D:Hyperaldosteronism

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Disease Term
Synonyms Aldersteronism, ALDOSTERONISM, Conn S Syndrome, Conn Syndrome, Conns Syndrome, HYPERALDOSTERONISM PRIMARY, Primary Aldersteronism, Primary Hyperaldosteronism, Secondary Aldersteronism, SYNDROME CONN
Documents 119
Hot Single Events 33
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperaldosteronism. They are ordered first by their relevance to Hyperaldosteronism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT177714 Binding of GALNT3 and REN 1 0.01 2.36 0.12 70.88
2 INT263249 Binding of ADD1 and REN 1 0.03 0.82 0 67.20
3 INT263248 Binding of ADD1 and RAPGEF5 1 0.01 0.84 0 53.04
4 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 0.02 2.42 0.51 5.00
5 INT175016 Binding of REN and S100A6 2 0.11 1.13 0.37 5.00
6 INT175017 Negative_regulation of Binding of REN and S100A6 1 0.13 0.45 0.29 5.00
7 INT271350 MPO Positive_regulation of TIMP1 1 0.05 1.66 0.29 5.00
8 INT175018 Positive_regulation of Binding of REN and S100A6 1 0.15 0.45 0.29 5.00
9 INT89612 Binding of FABP3 and MB 3 0.34 1.49 0.22 5.00
10 INT271345 Negative_regulation of PIGF Negative_regulation of FLT1 1 0.02 1.17 0.13 5.00
11 INT200213 PAH Positive_regulation of SDHD 1 0.21 2.43 0.1 5.00
12 INT271343 Binding of CRP and PAPPA 1 0.20 0.86 0.1 5.00
13 INT271349 ACCS Positive_regulation of PAPPA 1 0.06 0.87 0.09 5.00
14 INT271347 Negative_regulation of Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
15 INT271354 MPO Regulation of Gene_expression of CRP 1 0.16 1.74 0.08 5.00
16 INT271346 Binding of TNNT2 and ACCS 1 0.01 0.67 0.08 5.00
17 INT271351 MPO Positive_regulation of CRP 1 0.07 1.69 0.08 5.00
18 INT271355 PGF Positive_regulation of PIGF 1 0.01 0.99 0.06 5.00
19 INT106823 Binding of MBP and PAPPA 2 0.17 3.89 0.05 5.00
20 INT200212 Binding of EPAS1 and VHL 3 0.06 4.1 0.05 5.00
21 INT327451 HTN1 Positive_regulation of Adra1a 1 0.00 1.36 0.03 5.00
22 INT271328 FABP3 Positive_regulation of Binding of FABP3 and MB 1 0.00 0.81 0.03 5.00
23 INT271348 Binding of CHKB and MB 1 0.01 1.01 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperaldosteronism. They are ordered first by their pain relevance and then by number of times they were reported in Hyperaldosteronism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT29058 Localization of ADAR 2 0.75 3.88 0.46 100.00
2 INT5454 Localization of CRH 124 0.79 79.18 41.53 100.00
3 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08 99.92
4 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37 99.90
5 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 99.86
6 INT253030 Binding of HPP1 1 0.03 1.43 0.04 99.78
7 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 99.74
8 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26 99.60
9 INT654 Localization of REN 250 0.81 75.12 47.86 99.54
10 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 99.52
11 INT1116 Regulation of Ren 103 0.62 27.66 33.26 98.66
12 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 98.32
13 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 97.84
14 INT16205 Localization of ras 25 0.73 18.99 1.85 96.28
15 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 95.04
16 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3 95.04
17 INT6947 Negative_regulation of Gene_expression of POMC 37 0.59 10.32 14.14 94.68
18 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 94.20
19 INT39948 Binding of FLNA 45 0.42 58.05 4.27 93.72
20 INT105746 Regulation of ECT 22 0.39 7.6 7.47 93.16
21 INT19993 Negative_regulation of Ren1 43 0.58 20.89 5.04 92.00
22 INT49 Negative_regulation of Ren 129 0.59 37.48 35.62 90.60
23 INT11673 Positive_regulation of ECT 43 0.59 13.93 11.25 90.20
24 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 90.08
25 INT263251 Binding of CYP11B2 1 0.05 0.82 0 89.48
26 INT13752 Binding of Scn4a 24 0.36 5.68 14.16 88.56
27 INT661 Gene_expression of REN 100 0.78 48.21 11.36 88.08
28 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 83.60
29 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 83.60
30 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 83.12
31 INT18897 Binding of CHGA 11 0.36 10.12 1.17 81.08
32 INT18898 Positive_regulation of CHGA 38 0.67 28.99 4.86 80.32
33 INT62950 Gene_expression of NPPB 73 0.75 65.91 6.54 80.12
34 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 77.52
35 INT15509 Negative_regulation of HMBS 14 0.58 13.13 2.78 75.00
36 INT159472 Localization of NPPB 32 0.79 33.67 3.59 73.00
37 INT120752 Positive_regulation of Gene_expression of NPPB 17 0.67 16.4 2.21 72.16
38 INT4587 Negative_regulation of Serping1 32 0.47 19.11 5.92 66.96
39 INT177716 Gene_expression of GALNT3 7 0.53 6.91 0.75 63.12
40 INT177717 Positive_regulation of Gene_expression of GALNT3 2 0.03 2.84 0.18 63.12
41 INT159473 Regulation of Localization of NPPB 2 0.61 1 0.25 62.48
42 INT159886 Regulation of Gene_expression of NPPB 3 0.44 0.9 0.04 62.48
43 INT66937 Binding of NR3C2 3 0.26 0.77 0 60.64
44 INT249 Localization of GHRH 215 0.80 78.02 51.87 56.24
45 INT20664 Binding of ACE 60 0.48 35.27 9.16 54.40
46 INT8225 Localization of CHGA 26 0.78 13.52 9.4 52.76
47 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 52.24
48 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 50.00
49 INT131788 Positive_regulation of NPPB 87 0.67 86.1 8.81 47.76
50 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 46.56
51 INT47734 Positive_regulation of RAPGEF5 19 0.56 13.16 1.41 43.24
52 INT84264 Regulation of NPPB 22 0.61 21.18 1.94 43.12
53 INT2140 Regulation of REN 104 0.62 28.24 24.49 43.04
54 INT16277 Regulation of CHGA 16 0.44 11.31 4.43 29.20
55 INT21609 Positive_regulation of RASGRP1 58 0.50 40.78 5.47 25.56
56 INT8065 Binding of AGT 54 0.48 20.54 10.85 21.44
57 INT2824 Positive_regulation of HTN1 10 0.40 10.41 1.4 20.56
58 INT46646 Localization of FLNA 19 0.73 18.83 2.53 18.72
59 INT26369 Gene_expression of S100A6 19 0.65 5.39 1.81 18.28
60 INT1372 Regulation of Localization of REN 50 0.62 5.76 9.81 17.92
61 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 17.64
62 INT98096 Positive_regulation of CHKA 14 0.42 12.23 1.61 17.44
63 INT58571 Positive_regulation of ALDOB 6 0.49 5.63 0.53 16.52
64 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 16.12
65 INT27989 Positive_regulation of Gene_expression of REN 18 0.55 12.69 2.11 10.48
66 INT4336 Negative_regulation of Gene_expression of REN 13 0.58 7.22 1.43 5.12
67 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
68 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
69 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
70 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 5.00
71 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 5.00
72 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
73 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
74 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
75 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
76 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 5.00
77 INT214 Localization of AVP 370 0.81 208.51 91.09 5.00
78 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
79 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
80 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
81 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
82 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
83 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
84 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 5.00
85 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
86 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
87 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
88 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
89 INT99610 Localization of MMP9 126 0.79 48.46 32.67 5.00
90 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 5.00
91 INT86437 Binding of IL6 154 0.48 121.22 29.3 5.00
92 INT129956 Gene_expression of MMP13 145 0.72 60.48 26.98 5.00
93 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
94 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
95 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 5.00
96 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
97 INT23257 Regulation of CRP 127 0.62 100.05 21.87 5.00
98 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 5.00
99 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 5.00
100 INT20631 Positive_regulation of CHKB 166 0.69 109.86 17.92 5.00
101 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
102 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 5.00
103 INT74587 Gene_expression of MMP8 31 0.78 24.4 14.91 5.00
104 INT5904 Localization of MPO 62 0.81 36.37 14.64 5.00
105 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
106 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 5.00
107 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
108 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32 5.00
109 INT3962 Regulation of AGT 50 0.62 20.96 13.01 5.00
110 INT16772 Gene_expression of MPO 81 0.78 90.98 11.9 5.00
111 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
112 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
113 INT398 Localization of AGT 45 0.78 16.97 11.54 5.00
114 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 5.00
115 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 5.00
116 INT110110 Gene_expression of ACCS 85 0.58 75.88 10.2 5.00
117 INT9548 Gene_expression of CHKB 99 0.65 50.86 9.03 5.00
118 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96 5.00
119 INT129962 Positive_regulation of Gene_expression of MMP13 41 0.65 20.74 8.54 5.00
120 INT8637 Negative_regulation of Dbp 112 0.50 33.28 8.4 5.00
121 INT56223 Positive_regulation of MPO 35 0.70 43 8.2 5.00
122 INT1124 Negative_regulation of CD40LG 53 0.57 36.26 7 5.00
123 INT16722 Negative_regulation of MPO 25 0.59 18.55 6.99 5.00
124 INT78182 Positive_regulation of ACCS 43 0.43 46.39 6.78 5.00
125 INT24907 Gene_expression of PAPPA 42 0.75 28.32 6.63 5.00
126 INT91721 Binding of IL18 21 0.48 21.17 6.56 5.00
127 INT34232 Regulation of TIMP1 37 0.61 18.76 6.05 5.00
128 INT2890 Positive_regulation of MB 39 0.70 29.58 6.01 5.00
129 INT21103 Gene_expression of Dbp 48 0.61 22.6 5.59 5.00
130 INT107386 Negative_regulation of AGTR1 37 0.55 35.94 5.15 5.00
131 INT47662 Localization of CHKB 34 0.81 22.63 5.14 5.00
132 INT95631 Positive_regulation of Gene_expression of MMP8 16 0.50 13.75 5.12 5.00
133 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 5.00
134 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93 5.00
135 INT200218 Localization of SDHD 1 0.69 48.58 4.57 5.00
136 INT52818 Localization of NR3C1 13 0.69 7.65 4.57 5.00
137 INT4679 Negative_regulation of RAPGEF5 55 0.57 47.51 4.55 5.00
138 INT99608 Transcription of MMP9 18 0.65 9.67 4.11 5.00
139 INT26368 Positive_regulation of S100A6 30 0.45 9.72 3.89 5.00
140 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 5.00
141 INT117614 Positive_regulation of PAPPA 18 0.67 11.9 3.76 5.00
142 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 5.00
143 INT9110 Binding of PAH 32 0.41 42.1 3.1 5.00
144 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 5.00
145 INT19177 Negative_regulation of GRHPR 19 0.53 12.65 2.71 5.00
146 INT50080 Binding of APOE 38 0.45 29.61 2.67 5.00
147 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 5.00
148 INT183810 Positive_regulation of Positive_regulation of MMP9 9 0.52 4.15 2.46 5.00
149 INT200217 Localization of PAH 10 0.36 15.51 2.46 5.00
150 INT63333 Gene_expression of RET 24 0.76 30.09 2.41 5.00
151 INT25438 Positive_regulation of Positive_regulation of Pomc 6 0.48 4 2.37 5.00
152 INT46713 Binding of TNNC1 10 0.35 6.35 2.28 5.00
153 INT60279 Gene_expression of VHL 70 0.78 75.21 2.21 5.00
154 INT158016 Positive_regulation of VEGFC 7 0.49 6.58 2.18 5.00
155 INT3533 Binding of REN 24 0.37 10.84 2.16 5.00
156 INT21611 Negative_regulation of RASGRP1 20 0.35 11.76 2.15 5.00
157 INT64538 Binding of TNNI3 17 0.48 11.65 1.83 5.00
158 INT89614 Positive_regulation of FABP3 12 0.50 10.16 1.75 5.00
159 INT98497 Regulation of PAPPA 5 0.44 3.18 1.74 5.00
160 INT118946 Binding of FABP4 4 0.44 3.97 1.71 5.00
161 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7 5.00
162 INT85297 Positive_regulation of Gene_expression of TNNI3 29 0.50 29.77 1.68 5.00
163 INT68187 Gene_expression of TNNT2 21 0.67 10.22 1.64 5.00
164 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61 5.00
165 INT49706 Positive_regulation of TNNT2 22 0.69 12.65 1.56 5.00
166 INT110201 Positive_regulation of Sbp 10 0.49 5.25 1.55 5.00
167 INT60552 Localization of TNNI3 56 0.79 20.05 1.44 5.00
168 INT39050 Positive_regulation of PGF 14 0.49 8.05 1.43 5.00
169 INT16184 Negative_regulation of CHKB 20 0.53 10.61 1.42 5.00
170 INT4029 Positive_regulation of HYAL1 10 0.69 2 1.39 5.00
171 INT75183 Negative_regulation of TNNI3 19 0.53 9.34 1.32 5.00
172 INT152982 Negative_regulation of ACCS 14 0.37 9.63 1.3 5.00
173 INT11367 Localization of MB 9 0.78 9.34 1.24 5.00
174 INT19520 Negative_regulation of SDHB 4 0.37 1.57 1.24 5.00
175 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23 5.00
176 INT158540 Negative_regulation of HTN1 4 0.34 7.25 1.22 5.00
177 INT187123 Negative_regulation of Positive_regulation of MMP9 7 0.42 2.54 1.17 5.00
178 INT147213 Negative_regulation of Gene_expression of Dbp 5 0.34 2.88 1.16 5.00
179 INT188774 Binding of RAPGEF5 12 0.29 13.55 1.04 5.00
180 INT133846 Binding of NPPB 14 0.42 11.52 0.98 5.00
181 INT43919 Negative_regulation of S100A6 19 0.16 4.45 0.96 5.00
182 INT171435 Gene_expression of SDHD 14 0.58 26.55 0.91 5.00
183 INT23921 Negative_regulation of NPPB 13 0.58 16.19 0.9 5.00
184 INT107381 Positive_regulation of Gene_expression of PAPPA 4 0.49 2.32 0.85 5.00
185 INT200222 Positive_regulation of Localization of SDHD 1 0.43 7.07 0.84 5.00
186 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72 5.00
187 INT114842 Localization of RET 3 0.71 5.98 0.71 5.00
188 INT79784 Positive_regulation of RET 15 0.57 17.43 0.71 5.00
189 INT200216 Binding of SDHD 3 0.37 4.51 0.71 5.00
190 INT66940 Regulation of RET 7 0.52 5.61 0.69 5.00
191 INT11551 Localization of VHL 12 0.65 22.76 0.68 5.00
192 INT200219 Positive_regulation of VHL 18 0.50 15.38 0.67 5.00
193 INT254132 Positive_regulation of Localization of NPPB 2 0.40 2.9 0.58 5.00
194 INT164465 Negative_regulation of Sbp 12 0.33 10.31 0.56 5.00
195 INT271362 Positive_regulation of PIGF 1 0.19 4.16 0.54 5.00
196 INT271367 Protein_catabolism of ACCS 1 0.06 2.34 0.5 5.00
197 INT89615 Localization of FABP3 5 0.79 3.5 0.42 5.00
198 INT200221 Positive_regulation of SDHD 3 0.43 6.59 0.42 5.00
199 INT166903 Negative_regulation of Gene_expression of NPPB 5 0.43 4.18 0.41 5.00
200 INT175024 Positive_regulation of Localization of NR3C1 1 0.10 0.5 0.41 5.00
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