D:Hyperandrogenism

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Disease Term
Synonyms Hyperandrogenisation Syndrome, Hyperandrogenization Syndrome
Documents 60
Hot Single Events 63
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperandrogenism. They are ordered first by their relevance to Hyperandrogenism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT65676 Binding of CGA and PLOD1 3 0.23 1.68 0.1 93.96
2 INT278251 Binding of PCOS1 and Hypism 1 0.00 1.22 0.04 92.56
3 INT278250 Binding of PCOS1 and Ins1 1 0.00 1.23 0.04 92.56
4 INT251469 INS Negative_regulation of Gene_expression of SHBG 2 0.11 4.11 0.08 87.36
5 INT295432 FSHR Positive_regulation of PCOS1 1 0.06 1.24 0 81.76
6 INT332907 Binding of LPL and SUGT1 1 0.00 1.3 0 80.96
7 INT186540 Binding of Cort and Hpse 1 0.05 0.92 0.08 76.16
8 INT332943 Binding of SNRNP70 and Adipoq 1 0.00 1.35 0 73.20
9 INT332904 Binding of LEP and SNRNP70 1 0.00 1.34 0 72.16
10 INT332905 Binding of LPL and SNRNP70 1 0.01 1.34 0 71.52
11 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55 71.20
12 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71 70.48
13 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0 62.76
14 INT350116 FSHR Positive_regulation of Gene_expression of CGA 1 0.01 1.28 0 56.40
15 INT284891 FSHR Positive_regulation of Gene_expression of PLOD1 2 0.03 1.32 0.11 55.56
16 INT91391 Crh Regulation of Localization of Gnrh1 2 0.36 1.78 0.61 54.56
17 INT59540 Crh Regulation of Gnrh1 2 0.36 2.61 0.58 54.56
18 INT350117 GNRHR Negative_regulation of Localization of FSHR 1 0.01 1.06 0 51.84
19 INT350113 GNRHR Negative_regulation of Localization of PLOD1 1 0.01 1.06 0 51.84
20 INT350115 GNRH1 Negative_regulation of Localization of PLOD1 1 0.04 0.99 0 50.56
21 INT350122 GNRH1 Negative_regulation of Localization of FSHR 1 0.05 0.99 0 50.56
22 INT186539 Crh Regulation of Hpse 1 0.09 0.52 0.1 47.84
23 INT350119 Positive_regulation of GNRH1 Positive_regulation of PLOD1 1 0.04 0.86 0.03 47.68
24 INT350114 Positive_regulation of GNRH1 Positive_regulation of FSHR 1 0.05 0.86 0.03 47.68
25 INT45780 GNRH1 Positive_regulation of PLOD1 3 0.07 1.02 0.63 47.28
26 INT54584 GNRH1 Positive_regulation of FSHR 3 0.48 2.02 0.54 46.84
27 INT334918 GNRH1 Positive_regulation of Gene_expression of FSHR 2 0.11 1.27 0.03 46.84
28 INT290565 Binding of Rare1 and Rorb 1 0.00 0.32 0.12 46.32
29 INT290563 Binding of Rxrg and Rorb 1 0.00 0.2 0.12 41.28
30 INT350121 INS Negative_regulation of Positive_regulation of SHBG 1 0.09 1.48 0.04 40.48
31 INT350118 INS Negative_regulation of SHBG 1 0.09 1.42 0.04 40.48
32 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83 5.00
33 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69 5.00
34 INT177426 Izumo1 Positive_regulation of Positive_regulation of Fig4 1 0.16 0.59 0.34 5.00
35 INT177425 Binding of Fig4 and Izumo1 1 0.12 0.59 0.23 5.00
36 INT295430 BRD2 Positive_regulation of PLOD1 1 0.02 0.33 0.22 5.00
37 INT295434 BRD2 Positive_regulation of Gene_expression of GNRH1 1 0.02 0.07 0.2 5.00
38 INT287145 Binding of PNN and Shbg 1 0.07 0.14 0.18 5.00
39 INT65677 Binding of CGA and FSHR 2 0.25 0.29 0.16 5.00
40 INT295433 Binding of PLOD1 and SCN5A 1 0.07 0.25 0.16 5.00
41 INT213261 TNF Positive_regulation of CRP 1 0.24 1.59 0.06 5.00
42 INT323043 Binding of CYP21A1P and HLA-DOA 1 0.04 1.48 0.06 5.00
43 INT323042 Binding of CYP21A2 and HLA-DOA 1 0.04 1.49 0.06 5.00
