0.09 1.69 0 5.00
49 INT353108 Binding of VEGFA and Pgf 1 0.02 2.17 0 5.00
50 INT353107 Binding of VEGFA and Vegfb 1 0.02 1.08 0 5.00
51 INT353110 Binding of VEGFA and Eo 1 0.00 0.67 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Histoplasma Infection. They are ordered first by their pain relevance and then by number of times they were reported in Histoplasma Infection. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT168001 Localization of Cms1 5 0.59 1.78 0.21 97.36
2 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 94.74
3 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 94.36
4 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 89.52
5 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 87.64
6 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 87.24
7 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 86.96
8 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 85.96
9 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 85.96
10 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 85.96
11 INT187295 Gene_expression of Serpinb1a 6 0.58 13.73 5.05 81.40
12 INT6510 Gene_expression of AFP 130 0.78 119.2 9.19 80.36
13 INT211112 Positive_regulation of Etn1 3 0.28 4.28 0.92 80.24
14 INT8547 Gene_expression of MUC16 116 0.78 75.97 12.18 80.16
15 INT6852 Localization of TNF 883 0.81 705.95 270.84 78.72
16 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 78.44
17 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 77.60
18 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 76.68
19 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 69.12
20 INT182853 Negative_regulation of Gene_expression of AAVS1 7 0.14 2.48 0.59 67.52
21 INT6481 Binding of TNF 624 0.48 510.2 214.82 66.80
22 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 66.24
23 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 61.76
24 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 58.80
25 INT212916 Positive_regulation of Binding of 5 0.24 1.74 0.04 58.80
26 INT20205 Binding of IgG 108 0.46 66.68 8.57 58.28
27 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 57.60
28 INT192406 Regulation of Ighm 16 0.31 5.58 0.29 52.72
29 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98 51.84
30 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 50.16
31 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 50.00
32 INT118124 Binding of USE1 24 0.16 16.64 5.44 39.44
33 INT56160 Binding of Ifx 14 0.36 11.39 5.74 33.76
34 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 31.60
35 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18 30.92
36 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 27.68
37 INT1631 Binding of Hdl1 42 0.36 49.22 2.92 24.88
38 INT268770 Positive_regulation of am 1 0.02 0.59 0.03 16.80
39 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 14.08
40 INT72798 Binding of ADA 12 0.47 7.84 3.39 12.52
41 INT35009 Binding of CSAD 12 0.41 10.74 3.21 6.24
42 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
43 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
44 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
45 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
46 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
47 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
48 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
49 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 5.00
50 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
51 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
52 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
53 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
54 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
55 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
56 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
57 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
58 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
59 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
60 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
61 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06 5.00
62 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
63 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
64 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
65 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
66 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
67 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 5.00
68 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 5.00
69 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
70 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
71 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
72 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
73 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
74 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
75 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 5.00
76 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
77 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
78 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
79 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 5.00
80 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 5.00
81 INT11807 Gene_expression of Il2 266 0.78 112 64.97 5.00
82 INT11937 Localization of Il6 228 0.81 139.83 64.39 5.00
83 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
84 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
85 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
86 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
87 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
88 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
89 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
90 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
91 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 5.00
92 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
93 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
94 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
95 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
96 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
97 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
98 INT117598 Regulation of ACR 118 0.26 41.25 48.01 5.00
99 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 5.00
100 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
101 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07 5.00
102 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
103 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
104 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
105 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
106 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2 5.00
107 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
108 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
109 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
110 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 5.00
111 INT10763 Localization of IL2 157 0.80 81.11 33.21 5.00
112 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58 5.00
113 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 5.00
114 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 5.00
115 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 5.00
116 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
117 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 5.00
118 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 5.00
119 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
120 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
121 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
122 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
123 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
124 INT85395 Gene_expression of Scn11a 62 0.78 17.97 26.89 5.00
125 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
126 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
127 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95 5.00
128 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
129 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71 5.00
130 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 5.00
131 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
132 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 5.00
133 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 5.00
134 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 5.00
135 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 5.00
136 INT150022 Positive_regulation of Il17a 69 0.64 70.04 21.87 5.00
137 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63 5.00
138 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
139 INT160564 Gene_expression of Il22 64 0.55 59.29 20.9 5.00
140 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85 5.00
141 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
142 INT86751 Negative_regulation of Il10 62 0.59 40.1 20.51 5.00
143 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 5.00
144 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98 5.00
145 INT7336 Positive_regulation of VIP 60 0.70 24.2 19.62 5.00
146 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 5.00
147 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 5.00
148 INT116978 Gene_expression of CCR6 53 0.78 56 17.73 5.00
149 INT9656 Regulation of Gene_expression of Il6 57 0.62 33.3 17.71 5.00
150 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
151 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
152 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 5.00
153 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 5.00
154 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 5.00
155 INT22900 Positive_regulation of Cd4 126 0.67 82.77 16.43 5.00
156 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38 5.00
157 INT10918 Gene_expression of ITGB2 93 0.76 71.8 16.34 5.00
158 INT104045 Regulation of Hand1 65 0.35 51.32 16.26 5.00
159 INT52107 Transcription of IL8 63 0.72 41.66 16.06 5.00
160 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
161 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
162 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 5.00
163 INT69952 Positive_regulation of IK 45 0.32 16.08 14.59 5.00
164 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 5.00
165 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 5.00
166 INT161515 Positive_regulation of Gene_expression of Il17a 50 0.64 41.52 13.82 5.00
167 INT69878 Positive_regulation of Gene_expression of Gtf3a 48 0.29 36.78 13.57 5.00
168 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 5.00
169 INT20378 Localization of Hand1 53 0.71 41.96 13.31 5.00
170 INT132178 Binding of CD80 41 0.47 15.55 12.98 5.00
171 INT52905 Gene_expression of Cd4 84 0.78 45.68 12.75 5.00
172 INT10870 Regulation of IgG 67 0.59 43.27 12.74 5.00
173 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 5.00
174 INT51014 Transcription of IL2 42 0.71 21.56 12.7 5.00
175 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
176 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
177 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
178 INT87239 Localization of Il12a 51 0.75 31.95 12.05 5.00
179 INT69158 Localization of IL4 48 0.71 31.3 11.98 5.00
180 INT36287 Binding of CD4 96 0.47 58.93 11.88 5.00
181 INT111476 Gene_expression of TP63 88 0.76 61.08 11.64 5.00
182 INT65713 Localization of ICAM1 42 0.81 39.55 11.49 5.00
183 INT23402 Binding of HLA-DOA 74 0.48 52.01 10.89 5.00
184 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88 5.00
185 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 5.00
186 INT133172 Gene_expression of Il12b 98 0.75 52.16 10.68 5.00
187 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
188 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16 5.00
189 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14 5.00
190 INT73504 Binding of CD28 35 0.45 15.99 10.04 5.00
191 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 5.00
192 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 5.00
193 INT80549 Binding of ICAM1 53 0.47 42.76 9.72 5.00
194 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 5.00
195 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5 5.00
196 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 5.00
197 INT93045 Negative_regulation of Gene_expression of Hand2 31 0.43 25.26 9.24 5.00
198 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 5.00
199 INT73497 Regulation of IL10 33 0.45 22.6 9.19 5.00
200 INT285 Positive_regulation of Salpa1 73 0.68 61.47 9.19 5.00
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