D:Holoprosencephaly

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Disease Term
Synonyms ALOBAR HOLOPROSENCEPHALIES, Alobar Holoprosencephaly, Arhinencephalies, Arhinencephaly, Familial Alobar Holoprosencephaly, Hereditary Alobar Holoprosencephaly, Holoprosencephalies, Holoprosencephalies Alobar, Holoprosencephalies Lobar, Holoprosencephalies Semilobar, Holoprosencephaly Alobar
Documents 12
Hot Single Events 9
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Holoprosencephaly. They are ordered first by their relevance to Holoprosencephaly and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT60181 Binding of HTR5A and Pik3c3 1 0.03 0.1 0.29 100.00
2 INT302364 Binding of Arx and Reln 1 0.32 1.25 0 48.16
3 INT302370 Binding of Arx and Dcx 1 0.35 1.25 0 48.16
4 INT302373 Binding of Arx and Tuba1a 1 0.30 1.26 0 48.16
5 INT302368 Binding of Arx and Pafah1b1 1 0.27 1.25 0 48.16
6 INT36683 Gh1 Regulation of Gnrhr 3 0.08 1.25 0.95 5.00
7 INT261378 Nsdhl Negative_regulation of Gene_expression of Flvcr2 1 0.01 0.34 0.7 5.00
8 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58 5.00
9 INT36684 Gh1 Regulation of Prl 2 0.18 1.25 0.48 5.00
10 INT302369 Binding of Arx and Dlx1 1 0.34 0 0.43 5.00
11 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41 5.00
12 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41 5.00
13 INT302371 Dlx1 Regulation of Gene_expression of Arx 1 0.28 0 0.35 5.00
14 INT261375 Binding of Nsdhl and Pparg 1 0.05 1.03 0.25 5.00
15 INT261394 Nsdhl Negative_regulation of nt 1 0.01 1.69 0.24 5.00
16 INT261389 Nsdhl Positive_regulation of Esr2 1 0.06 1.04 0.23 5.00
17 INT302367 Dlx2 Regulation of Gene_expression of Arx 1 0.59 0.23 0.22 5.00
18 INT261373 Nsdhl Positive_regulation of Gene_expression of Gfap 1 0.10 2.05 0.19 5.00
19 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19 5.00
20 INT302372 Arx Negative_regulation of Gene_expression of Calb2 1 0.13 0.05 0.18 5.00
21 INT261400 Binding of nt and ADHD1 1 0.00 1.69 0.18 5.00
22 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18 5.00
23 INT261384 Nsdhl Negative_regulation of Gene_expression of Mbp 1 0.01 1.43 0.14 5.00
24 INT261381 Nsdhl Regulation of Gene_expression of S100b 1 0.06 0.82 0.13 5.00
25 INT261390 Binding of Nsdhl and Bdnf 1 0.05 1.33 0.12 5.00
26 INT261380 Nsdhl Negative_regulation of P4hb 1 0.02 1.36 0.11 5.00
27 INT261379 Nsdhl Positive_regulation of Thra 1 0.07 1.12 0.11 5.00
28 INT261391 Binding of Nsdhl and P4hb 1 0.02 1.3 0.1 5.00
29 INT261398 Nsdhl Positive_regulation of Binding of Nsdhl and Med1 1 0.01 2.14 0.09 5.00
30 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09 5.00
31 INT261371 Nsdhl Negative_regulation of Positive_regulation of Bdnf 1 0.06 1.18 0.09 5.00
32 INT261376 Nsdhl Positive_regulation of Gene_expression of Nrgn 1 0.06 0.86 0.08 5.00
33 INT261399 Nsdhl Positive_regulation of Binding of Nsdhl and Syn1 1 0.00 0.65 0.07 5.00
34 INT261386 Nsdhl Positive_regulation of Map2 1 0.08 0.59 0.07 5.00
35 INT261395 Nsdhl Positive_regulation of Syn1 1 0.00 0.59 0.07 5.00
36 INT261392 Binding of Nsdhl and Syn1 1 0.00 0.65 0.07 5.00
37 INT261385 LH Regulation of Localization of Nsdhl 1 0.02 0.65 0.05 5.00
