D:Hoarseness

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Disease Term
Synonyms Hoarse, Hoarseness Neurogenic, Hoarseness Of Voice, HOARSENESS VOICE, Hoarsenesses, NEUROGENIC HOARSENESS, NEUROGENIC HOARSENESSES, VOICE HOARSENESS
Documents 585
Hot Single Events 42
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hoarseness. They are ordered first by their relevance to Hoarseness and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131130 Binding of PKD1 and Krt16 1 0.01 1 0.08 59.44
2 INT175596 Binding of ACAT1 and HGF 1 0.01 1.58 0.18 43.76
3 INT220698 Binding of CHRNE and SFTPA1 1 0.01 0.75 0.06 14.56
4 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68 5.00
5 INT190826 ELANE Positive_regulation of Localization of MUC1 1 0.07 0 0.29 5.00
6 INT354926 IL6 Regulation of Gene_expression of ALB 1 0.14 1.3 0.23 5.00
7 INT354924 IL6 Positive_regulation of Gene_expression of ALB 1 0.26 1.3 0.23 5.00
8 INT190827 KCNA1 Regulation of Localization of MUC1 1 0.05 0.08 0.22 5.00
9 INT236467 MMP9 Negative_regulation of SNRPB 1 0.01 0.45 0.1 5.00
10 INT277890 Binding of Ids and Tas2r111-ps2 1 0.08 0.5 0.09 5.00
11 INT277889 Regulation of Binding of Ids and Tas2r111-ps2 1 0.09 0.5 0.09 5.00
12 INT354925 ALB Positive_regulation of ALPP 1 0.34 1.69 0.09 5.00
13 INT220697 Binding of CHRNE and DBP 1 0.02 1.15 0.08 5.00
14 INT213933 AR Negative_regulation of Cyp19a1 1 0.07 0.79 0.07 5.00
15 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 5.00
16 INT236466 SNRPB Positive_regulation of NFKB2 1 0.00 0.21 0.05 5.00
17 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 5.00
18 INT277892 IDS Regulation of Ids 1 0.18 0.41 0 5.00
19 INT277891 Binding of TPBG and M6pr-ps 1 0.02 0.06 0 5.00
20 INT236468 TP53 Positive_regulation of Protein_catabolism of SNRPB 1 0.00 0.52 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hoarseness. They are ordered first by their pain relevance and then by number of times they were reported in Hoarseness. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT227524 Positive_regulation of Gene_expression of Prep 13 0.48 7.69 3.28 100.00
2 INT61340 Regulation of Prep 7 0.50 6.13 2.31 99.48
3 INT168446 Gene_expression of Prep 25 0.64 15.17 5.94 99.48
4 INT33516 Positive_regulation of TSHR 4 0.49 2.5 0.93 98.72
5 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 98.28
6 INT4535 Localization of PROC 106 0.73 76.24 21.1 97.32
7 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 96.92
8 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 96.56
9 INT78199 Gene_expression of Neu1 65 0.75 62.88 7.16 96.36
10 INT80174 Positive_regulation of Gene_expression of Neu1 23 0.37 17.82 1.12 96.36
11 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 95.32
12 INT81761 Negative_regulation of Prep 12 0.55 8.48 4.73 94.16
13 INT10390 Gene_expression of Asah1 5 0.56 1.33 0.97 93.64
14 INT39180 Gene_expression of NPL 7 0.38 3.61 2.48 92.64
15 INT132477 Negative_regulation of TSHB 5 0.45 3.24 0.05 92.64
16 INT20210 Localization of Ngf 69 0.79 46.22 38.57 91.76
17 INT307060 Negative_regulation of AKTIP 6 0.01 2.79 0.08 91.08
18 INT56817 Regulation of Eno2 16 0.61 10.64 1.99 90.00
19 INT156723 Regulation of Localization of S100B 2 0.44 2.61 0.34 90.00
20 INT156722 Regulation of Localization of Eno2 1 0.44 1.38 0.09 90.00
21 INT202052 Negative_regulation of URB1 2 0.04 2.16 0.85 89.60
22 INT17742 Localization of S100B 44 0.80 17.14 4.65 89.48
23 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 89.44
24 INT29635 Localization of Eno2 9 0.76 6.05 1.35 89.28
25 INT87988 Gene_expression of ASAH1 9 0.77 9.75 1.18 88.28
26 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 87.76
27 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 86.76
28 INT86705 Gene_expression of BTG3 41 0.65 37.29 8.29 86.76
29 INT764 Gene_expression of OLAH 25 0.67 25.58 8.07 86.76
30 INT90860 Negative_regulation of ASAH1 1 0.51 0.47 0.09 86.72
31 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 85.12
32 INT44979 Positive_regulation of Pnp 11 0.59 5.61 2.41 85.08
33 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26 83.84
34 INT138335 Negative_regulation of Asah1 2 0.49 0.61 0.34 83.12
35 INT322475 Negative_regulation of PGAP1 9 0.36 4.78 4.69 82.20
36 INT131835 Positive_regulation of Wnk1 1 0.07 1.28 0.07 81.76
37 INT1922 Positive_regulation of CEACAM7 32 0.70 33.31 2.72 81.12
38 INT23376 Localization of NPL 7 0.47 2.59 3.29 81.00
39 INT256742 Positive_regulation of Cdr1 10 0.27 2.89 0.81 80.88
40 INT91702 Negative_regulation of GIF 4 0.42 1.58 0.08 80.88
41 INT91701 Negative_regulation of Reg3a 1 0.07 0.48 0.08 80.88
42 INT214 Localization of AVP 370 0.81 208.51 91.09 80.68
43 INT41928 Binding of AFP 9 0.36 7.85 0.7 78.12
44 INT322474 Regulation of PGAP1 1 0.38 4.82 5.06 77.60
45 INT6511 Positive_regulation of AFP 76 0.70 70.15 7.28 77.20
