D:Hyalinosis

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms HYALINE DEGENERATION, HYALINE THICKENING, Hyalinization, Hyalinosis Cutis Et Mucosae, Lipoid Proteinosis, Lipoidproteinoses, LIPOIDPROTEINOSIS, Lipoproteinoses, Lipoproteinosis, Urbach Wiethe Syndrome
Documents 121
Hot Single Events 34
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyalinosis. They are ordered first by their relevance to Hyalinosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT206764 Binding of AQP4 and Nqo1 8 0.05 13.45 2.84 82.88
2 INT140172 Binding of Nqo1 and IgG 5 0.17 6.68 1.2 63.32
3 INT235975 Binding of AQP4 and IgG 2 0.04 4.11 0.53 63.32
4 INT327789 Binding of IgG and Alms1 1 0.01 1.1 0.17 63.32
5 INT327790 Binding of Nqo1 and Alms1 1 0.00 1.1 0.17 63.32
6 INT327791 Binding of AQP4 and Alms1 1 0.03 1.1 0.17 63.32
7 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 23.60
8 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 22.84
9 INT277811 Binding of CD28 and DCPS 1 0.04 0.05 0 21.92
10 INT277809 Binding of CD4 and CD40LG 1 0.15 0 0 9.12
11 INT292882 Binding of S100A12 and TP63 1 0.06 0.51 0 9.08
12 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
13 INT246360 Binding of Cea and Muc6 1 0.00 1.09 0.12 5.00
14 INT246362 Binding of MUC2 and Cea 1 0.00 1.08 0.12 5.00
15 INT327792 Binding of IGFALS and Alms1 1 0.00 1.15 0.11 5.00
16 INT282684 FECH Positive_regulation of Negative_regulation of Ssbp3 1 0.00 1.54 0.08 5.00
17 INT277807 CD40LG Regulation of CD40 1 0.21 0.17 0.08 5.00
18 INT341680 Binding of DES and Vim 1 0.02 0.59 0.06 5.00
19 INT227072 Binding of LTF and PTPRC 1 0.00 0.51 0.04 5.00
20 INT340379 Binding of Rabep1 and Ocrl 1 0.08 0.62 0 5.00
21 INT340380 Binding of Cfl1 and Clcn4-2 1 0.13 0.82 0 5.00
22 INT320848 Binding of Npc1 and Npc2 1 0.39 0 0 5.00
23 INT340378 Binding of Cfl1 and Clcn5 1 0.15 0.82 0 5.00
24 INT277808 Binding of APCS and CD80 1 0.11 0.07 0 5.00
25 INT340377 Binding of Clcn4-2 and Clcn5 1 0.35 0.82 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyalinosis. They are ordered first by their pain relevance and then by number of times they were reported in Hyalinosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 100.00
2 INT2120 Gene_expression of CD79A 159 0.78 111.69 17.16 98.48
3 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 98.28
4 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 98.28
5 INT330537 Gene_expression of CAMK1G 1 0.03 1.02 0.12 98.28
6 INT27935 Binding of Vim 21 0.36 15.65 2.61 97.96
7 INT756 Gene_expression of C3 138 0.75 100.6 19.2 97.92
8 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 97.76
9 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 97.44
10 INT250282 Negative_regulation of AQP4 32 0.54 32.96 9.07 95.28
11 INT11775 Gene_expression of Ema 39 0.65 38.12 2.99 93.68
12 INT48219 Gene_expression of SLC4A1 34 0.75 33.18 2.84 93.68
13 INT48217 Gene_expression of SLC4A3 22 0.75 21.12 2.17 93.68
14 INT48218 Gene_expression of KRIT1 16 0.75 7.59 1.8 93.68
15 INT85983 Gene_expression of ELSPBP1 3 0.29 1.32 0.08 93.68
16 INT591 Negative_regulation of Serpinc1 44 0.57 31.73 8.82 93.36
17 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 92.60
18 INT51607 Positive_regulation of DES 33 0.67 32.24 3.29 92.16
19 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 91.56
20 INT242264 Binding of ACAT1 3 0.12 1.05 0.06 90.32
21 INT4988 Gene_expression of KRT1 64 0.77 43.4 4.12 88.84
22 INT36201 Gene_expression of ETFA 8 0.66 9.18 0.58 88.32
23 INT70273 Gene_expression of CALB2 9 0.75 7.85 2.54 88.12
24 INT113147 Positive_regulation of Acta2 6 0.34 4.24 1.66 87.92
25 INT320500 Gene_expression of CA5A 4 0.58 3.45 0.28 87.52