38 INT261382 Nsdhl Regulation of Il6 1 0.03 0.66 0.04 5.00
39 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04 5.00
40 INT261388 Nsdhl Regulation of Lif 1 0.08 0.67 0.04 5.00
41 INT261377 Nsdhl Positive_regulation of Lif 1 0.08 0.6 0.03 5.00
42 INT261383 Nsdhl Positive_regulation of Gene_expression of Il4 1 0.03 0.46 0.03 5.00
43 INT261355 Gh1 Regulation of Oxt 1 0.00 1.38 0 5.00
44 INT261357 Negative_regulation of Gh1 Regulation of Gnrhr 1 0.00 1.26 0 5.00
45 INT261356 Gh1 Regulation of Avp 1 0.00 1.38 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Holoprosencephaly. They are ordered first by their pain relevance and then by number of times they were reported in Holoprosencephaly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 100.00
2 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65 100.00
3 INT60174 Positive_regulation of Pik3c3 12 0.67 1.05 3.23 100.00
4 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44 99.92
5 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77 99.92
6 INT350 Localization of Th 79 0.80 10.26 41.17 99.76
7 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07 93.28
8 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83 92.40
9 INT142118 Regulation of Gene_expression of Runx2 2 0.61 2.92 0 80.60
10 INT5011 Negative_regulation of Gal 30 0.57 9.88 11.49 76.04
11 INT98111 Negative_regulation of Gdnf 12 0.59 10.85 9.29 76.04
12 INT142117 Regulation of Runx2 6 0.61 2.75 0.22 66.32
13 INT265814 Localization of Runx2 1 0.75 0.84 0 66.32
14 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19 61.52
15 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36 60.56
16 INT265823 Binding of WHSC1 1 0.08 1.17 0 56.12
17 INT29231 Regulation of Dbp 44 0.53 10.08 4.47 52.36
18 INT256628 Regulation of Nsdhl 2 0.11 4.12 0.43 52.36
19 INT261363 Negative_regulation of Gene_expression of Ptprg 1 0.01 0.84 0.31 48.68
20 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72 48.16
21 INT33884 Gene_expression of Ptprg 3 0.59 0.83 1.07 48.16
22 INT26248 Positive_regulation of Ptprg 12 0.40 1.42 9.48 38.88
23 INT43484 Binding of Runx2 7 0.37 3.22 0.95 30.88
24 INT265813 Regulation of Binding of Runx2 1 0.27 0.19 0 30.88
25 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 5.00
26 INT162 Regulation of Prl 794 0.62 165.01 322.24 5.00
27 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
28 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 5.00
29 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
30 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
31 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
32 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
33 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
34 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
35 INT4207 Regulation of Avp 267 0.62 63.72 115.33 5.00
36 INT1898 Regulation of Crh 220 0.62 61.33 102.64 5.00
37 INT2155 Negative_regulation of Sst 111 0.59 16.58 77.74 5.00
38 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16 5.00
39 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42 5.00
40 INT10359 Gene_expression of Ifng 159 0.78 79.6 72.14 5.00
41 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67 5.00
42 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 5.00
43 INT451 Regulation of Oxt 142 0.62 22.07 69.42 5.00
44 INT1782 Regulation of Gh1 125 0.62 22 55.74 5.00
45 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
46 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
47 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
48 INT60388 Gene_expression of Helt 90 0.07 19.18 41.72 5.00
49 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
50 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47 5.00
51 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 5.00
52 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
53 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 5.00
54 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
55 INT56224 Negative_regulation of Gene_expression of Ifng 40 0.58 23.34 25.08 5.00
56 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42 5.00
57 INT29704 Regulation of Casp3 51 0.56 22.13 22.79 5.00
58 INT84732 Positive_regulation of Hand2 81 0.69 62.07 22 5.00
59 INT5533 Binding of Oxt 43 0.48 8.69 18.35 5.00
60 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1 5.00
61 INT14887 Gene_expression of Mbp 55 0.75 36.13 16.11 5.00
62 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 5.00
63 INT6381 Negative_regulation of Chat 51 0.59 19.68 15.86 5.00
64 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
65 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 5.00
66 INT11945 Regulation of Chat 38 0.62 7.75 14.97 5.00
67 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
68 INT21646 Positive_regulation of Npy 40 0.70 31.31 13.57 5.00
69 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27 5.00
70 INT107875 Phosphorylation of Stat3 49 0.80 13.18 12.66 5.00
71 INT94464 Negative_regulation of Hand1 44 0.41 31.5 12.39 5.00
72 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 5.00
73 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35 5.00
74 INT14334 Negative_regulation of Il2 31 0.58 18.63 11.08 5.00
75 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 5.00
76 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53 5.00
77 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48 5.00
78 INT21794 Positive_regulation of Gene_expression of Npy 20 0.70 8.44 9.3 5.00
79 INT64346 Positive_regulation of S100B 95 0.70 63.11 9.17 5.00
80 INT70303 Negative_regulation of Il4 19 0.52 12.9 8.54 5.00
81 INT93673 Transcription of Creb1 19 0.66 9.27 8.26 5.00
82 INT200874 Positive_regulation of Localization of Gopc 27 0.38 5.69 7.5 5.00
83 INT111056 Negative_regulation of Gene_expression of Flvcr2 9 0.13 4.15 7.18 5.00
84 INT48239 Binding of Gtf3a 52 0.33 23.14 6.45 5.00
85 INT129918 Positive_regulation of Phosphorylation of Stat3 17 0.63 5.42 6.28 5.00
86 INT185252 Gene_expression of Dlx2 7 0.71 8.8 6.24 5.00
87 INT23465 Gene_expression of S100b 31 0.76 15.09 6.2 5.00
88 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05 5.00
89 INT3276 Binding of LH 16 0.37 4.76 5.94 5.00
90 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69 5.00
91 INT302338 Gene_expression of Arx 1 0.77 2.8 4.93 5.00
92 INT37335 Gene_expression of Nsdhl 45 0.51 24.36 4.58 5.00
93 INT75629 Gene_expression of Mtap2 41 0.66 8.19 4.51 5.00
94 INT94863 Gene_expression of Litaf 27 0.65 10.21 4.35 5.00
95 INT15450 Positive_regulation of Gene_expression of Cpe 11 0.34 4.53 4.34 5.00
96 INT113137 Positive_regulation of Ppp1r1b 14 0.65 0.89 4.21 5.00
97 INT117205 Transcription of Esr1 23 0.65 9.4 4.14 5.00
98 INT196736 Gene_expression of Ppp1r1b 24 0.55 2.01 3.99 5.00
99 INT77385 Gene_expression of Esr2 18 0.75 4.69 3.92 5.00
100 INT92017 Regulation of Gene_expression of Flvcr2 3 0.18 1.69 3.75 5.00
101 INT20422 Regulation of Gap43 10 0.61 5.24 3.73 5.00
102 INT37532 Positive_regulation of Bst1 5 0.40 2.23 3.37 5.00
103 INT73918 Transcription of Esr1 21 0.66 8.74 3.12 5.00
104 INT82168 Positive_regulation of S100b 20 0.68 9.72 3.08 5.00
105 INT88273 Gene_expression of Drd4 6 0.54 1.84 3.01 5.00
106 INT98686 Gene_expression of Calb2 28 0.51 12.07 2.84 5.00
107 INT7978 Positive_regulation of Nsdhl 9 0.43 5.6 2.63 5.00
108 INT178888 Gene_expression of CHDH 41 0.65 38.66 2.51 5.00
109 INT63394 Gene_expression of Drd5 7 0.76 1.85 2.3 5.00
110 INT302340 Positive_regulation of Gene_expression of Dlx2 2 0.64 3.43 2.15 5.00
111 INT197681 Binding of CHDH 40 0.48 33.72 2.13 5.00
112 INT19747 Regulation of Egf 14 0.46 4.67 1.68 5.00
113 INT139164 Gene_expression of Nrgn 6 0.72 1.31 1.59 5.00
114 INT138083 Positive_regulation of Gene_expression of Drd4 2 0.40 1.34 1.55 5.00
115 INT60172 Gene_expression of Htr5b 4 0.75 2.76 1.45 5.00
116 INT302345 Positive_regulation of Gene_expression of Arx 1 0.69 1.06 1.4 5.00
117 INT96643 Positive_regulation of Gene_expression of Gad2 3 0.49 0.15 1.18 5.00
118 INT63393 Positive_regulation of Gene_expression of Drd5 3 0.49 1.21 1.02 5.00
119 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9 5.00
120 INT29762 Negative_regulation of P4hb 4 0.21 1.41 0.86 5.00
121 INT73914 Negative_regulation of Transcription of Esr1 3 0.39 0.75 0.84 5.00
122 INT122472 Positive_regulation of Positive_regulation of Npy 6 0.51 2.66 0.83 5.00
123 INT302342 Localization of Arx 1 0.80 0.94 0.83 5.00
124 INT60170 Localization of Htr5b 1 0.73 9.57 0.83 5.00
125 INT294805 Gene_expression of Dlx1 4 0.70 0.45 0.81 5.00
126 INT84979 Regulation of CHDH 22 0.38 22.34 0.78 5.00
127 INT139165 Negative_regulation of Nrgn 1 0.54 1.08 0.76 5.00
128 INT28278 Positive_regulation of Binding of Oxt 2 0.43 0.75 0.76 5.00
129 INT186941 Localization of Nsdhl 2 0.46 2.7 0.74 5.00
130 INT60175 Binding of Htr5b 2 0.36 0.07 0.74 5.00
131 INT73917 Regulation of Transcription of Esr1 4 0.25 1.5 0.7 5.00
132 INT261350 Positive_regulation of Ifi205 1 0.02 0.13 0.66 5.00
133 INT302339 Regulation of Arx 1 0.45 1.23 0.66 5.00
134 INT196774 Positive_regulation of Gene_expression of Ppp1r1b 4 0.31 0.29 0.56 5.00
135 INT261352 Gene_expression of Ifi205 2 0.19 0.39 0.54 5.00
136 INT158440 Negative_regulation of Nsdhl 4 0.21 3.22 0.51 5.00
137 INT168225 Gene_expression of ge 3 0.12 0.09 0.5 5.00
138 INT302344 Localization of ge 1 0.04 0 0.47 5.00
139 INT150497 Regulation of Bst1 2 0.24 0.99 0.47 5.00
140 INT302337 Positive_regulation of Gene_expression of ge 1 0.03 0 0.46 5.00
141 INT217265 Positive_regulation of Gene_expression of Litaf 3 0.06 1.42 0.46 5.00
142 INT248207 Positive_regulation of Calb2 3 0.20 0.49 0.46 5.00
143 INT261353 Negative_regulation of Gene_expression of Nsdhl 1 0.17 0.71 0.43 5.00
144 INT302335 Gene_expression of Ebf1 1 0.55 0 0.41 5.00
145 INT302352 Positive_regulation of Binding of Dlx1 1 0.45 0 0.4 5.00
146 INT302343 Negative_regulation of Arx 1 0.51 0.76 0.4 5.00
147 INT7979 Binding of Nsdhl 6 0.30 3.71 0.4 5.00
148 INT302357 Binding of Dlx1 1 0.33 0 0.39 5.00
149 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38 5.00
150 INT186535 Negative_regulation of Gene_expression of Esr2 2 0.25 1.07 0.38 5.00
151 INT302351 Regulation of Gene_expression of Arx 1 0.45 0 0.35 5.00
152 INT186939 Positive_regulation of Positive_regulation of Nsdhl 2 0.31 0.86 0.34 5.00
153 INT60171 Transcription of Htr5b 1 0.52 0 0.34 5.00
154 INT60173 Negative_regulation of Localization of Htr5b 1 0.41 0 0.33 5.00
155 INT60179 Negative_regulation of Localization of HTR5A 1 0.41 0 0.33 5.00
156 INT147895 Regulation of Nrgn 2 0.57 1.05 0.32 5.00
157 INT302349 Regulation of Negative_regulation of Arx 1 0.39 0.27 0.31 5.00
158 INT302362 Positive_regulation of Positive_regulation of Calb2 1 0.11 0.12 0.3 5.00
159 INT60180 Localization of HTR5A 1 0.73 0 0.3 5.00
160 INT294806 Gene_expression of Dlx5 6 0.71 2.07 0.3 5.00
161 INT55142 Positive_regulation of P4hb 3 0.36 1.38 0.28 5.00
162 INT302358 Positive_regulation of Gene_expression of Calb2 1 0.12 0.11 0.27 5.00
163 INT302350 Negative_regulation of Gene_expression of Arx 1 0.58 0.26 0.26 5.00
164 INT244750 Gene_expression of Dbx1 2 0.46 0 0.21 5.00
165 INT261365 Binding of Tgs1 2 0.04 1.96 0.19 5.00
166 INT302346 Positive_regulation of Gene_expression of Ebf1 1 0.41 0 0.18 5.00
167 INT206946 Gene_expression of Rxra 4 0.60 2.2 0.17 5.00
168 INT302359 Gene_expression of Ebf3 1 0.63 0.11 0.14 5.00
169 INT302356 Binding of Arx 1 0.37 0.07 0.13 5.00
170 INT196324 Localization of Cyp2b10 5 0.73 2.81 0.13 5.00
171 INT206915 Regulation of Gene_expression of Nsdhl 2 0.22 1 0.13 5.00
172 INT302341 Positive_regulation of Arx 1 0.44 0.4 0.11 5.00
173 INT261366 Binding of P4hb 1 0.04 1.3 0.1 5.00
174 INT302347 Transcription of Arx 1 0.53 0.33 0.09 5.00
175 INT261354 Binding of Ssr4 1 0.02 1.1 0.09 5.00
176 INT206912 Positive_regulation of Gene_expression of Nsdhl 2 0.25 1.59 0.09 5.00
177 INT261361 Negative_regulation of Esr2 1 0.15 0.67 0.09 5.00
178 INT211942 Transcription of Runx2 3 0.69 2.46 0.08 5.00
179 INT140943 Positive_regulation of Ncoa1 3 0.67 1.96 0.08 5.00
180 INT302354 Gene_expression of Xic 1 0.02 0.08 0.08 5.00
181 INT261368 Negative_regulation of Ncs1 1 0.03 1.33 0.07 5.00
182 INT261349 Negative_regulation of Syn1 1 0.01 0.72 0.06 5.00
183 INT233259 Binding of LBX1 2 0.01 0.63 0.04 5.00
184 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04 5.00
185 INT261369 Positive_regulation of Positive_regulation of Tgfb3 1 0.08 1.14 0.03 5.00
186 INT208282 Positive_regulation of Vcan 2 0.13 1.02 0.03 5.00
187 INT261362 Positive_regulation of Tgfb3 1 0.08 1.14 0.03 5.00
188 INT302374 Binding of DLG3 1 0.04 1.08 0 5.00
189 INT302361 Positive_regulation of Localization of Arx 1 0.46 0.15 0 5.00
190 INT302375 Regulation of Binding of LBX1 1 0.01 0.45 0 5.00
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