D:Hypereosinophilic Syndrome

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Disease Term
Synonyms ENDOCARDITIS LOEFFLER, ENDOCARDITIS LOEFFLER S, Endocarditis Loefflers, EOSINOPHILIC LEUKEMIA, Eosinophilic Leukemias, Hypereosinophilic Syndrome Idiopathic, Hypereosinophilic Syndromes, Hypereosinophilic Syndromes Idiopathic, IDIOPATHIC HYPEREOSINOPHILIC SYNDROME, Idiopathic Hypereosinophilic Syndromes, Leukemia Eosinophilic
Documents 73
Hot Single Events 53
Hot Interactions 6

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypereosinophilic Syndrome. They are ordered first by their relevance to Hypereosinophilic Syndrome and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT214886 Binding of Atcay and FIP1L1 1 0.08 4.06 0 100.00
2 INT214885 Binding of PDGFRA and Atcay 1 0.08 4.05 0 100.00
3 INT350523 ABL1 Negative_regulation of Pmf1 1 0.01 2.19 0 92.00
4 INT350504 ABL1 Negative_regulation of JAK2 1 0.20 2.18 0 92.00
5 INT177958 IGHE Positive_regulation of TNF 1 0.03 2.23 0 85.20
6 INT177959 Positive_regulation of IGHE Positive_regulation of TNF 1 0.03 2.23 0 85.20
7 INT332588 Binding of RAPH1 and MND1 1 0.01 3.88 0.07 16.20
8 INT211105 Binding of CRS and IGHE 1 0.02 3.63 0.66 5.00
9 INT164902 Binding of IL1RL1 and IL33 4 0.37 1.2 0.53 5.00
10 INT274170 Il13 Regulation of Il4 3 0.09 2.75 0.51 5.00
11 INT294762 Il4 Regulation of Il13 2 0.09 0.92 0.32 5.00
12 INT177961 Binding of CCR3 and CCL11 1 0.04 0.73 0.26 5.00
13 INT177957 CCL11 Regulation of Binding of IL5 and CCL11 1 0.01 0.71 0.25 5.00
14 INT177960 Binding of IL5 and CCL11 1 0.03 0.71 0.25 5.00
15 INT319383 Binding of CCL18 and CCL22 1 0.19 1.07 0.25 5.00
16 INT344428 Il13 Positive_regulation of Gene_expression of Siglec5 1 0.27 0.46 0.21 5.00
17 INT177962 IL4 Positive_regulation of VCAM1 1 0.02 0.97 0.2 5.00
18 INT319381 Binding of ST2 and IL33 1 0.13 1.01 0.18 5.00
19 INT344429 Siglec5 Regulation of Gene_expression of Fn1 1 0.11 0.65 0.18 5.00
20 INT304169 Il33 Positive_regulation of Gene_expression of Itgam 1 0.02 1.18 0.15 5.00
21 INT344427 Il4 Regulation of Gene_expression of Siglec5 1 0.14 0.35 0.09 5.00
22 INT344433 Il13 Regulation of Gene_expression of Siglec5 1 0.18 0.35 0.09 5.00
23 INT304172 Il5 Positive_regulation of Bcl2l1 1 0.02 0.91 0.05 5.00
24 INT344434 TNF Positive_regulation of Gene_expression of Siglec5 1 0.43 0 0.04 5.00
25 INT344431 Il13 Positive_regulation of Siglec5 1 0.29 0 0.04 5.00
26 INT344430 Il4 Positive_regulation of Siglec5 1 0.23 0 0.04 5.00
27 INT319384 Binding of AR and SCGB2A2 1 0.01 1.36 0.04 5.00
28 INT344432 Il4 Positive_regulation of Gene_expression of Siglec5 1 0.32 0 0.04 5.00
29 INT319382 Binding of IL13 and CRISP3 1 0.09 0.87 0.03 5.00
30 INT277765 Binding of BCR and Abl1 1 0.18 1.55 0.03 5.00
31 INT332587 MND1 Positive_regulation of Binding of RAPH1 and MND1 1 0.00 2.21 0.03 5.00
32 INT304170 Binding of Apaf1 and Positive_regulation of Casp9 1 0.01 0.51 0 5.00
33 INT304175 IL1B Positive_regulation of Gene_expression of Vcam1 1 0.02 0.96 0 5.00
34 INT304135 Binding of CEL and Positive_regulation of CASP8 1 0.00 0.52 0 5.00
35 INT285291 TNF Positive_regulation of Gene_expression of Vcam1 2 0.10 3.1 0 5.00
36 INT304176 Binding of IL1B and Il13 1 0.00 0.96 0 5.00
37 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0 5.00
38 INT304167 Il4 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.94 0 5.00
39 INT304168 Binding of Gata1 and Sfpi1 1 0.08 0.07 0 5.00
40 INT347226 Hck Regulation of Gene_expression of Lyn 1 0.10 0.08 0 5.00
41 INT347225 Hck Regulation of Positive_regulation of Bcr 1 0.15 0.07 0 5.00
42 INT304171 Il13 Positive_regulation of Gene_expression of Vcam1 1 0.04 0.89 0 5.00
43 INT304174 Binding of IL1B and Il4 1 0.00 0.96 0 5.00
44 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 0.07 1.5 0 5.00
45 INT347224 Lyn Regulation of Positive_regulation of Bcr 1 0.14 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypereosinophilic Syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Hypereosinophilic Syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT275621 Positive_regulation of Atcay 3 0.06 2.15 0.04 100.00
2 INT214882 Gene_expression of Atcay 2 0.17 0.67 0 100.00
3 INT277763 Localization of DPM1 1 0.03 2.34 0 100.00
4 INT214883 Binding of Atcay 2 0.10 1.1 0.22 100.00
5 INT4465 Gene_expression of CEL 116 0.77 98.35 23.58 99.84
6 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 99.80
7 INT51264 Positive_regulation of TXK 21 0.54 10.69 1.1 99.76
8 INT119101 Negative_regulation of FIP1L1 1 0.31 1.02 0.1 99.72
9 INT319411 Negative_regulation of Transcription of PDGFB 1 0.15 1.03 0.07 99.62
10 INT119104 Negative_regulation of PDGFRL 1 0.07 1.08 0.13 99.60
11 INT91173 Gene_expression of Pdgfrb 33 0.65 32.55 3.09 99.56
12 INT20380 Gene_expression of Il5 172 0.78 104.75 34.78 99.54
13 INT304136 Positive_regulation of Fip1l1 1 0.24 1.7 0.05 99.48
14 INT74530 Transcription of PDGFB 7 0.65 4.56 1.47 99.42
15 INT153294 Binding of FIP1L1 1 0.36 0.7 0.08 98.92
16 INT304147 Gene_expression of Fip1l1 1 0.32 2.07 0 98.86
17 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 98.64
18 INT119103 Gene_expression of FIP1L1 2 0.49 2.95 0.11 98.06
19 INT181025 Localization of Sfpi1 3 0.80 4.96 0.38 98.04
20 INT119102 Gene_expression of PDGFRA 13 0.75 11.99 0.81 97.92
21 INT11203 Gene_expression of BCR 30 0.75 33.49 1.22 96.46
22 INT117002 Negative_regulation of Sfpi1 16 0.58 9.72 1 96.40
23 INT192748 Localization of BCR 4 0.68 2.4 0.18 96.10
24 INT241506 Localization of Abl1 2 0.54 2.37 0.04 96.02
25 INT73200 Positive_regulation of PDGFRB 10 0.67 9.67 0.48 95.80
26 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 95.52
27 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98 94.52
28 INT117004 Gene_expression of Sfpi1 21 0.75 15.95 5.29 94.24
29 INT69160 Positive_regulation of IL5 41 0.65 36.04 7.75 93.64
30 INT1125 Positive_regulation of IGHG3 130 0.69 112.07 13.18 93.52
31 INT277761 Gene_expression of DPM1 1 0.03 9.23 0.27 92.72
32 INT199573 Gene_expression of Abl1 33 0.65 20.79 0.75 92.32
33 INT304148 Gene_expression of Csf2ra 1 0.36 2.09 0.65 91.60
34 INT134909 Positive_regulation of TRIM21 1 0.67 0.95 0.16 90.56
35 INT207134 Positive_regulation of tryptase 11 0.47 11.16 1.21 90.44
36 INT150165 Gene_expression of MTTP 21 0.75 10.1 0.73 89.56
37 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57 88.96
38 INT5870 Negative_regulation of IFNA2 20 0.49 12 4.3 87.56
39 INT76416 Positive_regulation of Gene_expression of Il5 9 0.08 4.16 1.65 86.96
40 INT63401 Gene_expression of Il5 33 0.72 18.66 8.2 86.12
41 INT309257 Transcription of LMOD1 3 0.36 1.71 1.57 85.92
42 INT319401 Transcription of MYH11 1 0.36 1.01 0.09 85.92
43 INT319415 Transcription of FHL1 1 0.31 1.01 0.09 85.92
44 INT261746 Transcription of CNN1 2 0.47 1.01 0.09 85.92
45 INT319399 Transcription of MYRIP 1 0.29 0.99 0.08 85.92
46 INT319422 Transcription of PLN 1 0.14 0.99 0.08 85.92
47 INT319414 Transcription of ACTG2 1 0.24 0.99 0.08 85.92
48 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 85.80
49 INT3988 Positive_regulation of Gene_expression of IGHE 98 0.68 91.46 9.61 85.80
50 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 85.80
51 INT241510 Negative_regulation of Phosphorylation of Kit 3 0.31 2.06 0.03 84.68
52 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 84.64
53 INT213789 Phosphorylation of Kit 7 0.69 5.32 0.43 84.24
54 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 75.00
55 INT27495 Positive_regulation of IGLV2-14 1 0.67 3.28 0.34 75.00
56 INT344414 Positive_regulation of Gene_expression of Siglec5 1 0.57 2.82 1.26 74.56
57 INT304151 Gene_expression of Siglec5 2 0.74 17.33 6.03 73.76
58 INT277758 Negative_regulation of Fip1l1 1 0.06 0.5 0.04 71.48
59 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 68.72
60 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 66.40
61 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53 66.40
62 INT310747 Regulation of JAK2 2 0.33 1.58 0.05 65.36
63 INT122196 Gene_expression of TAL1 5 0.47 2.07 0.63 65.28
64 INT144019 Negative_regulation of Pdgfrb 21 0.58 14.93 1.26 65.04
65 INT16068 Gene_expression of SERPINB1 27 0.60 20.51 6.56 64.64
66 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 64.16
67 INT25493 Gene_expression of TFPI 74 0.76 39.44 14.78 63.92
68 INT273555 Negative_regulation of Bcr 17 0.57 9.65 0.44 63.76
69 INT234417 Positive_regulation of Gene_expression of ABL1 4 0.37 3.65 0.03 63.12
70 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 62.80
71 INT117662 Gene_expression of ABL1 21 0.69 18.76 0.39 62.60
72 INT74529 Binding of PDGFB 13 0.36 7.41 0.62 62.40
73 INT319408 Negative_regulation of Binding of PDGFB 1 0.15 0.89 0.09 62.40
74 INT350510 Localization of ABL1 1 0.40 2.51 0 62.04
75 INT22030 Negative_regulation of Cysltr1 31 0.39 21.83 12.49 61.84
76 INT134325 Positive_regulation of IL4R 3 0.36 4.75 0.63 53.76
77 INT228727 Transcription of Il5 4 0.27 5.13 0.9 47.08
78 INT304149 Positive_regulation of Transcription of Il5 1 0.09 1.81 0.08 47.08
79 INT304144 Localization of Csf2ra 1 0.32 0.3 0.27 45.96
80 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 44.20
81 INT98225 Regulation of Il5 8 0.45 5.07 2.06 43.68
82 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 42.04
83 INT144024 Negative_regulation of Phosphorylation of Pdgfrb 6 0.42 3.48 0.51 40.84
84 INT137908 Phosphorylation of Pdgfrb 14 0.81 8.44 2.45 40.28
85 INT113101 Gene_expression of Ccl11 41 0.76 22.36 5.47 39.76
86 INT304139 Gene_expression of Ccl26 1 0.36 1.33 0.08 39.32
87 INT277757 Gene_expression of Pmf1 3 0.12 4.14 0.23 39.16
88 INT312302 Gene_expression of Prss27 2 0.02 3.95 0.19 39.00
89 INT16449 Binding of IGHG3 67 0.48 39.55 10.59 36.56
90 INT43907 Binding of CD79A 28 0.48 28.11 3.04 36.56
91 INT177760 Negative_regulation of Gene_expression of IFN1@ 21 0.57 16.61 2.89 32.04
92 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 31.68
93 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 30.72
94 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83 29.16
95 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 28.76
96 INT273560 Negative_regulation of Crkl 2 0.22 2.5 0.14 21.84
97 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 21.68
98 INT54302 Positive_regulation of Gene_expression of Il4 126 0.68 86.18 30.75 21.68
99 INT126984 Positive_regulation of Gene_expression of Il5 29 0.69 20.61 6.72 20.96
100 INT61171 Gene_expression of S100A8 92 0.76 57.74 9.98 20.32
101 INT157342 Gene_expression of S100A9 19 0.60 21.27 3.37 20.32
102 INT94042 Positive_regulation of Gene_expression of S100A8 15 0.67 13.52 2.44 20.32
103 INT297918 Positive_regulation of Gene_expression of S100A9 2 0.37 2.15 0.07 20.32
104 INT63839 Binding of CRS 31 0.41 34.05 4.7 17.36
105 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 16.56
106 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 16.56
107 INT30738 Negative_regulation of Gene_expression of ALB 32 0.59 19.01 5.04 16.56
108 INT73731 Binding of RAPH1 9 0.33 14.58 0.5 16.20
109 INT332592 Binding of MND1 1 0.08 9.21 0.16 16.20
110 INT191601 Negative_regulation of Fdft1 2 0.04 2.13 0.33 8.84
111 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
112 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
113 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
114 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
115 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
116 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 5.00
117 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
118 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
119 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
120 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
121 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
122 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 5.00
123 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
124 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 5.00
125 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 5.00
126 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
127 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 5.00
128 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 5.00
129 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
130 INT100939 Gene_expression of Il13 176 0.73 125.1 43.38 5.00
131 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 5.00
132 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 5.00
133 INT60710 Gene_expression of Col7a1 217 0.78 113.2 35.2 5.00
134 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
135 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
136 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81 5.00
137 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
138 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
139 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 5.00
140 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32 5.00
141 INT15174 Gene_expression of Itgam 238 0.73 104.92 29.26 5.00
142 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
143 INT12124 Gene_expression of MAPK1 141 0.75 82.4 25.58 5.00
144 INT130186 Gene_expression of Ccl5 101 0.74 79.96 25.01 5.00
145 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
146 INT96156 Gene_expression of Cd40 144 0.77 56.95 21.7 5.00
147 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 5.00
148 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
149 INT62042 Positive_regulation of Gene_expression of IL4 67 0.56 42.05 20.39 5.00
150 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 5.00
151 INT65260 Positive_regulation of Col7a1 95 0.69 61.73 18.42 5.00
152 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3 5.00
153 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
154 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71 5.00
155 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 5.00
156 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 5.00
157 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 5.00
158 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 5.00
159 INT81627 Gene_expression of Fas 120 0.78 115.51 15.36 5.00
160 INT74449 Positive_regulation of B4GALNT1 53 0.30 34.49 14.96 5.00
161 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74 5.00
162 INT109511 Gene_expression of Bax 133 0.78 113.22 14.36 5.00
163 INT100938 Positive_regulation of Il13 47 0.69 42.11 14.36 5.00
164 INT20066 Gene_expression of Mdk 38 0.76 21.41 13.4 5.00
165 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
166 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 5.00
167 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 5.00
168 INT168409 Positive_regulation of Ccl5 47 0.64 45.84 10.83 5.00
169 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 5.00
170 INT83450 Positive_regulation of Localization of CCL2 28 0.70 22.14 9.83 5.00
171 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
172 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69 5.00
173 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 5.00
174 INT97439 Positive_regulation of Il5 46 0.60 25.6 9.47 5.00
175 INT132938 Phosphorylation of Insrr 21 0.03 10.55 8.88 5.00
176 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 5.00
177 INT8903 Gene_expression of IFNA2 58 0.71 38.23 8.68 5.00
178 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 5.00
179 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 5.00
180 INT2280 Negative_regulation of TNFAIP1 70 0.43 69.43 8.36 5.00
181 INT71308 Gene_expression of CCL11 33 0.76 25.66 7.83 5.00
182 INT78226 Gene_expression of Mbp 43 0.75 22.14 7.79 5.00
183 INT90603 Positive_regulation of Ahr 103 0.69 58.65 7.73 5.00
184 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 5.00
185 INT17997 Positive_regulation of Mch 23 0.49 12.71 6.67 5.00
186 INT181525 Localization of Il13 24 0.66 21.51 6.55 5.00
187 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36 5.00
188 INT6512 Gene_expression of PTH 103 0.77 76.29 6.33 5.00
189 INT60713 Binding of Col7a1 47 0.43 22.52 6.29 5.00
190 INT163756 Phosphorylation of Stat1 45 0.82 14.51 6.11 5.00
191 INT39758 Gene_expression of Fn1 57 0.65 34.38 6.02 5.00
192 INT8803 Gene_expression of IL3 32 0.78 21.06 6.01 5.00
193 INT126481 Gene_expression of Cxcr4 69 0.77 34.99 6 5.00
194 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93 5.00
195 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88 5.00
196 INT36921 Regulation of Mdk 14 0.26 6.49 5.8 5.00
197 INT146808 Positive_regulation of CCL18 25 0.69 11.98 5.71 5.00
198 INT69153 Positive_regulation of Gene_expression of IL5 22 0.32 23.59 5.7 5.00
199 INT53684 Negative_regulation of Gene_expression of ITGAM 23 0.59 14.36 5.66 5.00
200 INT118870 Positive_regulation of STAT1 36 0.67 26.18 5.46 5.00
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