D:Hyperbilirubinemia

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Disease Term
Synonyms Bilirubinaemia, Bilirubinemia, Bilirubinemias, HYPERBILIRUBINAEMIA, HYPERBILIRUBINEMIAS
Documents 281
Hot Single Events 79
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperbilirubinemia. They are ordered first by their relevance to Hyperbilirubinemia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT151713 Binding of Alb and Ugt1a2 1 0.03 0.41 0.07 92.96
2 INT278610 CDCA2 Negative_regulation of NR1H4 1 0.01 0.62 0.13 68.08
3 INT271635 Negative_regulation of GRIN1 Negative_regulation of Positive_regulation of Ltp 1 0.00 0.65 0.93 5.00
4 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 5.00
5 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39 5.00
6 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38 5.00
7 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38 5.00
8 INT228530 Gopc Positive_regulation of Gene_expression of Nos2 2 0.22 0.67 0.28 5.00
9 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25 5.00
10 INT260743 Mapk14 Regulation of Gene_expression of Il10 1 0.04 0.99 0.24 5.00
11 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21 5.00
12 INT228532 Positive_regulation of Gopc Positive_regulation of Ros1 1 0.03 0.55 0.2 5.00
13 INT228531 Gopc Positive_regulation of Ros1 1 0.03 0.55 0.2 5.00
14 INT266646 HMOX2 Regulation of Gene_expression of Hmox1 1 0.00 0.87 0.2 5.00
15 INT274386 Binding of CD4 and ERVW-1 1 0.05 3.07 0.18 5.00
16 INT278609 PPARA Positive_regulation of Gene_expression of SULT2A1 1 0.33 0 0.17 5.00
17 INT278614 NR1I2 Regulation of Gene_expression of SULT2A1 1 0.11 0.11 0.15 5.00
18 INT278607 SULT2A1 Positive_regulation of Binding of PPARA 1 0.24 0 0.11 5.00
19 INT227400 Binding of DLAT and HCC 1 0.01 2.82 0.11 5.00
20 INT278683 PPARA Regulation of Chst10 1 0.22 0.09 0.08 5.00
21 INT273520 NBN Positive_regulation of CDIPT 1 0.06 0.82 0.08 5.00
22 INT278611 Binding of CASR and SULT2A1 1 0.03 0 0.07 5.00
23 INT278602 Binding of SULT2A1 and NR1I3 1 0.04 0 0.07 5.00
24 INT227418 Binding of DLAT and Pdc 1 0.05 1.01 0.07 5.00
25 INT278604 GSR Regulation of Gene_expression of SULT2A1 1 0.02 0.05 0.07 5.00
26 INT278684 Binding of NR1I3 and Rxra 1 0.00 0 0.07 5.00
27 INT278600 Binding of CASR and SULT2A1 Positive_regulation of SULT2A1 1 0.03 0 0.07 5.00
28 INT278685 Binding of CASR and Rxra 1 0.00 0 0.07 5.00
29 INT278613 NR3C1 Regulation of Gene_expression of SULT2A1 1 0.02 0.05 0.07 5.00
30 INT278601 NR1I2 Negative_regulation of Gene_expression of SULT2A1 1 0.10 0 0.06 5.00
31 INT278606 CASR Regulation of SULT2A1 1 0.04 0 0.05 5.00
32 INT278612 NR1I2 Regulation of SULT2A1 1 0.13 0 0.05 5.00
33 INT278603 NR1I2 Positive_regulation of Transcription of SULT2A1 1 0.12 0 0.05 5.00
34 INT227333 Il2 Positive_regulation of Hmox1 1 0.05 0.93 0.04 5.00
35 INT212584 IFNA1 Regulation of Gene_expression of CD4 1 0.21 0.98 0.03 5.00
36 INT278608 PPARA Positive_regulation of UGT1A9 1 0.25 0.29 0.03 5.00
37 INT273519 NBN Negative_regulation of YOD1 1 0.03 0.56 0.03 5.00
38 INT274384 AGRP Negative_regulation of HIVEP1 1 0.00 0.77 0.03 5.00
39 INT331909 Binding of ALB and SPARC 1 0.06 2.01 0 5.00
40 INT273518 Binding of ALB and NBN 1 0.06 0.47 0 5.00
41 INT274385 Binding of ABAT and CDIPT 1 0.00 1.21 0 5.00
42 INT347226 Hck Regulation of Gene_expression of Lyn 1 0.10 0.08 0 5.00
43 INT274387 Binding of POLA1 and IGSF9 1 0.01 0.58 0 5.00
44 INT347225 Hck Regulation of Positive_regulation of Bcr 1 0.15 0.07 0 5.00
45 INT278605 CDCA2 Positive_regulation of NR1H4 1 0.01 0.36 0 5.00
46 INT315889 Binding of B4GALNT1 and IKBKAP 1 0.00 0.68 0 5.00
47 INT284184 Binding of Akt1 and Pdgfrb 1 0.00 0.14 0 5.00
48 INT318806 Binding of VEGFA and NCOA1 1 0.00 0.22 0 5.00
49 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 0.14 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperbilirubinemia. They are ordered first by their pain relevance and then by number of times they were reported in Hyperbilirubinemia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT56251 Binding of NBN 4 0.38 3.16 0.62 100.00
2 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 100.00
3 INT260849 Gene_expression of NBN 9 0.67 7.11 0.16 100.00
