D:Hyperaesthesia

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Heightened Sensation, Heightened Sensation Of Skin, Hyperaesthesias, Hyperaesthetic Sensation, Hyperaesthetic Sensations, Hyperesthesia, Hyperesthesia Tactile, Hyperesthesia Thermal, HYPERESTHESIAS, Hyperesthesias Tactile, Hyperesthesias Thermal
Documents 516
Hot Single Events 36
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperaesthesia. They are ordered first by their relevance to Hyperaesthesia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT321602 Binding of C4A and PRTN3 1 0.00 0.99 0.27 87.28
2 INT321601 Binding of C3 and PRTN3 1 0.00 0.99 0.27 86.96
3 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
4 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
5 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
6 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
7 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
8 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
9 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
10 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
11 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
12 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
13 INT240119 Prok2 Regulation of Trem1 1 0.04 0.66 0.13 5.00
14 INT240121 Hdc Regulation of Trem1 1 0.06 0.66 0.13 5.00
15 INT240120 Irg1 Regulation of Trem1 1 0.05 0.66 0.13 5.00
16 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 5.00
17 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 5.00
18 INT320659 Vsig2 Positive_regulation of Transcription of Nos2 1 0.07 0.65 0.07 5.00
19 INT345966 Binding of Arid1a and al44 1 0.00 1.56 0.05 5.00
20 INT345965 Binding of Lep and al44 1 0.01 1.43 0.05 5.00
21 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 5.00
22 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 5.00
23 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 5.00
24 INT240122 Nab2 Regulation of Egr1 1 0.09 0.59 0 5.00
25 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0 5.00
26 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0 5.00
27 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0 5.00
28 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0 5.00
29 INT261844 Lyn Positive_regulation of Lyn Regulation of Trpv4 1 0.01 0.19 0 5.00
30 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperaesthesia. They are ordered first by their pain relevance and then by number of times they were reported in Hyperaesthesia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT25915 Negative_regulation of RPL7AP5 9 0.38 3.56 8.5 100.00
2 INT22700 Positive_regulation of Gene_expression of Tac1 13 0.69 6.89 8.2 99.90
3 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 99.70
4 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15 99.60
5 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.24
6 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 99.24
7 INT240105 Negative_regulation of Prok1 1 0.04 1.12 0.58 98.84
8 INT25057 Positive_regulation of Hmmr 14 0.28 5.09 9.63 98.60
9 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 98.36
10 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 98.36
11 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 98.00
12 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 97.76
13 INT80251 Binding of Nos1 21 0.30 8.24 11.31 97.76
14 INT6385 Regulation of Man2a2 48 0.61 7.8 24.68 97.74
15 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 97.08
16 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 96.50
17 INT51180 Regulation of Nkx2-2 5 0.26 2.16 4.14 96.36
18 INT7039 Regulation of Nkx1-1 22 0.44 10.51 20.89 96.04
19 INT18489 Binding of Man2a2 59 0.48 11.27 29.38 95.20
20 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27 93.96
21 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 92.56
22 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 92.52
23 INT46643 Negative_regulation of HYAL1 7 0.37 4.65 1.55 92.24
24 INT8159 Binding of ELL 7 0.36 12.62 0.84 91.32
25 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 90.96
26 INT7134 Localization of KNG1 127 0.79 65.73 67.97 89.56
27 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 89.12
28 INT756 Gene_expression of C3 138 0.75 100.6 19.2 89.12
29 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 89.12
30 INT102631 Localization of HYAL1 4 0.26 1.79 0.46 89.12
31 INT22707 Positive_regulation of Eno2 36 0.69 27.31 5.07 88.52
32 INT220273 Positive_regulation of Msu 9 0.33 5.83 1.41 85.80
33 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 83.72
34 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 83.52
35 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 80.88
36 INT4422 Positive_regulation of Gene_expression of Alb 30 0.50 18.56 6.12 80.88
37 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 79.72
38 INT11021 Gene_expression of Tme 12 0.52 8.54 0.33 78.40
39 INT15201 Positive_regulation of CHRM1 8 0.54 2.14 2.35 77.76
40 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 77.56
41 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83 76.48
42 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51 76.20
43 INT87181 Gene_expression of Abo 4 0.57 2.81 1.19 74.92
44 INT1254 Gene_expression of Dut 2 0.65 1.71 1.02 73.76
45 INT27446 Negative_regulation of CTSA 11 0.57 5.58 3.08 72.56
46 INT63719 Positive_regulation of Transcription of Hdc 3 0.52 3.91 1.01 72.04
47 INT63716 Transcription of Hdc 10 0.69 7.57 1.82 71.72
48 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 70.96
49 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 70.40
50 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 69.56
51 INT117561 Positive_regulation of Transcription of Tac1 6 0.69 3.19 3.78 69.32
52 INT4723 Transcription of Tac1 26 0.71 8.33 11.18 68.92
53 INT4984 Positive_regulation of Positive_regulation of Tac1 11 0.50 5.34 8.73 67.80
54 INT48642 Positive_regulation of TCEA1 92 0.70 24.59 53.64 67.32
55 INT191589 Gene_expression of Msu 9 0.46 7.08 1.33 66.72
56 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 63.96
57 INT17349 Negative_regulation of Akr1b1 41 0.59 27.03 10.65 63.04
58 INT6063 Positive_regulation of Bche 17 0.66 6.07 3.08 62.60
59 INT163980 Gene_expression of Hdc 12 0.65 4.47 1.96 62.00
60 INT3364 Binding of SGCG 87 0.47 31.93 17.24 61.28
61 INT220276 Negative_regulation of Msu 2 0.16 1.67 0.58 58.08
62 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 57.68
63 INT49009 Regulation of Trpc3 2 0.26 0.29 0.99 57.68
64 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 57.64
65 INT2229 Positive_regulation of Man2a2 50 0.69 7.47 30.33 56.40
66 INT27596 Negative_regulation of Positive_regulation of Man2a2 4 0.42 0.47 1.78 56.40
67 INT222847 Gene_expression of Irg1 2 0.49 2.38 0.51 55.04
68 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 54.72
69 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 54.28
70 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 48.64
71 INT345961 Negative_regulation of D0Ffm3 1 0.03 3.73 0.07 47.72
72 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 47.24
73 INT72523 Regulation of TCEA1 18 0.45 3.19 7.6 46.72
74 INT114830 Positive_regulation of Regulation of TCEA1 2 0.41 0.11 0.94 46.72
75 INT224149 Negative_regulation of Trem1 2 0.37 3.44 0.56 44.60
76 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 44.32
77 INT320654 Negative_regulation of Localization of Vsig2 1 0.24 0.75 0.17 41.48
78 INT7147 Localization of Vsig2 7 0.49 4.42 0.86 40.92
79 INT240115 Regulation of Positive_regulation of Msu 1 0.17 0.5 0.03 39.92
80 INT240110 Positive_regulation of Positive_regulation of Trem1 1 0.25 0.9 0.19 39.84
81 INT146142 Positive_regulation of Trem1 11 0.44 7.75 1.46 39.36
82 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 38.24
83 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 38.08
84 INT64816 Transcription of Jun 31 0.69 16.01 7.64 36.76
85 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 34.20
86 INT144292 Binding of Ppt1 9 0.37 2.02 1.71 33.84
87 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 31.80
88 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61 31.48
89 INT39972 Gene_expression of CPA1 7 0.65 3.17 0.26 31.44
90 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 31.32
91 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 27.60
92 INT34370 Positive_regulation of Cfp 26 0.46 15.21 6.12 26.40
93 INT61845 Transcription of Homer1 9 0.72 2.28 1.85 25.16
94 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 25.00
95 INT165400 Positive_regulation of TST 13 0.68 4.25 0.35 25.00
96 INT308015 Phosphorylation of IFNAR1 1 0.27 1.11 0.28 21.16
97 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 18.28
98 INT240117 Negative_regulation of Gzmd 1 0.13 0.66 0.15 17.64
99 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76 15.44
100 INT345951 Negative_regulation of Arid1a 1 0.10 6.11 0.33 15.44
101 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 15.00
102 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 13.88
103 INT53816 Negative_regulation of Binding of Grin1 2 0.39 0 0.3 13.88
104 INT11246 Binding of Grin1 65 0.48 14.53 36.93 13.44
105 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15 11.60
106 INT240112 Transcription of Trem1 1 0.43 1.52 0.59 6.56
107 INT240116 Positive_regulation of Transcription of Trem1 1 0.29 0.82 0.23 6.56
108 INT2649 Regulation of Calca 433 0.62 146.05 330.95 5.00
109 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
110 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
111 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
112 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
113 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 5.00
114 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 5.00
115 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 5.00
116 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 5.00
117 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
118 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 5.00
119 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
120 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
121 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
122 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
123 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66 5.00
124 INT10166 Localization of Tnf 237 0.81 153.95 88.64 5.00
125 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
126 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
127 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 5.00
128 INT123584 Gene_expression of Trpa1 176 0.78 83 78.65 5.00
129 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
130 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
131 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 5.00
132 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
133 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 5.00
134 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
135 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 5.00
136 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 5.00
137 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 5.00
138 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
139 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 5.00
140 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
141 INT11491 Positive_regulation of KNG1 128 0.67 60.41 58.74 5.00
142 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 5.00
143 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 5.00
144 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 5.00
145 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 5.00
146 INT5623 Positive_regulation of Nppa 174 0.70 69.96 52.33 5.00
147 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 5.00
148 INT121416 Gene_expression of Trpm8 101 0.78 52.7 47.85 5.00
149 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
150 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 5.00
151 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65 5.00
152 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 5.00
153 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 5.00
154 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
155 INT95646 Negative_regulation of Faah 63 0.59 25.61 36.78 5.00
156 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19 5.00
157 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11 5.00
158 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 5.00
159 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 5.00
160 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02 5.00
161 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72 5.00
162 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8 5.00
163 INT8205 Negative_regulation of Nppa 77 0.59 26.43 25.72 5.00
164 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
165 INT112036 Phosphorylation of Trpv1 51 0.82 18.59 25.6 5.00
166 INT13415 Positive_regulation of Hpse 58 0.70 24.9 25.53 5.00
167 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
168 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 5.00
169 INT117600 Positive_regulation of Trpm8 65 0.70 31.96 24.46 5.00
170 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 5.00
171 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72 5.00
172 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25 5.00
173 INT24569 Negative_regulation of Pain1 26 0.41 21.82 21.08 5.00
174 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 5.00
175 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95 5.00
176 INT51474 Binding of Il6 55 0.48 44.99 20.52 5.00
177 INT66281 Transcription of Nos2 81 0.71 39.49 20.37 5.00
178 INT49985 Transcription of Il6 62 0.72 40.13 20.29 5.00
179 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89 5.00
180 INT99058 Regulation of PAG1 18 0.45 21.62 18.5 5.00
181 INT90937 Negative_regulation of Gene_expression of Trpv1 34 0.59 22.74 18.12 5.00
182 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87 5.00
183 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3 5.00
184 INT68681 Transcription of VEGFA 132 0.71 80.47 17.03 5.00
185 INT20216 Localization of NGF 40 0.80 18.16 16.61 5.00
186 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 5.00
187 INT149816 Gene_expression of Prok2 21 0.78 18.99 15.68 5.00
188 INT178828 Regulation of Pain1 12 0.14 16.1 15.64 5.00
189 INT114025 Transcription of Nos1 20 0.70 16.48 15.63 5.00
190 INT3545 Positive_regulation of Mtx1 27 0.42 11.97 14.83 5.00
191 INT10173 Binding of Tnf 45 0.48 35.6 14.32 5.00
192 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16 5.00
193 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99 5.00
194 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61 5.00
195 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34 5.00
196 INT233113 Regulation of Trpm8 24 0.61 18.08 13.17 5.00
197 INT2578 Binding of Ins1 74 0.48 33.57 12.92 5.00
198 INT10870 Regulation of IgG 67 0.59 43.27 12.74 5.00
199 INT121242 Positive_regulation of Gene_expression of Nos3 37 0.69 31.96 12.71 5.00
200 INT96924 Positive_regulation of Hspg2 40 0.49 14.5 12.32 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox