D:Hyperacusis

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pChart

Disease Term
Synonyms Auditory Hyperesthesia, AUDITORY HYPERESTHESIAS, Disturbance Loudness Perception, Disturbances Loudness Perception, HYPERACUSES, Hyperacusia, Hyperacusias, Hyperesthesia Auditory, Hyperesthesias Auditory, LOUDNESS PERCEPTION DISTURBANCE, Loudness Perception Disturbances
Documents 273
Hot Single Events 14
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperacusis. They are ordered first by their relevance to Hyperacusis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT342165 Binding of Aqp1 and Nav1 1 0.25 0.57 1.25 5.00
2 INT262367 Tcas1 Positive_regulation of Localization of Adh4 1 0.01 1.91 1.01 5.00
3 INT176010 Binding of MTHFR and ZNF677 1 0.00 0.7 0.5 5.00
4 INT176009 Binding of GRHPR and ZNF677 1 0.00 0.57 0.36 5.00
5 INT342164 Binding of Csf2 and Nkx2-1 1 0.01 0.52 0.26 5.00
6 INT342163 Nkx2-1 Regulation of Gene_expression of Aqp1 1 0.06 0.51 0.2 5.00
7 INT313273 Binding of GRIN1 and MAP2 1 0.16 0.79 0.04 5.00
8 INT308927 Gtf2i Positive_regulation of Gene_expression of Parp1 1 0.24 0 0 5.00
9 INT313271 Binding of GRIN1 and GRIN2B 1 0.24 0.06 0 5.00
10 INT313272 Binding of DLG4 and GRIN1 1 0.09 0.06 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperacusis. They are ordered first by their pain relevance and then by number of times they were reported in Hyperacusis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT105603 Binding of Cpz 2 0.31 1.92 1.54 98.48
2 INT211224 Positive_regulation of Serpind1 8 0.59 12.15 1.8 98.44
3 INT33220 Negative_regulation of ras 110 0.58 70.21 9.19 98.04
4 INT90621 Positive_regulation of Gene_expression of FOSB 3 0.34 2.85 0.83 96.28
5 INT63074 Gene_expression of FOSB 19 0.53 13.58 4.91 95.88
6 INT32579 Binding of C4B 14 0.36 14.99 7.79 92.20
7 INT216065 Localization of C4B 2 0.21 2.86 2.01 92.20
8 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 88.00
9 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 86.56
10 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 81.32
11 INT349975 Positive_regulation of Gene_expression of CCKBR 1 0.12 0.5 0 81.20
12 INT349977 Gene_expression of CCKBR 1 0.16 0.25 0 81.20
13 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 80.76
14 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 80.76
15 INT308914 Binding of Gtf2i 1 0.47 0.99 0.08 78.80
16 INT308905 Gene_expression of Gtf2i 1 0.65 1.73 0.25 76.00
17 INT308910 Gene_expression of Gtf2ird1 2 0.78 2.21 1.09 74.56
18 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 73.88
19 INT21686 Positive_regulation of Gene_expression of ras 19 0.42 13.79 4.28 71.68
20 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 71.68
21 INT93329 Positive_regulation of SRSF1 2 0.13 1.06 0.67 68.48
22 INT131748 Binding of Csad 5 0.32 5.23 3.32 68.32
23 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 68.04
24 INT65375 Positive_regulation of CCKBR 2 0.67 1.71 0.3 68.04
25 INT308909 Negative_regulation of Gtf2ird1 4 0.54 2.13 0.29 67.36
26 INT30317 Regulation of TH 14 0.43 7.27 5.38 66.48
27 INT349979 Negative_regulation of CCKBR 1 0.16 4.34 0.22 62.88
28 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 60.88
29 INT85301 Gene_expression of Ndp 6 0.52 4.19 4.5 59.76
30 INT6761 Binding of CALCA 100 0.48 26.71 62.05 56.76
31 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 55.08
32 INT626 Localization of CALCA 289 0.81 125.39 221.15 55.08
33 INT32581 Positive_regulation of C4B 9 0.45 11.17 9.05 51.20
34 INT285861 Gene_expression of GRM7 1 0.02 2.44 2.04 45.20
35 INT264847 Gene_expression of GRM1 4 0.34 1.88 2.87 43.48
36 INT27627 Binding of Rac1 41 0.41 22.88 13.68 39.72
37 INT308907 Negative_regulation of Gtf2i 1 0.31 1.22 0.16 36.80
38 INT103959 Gene_expression of ATP1A2 3 0.67 2.47 1.68 36.60
39 INT307799 Negative_regulation of Negative_regulation of ras 2 0.25 3 0.03 34.32
40 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 34.00
41 INT285862 Positive_regulation of GRM7 1 0.01 0.8 0.82 34.00
42 INT26462 Gene_expression of DNAH8 44 0.78 19.36 7.31 33.68
43 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 32.92
44 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 32.92
45 INT257964 Gene_expression of GABRE 1 0.60 0.86 0.71 32.32
46 INT349981 Negative_regulation of Negative_regulation of CCKBR 1 0.12 1.14 0.06 32.12
47 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 30.76
48 INT6594 Gene_expression of HTR1D 60 0.75 10.15 27.13 28.32
49 INT349980 Positive_regulation of Positive_regulation of CCKBR 1 0.12 0.59 0.03 27.92
50 INT179654 Positive_regulation of Eln 5 0.44 4.3 0.43 27.12