4 INT35103 Positive_regulation of Positive_regulation of SLC17A5 5 0.12 7.51 1.25 100.00
5 INT170147 Positive_regulation of Regulation of Crp 1 0.03 0.99 0 99.96
6 INT22454 Regulation of Crp 213 0.62 160.67 49.24 99.96
7 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 99.96
8 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 99.96
9 INT3206 Positive_regulation of Got1 39 0.69 19.36 17.02 99.96
10 INT15229 Positive_regulation of CNDP1 21 0.69 15.86 4.06 99.96
11 INT36449 Negative_regulation of G6PD 74 0.59 54.15 8.85 99.88
12 INT284 Positive_regulation of Ggt6 18 0.67 13.56 4.62 99.88
13 INT4187 Gene_expression of Glce 2 0.67 1.16 0.89 99.76
14 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 99.60
15 INT67038 Positive_regulation of Positive_regulation of ALPP 5 0.08 2.61 0.77 99.60
16 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.58
17 INT66651 Negative_regulation of SLC45A2 3 0.57 1.31 1.12 99.40
18 INT4134 Negative_regulation of Glce 11 0.58 2.97 4.28 98.92
19 INT712 Positive_regulation of LDHA 160 0.70 175.25 19.11 98.84
20 INT231412 Positive_regulation of NBN 3 0.55 3.13 0.07 98.80
21 INT109476 Gene_expression of UGT1A7 5 0.78 0.9 0.32 98.72
22 INT230 Positive_regulation of GGTLC1 14 0.68 11.78 1.55 98.60
23 INT2316 Positive_regulation of Ugt1a5 5 0.67 0.84 1.52 98.44
24 INT41314 Gene_expression of GGTLC1 9 0.59 5.61 1.79 98.42
25 INT86947 Gene_expression of Arigg3 6 0.58 3.62 0.57 98.32
26 INT10923 Positive_regulation of Lipg 30 0.50 22.87 4.26 98.28
27 INT251082 Gene_expression of Serpina3c 2 0.65 2.3 0.07 98.26
28 INT347222 Gene_expression of Ugt1a1 1 0.44 0.28 0 98.26
29 INT347218 Positive_regulation of Gene_expression of Ugt1a1 1 0.32 0.28 0 98.26
30 INT347220 Positive_regulation of Gene_expression of Serpina3c 1 0.49 0.28 0 98.26
31 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 98.08
32 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 98.06
33 INT349463 Negative_regulation of Gene_expression of UGT1A1 1 0.22 1.05 0 97.84
34 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43 97.52
35 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47 97.44
36 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75 97.44
37 INT1624 Gene_expression of Cea 212 0.76 180.44 34.21 97.24
38 INT266627 Positive_regulation of Ugt1a2 3 0.04 5.54 0.56 96.08
39 INT266626 Binding of Ugt1a2 1 0.00 1.35 0.04 96.08
40 INT12035 Regulation of F2 21 0.45 12.66 1.47 95.68
41 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 95.52
42 INT273524 Regulation of UGT1A7 1 0.09 0.91 0 95.44
43 INT19947 Negative_regulation of B3GAT2 10 0.57 4.2 7.95 95.04
44 INT24756 Negative_regulation of Negative_regulation of B3GAT2 1 0.02 0.62 0.14 95.04
45 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 95.00
46 INT21756 Regulation of Alb 15 0.43 8.21 1.19 94.40
47 INT59870 Gene_expression of F3 51 0.65 51.83 14.01 92.96
48 INT86446 Protein_catabolism of Lipg 9 0.50 3.52 1.25 92.84
49 INT105897 Regulation of UGT1A1 3 0.60 1.6 0.13 92.48
50 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 92.48
51 INT234 Binding of Alb 151 0.48 52.34 32.97 91.84
52 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 91.60
53 INT231413 Negative_regulation of NBN 3 0.46 4.6 0.11 91.44
54 INT76924 Positive_regulation of Slc17a5 71 0.70 41.21 19.31 91.28
55 INT6480 Positive_regulation of IL1RN 59 0.69 33.7 16.66 91.16
56 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 90.52
57 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64 90.04
58 INT12333 Regulation of CYP3A 18 0.62 2.25 6.74 90.00
59 INT347219 Positive_regulation of Dleu2 1 0.67 1.59 0.14 90.00
60 INT273525 Regulation of NBN 1 0.49 1.28 0.05 89.40
61 INT9547 Regulation of TNNI3 25 0.56 14.22 2.22 89.24
62 INT9550 Gene_expression of TNNI3 113 0.78 86.79 10.56 88.84
63 INT14701 Negative_regulation of IFNA1 118 0.54 84.19 20.08 88.52
64 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 86.32
65 INT4391 Gene_expression of SERPINA1 47 0.78 41.43 9.7 85.40
66 INT72141 Binding of Apoe 11 0.37 10.91 3.27 85.20
67 INT50080 Binding of APOE 38 0.45 29.61 2.67 85.20
68 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 84.56
69 INT239104 Regulation of PR@ 3 0.21 1.33 1.63 84.52