46 INT16997 Binding of PRTN3 34 0.48 33.44 6.45 76.24
47 INT123977 Binding of Lat 2 0.32 0.56 0.39 76.00
48 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 75.16
49 INT17114 Positive_regulation of AHSG 6 0.45 6 0.45 74.40
50 INT70860 Binding of SNRPB 17 0.35 7 1.46 73.56
51 INT74520 Positive_regulation of CD68 30 0.61 31.68 7.59 73.36
52 INT69727 Gene_expression of QPCT 18 0.65 5.45 3.05 73.12
53 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 72.76
54 INT139936 Negative_regulation of Ts1 1 0.57 1.24 0.16 72.76
55 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 71.12
56 INT149441 Positive_regulation of MCF2L 5 0.61 3.96 1.82 70.80
57 INT202055 Positive_regulation of URB1 7 0.32 5.41 2.34 69.56
58 INT18934 Gene_expression of GER 16 0.66 14.71 1.29 69.52
59 INT2544 Localization of PTH 39 0.81 30.55 2.22 67.28
60 INT217952 Negative_regulation of MYH7 2 0.01 1.85 0.09 66.96
61 INT27534 Negative_regulation of Gba 10 0.57 6.23 0.38 65.96
62 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 65.52
63 INT154706 Gene_expression of Tg 9 0.38 4.95 0.64 65.12
64 INT48240 Binding of Ngf 46 0.46 23.51 24.42 64.56
65 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 64.40
66 INT48212 Binding of ATM 5 0.47 3.89 0.57 60.96
67 INT6625 Negative_regulation of Pth 96 0.58 57.6 8.24 60.60
68 INT236475 Localization of SNRPB 1 0.04 2.85 0.13 57.04
69 INT236479 Positive_regulation of Localization of SNRPB 1 0.03 1.39 0 57.04
70 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 56.96
71 INT237257 Gene_expression of Rhbdl1 3 0.67 5.15 4.31 56.60
72 INT237259 Positive_regulation of Gene_expression of Rhbdl1 1 0.50 3.58 0 56.60
73 INT144481 Gene_expression of SERPING1 55 0.77 50.4 4.75 55.76
74 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 55.44
75 INT47950 Negative_regulation of ELOVL1 15 0.41 20.33 1.41 54.16
76 INT106952 Positive_regulation of NPC1 23 0.43 22.9 0.94 51.44
77 INT237256 Positive_regulation of Rhbdl1 6 0.47 4.64 0.78 47.88
78 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 45.84
79 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 45.48
80 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 45.32
81 INT194253 Positive_regulation of FIG4 2 0.27 1.39 0.12 43.28
82 INT6514 Positive_regulation of Gene_expression of PTH 28 0.67 30.28 1.37 42.44
83 INT252166 Negative_regulation of Cdr1 6 0.17 2.42 0.69 42.44
84 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 40.92
85 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 38.16
86 INT229301 Gene_expression of NR0B2 3 0.18 3.49 0.16 37.92
87 INT240280 Gene_expression of IGFALS 14 0.42 20.38 0.95 37.72
88 INT175556 Regulation of Positive_regulation of PTH 3 0.39 2.34 0.12 33.52
89 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 31.84
90 INT6557 Gene_expression of Eno2 65 0.77 54.42 8.17 31.84
91 INT266786 Binding of ASAH1 2 0.11 3.87 0.44 31.44
92 INT36479 Binding of NR0B2 2 0.36 3.5 0.21 31.44
93 INT18897 Binding of CHGA 11 0.36 10.12 1.17 31.08
94 INT61341 Positive_regulation of Prep 12 0.63 6.08 3.37 30.12
95 INT332592 Binding of MND1 1 0.08 9.21 0.16 29.92
96 INT3911 Gene_expression of TNFAIP1 29 0.65 21.68 1.85 28.76
97 INT703 Positive_regulation of Pth 177 0.70 127.09 27.26 27.64
98 INT22715 Positive_regulation of Gene_expression of Pth 29 0.64 22.53 2.31 27.64
99 INT6624 Gene_expression of Pth 135 0.76 110.27 27.54 27.04
100 INT16618 Negative_regulation of SERPING1 81 0.59 86.28 7.17 25.36
101 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 25.00
102 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 22.64
103 INT202053 Regulation of URB1 2 0.06 4.52 0.34 21.52
104 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 20.96
105 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 20.60
106 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 20.52
107 INT190833 Regulation of KCNA1 8 0.53 6.61 4.66 20.16
108 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 18.32
109 INT24978 Binding of SFTPA1 22 0.47 15.09 7.76 14.56
110 INT37105 Binding of CHRNE 3 0.31 6.88 0.87 14.28
111 INT860 Regulation of ALB 48 0.60 25.11 8.95 13.88
112 INT10824 Negative_regulation of Cyp19a1 38 0.57 25.18 3.56 12.08
113 INT81347 Regulation of Cyp19a1 7 0.40 2.1 1.94 11.20
114 INT196308 Positive_regulation of Binding of Tcm 2 0.42 0.49 0.09 10.40
115 INT109102 Binding of Tcm 13 0.39 3.67 0.58 10.04
116 INT146784 Gene_expression of MYOD1 13 0.74 4.41 0.54 9.36
117 INT10214 Gene_expression of VIM 153 0.78 115.88 16.29 7.92
118 INT302520 Negative_regulation of Gene_expression of Slc28a1 2 0.12 1.85 0.19 5.48
119 INT212624 Gene_expression of Slc28a1 9 0.53 3.47 0.44 5.12
120 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
121 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
122 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
123 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
124 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
125 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
126 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
127 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
128 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
129 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
130 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 5.00
131 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
132 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
133 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
134 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
135 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
136 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 5.00
137 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 5.00
138 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 5.00
139 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
140 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
141 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
142 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
143 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
144 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
145 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
146 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
147 INT27954 Positive_regulation of Gene_expression of Ngf 87 0.70 57.91 51.96 5.00
148 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 5.00
149 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
150 INT2463 Localization of CCK 101 0.81 37.54 47.59 5.00
151 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
152 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
153 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
154 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
155 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02 5.00
156 INT89 Positive_regulation of Gast 187 0.70 80.49 42.07 5.00
157 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
158 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
159 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
160 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
161 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38 5.00
162 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
163 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
164 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
165 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
166 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
167 INT55737 Positive_regulation of MMP2 101 0.68 59.11 27.71 5.00
168 INT5206 Gene_expression of AR 316 0.78 113.83 27.29 5.00
169 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
170 INT111081 Gene_expression of CA1 19 0.75 51.09 26.64 5.00
171 INT2609 Localization of ELANE 111 0.81 50.22 26.63 5.00
172 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
173 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14 5.00
174 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
175 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 5.00
176 INT48235 Negative_regulation of NPEPPS 72 0.46 44.54 25.03 5.00
177 INT151758 Gene_expression of PYCARD 91 0.63 14.54 24.27 5.00
178 INT22708 Gene_expression of MUC1 297 0.78 232.71 24.19 5.00
179 INT10835 Regulation of IL8 79 0.49 53.04 24.14 5.00
180 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 5.00
181 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
182 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
183 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 5.00
184 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 5.00
185 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
186 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 5.00
187 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 5.00
188 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46 5.00
189 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
190 INT70970 Binding of COPD 144 0.42 180.34 18.29 5.00
191 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
192 INT48238 Regulation of Gene_expression of Ngf 25 0.62 11.48 16.42 5.00
193 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 5.00
194 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
195 INT1154 Negative_regulation of CCK 24 0.59 9.3 15.32 5.00
196 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
197 INT18773 Localization of ALB 117 0.80 69.18 13.8 5.00
198 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
199 INT81629 Positive_regulation of Fas 58 0.70 59.63 12.94 5.00
200 INT2673 Negative_regulation of PROC 93 0.57 50.34 12.79 5.00
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