51 INT308912 Positive_regulation of Gtf2ird1 1 0.46 1.43 0 26.48
52 INT308913 Positive_regulation of Clip2 1 0.42 0.77 0 25.68
53 INT349982 Negative_regulation of Localization of CCKBR 1 0.12 0.61 0.03 24.40
54 INT349978 Localization of CCKBR 1 0.20 0.72 0.07 23.92
55 INT83313 Gene_expression of Htr1b 4 0.75 5.1 5.73 20.80
56 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35 20.36
57 INT116347 Positive_regulation of Positive_regulation of GRIN1 12 0.49 3.63 11.44 17.48
58 INT10847 Gene_expression of LAMC2 39 0.75 27 12.09 17.12
59 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1 16.32
60 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91 16.32
61 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 16.28
62 INT48536 Positive_regulation of Grm8 46 0.61 14.31 23.56 15.92
63 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 15.36
64 INT234493 Gene_expression of sch 5 0.67 3.87 1.22 14.92
65 INT186507 Localization of ATP1A2 2 0.74 3.35 3.04 12.08
66 INT186510 Localization of KCNN3 3 0.75 1.6 1.66 9.92
67 INT157927 Gene_expression of Scn1a 5 0.64 6.55 2.02 7.12
68 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
69 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 5.00
70 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
71 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 5.00
72 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 5.00
73 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 5.00
74 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 5.00
75 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
76 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
77 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 5.00
78 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 5.00
79 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
80 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
81 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
82 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
83 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 5.00
84 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 5.00
85 INT2541 Binding of Calca 200 0.48 67.14 134.62 5.00
86 INT1026 Binding of Lbp 207 0.48 150.96 119.16 5.00
87 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
88 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
89 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
90 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79 5.00
91 INT74376 Gene_expression of Cnr1 173 0.78 73.43 89.7 5.00
92 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88 5.00
93 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
94 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 5.00
95 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
96 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
97 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 5.00
98 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 5.00
99 INT19488 Localization of ABAT 56 0.69 21.51 50.56 5.00
100 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
101 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
102 INT4776 Localization of TAC1 82 0.78 16.89 45.21 5.00
103 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
104 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 5.00
105 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
106 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
107 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5 5.00
108 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
109 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
110 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
111 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 5.00
112 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
113 INT104567 Gene_expression of Aqp1 47 0.78 44.84 28.68 5.00
114 INT154007 Gene_expression of da 46 0.56 15.28 28.22 5.00
115 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
116 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46 5.00
117 INT75418 Negative_regulation of Cnr1 41 0.59 14.65 27.28 5.00
118 INT36428 Binding of Chdh 42 0.47 48.04 26.54 5.00
119 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94 5.00
120 INT6270 Binding of HTR1D 55 0.47 9.54 22.86 5.00
121 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 5.00
122 INT109650 Gene_expression of Aqp4 87 0.78 51.52 20.72 5.00
123 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65 5.00
124 INT9782 Binding of HTR1B 43 0.47 12.08 19.83 5.00
125 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 5.00
126 INT12031 Negative_regulation of Car1 44 0.59 20.46 19.36 5.00
127 INT99058 Regulation of PAG1 18 0.45 21.62 18.5 5.00
128 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51 5.00
129 INT111050 Negative_regulation of Gene_expression of Nav1 23 0.58 5.97 17.06 5.00
130 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 5.00
131 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 5.00
132 INT112207 Binding of Nav1 27 0.47 7.1 15.43 5.00
133 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
134 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 5.00
135 INT180497 Binding of MRI1 45 0.42 28.35 14.77 5.00
136 INT63553 Binding of PAG1 14 0.48 12.51 14.76 5.00
137 INT194421 Gene_expression of DCLK3 27 0.40 1.26 13.94 5.00
138 INT6365 Localization of Edn1 56 0.81 18.84 13.83 5.00
139 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
140 INT88365 Regulation of Faah 18 0.45 6.63 12.54 5.00
141 INT50580 Binding of PPIG 39 0.36 11.17 12.34 5.00
142 INT11244 Transcription of CALCA 21 0.69 3.61 12.27 5.00
143 INT104569 Gene_expression of Aqp2 23 0.60 16.56 12.23 5.00
144 INT32054 Gene_expression of Tnc 14 0.59 9.36 12.22 5.00
145 INT102448 Gene_expression of RAMP1 23 0.75 4.62 10.9 5.00
146 INT106565 Negative_regulation of Gene_expression of Cnr1 19 0.59 6.98 9.93 5.00
147 INT6065 Localization of GRIN1 15 0.74 3.15 9.81 5.00
148 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
149 INT73342 Protein_catabolism of Faah 19 0.97 5.11 8.99 5.00
150 INT5359 Protein_catabolism of Abat 12 0.62 5.11 8.54 5.00
151 INT83607 Positive_regulation of CSAD 13 0.59 14.24 8.07 5.00
152 INT75932 Binding of Csf2 45 0.37 33.2 8.01 5.00
153 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75 5.00
154 INT96619 Negative_regulation of CSAD 7 0.36 8.96 7.47 5.00
155 INT102572 Gene_expression of Ccnd1 79 0.69 56.37 7.34 5.00
156 INT327801 Positive_regulation of Gene_expression of Aqp2 6 0.44 7.67 7.24 5.00
157 INT25772 Regulation of HTR1B 15 0.60 3.8 7.17 5.00
158 INT25 Positive_regulation of LAMC2 19 0.67 8.64 7.06 5.00
159 INT264641 Binding of AES 25 0.42 18.56 6.98 5.00
160 INT270 Regulation of MAOA 17 0.60 2.58 6.84 5.00
161 INT138833 Binding of MTHFR 12 0.46 16.08 6.4 5.00
162 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32 5.00
163 INT22187 Localization of HTR1D 6 0.78 5.26 5.97 5.00
164 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89 5.00
165 INT27408 Phosphorylation of POMC 9 0.80 2.18 5.88 5.00
166 INT48004 Positive_regulation of Negative_regulation of PTGS1 12 0.49 4.07 5.87 5.00
167 INT84572 Gene_expression of Zmat3 67 0.07 37.61 5.86 5.00
168 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 5.00
169 INT180035 Positive_regulation of Gene_expression of Chdh 2 0.22 8.21 5.78 5.00
170 INT59969 Positive_regulation of Htr1a 12 0.67 5.07 5.73 5.00
171 INT69944 Positive_regulation of Ndp 7 0.38 4.81 5.6 5.00
172 INT156134 Regulation of Gene_expression of Aqp1 5 0.59 7.2 5.3 5.00
173 INT201130 Localization of AES 31 0.63 25.45 5.12 5.00
174 INT85328 Negative_regulation of Aqp1 5 0.54 6.02 4.94 5.00
175 INT5561 Negative_regulation of GRIN2D 10 0.50 2.46 4.88 5.00
176 INT105256 Positive_regulation of Gene_expression of F2rl1 6 0.68 10.09 4.83 5.00
177 INT98613 Gene_expression of CSAD 7 0.53 7.86 4.8 5.00
178 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73 5.00
179 INT70356 Gene_expression of GRIN2D 10 0.74 2.11 4.7 5.00
180 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 5.00
181 INT160023 Regulation of Aqp4 9 0.45 8.41 4.19 5.00
182 INT102452 Gene_expression of RAMP2 6 0.69 7.11 3.77 5.00
183 INT116220 Localization of HTR1B 5 0.78 1.86 3.75 5.00
184 INT85326 Positive_regulation of Aqp1 7 0.65 5.9 3.71 5.00
185 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 5.00
186 INT17716 Gene_expression of Aldh2 14 0.77 4.38 3.61 5.00
187 INT104570 Localization of Aqp1 8 0.77 5.83 3.51 5.00
188 INT192951 Negative_regulation of AES 15 0.38 6.38 3.5 5.00
189 INT156132 Gene_expression of Aqp9 26 0.49 14.33 3.48 5.00
190 INT86082 Localization of Htr1b 4 0.73 2.77 3.46 5.00
191 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36 5.00
192 INT109448 Negative_regulation of MTHFR 8 0.58 7.62 3.11 5.00
193 INT123815 Gene_expression of Parp1 42 0.67 27.82 3.02 5.00
194 INT262476 Gene_expression of Aqp8 21 0.34 7.94 2.76 5.00
195 INT53755 Positive_regulation of Dcn 8 0.43 2.91 2.74 5.00
196 INT122557 Localization of Chdh 6 0.74 4.44 2.6 5.00
197 INT66002 Binding of LAMC2 9 0.47 4.5 2.54 5.00
198 INT52482 Positive_regulation of PTPRU 5 0.42 0.39 2.27 5.00
199 INT82587 Positive_regulation of Gene_expression of GRIN1 8 0.67 3.66 2.18 5.00
200 INT300260 Localization of AKR1A1 3 0.10 3.1 2.18 5.00
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