70 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29 84.48
71 INT64538 Binding of TNNI3 17 0.48 11.65 1.83 84.28
72 INT10049 Negative_regulation of SERPINA1 56 0.59 44.52 9.93 84.16
73 INT63607 Positive_regulation of Pbrgcsf1 11 0.42 5.48 2.81 83.44
74 INT7995 Positive_regulation of Lta 28 0.66 14.98 9.8 83.12
75 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 82.52
76 INT122448 Regulation of Gene_expression of ABCB1 13 0.62 3.67 3.5 82.12
77 INT9552 Positive_regulation of TNNI3 209 0.70 128.67 19.15 81.00
78 INT85297 Positive_regulation of Gene_expression of TNNI3 29 0.50 29.77 1.68 81.00
79 INT227413 Gene_expression of DLAT 12 0.44 13.21 1.36 80.72
80 INT274389 Regulation of CDIPT 2 0.09 1.69 2.96 79.16
81 INT12237 Positive_regulation of Lipg 19 0.60 11.09 2.92 77.52
82 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 77.36
83 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 77.36
84 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 77.36
85 INT118575 Positive_regulation of G6PD 9 0.50 3.35 0.18 77.04
86 INT26606 Gene_expression of RNASE1 19 0.65 7.18 1.46 74.56
87 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 73.76
88 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98 73.48
89 INT105114 Gene_expression of Arigg4 16 0.52 21.88 4.56 73.44
90 INT26607 Gene_expression of Agl 2 0.08 1.77 0.35 73.36
91 INT2317 Gene_expression of Ugt1a5 2 0.58 0.35 0.68 72.72
92 INT55344 Gene_expression of Ros1 396 0.54 217.64 59.98 71.28
93 INT15007 Gene_expression of Pbrgcsf1 31 0.49 17.82 6.99 71.28
94 INT79671 Positive_regulation of Gene_expression of Pbrgcsf1 8 0.32 4.25 0.57 71.28
95 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 70.72
96 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 70.12
97 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44 69.92
98 INT18654 Gene_expression of HRH2 9 0.67 5.73 2.19 69.84
99 INT39560 Positive_regulation of F10 25 0.67 10.67 2.5 69.64
100 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 69.24
101 INT4437 Positive_regulation of ABCB7 11 0.68 11.26 1.33 68.40
102 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69 68.24
103 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 68.24
104 INT69781 Negative_regulation of FGF2 22 0.42 17.25 4.24 67.48
105 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 67.40
106 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 66.60
107 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 66.60
108 INT172458 Regulation of Gopc 155 0.53 62.57 24.86 66.56
109 INT16404 Regulation of CD4 54 0.61 33.05 10.29 66.48
110 INT2976 Regulation of Bche 29 0.45 8.56 9.42 65.36
111 INT16177 Positive_regulation of UGT1A3 3 0.57 0.98 0.41 63.84
112 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 63.24
113 INT118291 Binding of TXK 19 0.10 11.77 1.94 62.80
114 INT615 Regulation of Alb 66 0.62 33.43 15.33 62.40
115 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 62.24
116 INT320147 Phosphorylation of Bcr 2 0.67 0.64 0.11 61.76
117 INT2135 Regulation of Gpt 13 0.44 2.17 3.03 61.68
118 INT49266 Positive_regulation of Arigg4 37 0.47 53.79 11.2 61.44
119 INT100427 Binding of SERPINA1 9 0.36 9.63 2.51 59.92
120 INT3286 Positive_regulation of Gpt 90 0.69 45.08 28.34 59.52
121 INT49862 Negative_regulation of Positive_regulation of Gpt 8 0.41 3.49 2.6 59.52
122 INT97189 Gene_expression of Cd33 10 0.73 7.7 0.44 57.20
123 INT19706 Binding of Arigg4 2 0.02 1.76 0.16 57.16
124 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 56.96
125 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54 56.96
126 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55 56.96
127 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32 56.96
128 INT87844 Binding of IL1RN 40 0.41 24.37 11.92 56.92
129 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 56.32
130 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42 56.32
131 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6 56.32
132 INT219022 Positive_regulation of IgM 1:10240 1 0.01 1.44 0.16 52.72
133 INT6852 Localization of TNF 883 0.81 705.95 270.84 50.72
134 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 49.64
135 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 49.52
136 INT101693 Gene_expression of Ggt1 2 0.65 4.92 0.81 49.52
137 INT288 Positive_regulation of Sct 88 0.70 32.83 24.5 49.28
138 INT2367 Binding of Sct 34 0.42 8.46 8.62 49.28
139 INT260738 Gene_expression of Ugt1a2 2 0.02 2.22 0.5 49.04
140 INT189833 Negative_regulation of Phosphorylation of Stat1 4 0.51 1.1 0.3 47.28
141 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 46.80
142 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11 46.80
143 INT273556 Phosphorylation of Crkl 9 0.37 8.43 0.33 46.80
144 INT200803 Phosphorylation of Stat5a 2 0.59 1.23 0 46.80
145 INT6475 Positive_regulation of TNFRSF1B 9 0.43 5.19 0.92 46.24
146 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 45.32
147 INT51014 Transcription of IL2 42 0.71 21.56 12.7 44.24
148 INT141367 Negative_regulation of Transcription of IL2 9 0.32 2.07 2.43 44.24
149 INT5055 Positive_regulation of IFNG 89 0.69 64.03 23.05 42.40
150 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 41.28
151 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 41.28
152 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 41.20
153 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 41.16
154 INT166835 Regulation of HBB 1 0.02 1.08 0.08 40.96
155 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 39.92
156 INT156097 Negative_regulation of Localization of VEGFA 70 0.58 34.96 4.17 38.12
157 INT260740 Negative_regulation of Localization of Vegfa 1 0.10 0.19 0.12 38.12
158 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 37.68
159 INT12442 Localization of Vegfa 11 0.73 4.85 1.68 37.16
160 INT273555 Negative_regulation of Bcr 17 0.57 9.65 0.44 36.00
161 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 35.72
162 INT251 Regulation of INS 398 0.62 232.47 55.04 34.64
163 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 34.24
164 INT14294 Localization of RNASE1 2 0.36 1.32 0.53 33.12
165 INT9854 Localization of GGT1 11 0.78 6.09 3.57 31.68
166 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 31.20
167 INT504 Gene_expression of GPT 42 0.75 27.54 3.99 30.24
168 INT8670 Negative_regulation of Afp 27 0.58 19.85 2.87 29.80
169 INT20622 Gene_expression of LDHA 107 0.76 77.97 16.3 29.24
170 INT14292 Localization of Agl 2 0.10 1.31 0.53 29.04
171 INT107307 Transcription of IFNA1 30 0.52 18.16 9.61 27.84
172 INT320849 Binding of CARTPT 5 0.14 1.85 0.54 27.60
173 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 24.64
174 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 24.64
175 INT148944 Transcription of UGT1A1 3 0.59 0.07 1.84 22.40
176 INT278672 Positive_regulation of Transcription of UGT1A1 1 0.27 0.07 0.22 22.40
177 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 22.28
178 INT199553 Gene_expression of Bcr 25 0.76 13.83 0.48 21.48
179 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 20.80
180 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 20.80
181 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 20.80
182 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 20.80
183 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 19.04
184 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 19.04
185 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 18.72
186 INT546 Binding of ALB 311 0.48 85.98 60.14 18.36
187 INT10048 Positive_regulation of SERPINA1 11 0.68 8.59 2.43 14.56
188 INT98068 Gene_expression of SCN2A 19 0.75 14.42 3.31 14.48
189 INT94827 Gene_expression of HBS1L 24 0.67 26.11 1.61 13.28
190 INT214059 Binding of GZMB 2 0.02 1.36 0.35 10.60
191 INT90584 Gene_expression of GZMB 15 0.14 13.81 1.86 10.04
192 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 8.72
193 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 8.72
194 INT227417 Protein_catabolism of DLAT 1 0.44 1.51 0.27 7.40
195 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
196 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
197 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
198 INT3579 Localization of Oxt 555 0.81 43.35 292.44 5.00
199 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 5.00
200 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
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