D:Hypercapnia

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms None
Documents 780
Hot Single Events 154
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypercapnia. They are ordered first by their relevance to Hypercapnia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT10552 Penk Positive_regulation of Regulation of Cebpz 1 0.44 0.25 1.03 99.32
2 INT345966 Binding of Arid1a and al44 1 0.00 1.56 0.05 97.20
3 INT92196 Binding of EDNRB and Edn3 1 0.03 0.91 0 97.04
4 INT249131 Positive_regulation of C2 Positive_regulation of CEBPZ 1 0.05 0.43 0.07 96.72
5 INT201227 C2 Regulation of CEBPZ 2 0.06 1.19 0.07 96.28
6 INT345965 Binding of Lep and al44 1 0.01 1.43 0.05 93.60
7 INT284570 Binding of Avp and Il6 1 0.04 2.17 0.13 88.60
8 INT149730 LOC500077 Regulation of Cebpz 1 0.34 1.23 0.77 81.76
9 INT249130 Positive_regulation of C2 Positive_regulation of CEBPZ 1 0.05 0.25 0 77.80
10 INT249129 C2 Positive_regulation of CEBPZ 1 0.05 0.25 0 77.00
11 INT50514 CSAD Regulation of Cebpz 1 0.02 0.48 0.38 49.76
12 INT50515 CSAD Positive_regulation of CSAD Regulation of Cebpz 1 0.00 0.48 0.38 49.76
13 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97 5.00
14 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67 5.00
15 INT246336 Fig4 Regulation of Localization of Nts 1 0.18 0 0.66 5.00
16 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 5.00
17 INT340212 Csf2 Positive_regulation of Pttg1ip 1 0.02 0.46 0.49 5.00
18 INT132792 IL4 Positive_regulation of IL6 4 0.28 1.81 0.47 5.00
19 INT132801 IL4 Positive_regulation of Localization of IL6 2 0.26 1.47 0.26 5.00
20 INT274094 EDN1 Positive_regulation of AGT 1 0.16 0.95 0.2 5.00
21 INT274353 DST Regulation of Gopc 1 0.00 0 0.17 5.00
22 INT353041 IL4 Positive_regulation of Localization of IL1B 1 0.02 0.99 0.16 5.00
23 INT353036 IL4 Positive_regulation of Localization of IL10 1 0.03 0.99 0.16 5.00
24 INT353040 IL4 Positive_regulation of IL8 1 0.02 0.99 0.16 5.00
25 INT353037 IL4 Positive_regulation of IL2 1 0.02 0.99 0.16 5.00
26 INT353038 IL4 Positive_regulation of Localization of IL2 1 0.02 0.99 0.16 5.00
27 INT353039 IL4 Positive_regulation of Localization of IL8 1 0.02 0.99 0.16 5.00
28 INT257937 Binding of CSF2 and INVS 1 0.04 1.1 0.14 5.00
29 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14 5.00
30 INT291967 INA Positive_regulation of NA 1 0.00 0.98 0.14 5.00
31 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14 5.00
32 INT177589 Binding of HBG1 and C7orf49 1 0.00 0 0.12 5.00
33 INT353318 NOS1 Positive_regulation of Localization of Tbxa2r 1 0.04 0.71 0.12 5.00
34 INT223088 Binding of ELF3 and NAGLU 1 0.14 0.84 0.09 5.00
35 INT223089 Binding of IDS and NAGLU 1 0.26 0.72 0.09 5.00
36 INT171616 Sh2d1b2 Negative_regulation of Pitm1 1 0.01 0.47 0.08 5.00
37 INT337118 MCRS1 Negative_regulation of C7orf49 1 0.00 0.66 0.04 5.00
38 INT353314 Edn1 Positive_regulation of Kalrn 1 0.03 0.21 0.04 5.00
39 INT274095 Binding of EDNRA and OPA1 1 0.12 0.65 0.04 5.00
40 INT353317 Edn1 Positive_regulation of RHOA 1 0.19 0.16 0.04 5.00
41 INT315034 Ass1 Positive_regulation of Cacna1f 1 0.00 0 0.03 5.00
42 INT315033 Binding of Calm3 and Vsig2 1 0.00 0 0 5.00
43 INT256210 NPPB Regulation of PVR 1 0.24 1.14 0 5.00
44 INT221910 Binding of SRI and COPD 1 0.01 1.27 0 5.00
45 INT274096 Binding of EDN1 and EDNRA Positive_regulation of Positive_regulation of EDN1 1 0.22 0.78 0 5.00
46 INT315029 Binding of Calm3 and Cacna1f 1 0.04 0 0 5.00
47 INT256209 AVP Regulation of PVR 1 0.06 0.99 0 5.00
48 INT315035 Binding of NAE1 and Cav1 1 0.01 0.7 0 5.00
49 INT353316 Prkg1 Positive_regulation of Phosphorylation of PRKG1 1 0.00 0.06 0 5.00
50 INT256211 NPPB Regulation of PDAP1 1 0.28 1.14 0 5.00
51 INT315031 Binding of Cacna1f and Vsig2 1 0.02 0 0 5.00
52 INT195460 Binding of CHM and CEBPZ 1 0.03 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypercapnia. They are ordered first by their pain relevance and then by number of times they were reported in Hypercapnia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT738 Regulation of POMC 459 0.62 111.19 243.74 100.00
2 INT130730 Negative_regulation of C2 11 0.57 3.81 1.7 100.00
3 INT189927 Gene_expression of Arid1a 8 0.59 9.03 0.43 100.00
4 INT345950 Positive_regulation of Gene_expression of Arid1a 1 0.12 3.63 0.37 100.00
5 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 100.00
6 INT2531 Positive_regulation of Cebpz 166 0.00 43.08 38.86 99.98
7 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 99.98
8 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 99.98
9 INT477 Localization of Avp 813 0.81 131.58 300.4 99.92
10 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 99.88
11 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72 99.88
12 INT35261 Positive_regulation of Positive_regulation of Cebpz 13 0.41 2.52 3.87 99.84
13 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6 99.84
14 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 99.82
15 INT345962 Positive_regulation of Ahi1 1 0.10 4.11 0 99.78
16 INT2532 Negative_regulation of Cebpz 98 0.00 53.06 28.57 99.68
17 INT201233 Localization of CEBPZ 4 0.62 0.82 0.77 99.68
18 INT156334 Gene_expression of Phox2b 2 0.77 0.26 0.59 99.68
19 INT169742 Negative_regulation of Gene_expression of Phox2b 1 0.37 0.17 0.45 99.68
20 INT1169 Negative_regulation of Bche 322 0.59 149.22 61.27 99.62
21 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74 99.58
22 INT92575 Positive_regulation of Regulation of CEBPZ 1 0.36 0.52 0.12 99.56
23 INT97987 Positive_regulation of Localization of CCRN4L 1 0.49 1.73 0.6 99.48
24 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.44
25 INT10551 Negative_regulation of Positive_regulation of Cebpz 14 0.38 3.22 4.6 99.44
26 INT45094 Regulation of Ibsp 3 0.59 1.57 1.46 99.44
27 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.44
28 INT218598 Localization of Amigo2 2 0.15 2.15 0.35 99.44
29 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.44
30 INT71764 Positive_regulation of Mri1 24 0.44 12.31 5.67 99.36
31 INT163581 Localization of Lep 27 0.79 18.99 4.08 99.34
32 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 99.32
33 INT316 Regulation of Cebpz 105 0.00 27.21 35.41 99.32
34 INT2330 Regulation of CB 78 0.10 20.46 32.6 99.28
35 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5 99.28
36 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81 99.28
37 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 99.24
38 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 99.20
39 INT70970 Binding of COPD 144 0.42 180.34 18.29 99.04
40 INT88625 Localization of CCRN4L 4 0.78 4.15 2.14 99.00
41 INT147792 Gene_expression of COPD 230 0.70 287.13 24.1 98.98
42 INT125312 Positive_regulation of COPD 134 0.59 162.55 20.27 98.74
43 INT214 Localization of AVP 370 0.81 208.51 91.09 98.72
44 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 98.72
45 INT79126 Gene_expression of Wdyhv1 1 0.07 0.8 1.36 98.60
46 INT25 Positive_regulation of LAMC2 19 0.67 8.64 7.06 98.60
47 INT91338 Binding of Lep 31 0.48 26.86 5.39 98.24
48 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65 98.24
49 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19 98.24
50 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 98.16
51 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 97.88
52 INT218600 Regulation of Gene_expression of Btg2 1 0.02 1.69 0.06 97.68
53 INT74980 Regulation of Htas2 3 0.44 0.36 1.32 97.56
54 INT218587 Gene_expression of Btg2 16 0.11 7.4 0.51 97.28
55 INT340203 Regulation of Smyd5 1 0.07 1.5 1.34 97.28
56 INT60436 Negative_regulation of COPD 76 0.37 84.22 9.08 97.04
57 INT45576 Positive_regulation of Ibsp 4 0.41 3.41 1.21 97.04
58 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78 96.96
59 INT103300 Negative_regulation of Gene_expression of CRTAC1 3 0.44 2.87 0.7 96.96
60 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 96.96
61 INT20055 Gene_expression of CRTAC1 19 0.58 15.49 4.73 96.96
62 INT3244 Negative_regulation of eCB 37 0.03 16.69 12.61 96.96
63 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 96.88
64 INT44608 Gene_expression of C2 45 0.75 15.84 5.05 96.76
65 INT111279 Positive_regulation of Gene_expression of C2 8 0.49 1.06 0.94 96.76
66 INT1116 Regulation of Ren 103 0.62 27.66 33.26 96.76
67 INT4588 Positive_regulation of Regulation of Ren 4 0.47 1.24 2.26 96.76
68 INT74505 Positive_regulation of Inadl2 12 0.35 2.1 7.83 96.68
69 INT24 Negative_regulation of Positive_regulation of LAMC2 1 0.42 0.55 0.21 96.56
70 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 96.52
71 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 96.24
72 INT63780 Positive_regulation of Localization of Ado 3 0.32 2.79 2.29 96.20
73 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 96.20
74 INT275594 Gene_expression of DYNC1I1 4 0.04 11.7 0.09 96.00
75 INT63779 Localization of Ado 6 0.64 4.8 3.81 95.88
76 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 95.64
77 INT65452 Negative_regulation of Cacna1c 8 0.09 0.8 1.44 95.20
78 INT35407 Positive_regulation of C2 25 0.69 7.74 2.59 95.04
79 INT37168 Positive_regulation of APCS 22 0.67 9.61 4.59 95.04
80 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 94.80
81 INT146387 Positive_regulation of Regulation of Mbp 1 0.43 0.25 1.71 94.76
82 INT259580 Negative_regulation of Binding of COPD 2 0.10 3.44 0.17 94.72
83 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 94.64
84 INT84021 Regulation of Mbp 8 0.57 6.79 3.09 94.48
85 INT102584 Regulation of Gdf15 3 0.60 1.11 1.81 94.48
86 INT38189 Regulation of Svs4 6 0.24 2.68 3.35 94.40
87 INT63781 Regulation of Ado 8 0.34 3.78 5.19 94.40
88 INT5118 Regulation of SST 97 0.62 34.35 51.74 93.28
89 INT16395 Gene_expression of CEBPZ 30 0.57 11.02 6.66 92.64
90 INT68758 Positive_regulation of Ros1 125 0.46 82.72 25.27 92.36
91 INT201232 Binding of CEBPZ 7 0.31 1.73 1.7 91.76
92 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 91.72
93 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 90.52
94 INT1703 Regulation of PCa 52 0.52 23.65 20.6 90.44
95 INT254724 Negative_regulation of DHFR 2 0.42 3.92 1.39 90.20
96 INT14166 Positive_regulation of Ahr 32 0.61 20.78 7.47 90.20
97 INT1114 Localization of Ins1 748 0.80 192.95 165.48 90.04
98 INT74272 Localization of CPOX 39 0.63 25.12 10.53 89.76
99 INT123841 Regulation of MMD 4 0.30 1.93 0.39 89.68
100 INT149125 Gene_expression of Slc4a3 25 0.78 3.45 2.41 89.56
101 INT118912 Regulation of Positive_regulation of cerebral blood flow 1 0.01 0.82 0.23 89.48
102 INT38363 Negative_regulation of Slc4a4 4 0.36 0.09 0.5 89.44
103 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65 89.36
104 INT88868 Binding of MCS 45 0.40 37.43 7.98 89.16
105 INT17916 Gene_expression of LOC308670 4 0.02 1.62 0.81 89.00
106 INT2339 Positive_regulation of CB 30 0.29 10.68 9.12 88.68
107 INT894 Binding of Avp 84 0.48 29.16 29.63 88.60
108 INT51474 Binding of Il6 55 0.48 44.99 20.52 88.60
109 INT74051 Negative_regulation of Localization of Car2 27 0.38 9.58 5.1 88.32
110 INT273279 Negative_regulation of Localization of Tmie 2 0.07 1.72 0.2 88.32
111 INT170507 Localization of Tmie 27 0.43 6.25 1.31 87.80
112 INT19511 Localization of Il6 212 0.81 118.17 67.67 87.80
113 INT17561 Localization of Car2 303 0.79 60.95 44.52 87.68
114 INT685 Regulation of AVP 124 0.62 34.9 39.91 87.64
115 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 87.64
116 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 87.44
117 INT35009 Binding of CSAD 12 0.41 10.74 3.21 87.28
118 INT15213 Positive_regulation of Htas2 9 0.67 3.86 5.14 86.80
119 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 86.80
120 INT10924 Positive_regulation of Sysbp1 25 0.04 11.12 7.35 86.64
121 INT218593 Regulation of Gene_expression of Ecm1 1 0.04 1.49 0.1 86.56
122 INT132187 Gene_expression of Ecm1 14 0.21 8.12 3.52 86.56
123 INT170503 Positive_regulation of Localization of Tmie 11 0.29 3.27 0.61 86.48
124 INT47378 Positive_regulation of Negative_regulation of Cebpz 4 0.46 2.38 0.77 85.92
125 INT88098 Positive_regulation of 3110062M04Rik 10 0.48 4.37 4.45 85.76
126 INT57244 Positive_regulation of Caprin2 5 0.13 3.44 2.39 85.36
127 INT1893 Localization of Gh 1041 0.79 340.23 256.58 85.00
128 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 84.72
129 INT9757 Regulation of Slc4a4 3 0.23 0.31 1.17 84.60
130 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 84.40
131 INT5573 Negative_regulation of Gene_expression of Penk 113 0.59 21.83 64.66 84.40
132 INT218583 Regulation of Positive_regulation of Rela 1 0.05 1.51 0.21 84.28
133 INT15998 Gene_expression of Kcne2 7 0.46 8.1 1.61 84.24
134 INT142404 Gene_expression of THPO 18 0.77 4.39 0.56 84.24
135 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 84.12
136 INT74250 Negative_regulation of Gene_expression of Ins1 47 0.40 39.27 5.37 83.92
137 INT45575 Gene_expression of Ibsp 8 0.50 11.83 2.85 83.84
138 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2 83.72
139 INT52349 Gene_expression of CHM 7 0.77 17.33 0.28 83.52
140 INT10848 Negative_regulation of Gene_expression of AVP 13 0.59 6.76 2.71 83.28
141 INT654 Localization of REN 250 0.81 75.12 47.86 83.08
142 INT139009 Positive_regulation of Localization of Cir1 10 0.44 2.98 1.55 82.84
143 INT45090 Negative_regulation of IRGM 3 0.51 1.06 1.14 82.76
144 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 82.76
145 INT119803 Localization of Cir1 12 0.70 3.39 2 82.40
146 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54 82.36
147 INT179688 Negative_regulation of Gene_expression of COPD 13 0.35 16.06 0.97 82.16
148 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55 81.84
149 INT96919 Positive_regulation of Snd1 3 0.41 0.94 0.53 81.68
150 INT35132 Gene_expression of PDAP1 18 0.52 9.05 1.5 81.20
151 INT249132 Negative_regulation of Positive_regulation of C2 1 0.05 0.29 0 80.96
152 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27 80.96
153 INT9748 Negative_regulation of Sysbp1 28 0.35 8.93 3.87 80.96
154 INT48909 Localization of DLD 9 0.63 3.37 0.75 80.56
155 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 79.92
156 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 79.68
157 INT56580 Positive_regulation of Htr1b 16 0.67 2.95 7.97 79.68
158 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 79.68
159 INT14165 Negative_regulation of Ahr 14 0.51 8.35 4.17 79.52
160 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 79.20
161 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 79.04
162 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 78.12
163 INT3978 Regulation of Regulation of cerebral blood flow 2 0.00 0.57 1.16 77.20
164 INT3127 Gene_expression of SRI 38 0.68 26.29 3.82 77.08
165 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 76.16
166 INT92195 Negative_regulation of Edn3 3 0.43 1.92 0.43 75.84
167 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 75.00
168 INT2140 Regulation of REN 104 0.62 28.24 24.49 75.00
169 INT345960 Positive_regulation of D0Ffm3 1 0.03 2.33 0.07 74.96
170 INT10478 Protein_catabolism of Alms1 25 0.47 12.95 7.19 74.72
171 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 74.40
172 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 73.92
173 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 73.76
174 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 73.36
175 INT147793 Localization of COPD 70 0.64 89.01 7.3 73.36
176 INT215987 Regulation of Mri1 4 0.30 2.1 1.54 73.04
177 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62 72.24
178 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 71.68
179 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 71.56
180 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78 71.12
181 INT130727 Regulation of C2 12 0.32 5.95 0.81 70.84
182 INT246333 Localization of Sars 1 0.51 1.02 3.24 70.40
183 INT177596 Regulation of Gene_expression of C7orf49 1 0.03 0.13 0.11 70.36
184 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97 70.32
185 INT17740 Localization of ENO2 11 0.80 10.54 0.93 70.20
186 INT17742 Localization of S100B 44 0.80 17.14 4.65 69.84
187 INT177600 Gene_expression of C7orf49 21 0.52 7.1 6.92 69.76
188 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 69.52
189 INT220506 Binding of Cav1 13 0.45 5.46 0.38 69.44
190 INT108761 Localization of Alms1 24 0.70 13.92 3.74 69.40
191 INT99550 Regulation of FLNA 51 0.54 27.88 2.58 68.72
192 INT639 Regulation of LAMC2 8 0.44 4.68 2.92 67.72
193 INT195817 Gene_expression of ipv 28 0.58 31.04 1.86 67.12
194 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 66.96
195 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 66.64
196 INT10553 Regulation of GPER 13 0.15 2.12 3.02 66.48
197 INT10554 Regulation of Regulation of GPER 3 0.01 0.45 0.76 66.48
198 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 66.16
199 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 65.84
200 INT102255 Regulation of Prnp 35 0.62 18.97 3.25 65.04
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox