D:Hyperammonemia

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Disease Term
Synonyms None
Documents 68
Hot Single Events 39
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperammonemia. They are ordered first by their relevance to Hyperammonemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT349219 PTPRC Positive_regulation of Gene_expression of SLC3A2 1 0.11 0.53 0 70.96
2 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96 5.00
3 INT251704 Ache Regulation of Gene_expression of Acot1 1 0.08 1.68 0.87 5.00
4 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86 5.00
5 INT251706 Chat Regulation of Gene_expression of Acot1 1 0.06 1.64 0.85 5.00
6 INT251708 Chat Regulation of Acot1 1 0.03 1.64 0.84 5.00
7 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75 5.00
8 INT263236 DAG1 Positive_regulation of Prkcg 2 0.01 0.31 0.7 5.00
9 INT235082 CA2 Positive_regulation of NOS1 2 0.11 0.62 0.63 5.00
10 INT275063 CA2 Positive_regulation of Positive_regulation of CAMK4 1 0.01 0 0.59 5.00
11 INT275100 Pde4a Negative_regulation of RTP3 1 0.00 0.51 0.42 5.00
12 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42 5.00
13 INT275089 Pde4a Negative_regulation of stm 1 0.02 0.51 0.42 5.00
14 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42 5.00
15 INT275099 Pde9a Negative_regulation of RTP3 1 0.00 0.51 0.39 5.00
16 INT275093 Pde9a Negative_regulation of stm 1 0.00 0.51 0.39 5.00
17 INT275096 Pde9a Regulation of Ltp 1 0.00 0.11 0.35 5.00
18 INT275098 Pde9a Regulation of RTP3 1 0.00 0.11 0.35 5.00
19 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35 5.00
20 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25 5.00
21 INT349222 CSF2 Positive_regulation of Gene_expression of SLC7A7 1 0.17 0.4 0.13 5.00
22 INT310412 Binding of CP and TF 1 0.14 1.66 0.13 5.00
23 INT251712 Fig4 Regulation of Ache 1 0.02 0.23 0.08 5.00
24 INT251710 Fig4 Regulation of Chat 1 0.03 0.23 0.08 5.00
25 INT251705 Fig4 Regulation of Localization of Chat 1 0.05 0.23 0.08 5.00
26 INT251703 Fig4 Regulation of Localization of Ache 1 0.07 0.23 0.08 5.00
27 INT275064 Binding of CA2 and CALM1 2 0.06 0 0.07 5.00
28 INT275102 Prkcg Regulation of CREB1 1 0.01 0 0.06 5.00
29 INT275101 CAMK4 Positive_regulation of Prkcg 1 0.01 0 0.06 5.00
30 INT275103 CA2 Positive_regulation of Prkcg 1 0.01 0 0.06 5.00
31 INT275105 CALM3 Positive_regulation of Prkcg 1 0.00 0 0.06 5.00
32 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04 5.00
33 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04 5.00
34 INT349221 CSF2 Regulation of Gene_expression of SLC7A7 1 0.10 0.18 0.04 5.00
35 INT251701 Bche Regulation of Gene_expression of Acot1 1 0.03 0.25 0.03 5.00
36 INT349220 Binding of CASP3 and CD8A 1 0.00 0.18 0 5.00
37 INT349225 TREM1 Positive_regulation of LAMB1 1 0.00 0 0 5.00
38 INT349224 Binding of CSF2 and SLC7A7 1 0.12 0.38 0 5.00
39 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0 5.00
40 INT251702 Fig4 Regulation of Positive_regulation of Ache 1 0.07 0.42 0 5.00
41 INT311773 Binding of HBM and CYGB 1 0.02 0.14 0 5.00
42 INT349223 CSF2 Positive_regulation of SLC7A7 1 0.17 0.3 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperammonemia. They are ordered first by their pain relevance and then by number of times they were reported in Hyperammonemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5137 Binding of PCa 45 0.47 16.91 18.47 99.98
2 INT21869 Negative_regulation of Otc 16 0.58 8.43 3.67 99.78
3 INT1079 Positive_regulation of Ache 104 0.70 23.52 30.28 99.76
4 INT28009 Positive_regulation of Gene_expression of Ache 15 0.70 5.46 3.26 99.76
5 INT226585 Binding of Cntn2 1 0.28 0.84 0.16 99.44
6 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89 99.40
7 INT54492 Negative_regulation of Otc 4 0.43 1.19 0.88 99.34
8 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 98.72
9 INT27591 Negative_regulation of Gene_expression of Alb 30 0.58 17.03 5.99 98.72
10 INT9995 Localization of C6orf25 13 0.69 6.48 2.29 98.00
11 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 96.36
12 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 96.36
13 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 95.20
14 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 95.20
15 INT55960 Binding of Maob 2 0.47 1.47 0.25 95.08
16 INT54331 Positive_regulation of Glul 8 0.67 3.55 2.74 94.88
17 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 93.80
18 INT4422 Positive_regulation of Gene_expression of Alb 30 0.50 18.56 6.12 92.56
19 INT276 Regulation of Ache 83 0.62 16.75 25.99 92.52
20 INT55961 Positive_regulation of Maob 2 0.68 9.39 0.92 92.20
21 INT112729 Positive_regulation of Negative_regulation of COQ7 1 0.43 1.31 0.26 92.08
22 INT192783 Phosphorylation of Myo5a 1 0.04 2.01 0.12 91.96
23 INT112728 Negative_regulation of COQ7 1 0.50 4.8 0.89 91.64
24 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 91.56
25 INT348636 Negative_regulation of OTC 1 0.43 3.39 0 88.88
26 INT348634 Protein_catabolism of OTC 1 0.89 0.96 0 88.88
27 INT348635 Positive_regulation of Protein_catabolism of OTC 1 0.50 0.96 0 88.88
28 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 86.88
29 INT112203 Negative_regulation of ACADM 1 0.51 4.02 0.22 86.20
30 INT19072 Regulation of Gene_expression of Ache 14 0.62 2.74 5.29 85.68
31 INT46357 Regulation of Gene_expression of Acot1 4 0.45 1.1 0.26 85.68
32 INT4735 Gene_expression of Acot1 80 0.71 13.22 26.68 84.12
33 INT172677 Gene_expression of SHE 65 0.59 25.86 3.85 83.40
34 INT54540 Negative_regulation of Cps1 7 0.58 2.64 2.26 82.48
35 INT84026 Positive_regulation of SLC7A7 8 0.67 3.12 0.33 81.72
36 INT28031 Negative_regulation of Binding of Otc 1 0.43 0.36 0.22 81.72
37 INT28030 Binding of Otc 5 0.37 2.72 4.3 81.28
38 INT3882 Positive_regulation of SARNP 2 0.31 1.46 0.82 80.48
39 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 80.16
40 INT82587 Positive_regulation of Gene_expression of GRIN1 8 0.67 3.66 2.18 79.28
41 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 78.96
42 INT316 Regulation of Cebpz 105 0.00 27.21 35.41 75.00
43 INT8866 Positive_regulation of TAT 30 0.67 18.06 5.57 74.40
44 INT81904 Positive_regulation of FDPS 5 0.67 2.83 0.85 74.40
45 INT178338 Gene_expression of Tbx15 50 0.65 38.65 12.19 73.76
46 INT220295 Gene_expression of MARS 6 0.47 4.74 0.35 72.00
47 INT220294 Positive_regulation of Gene_expression of MARS 3 0.35 2.45 0.05 72.00
48 INT69029 Gene_expression of PTPRC 127 0.75 74.26 11.57 70.96
49 INT11353 Gene_expression of SLC3A2 13 0.58 7.31 2.33 70.96
50 INT1354 Negative_regulation of Acot1 87 0.43 15.01 36.44 68.72
51 INT32052 Positive_regulation of Negative_regulation of Acot1 2 0.24 0.73 0.41 68.72
52 INT160251 Gene_expression of Myo5a 48 0.63 37.14 3.16 67.96
53 INT160258 Negative_regulation of Myo5a 3 0.35 3.96 0.09 67.96
54 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 65.24
55 INT251699 Negative_regulation of Negative_regulation of G4 1 0.23 0.88 0.06 65.24
56 INT156287 Negative_regulation of G4 7 0.41 1.35 0.08 62.96
57 INT53451 Regulation of TAT 6 0.44 3.07 1.61 62.76
58 INT54493 Negative_regulation of Ogdh 1 0.37 0.26 0.18 61.48
59 INT251695 Negative_regulation of Gene_expression of G4 1 0.23 0.32 0.03 60.72
60 INT205868 Gene_expression of G4 4 0.42 1.1 0.03 60.00
61 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09 58.40
62 INT2570 Negative_regulation of Gene_expression of Ache 13 0.43 2.88 2.18 53.44
63 INT9126 Negative_regulation of Xdh 20 0.58 8.58 3.28 51.64
64 INT2531 Positive_regulation of Cebpz 166 0.00 43.08 38.86 50.00
65 INT35261 Positive_regulation of Positive_regulation of Cebpz 13 0.41 2.52 3.87 50.00
66 INT56918 Negative_regulation of TAT 11 0.57 5.92 2.44 48.96
67 INT82660 Negative_regulation of OTOR 3 0.38 1.6 0.69 48.96
68 INT1120 Gene_expression of C3 33 0.67 22.86 7.56 46.88
69 INT238250 Regulation of Gene_expression of C3 2 0.27 2.16 0.98 46.88
70 INT45447 Positive_regulation of Gene_expression of C3 2 0.42 0.9 0.49 46.88
71 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 41.92
72 INT39469 Negative_regulation of Alb 21 0.41 13.33 2.68 39.80
73 INT14717 Gene_expression of TAT 20 0.75 10.67 3.66 39.08
74 INT79597 Positive_regulation of Negative_regulation of PDE5A 5 0.50 3.39 0.41 38.80
75 INT49584 Negative_regulation of Glul 3 0.52 1.16 1.88 38.56
76 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 37.36
77 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 37.16
78 INT84527 Positive_regulation of Gene_expression of F3 16 0.49 15.83 2.85 37.16
79 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 36.44
80 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 35.84
81 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27 35.80
82 INT226583 Regulation of Cntn2 1 0.34 0.63 0.08 35.68
83 INT226584 Negative_regulation of Cntn2 1 0.37 1.42 0.08 32.00
84 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 31.44
85 INT20059 Protein_catabolism of Ache 15 0.98 3.73 4.87 31.28
86 INT251700 Positive_regulation of Protein_catabolism of Ache 1 0.46 0.44 0.14 31.28
87 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 30.20
88 INT19071 Localization of Ache 66 0.81 5.1 16.27 28.40
89 INT328535 Localization of Nacc1 1 0.15 0.68 0 28.12
90 INT95580 Positive_regulation of Afm 5 0.21 5.51 2.04 27.88
91 INT15584 Binding of S100A12 14 0.48 15.14 3 26.00
92 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 22.16
93 INT11814 Positive_regulation of Alb 43 0.63 31.71 6.28 21.56
94 INT8237 Positive_regulation of Kng1 16 0.69 4.41 2.12 17.28
95 INT169591 Gene_expression of FAT1 23 0.67 10.73 0.77 11.60
96 INT114993 Binding of Myo5a 15 0.30 11.46 5.48 8.24
97 INT164189 Gene_expression of TREM1 82 0.62 60.77 5.85 7.20
98 INT205995 Gene_expression of SLC7A7 11 0.75 10.61 1.21 7.20
99 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
100 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
101 INT1352 Localization of Acot1 728 0.80 73.01 296.01 5.00
102 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 5.00
103 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 5.00
104 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
105 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 5.00
106 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36 5.00
107 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
108 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
109 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 5.00
110 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
111 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 5.00
112 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
113 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 5.00
114 INT15898 Positive_regulation of Prkaca 199 0.70 50.89 87.54 5.00
115 INT13036 Positive_regulation of Positive_regulation of Ltp 105 0.51 23.71 77.66 5.00
116 INT12536 Localization of Prkcg 101 0.80 36.37 73.81 5.00
117 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
118 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 5.00
119 INT13276 Regulation of Ltp 107 0.53 30.78 69.13 5.00
120 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
121 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
122 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 5.00
123 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
124 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 5.00
125 INT1316 Positive_regulation of Acot1 129 0.60 18.86 56.13 5.00
126 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7 5.00
127 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 5.00
128 INT122041 Binding of Ppara 308 0.48 189.17 51.48 5.00
129 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
130 INT66383 Phosphorylation of Prkaca 143 0.80 30.85 43.38 5.00
131 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 5.00
132 INT3188 Regulation of Localization of Acot1 84 0.59 8.94 38.56 5.00
133 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 5.00
134 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78 5.00
135 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23 5.00
136 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 5.00
137 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 5.00
138 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
139 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 5.00
140 INT11650 Negative_regulation of Gpt 122 0.59 69.15 30.36 5.00
141 INT32165 Binding of CALM1 92 0.48 24.19 29.57 5.00
142 INT9650 Gene_expression of LPA 141 0.75 104.57 29 5.00
143 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
144 INT115385 Negative_regulation of Ppara 154 0.58 129.05 27.58 5.00
145 INT54467 Localization of Ltp 41 0.58 8.86 26.88 5.00
146 INT32826 Positive_regulation of Gene_expression of Ltp 52 0.45 10.34 26.8 5.00
147 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59 5.00
148 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
149 INT11014 Phosphorylation of CREB1 72 0.81 26.35 25.64 5.00
150 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35 5.00
151 INT74688 Regulation of Nos1 55 0.62 22.16 25.3 5.00
152 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 5.00
153 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07 5.00
154 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
155 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
156 INT81210 Positive_regulation of PRKG1 71 0.70 26.83 19.89 5.00
157 INT70614 Gene_expression of FAS 118 0.75 112.33 19.01 5.00
158 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
159 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 5.00
160 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65 5.00
161 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31 5.00
162 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 5.00
163 INT2383 Positive_regulation of CP 33 0.67 25.41 15.38 5.00
164 INT4851 Positive_regulation of Chat 53 0.70 9.21 15.11 5.00
165 INT11945 Regulation of Chat 38 0.62 7.75 14.97 5.00
166 INT34952 Regulation of ABAT 28 0.61 6.05 14.39 5.00
167 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36 5.00
168 INT22301 Positive_regulation of Gene_expression of CSF2 66 0.63 59.49 14.24 5.00
169 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24 5.00
170 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 5.00
171 INT197366 Positive_regulation of Localization of Ltp 18 0.39 3.8 13.08 5.00
172 INT21987 Positive_regulation of Rorb 30 0.33 12.7 12.24 5.00
173 INT39587 Gene_expression of CP 42 0.65 31.48 11.87 5.00
174 INT3597 Positive_regulation of Pla2g1b 37 0.63 17.94 11.41 5.00
175 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32 5.00
176 INT1252 Binding of Ache 46 0.48 9.94 10.25 5.00
177 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 5.00
178 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84 5.00
179 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
180 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22 5.00
181 INT54588 Positive_regulation of CREB1 38 0.67 12.01 9.18 5.00
182 INT14301 Binding of CSF2 82 0.48 67.95 8.98 5.00
183 INT73558 Regulation of IK 23 0.23 12.02 8.73 5.00
184 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
185 INT178174 Gene_expression of Tnfsf10 78 0.76 56.83 8.64 5.00
186 INT64815 Binding of Jun 49 0.48 21.47 8.59 5.00
187 INT105777 Gene_expression of Pde4a 30 0.76 12.67 8.52 5.00
188 INT80034 Positive_regulation of Gene_expression of FAS 32 0.67 30.34 8.51 5.00
189 INT15308 Localization of Chat 29 0.81 2.35 8.47 5.00
190 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47 5.00
191 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37 5.00
192 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 5.00
193 INT114873 Phosphorylation of Stat3 63 0.82 30.19 8.23 5.00
194 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 5.00
195 INT73595 Positive_regulation of BAX 61 0.61 56.97 7.82 5.00
196 INT113 Positive_regulation of MBD2 33 0.49 6.76 7.49 5.00
197 INT17041 Gene_expression of PER1 24 0.66 5.31 7.12 5.00
198 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
199 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 5.00
200 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 5.00
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