44 INT332942 Binding of PPARA and A.seq 1 0.01 0.2 0.05 5.00
45 INT213263 INS Positive_regulation of EDN1 1 0.12 0.54 0.04 5.00
46 INT332906 Binding of PPARA and TF 1 0.03 0.1 0.04 5.00
47 INT213262 IL6 Positive_regulation of CYP19A1 1 0.11 1.63 0.03 5.00
48 INT332944 Binding of HAT1 and Polr2a 1 0.00 0.27 0.03 5.00
49 INT332938 Suv39h1 Positive_regulation of Hist1h3f 1 0.06 0.12 0.03 5.00
50 INT332937 Hnmt Positive_regulation of Hist1h3f 1 0.01 0.12 0.03 5.00
51 INT294922 GH1 Positive_regulation of Gene_expression of GHRH 1 0.02 0.2 0 5.00
52 INT213264 INS Positive_regulation of Localization of IGF1 1 0.16 1.77 0 5.00
53 INT295431 FSHR Positive_regulation of CGA 1 0.29 0.27 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperandrogenism. They are ordered first by their pain relevance and then by number of times they were reported in Hyperandrogenism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 99.98
2 INT2261 Gene_expression of Lhb 121 0.77 42.78 26.04 99.92
3 INT7224 Positive_regulation of Gene_expression of Lhb 18 0.45 10.22 3.4 99.92
4 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 99.84
5 INT5135 Negative_regulation of GNRH1 106 0.58 36.63 27.71 99.52
6 INT4146 Binding of SHBG 49 0.47 31 4.71 99.48
7 INT5868 Positive_regulation of GNRH1 122 0.69 20.96 32.8 99.40
8 INT5128 Positive_regulation of Lhb 232 0.69 44.23 71.26 99.40
9 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38 99.08
10 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 98.48
11 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 98.28
12 INT28020 Binding of Adipoq 10 0.36 11.49 0.77 98.24
13 INT5345 Positive_regulation of BRD2 14 0.67 6.72 3.43 97.76
14 INT4144 Gene_expression of SHBG 64 0.68 39.94 6.08 97.60
15 INT2123 Positive_regulation of Gnrh1 209 0.70 24.2 68.97 97.52
16 INT13415 Positive_regulation of Hpse 58 0.70 24.9 25.53 97.44
17 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 97.20
18 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 96.92
19 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 96.70
20 INT205578 Negative_regulation of Wnt4 1 0.43 1.69 0 96.68
21 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 96.04
22 INT14572 Binding of INS 205 0.48 175.43 13.38 95.60
23 INT32256 Gene_expression of PLXNA3 11 0.75 7.8 4.92 95.36
24 INT14724 Negative_regulation of CYP19A1 233 0.59 96.56 18.26 95.28
25 INT1893 Localization of Gh 1041 0.79 340.23 256.58 95.12
26 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 95.12
27 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 94.32
28 INT5344 Negative_regulation of BRD2 12 0.56 4.71 1.89 94.24
29 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 93.76
30 INT7396 Regulation of Localization of GNRH1 81 0.62 6.57 31.31 93.04
31 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59 92.68
32 INT70622 Binding of Hypism 9 0.04 14.9 0.59 92.16
33 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 91.20
34 INT1046 Gene_expression of LH 180 0.77 29.75 66.87 90.72
35 INT17451 Positive_regulation of Tst 23 0.67 8.85 9.52 90.56
36 INT8089 Binding of Gnrh1 47 0.48 10.04 13.99 90.12
37 INT148756 Regulation of Adipoq 10 0.60 7.83 0.67 90.08
38 INT205585 Regulation of Wnt4 1 0.45 0.7 0 89.80
39 INT205581 Regulation of Negative_regulation of Wnt4 1 0.27 0.7 0 89.80
40 INT3602 Negative_regulation of Shbg 148 0.53 69.05 11.65 89.72
41 INT16202 Negative_regulation of Positive_regulation of Shbg 8 0.58 5.24 1.86 89.72
42 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13 89.72
43 INT134176 Gene_expression of ADRA2A 4 0.58 1.45 0.25 89.16
44 INT44817 Negative_regulation of Gene_expression of Shbg 9 0.34 9.84 1.11 87.96
45 INT7067 Negative_regulation of Gene_expression of SHBG 7 0.41 5.08 0.48 87.04
46 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 86.32
47 INT32688 Positive_regulation of Gene_expression of Shbg 14 0.45 7.01 1.6 86.32
48 INT241764 Positive_regulation of Positive_regulation of Shbg 3 0.27 1.95 0 86.32
49 INT9832 Gene_expression of Shbg 96 0.75 56.71 12.19 85.88
50 INT186542 Regulation of MTAP 3 0.06 1.66 0.46 85.72
51 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31 85.60
52 INT205583 Gene_expression of Hnf1b 1 0.59 2.09 0 85.56
53 INT205579 Positive_regulation of Gene_expression of Hnf1b 1 0.44 2.1 0 85.56
54 INT163993 Gene_expression of Hnf1a 2 0.65 1.38 0.49 85.36
55 INT205577 Positive_regulation of Gene_expression of Hnf1a 1 0.49 1.1 0 85.36
56 INT205576 Positive_regulation of Hnf1a 2 0.49 1.1 0 85.12
57 INT205582 Positive_regulation of Hnf1b 1 0.44 1.05 0 85.12
58 INT12575 Regulation of Hpse 33 0.59 17.7 18.45 82.12
59 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 81.80
60 INT738 Regulation of POMC 459 0.62 111.19 243.74 81.72
61 INT177438 Negative_regulation of GNRHR 3 0.18 3.39 0.4 81.48
62 INT45176 Negative_regulation of LPL 34 0.59 22.22 2.01 80.96
63 INT144391 Gene_expression of RETN 42 0.75 40.48 10.47 80.60
64 INT5127 Localization of Lhb 488 0.80 50.48 162.66 78.96
65 INT173703 Positive_regulation of PCOS1 3 0.01 3.76 1.05 78.76
66 INT812 Localization of INS 1026 0.81 515.6 145.31 77.28
67 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 76.80
68 INT7035 Regulation of CGA 87 0.45 29.04 28.45 76.80
69 INT9178 Regulation of Localization of Ghrh 13 0.45 2.28 5.08 75.60
70 INT2157 Positive_regulation of Gene_expression of LH 24 0.69 6.07 8.67 74.24
71 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46 73.20
72 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85 73.20
73 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77 72.16
74 INT75908 Regulation of LEP 77 0.60 60.16 15.19 72.16
75 INT75907 Binding of LEP 53 0.46 46.65 8.44 72.16
76 INT68496 Binding of PGR 26 0.48 16.36 2.09 71.84
77 INT38265 Gene_expression of LPL 22 0.78 10.59 1.09 71.52
78 INT45839 Regulation of LPL 10 0.55 7.64 0.55 71.52
79 INT214478 Binding of LPL 2 0.25 1.91 0 71.52
80 INT5100 Positive_regulation of Ghrh 100 0.64 24.2 30.21 71.44
81 INT5095 Localization of Ghrh 185 0.81 28.09 62.08 70.88
82 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 70.48
83 INT186541 Positive_regulation of ADRA1A 3 0.45 2.29 0.86 70.36
84 INT5130 Regulation of GNRH1 139 0.62 31.95 42.08 70.08
85 INT8340 Negative_regulation of SHBG 49 0.57 35.96 4.73 70.00
86 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 69.36
87 INT287142 Regulation of PNN 1 0.18 0.58 0 69.36
88 INT19211 Binding of Shbg 35 0.48 16.29 3.31 68.72
89 INT2085 Positive_regulation of LH 441 0.70 60.15 191.02 68.16
90 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 68.00
91 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 67.04
92 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 65.84
93 INT270788 Regulation of AMH 4 0.54 7.54 0.2 65.76
94 INT205587 Negative_regulation of Cyp17a1 1 0.28 0.24 0 65.12
95 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 64.16
96 INT27728 Negative_regulation of Gene_expression of LHB 2 0.04 1.59 0.53 64.00
97 INT542 Gene_expression of Fshb 14 0.75 5.22 3.24 63.36
98 INT4147 Gene_expression of LHB 8 0.49 3.94 2.88 63.36
99 INT49343 Positive_regulation of Ar 8 0.42 4.38 0.58 60.96
100 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 59.52
101 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 57.80
102 INT2982 Positive_regulation of Gene_expression of CGA 17 0.59 9.08 1.99 56.80
103 INT7972 Positive_regulation of Gene_expression of PLOD1 15 0.42 5.73 1.96 56.80
104 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 56.40
105 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 55.84
106 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 55.56
107 INT1562 Localization of Crh 499 0.81 126.74 236.68 54.56
108 INT158 Localization of Prl 2431 0.81 378.96 952.2 54.32
109 INT439 Localization of Gnrh1 976 0.81 100.96 363.25 53.64
110 INT68473 Binding of Coc 13 0.40 2.99 8.89 52.92
111 INT157227 Localization of Tst 9 0.74 6.78 0.58 50.68
112 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 50.48
113 INT920 Localization of PLOD1 223 0.81 42.25 78.7 49.92
114 INT912 Localization of FSHR 91 0.79 23.61 15.58 49.80
115 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 48.96
116 INT5131 Gene_expression of GNRH1 109 0.78 28.79 23.94 48.32
117 INT15609 Positive_regulation of Gene_expression of GNRH1 17 0.49 5.15 3.34 48.32
118 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9 47.76
119 INT546 Binding of ALB 311 0.48 85.98 60.14 47.04
120 INT324622 Regulation of Gene_expression of AMH 1 0.39 0.51 0.04 46.96
121 INT77959 Binding of Rare1 3 0.04 1.26 0.27 46.32
122 INT4145 Gene_expression of FSHR 124 0.77 44.98 13.04 46.24
123 INT251 Regulation of INS 398 0.62 232.47 55.04 45.68
124 INT89467 Gene_expression of Lhcgr 9 0.36 1.59 1.62 45.40
125 INT60339 Gene_expression of CYP21A2 8 0.66 4.04 2.77 45.20
126 INT127273 Gene_expression of AMH 24 0.78 9.53 0.47 45.20
127 INT26538 Positive_regulation of FSHR 103 0.69 30.95 15.33 44.80
128 INT15837 Binding of CGA 31 0.41 12.06 3.17 39.92
129 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 39.48
130 INT1512 Binding of Prl 73 0.48 26.22 20.63 39.44
131 INT21156 Binding of PLXNA3 21 0.36 7.95 3.3 38.00
132 INT58488 Positive_regulation of Gene_expression of Rorb 7 0.19 1.98 1.63 37.16
133 INT1644 Regulation of FSHR 77 0.55 15.62 21.49 37.04
134 INT58489 Gene_expression of Rorb 51 0.41 4.7 5.39 36.56
135 INT194343 Gene_expression of ABCC8 8 0.65 8.15 0.77 35.44
136 INT3002 Binding of SUGT1 62 0.24 55.9 14.91 34.64
137 INT5710 Negative_regulation of Localization of Lhb 146 0.57 20.51 58.33 33.68
138 INT80305 Gene_expression of IGKV2-30 6 0.04 3.68 1.01 33.48
139 INT13742 Gene_expression of Son 45 0.58 2.98 4.19 31.96
140 INT259197 Negative_regulation of Lepr 2 0.11 0.33 0 30.36
141 INT1586 Regulation of Binding of POMC 7 0.45 1.14 2.61 27.52
142 INT695 Binding of POMC 304 0.48 56.66 126.85 26.88
143 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71 25.00
144 INT16254 Positive_regulation of Gene_expression of Ngf 144 0.70 80.61 82.08 23.16
145 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 22.76
146 INT323049 Positive_regulation of IGKV2-30 1 0.00 3.44 0.07 21.40
147 INT28325 Negative_regulation of Tst 13 0.51 12.41 3.16 20.76
148 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 20.60
149 INT7232 Regulation of Negative_regulation of Lhb 9 0.45 3.63 3.29 20.28
150 INT306408 Regulation of Gene_expression of Tst 1 0.05 1.69 0.11 20.28
151 INT27774 Gene_expression of Tst 13 0.68 12.86 4.83 19.80
152 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 18.80
153 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81 18.16
154 INT29424 Negative_regulation of Positive_regulation of Lhb 21 0.56 4.58 4.03 18.16
155 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9 18.12
156 INT213272 Negative_regulation of Phosphorylation of INS 7 0.40 9.13 0.44 18.12
157 INT213275 Positive_regulation of Gene_expression of SHBG 6 0.46 4.24 0.19 17.92
158 INT197662 Negative_regulation of Positive_regulation of SHBG 5 0.39 3.54 0.52 16.96
159 INT231587 Regulation of SBDS 5 0.16 1.1 0.93 16.60
160 INT148210 Positive_regulation of Positive_regulation of SHBG 3 0.45 1.89 0.18 15.92
161 INT86475 Binding of ACAA1 7 0.28 1.83 5.11 15.60
162 INT7397 Negative_regulation of Localization of GNRH1 86 0.59 15.45 29.78 15.04
163 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 14.56
164 INT32963 Negative_regulation of Localization of GNRHR 3 0.29 2.48 0.84 14.56
165 INT323048 Binding of CYP21A2 1 0.37 1.9 0 12.56
166 INT1646 Negative_regulation of Localization of FSHR 17 0.58 7.36 3.46 11.84
167 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 10.40
168 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17 9.52
169 INT11622 Gene_expression of Coc 26 0.57 10.56 5.52 8.04
170 INT550 Negative_regulation of LDLR 66 0.43 44.71 3.04 7.44
171 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.68
172 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 5.68
173 INT266556 Positive_regulation of AMH 9 0.70 4.33 0.82 5.12
174 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 5.00
175 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 5.00
176 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
177 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 5.00
178 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
179 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 5.00
180 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 5.00
181 INT1114 Localization of Ins1 748 0.80 192.95 165.48 5.00
182 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
183 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 5.00
184 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 5.00
185 INT252 Localization of GH1 529 0.80 227.4 122.05 5.00
186 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 5.00
187 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 5.00
188 INT1793 Localization of CGA 379 0.81 67.38 114.69 5.00
189 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
190 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
191 INT1898 Regulation of Crh 220 0.62 61.33 102.64 5.00
192 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
193 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 5.00
194 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 5.00
195 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
196 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 5.00
197 INT2055 Regulation of Gnrh1 185 0.62 23.65 71.26 5.00
198 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 5.00
199 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 5.00
200 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
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