26 INT49325 Gene_expression of Cd34 102 0.78 82.75 8.97 86.96
27 INT105781 Positive_regulation of Krt7 4 0.04 3.34 0.3 86.88
28 INT249062 Positive_regulation of Positive_regulation of DES 1 0.49 1.29 0.03 86.88
29 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 85.52
30 INT105782 Positive_regulation of Krt20 9 0.20 9.62 0.53 85.40
31 INT204122 Gene_expression of GJA8 13 0.47 22.98 3.04 85.28
32 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 85.04
33 INT157959 Binding of AQP4 32 0.48 43.44 7.44 82.88
34 INT58192 Positive_regulation of MRI1 86 0.61 53.81 24.68 81.60
35 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 79.56
36 INT47555 Positive_regulation of endogenous protoporphyrin 1 0.21 0.98 0.1 79.20
37 INT153300 Negative_regulation of Gene_expression of CRP 48 0.58 39.97 7.58 78.08
38 INT180497 Binding of MRI1 45 0.42 28.35 14.77 75.76
39 INT251679 Negative_regulation of Gene_expression of AQP4 2 0.38 10.37 0.77 74.20
40 INT140413 Gene_expression of AQP4 113 0.78 139.25 25.53 73.88
41 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 69.92
42 INT327780 Negative_regulation of Negative_regulation of AQP4 1 0.33 1.12 0.18 69.16
43 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 66.24
44 INT140414 Positive_regulation of AQP4 25 0.64 23.43 2.47 64.80
45 INT8694 Binding of Lgals3 38 0.48 14.82 8.05 64.68
46 INT160392 Negative_regulation of Tnfrsf8 2 0.08 3.06 0.12 63.04
47 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 62.00
48 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 62.00
49 INT98096 Positive_regulation of CHKA 14 0.42 12.23 1.61 62.00
50 INT58571 Positive_regulation of ALDOB 6 0.49 5.63 0.53 62.00
51 INT157960 Regulation of AQP4 11 0.48 21.36 3.06 60.32
52 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 59.36
53 INT353564 Localization of SELENBP1 1 0.75 1.09 0 59.36
54 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 56.48
55 INT56817 Regulation of Eno2 16 0.61 10.64 1.99 55.28
56 INT23955 Regulation of Vim 16 0.25 14.21 2.04 53.04
57 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52 52.80
58 INT12082 Localization of IL6 365 0.81 241.78 105.78 52.36
59 INT23775 Regulation of S100B 24 0.62 16.75 2.57 52.24
60 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 50.80
61 INT92941 Binding of ASAP1 24 0.39 12.38 1.25 44.20
62 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 43.88
63 INT191534 Negative_regulation of EGFL7 10 0.06 7.52 1.98 43.72
64 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 41.84
65 INT277824 Positive_regulation of TRDC 1 0.02 0.24 0.03 41.80
66 INT37168 Positive_regulation of APCS 22 0.67 9.61 4.59 41.16
67 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 39.88
68 INT140411 Gene_expression of Nqo1 45 0.60 62.35 8.7 33.04
69 INT327776 Negative_regulation of Gene_expression of Nqo1 2 0.02 2.39 0.69 33.04
70 INT183817 Localization of BEST1 6 0.26 5.22 0.16 30.80
71 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 28.24
72 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 27.68
73 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 26.40
74 INT38255 Localization of Chkb 32 0.80 10.98 11.07 25.20
75 INT38348 Positive_regulation of Localization of Chkb 9 0.64 2.75 3.37 25.20
76 INT133354 Regulation of Chkb 9 0.60 4.35 3.15 25.20
77 INT310569 Regulation of Localization of Chkb 3 0.09 1.49 0.49 25.20
78 INT336086 Positive_regulation of Regulation of Chkb 1 0.02 0.19 0 25.20
79 INT16214 Localization of F13A1 36 0.74 21.8 4.87 25.00
80 INT88278 Binding of Kit 33 0.37 24.45 4.13 25.00
81 INT51066 Binding of S100B 24 0.48 13.5 0.97 25.00
82 INT39357 Binding of Afp 5 0.48 3.58 0.85 25.00
83 INT160391 Binding of Tnfrsf8 2 0.07 2.52 0.07 25.00
84 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 24.40
85 INT353566 Positive_regulation of SELENBP1 1 0.70 2.44 0 22.28
86 INT73504 Binding of CD28 35 0.45 15.99 10.04 21.76
87 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 16.92
88 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 16.36
89 INT261207 Binding of NEFL 2 0.06 1.09 0.04 15.68
90 INT82374 Binding of SYP 13 0.36 13.69 0.85 13.60
91 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 13.40
92 INT69264 Gene_expression of KIT 207 0.78 179.41 8.95 13.40
93 INT111477 Gene_expression of KRT7 90 0.74 86.76 4.07 13.40
94 INT157357 Binding of IL2RA 6 0.44 5.18 1.63 12.92
95 INT4133 Binding of Npc1 14 0.47 8.24 0.33 12.56
96 INT336087 Regulation of Alk 1 0.05 0.23 0 11.92
97 INT63640 Gene_expression of SELENBP1 2 0.78 31.15 0.08 11.52
98 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 11.44
99 INT4208 Regulation of Got1 23 0.44 6.72 6.62 11.36
100 INT102729 Gene_expression of APCS 20 0.65 8.86 2.52 11.12
101 INT373 Regulation of Ldha 37 0.61 17.86 11.41 10.96
102 INT84704 Positive_regulation of Nqo1 18 0.70 18.64 5.65 8.44
103 INT36798 Gene_expression of Mki67 178 0.77 132 8.24 8.08
104 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 7.12
105 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
106 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
107 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
108 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
109 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
110 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 5.00
111 INT671 Positive_regulation of Cea 221 0.69 164.5 47.79 5.00
112 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
113 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
114 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
115 INT173693 Localization of Gopc 249 0.65 70.49 38.81 5.00
116 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
117 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 5.00
118 INT11325 Gene_expression of HLA-E 209 0.76 98.05 33.72 5.00
119 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
120 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
121 INT66200 Gene_expression of Gfap 215 0.78 88.04 28.25 5.00
122 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
123 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
124 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
125 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
126 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
127 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
128 INT4369 Gene_expression of Ldha 157 0.76 88.12 22.45 5.00
129 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
130 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 5.00
131 INT170444 Binding of Gopc 172 0.39 45.05 20.71 5.00
132 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
133 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 5.00
134 INT24225 Gene_expression of Alms1 93 0.62 52.75 16.93 5.00
135 INT14587 Positive_regulation of Cl 44 0.20 20.37 16.72 5.00
136 INT170335 Gene_expression of INCENP 176 0.54 91.62 15.31 5.00
137 INT106745 Localization of CRP 65 0.81 66.44 15.21 5.00
138 INT37722 Gene_expression of NCAM1 103 0.75 81.57 14.18 5.00
139 INT36177 Binding of Alms1 70 0.31 35.47 13.81 5.00
140 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
141 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 5.00
142 INT20264 Gene_expression of Chkb 29 0.46 13.14 13.65 5.00
143 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61 5.00
144 INT132178 Binding of CD80 41 0.47 15.55 12.98 5.00
145 INT8224 Gene_expression of CHGA 73 0.75 53.63 12.31 5.00
146 INT69436 Negative_regulation of Gene_expression of ROS1 81 0.38 46.58 12.22 5.00
147 INT79545 Positive_regulation of Gene_expression of ESR1 82 0.64 39.42 12.18 5.00
148 INT148207 Gene_expression of CTLA4 53 0.77 29.13 12.07 5.00
149 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 5.00
150 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 5.00
151 INT25963 Gene_expression of DES 122 0.75 98.81 11.25 5.00
152 INT13240 Gene_expression of TF 94 0.76 57.81 10.99 5.00
153 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 5.00
154 INT32344 Localization of LTF 30 0.80 15.28 10.09 5.00
155 INT19620 Binding of CD86 30 0.47 12.01 9.89 5.00
156 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25 5.00
157 INT2139 Negative_regulation of Cea 55 0.43 43.59 9.14 5.00
158 INT20205 Binding of IgG 108 0.46 66.68 8.57 5.00
159 INT22383 Binding of IL2 59 0.48 39.06 8.56 5.00
160 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52 5.00
161 INT28671 Positive_regulation of Gene_expression of HLA-E 43 0.67 22.85 8.39 5.00
162 INT132278 Binding of CTLA4 32 0.39 18.69 8.17 5.00
163 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 5.00
164 INT95414 Positive_regulation of Alms1 40 0.41 20.3 8.1 5.00
165 INT93914 Gene_expression of CD80 70 0.75 36.35 7.74 5.00
166 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53 5.00
167 INT58365 Gene_expression of LTF 51 0.78 44.14 7.25 5.00
168 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19 5.00
169 INT93003 Binding of CD40 28 0.47 20.25 7.13 5.00
170 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
171 INT140170 Binding of Nqo1 24 0.38 36.16 6.79 5.00
172 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 5.00
173 INT92916 Gene_expression of Acta2 50 0.74 17.52 6.11 5.00
174 INT15132 Gene_expression of TNFRSF1A 33 0.75 20.09 5.93 5.00
175 INT18677 Gene_expression of F3 50 0.65 30.86 5.86 5.00
176 INT52904 Positive_regulation of LTF 21 0.67 15.58 5.78 5.00
177 INT39900 Positive_regulation of Gene_expression of Ldha 36 0.50 20.35 5.22 5.00
178 INT22597 Positive_regulation of TF 43 0.68 27.27 5.17 5.00
179 INT19187 Gene_expression of Lgals3 24 0.73 19.72 5.03 5.00
180 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
181 INT191343 Gene_expression of IDO1 23 0.55 11.3 4.81 5.00
182 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8 5.00
183 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73 5.00
184 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 5.00
185 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58 5.00
186 INT133630 Negative_regulation of Gene_expression of ESR1 42 0.52 23.89 4.57 5.00
187 INT79902 Gene_expression of AQP1 33 0.78 24.72 4.55 5.00
188 INT142488 Positive_regulation of Gene_expression of Chkb 7 0.23 4.09 4.54 5.00
189 INT203050 Binding of PDCD1 12 0.48 12.93 4.5 5.00
190 INT141665 Gene_expression of AGRP 83 0.67 43.43 4.24 5.00
191 INT72747 Localization of IgG 55 0.53 30.88 4.19 5.00
192 INT138872 Gene_expression of SPINK5 21 0.58 30.11 4.12 5.00
193 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1 5.00
194 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07 5.00
195 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 5.00
196 INT14880 Positive_regulation of Car3 14 0.65 9.19 3.73 5.00
197 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 5.00
198 INT36799 Negative_regulation of Ighm 21 0.41 17.47 3.65 5.00
199 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3 5.00
200 INT55002 Gene_expression of ASAP1 46 0.64 22.8 3.2 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox