D:Hyperinsulinism

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Disease Term
Synonyms Acute Insulin Response, Compensatory Hyperinsulinemia, Endogenous Hyperinsulinism, EXOGENOUS HYPERINSULINISM, High Insulin, HYPERINSULINAEMIA, Hyperinsulinemia, Hyperinsulinemia Compensatory, Hyperinsulinism Disorder, HYPERINSULINISM ENDOGENOUS, HYPERINSULINISM EXOGENOUS
Documents 578
Hot Single Events 200
Hot Interactions 145

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperinsulinism. They are ordered first by their relevance to Hyperinsulinism and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT172818 Binding of T2dm2 and Hypism 1 0.00 3.62 0.1 100.00
2 INT58648 Binding of HSD11B1 and INS 1 0.04 1.65 0.07 100.00
3 INT58649 Binding of INS and Serpine1 1 0.01 1.64 0.07 100.00
4 INT321412 ABCC8 Positive_regulation of Gene_expression of SELE 1 0.00 1.18 0.03 100.00
5 INT207846 Hypism Regulation of INS 1 0.06 1.14 0.04 100.00
6 INT207845 Binding of INS and Hypism 3 0.04 2.88 0.22 100.00
7 INT45822 Pah Positive_regulation of Localization of Ins1 1 0.01 0.3 0.73 100.00
8 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23 100.00
9 INT172836 Binding of INS and T2dm2 1 0.00 1.65 0.08 100.00
10 INT39263 POMC Negative_regulation of INS 1 0.23 0.6 0.22 100.00
11 INT109959 INS Positive_regulation of FBF1 1 0.27 0.24 0.09 100.00
12 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6 100.00
13 INT317638 Ins1 Positive_regulation of Gene_expression of Drd1a 1 0.14 0.86 0.59 100.00
14 INT317634 Ins1 Positive_regulation of Drd1a 1 0.14 0.86 0.59 100.00
15 INT246693 Zglp1 Positive_regulation of Localization of Ide 1 0.08 0.34 0.27 100.00
16 INT271071 Binding of ACTA1 and Hypism 1 0.00 1.54 0.15 100.00
17 INT164923 INS Positive_regulation of GIP 1 0.43 0.18 0.11 100.00
18 INT301619 Positive_regulation of Irs1 Positive_regulation of Gene_expression of Srebf1 1 0.10 0.67 0.08 100.00
19 INT278251 Binding of PCOS1 and Hypism 1 0.00 1.22 0.04 100.00
20 INT278250 Binding of PCOS1 and Ins1 1 0.00 1.23 0.04 100.00
21 INT238315 Binding of Ins1 and Hypism 1 0.00 0.37 0.04 100.00
22 INT308643 Binding of Proc and Renbp 1 0.00 1.61 0 100.00
23 INT267155 Binding of INS and SUGT1 1 0.02 0.81 0.04 99.80
24 INT218615 Negative_regulation of INS Negative_regulation of Gene_expression of IGF1 1 0.33 0.89 0 99.72
25 INT323502 Ghrl Positive_regulation of Localization of Ins1 1 0.15 1.58 0.33 99.58
26 INT301646 Srebf1 Negative_regulation of Gene_expression of Irs2 1 0.08 0.62 0.08 99.50
27 INT246689 Zglp1 Positive_regulation of Ide 1 0.06 0.28 0.27 99.36
28 INT150048 Ins1 Positive_regulation of Rps6kb1 2 0.23 0.83 0.04 99.32
29 INT150050 Mtor Positive_regulation of Rps6kb1 3 0.49 1.44 0.3 99.32
30 INT295616 ACACB Regulation of INS 1 0.02 0.6 0 99.30
31 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12 99.18
32 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12 98.98
33 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3 98.96
34 INT150051 Mtor Positive_regulation of Eif4ebp1 1 0.50 0.46 0 98.96
35 INT150049 Ins1 Positive_regulation of Eif4ebp1 1 0.24 0.46 0 98.96
36 INT255761 hs Regulation of TNF 1 0.07 1.33 0 98.72
37 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0 98.66
38 INT278016 Gh Positive_regulation of Localization of Ins1 1 0.16 1.22 0.26 98.16
39 INT323494 Ghrl Regulation of Ins1 1 0.16 2.12 0.17 98.00
40 INT253086 INS Negative_regulation of LPL 1 0.08 0.56 0 97.88
41 INT182783 INS Positive_regulation of Gene_expression of ETV3 1 0.01 1.89 0 97.68
42 INT182784 IGF1 Positive_regulation of Gene_expression of INS 1 0.02 1.87 0 97.32
43 INT182778 IGF1 Positive_regulation of Gene_expression of ETV3 1 0.03 1.89 0 97.32
44 INT246840 Binding of Ins1 and Gopc 1 0.05 0.15 0.08 97.08
45 INT246839 Binding of Irs1 and Gopc 1 0.16 0.15 0.08 97.08
46 INT182777 IAPP Positive_regulation of Gene_expression of ETV3 1 0.06 1.88 0 96.88
47 INT182776 IAPP Positive_regulation of Gene_expression of INS 1 0.03 1.87 0 96.88
48 INT52894 Gcg Negative_regulation of Ins1 1 0.16 0.18 0.09 96.76
49 INT130284 Ins1 Negative_regulation of Gene_expression of Npy 1 0.32 0.1 2.47 96.56
50 INT253154 TNF Positive_regulation of Ptpn1 1 0.73 0.91 0.15 96.36
51 INT179493 Adipoq Positive_regulation of Ins1 1 0.20 0.99 0.12 96.00
52 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6 95.96
53 INT139903 Ins1 Positive_regulation of Gpr83 1 0.13 1.43 0.22 95.96
54 INT32395 POMC Positive_regulation of INS 1 0.41 0.52 0.19 95.92
55 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21 95.72
56 INT321407 EDN1 Positive_regulation of Phosphorylation of IRS1 1 0.06 1.07 0.03 95.64
57 INT301628 Irs2 Negative_regulation of Transcription of G6pc 1 0.04 0.65 0.08 95.52
58 INT301649 Irs1 Negative_regulation of Transcription of G6pc 1 0.05 0.65 0.08 95.52
59 INT328387 INS Negative_regulation of Gene_expression of Ghrl 1 0.01 0.6 0.05 95.52
60 INT26175 POMC Positive_regulation of GCG 2 0.47 0.57 0.28 95.44
61 INT280053 Negative_regulation of Dpp4 Negative_regulation of Protein_catabolism of Zglp1 1 0.02 0.71 0.1 95.44
62 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44 95.20
63 INT139902 Kcne2 Positive_regulation of Gpr83 1 0.03 1.43 0.22 95.20
64 INT114546 Ins1 Positive_regulation of Positive_regulation of Trpv1 1 0.39 0.19 0.86 95.16
65 INT114547 Ins1 Positive_regulation of Trpv1 1 0.36 0.19 0.77 95.16
66 INT301655 Irs1 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08 94.88
67 INT301641 Irs2 Negative_regulation of Transcription of Pck1 1 0.03 0.65 0.08 94.88
68 INT174283 Lep Negative_regulation of Agrp 1 0.32 0.48 0 94.88
69 INT202231 Binding of IGF1 and INS 2 0.28 1.38 0.03 94.64
70 INT164924 GIP Regulation of GYPC 1 0.07 0.33 0.23 94.44
71 INT202246 Binding of INS and Igfbp1 1 0.05 0.38 0 94.40
72 INT251469 INS Negative_regulation of Gene_expression of SHBG 2 0.11 4.11 0.08 93.68
73 INT323493 Binding of Ins1 and Ghrl 1 0.12 1.25 0 93.32
74 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2 93.28
75 INT323486 Ghrl Regulation of Localization of Ins1 1 0.21 2.07 0.07 93.20
76 INT184105 Il6 Positive_regulation of Socs3 2 0.42 1.34 0.48 92.96
77 INT174285 Agrp Positive_regulation of Positive_regulation of Ins1 1 0.09 0.49 0 92.96
78 INT174286 Agrp Positive_regulation of Ins1 1 0.09 0.49 0 92.96
79 INT174287 Agrp Positive_regulation of Lep 1 0.19 0.49 0 92.96
80 INT52893 Ins1 Positive_regulation of Localization of Sst 1 0.29 0.17 0.09 92.60
81 INT301653 Mlxipl Positive_regulation of Gene_expression of Scd1 1 0.08 0.5 0.05 92.56
82 INT350121 INS Negative_regulation of Positive_regulation of SHBG 1 0.09 1.48 0.04 92.40
83 INT350118 INS Negative_regulation of SHBG 1 0.09 1.42 0.04 92.40
84 INT299295 OR3A4P Negative_regulation of Phosphorylation of AKT1 1 0.00 0.22 0 92.16
85 INT323485 Ghrl Negative_regulation of Localization of Ins1 1 0.15 1.99 0.05 91.76
86 INT257873 Ins1 Positive_regulation of Pik3cg 1 0.13 1.05 0.11 91.68
87 INT257881 Ins1 Positive_regulation of Mtor 1 0.05 0.37 0.04 91.68
88 INT255747 hs Positive_regulation of Phosphorylation of Gopc 1 0.07 1.33 0 91.64
89 INT255752 hs Positive_regulation of Phosphorylation of Slc2a4 1 0.08 1.32 0 91.64
90 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0 91.52
91 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0 91.52
92 INT257870 Agt Positive_regulation of Akt1 2 0.18 1.5 0.09 91.20
93 INT257875 Agt Positive_regulation of Pik3cg 1 0.06 0.37 0.04 91.20
94 INT257874 Agt Positive_regulation of Mtor 1 0.04 0.37 0.04 91.20
95 INT257868 Agt Positive_regulation of Rps6kb1 1 0.10 0.37 0.04 91.20
96 INT278012 Gh Positive_regulation of Gene_expression of Ins1 1 0.11 1.24 0.26 90.88
97 INT301639 Positive_regulation of Mlxipl Positive_regulation of Gene_expression of Pklr 1 0.03 0.52 0 90.84
98 INT246147 AKT1 Positive_regulation of Phosphorylation of RNF123 1 0.01 0.09 0 90.56
99 INT246149 AKT1 Regulation of Gene_expression of RNF123 1 0.02 0.09 0 90.56
100 INT121362 Trpv1 Regulation of Localization of Ins1 1 0.51 0.17 1.12 90.48
101 INT329224 Prkag1 Positive_regulation of Localization of Ins1 1 0.03 1.14 0 90.48
102 INT323503 STARD7 Positive_regulation of Ghrl 1 0.24 1.92 0.05 90.00
103 INT350016 Binding of CD40LG and ARID1B 1 0.01 3.26 0.21 89.20
104 INT246843 Positive_regulation of Binding of Irs1 and Ppp1r13b 1 0.18 0.28 0.16 89.16
105 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28 88.76
106 INT64590 Gnrhr Positive_regulation of Positive_regulation of Ins1 1 0.14 0.33 0.12 88.68
107 INT255023 Negative_regulation of DPP4 Positive_regulation of GIP 1 0.35 0.27 0 88.60
108 INT213264 INS Positive_regulation of Localization of IGF1 1 0.16 1.77 0 88.28
109 INT240808 Arc Regulation of Ins1 1 0.09 1.41 0.54 87.76
110 INT240807 Arc Regulation of Gene_expression of Lepr 1 0.05 0.72 0.28 87.76
111 INT238314 Pik3cb Negative_regulation of Localization of Slc2a4 1 0.06 0.25 0.05 87.48
112 INT246845 Binding of PIK3CA and Ppp1r13b 1 0.13 0.15 0.08 87.40
113 INT240620 Binding of INS and SHBG 4 0.12 3.35 0.15 86.92
114 INT246686 Ide Regulation of Ros1 1 0.03 0.41 0.22 86.92
115 INT164925 GIP Positive_regulation of Localization of INS 2 0.59 0.86 0.09 86.92
116 INT115258 Insr Positive_regulation of Phosphorylation of Irs1 1 0.19 0.26 0.08 86.08
117 INT328378 GH1 Regulation of Gene_expression of Ghrl 1 0.02 0.39 0.25 85.84
118 INT314624 Ex Regulation of GCG 1 0.01 0.67 0 85.60
119 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17 85.44
120 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08 85.32
121 INT314621 Ex Regulation of INS 1 0.06 0.67 0 84.88
122 INT348222 Binding of Ins1 and Glp1r 1 0.05 0.82 0.03 84.80
123 INT172835 Binding of AGT and T2dm2 1 0.00 1.73 0 84.56
124 INT172839 Binding of ANGPT2 and T2dm2 1 0.00 1.72 0 83.92
125 INT246684 exf Regulation of Gene_expression of Ros1 1 0.00 0.42 0.22 83.68
126 INT56111 Ins1 Regulation of Localization of Gip 1 0.13 0.23 0.09 83.44
127 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37 83.44
128 INT240623 Binding of CRP and Apob 1 0.01 0.52 0.04 82.56
129 INT19288 Il4i1 Positive_regulation of Localization of Ins1 1 0.32 0.26 0 82.52
130 INT256578 Bglap Positive_regulation of Gene_expression of Ins1 1 0.38 0.43 0.04 82.48
131 INT256570 Bglap Positive_regulation of Gene_expression of Gck 1 0.48 0.43 0.04 82.48
132 INT256575 Bglap Positive_regulation of Gene_expression of Gopc 1 0.20 0.43 0.04 82.48
133 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15 82.24
134 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08 81.76
135 INT301659 Gene_expression of Mapk8 Positive_regulation of Positive_regulation of Srebf1 1 0.33 0.8 0.08 81.76
136 INT295617 UBXN11 Negative_regulation of SPTLC1 1 0.03 0.57 0 81.52
137 INT178269 Slc11a2 Regulation of a 1 0.06 0.97 0.16 81.12
138 INT178266 Raly Regulation of a 1 0.14 0.97 0.16 81.12
139 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2 80.60
140 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2 80.60
141 INT305335 Olfr927-ps1 Negative_regulation of Akr1b3 1 0.02 1.6 0.17 80.24
142 INT255751 hs Regulation of Ins1 1 0.05 1.24 0 80.24
143 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88 80.16
144 INT246688 exf Negative_regulation of Gene_expression of Ros1 1 0.01 0.43 0.25 80.12
145 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0 80.12
146 INT256573 Gopc Regulation of Ins1 1 0.10 0.71 0 79.04
147 INT230818 Ins1 Positive_regulation of Gene_expression of Agt 1 0.07 1.11 0.04 78.12
148 INT230820 Ins1 Positive_regulation of ras 1 0.12 1.1 0.04 78.12
149 INT230817 Ins1 Positive_regulation of Regulation of Agt 1 0.07 1.11 0.04 78.12
150 INT301629 Ins1 Positive_regulation of Mlxipl 1 0.00 0.36 0 77.60
151 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64 77.56
152 INT256574 Lep Regulation of Ins1 1 0.36 0.83 0 76.72
153 INT301656 Ins1 Positive_regulation of Srebf1 1 0.02 0.73 0.07 76.72
154 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 76.48
155 INT282421 Mapk8 Negative_regulation of Ins1 1 0.06 2.48 0.31 76.32
156 INT284312 Negative_regulation of Binding of IRS1 and SART3 1 0.08 0.32 0 75.44
157 INT284313 Binding of IRS1 and SART3 1 0.07 0.32 0 75.04
158 INT179492 Binding of Ins1 and Adipoq 1 0.16 1.16 0.23 74.56
159 INT301647 Negative_regulation of Mapk8 Positive_regulation of Irs1 1 0.08 0.83 0.04 73.64
160 INT301626 Mapk8 Positive_regulation of Irs1 1 0.09 0.83 0.04 73.64
161 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38 73.20
162 INT350011 Binding of BMI1 and IL6 1 0.01 0.58 0.1 73.20
163 INT218614 INS Positive_regulation of Binding of IGF1 1 0.39 0.79 0.05 72.96
164 INT218308 Binding of HPRT1 and Grb10 1 0.26 0.07 0 70.48
165 INT253137 Ptpn1 Negative_regulation of Ins1 1 0.19 4.11 0.63 70.40
166 INT229986 Binding of CAMK4 and HSD11B1 1 0.01 1 0.1 70.40
167 INT230003 Binding of CAMK4 and Hdl1 1 0.00 1 0.1 70.00
168 INT350120 FSHR Regulation of CYP19A1 1 0.01 3.02 0 69.36
169 INT278018 Gh Negative_regulation of Phosphorylation of Ins1 1 0.13 1.5 0.29 68.24
170 INT309001 Ins1 Positive_regulation of Mmp9 1 0.20 1.96 0.83 67.52
171 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08 67.12
172 INT172830 INS Positive_regulation of Agtrap 1 0.01 1.17 0 67.04
173 INT256571 Bglap Positive_regulation of Localization of Ins1 1 0.53 0.25 0.04 66.72
174 INT186540 Binding of Cort and Hpse 1 0.05 0.92 0.08 66.64
175 INT255025 Positive_regulation of GLP1R Positive_regulation of Localization of INS 1 0.17 0.12 0 66.64
176 INT178267 Alb Positive_regulation of Gene_expression of a 1 0.19 0.9 0 66.48
177 INT178268 Alb Regulation of Gene_expression of a 1 0.18 0.9 0 66.48
178 INT352516 Binding of POMT1 and Adipoq 1 0.01 0.4 0 65.48
179 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55 64.68
180 INT218616 Binding of IGFBP3 and INS 1 0.07 0.68 0.05 64.64
181 INT91391 Crh Regulation of Localization of Gnrh1 2 0.36 1.78 0.61 64.16
182 INT59540 Crh Regulation of Gnrh1 2 0.36 2.61 0.58 64.16
183 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71 63.96
184 INT256577 Bglap Regulation of Localization of Ins1 1 0.47 0.44 0.04 63.40
185 INT256572 Bglap Regulation of Gene_expression of Ins1 1 0.47 0.44 0 63.40
186 INT350116 FSHR Positive_regulation of Gene_expression of CGA 1 0.01 1.28 0 63.00
187 INT270759 Binding of HSD11B1 and TERT 1 0.07 1.67 0 62.88
188 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12 62.48
189 INT284891 FSHR Positive_regulation of Gene_expression of PLOD1 2 0.03 1.32 0.11 62.16
190 INT278015 Gh Regulation of Ins1 1 0.10 1.47 0.27 60.24
191 INT350117 GNRHR Negative_regulation of Localization of FSHR 1 0.01 1.06 0 58.44
192 INT350113 GNRHR Negative_regulation of Localization of PLOD1 1 0.01 1.06 0 58.44
193 INT246692 Zglp1 Regulation of Gene_expression of Ros1 1 0.04 0.38 0.24 58.12
194 INT296954 NRIP1 Negative_regulation of Gene_expression of UCP1 1 0.30 1.05 0 58.12
195 INT127966 GPT Positive_regulation of SLC17A5 1 0.50 1.81 0.14 57.52
196 INT323487 Ghrl Positive_regulation of Phosphorylation of Akt1 1 0.09 0.77 0 57.20
197 INT350115 GNRH1 Negative_regulation of Localization of PLOD1 1 0.04 0.99 0 57.16
198 INT350122 GNRH1 Negative_regulation of Localization of FSHR 1 0.05 0.99 0 57.16
199 INT305164 Ins1 Regulation of Phosphorylation of Olfr473 1 0.01 0.49 0 56.96
200 INT253129 Ins1 Regulation of Phosphorylation of Akt1 3 0.11 1.66 0.17 56.76

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperinsulinism. They are ordered first by their pain relevance and then by number of times they were reported in Hyperinsulinism. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 100.00
2 INT812 Localization of INS 1026 0.81 515.6 145.31 100.00
3 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 100.00
4 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 100.00
5 INT1114 Localization of Ins1 748 0.80 192.95 165.48 100.00
6 INT3213 Gene_expression of Ins1 511 0.76 357.59 53.32 100.00
7 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 100.00
8 INT3214 Localization of Ins1 527 0.80 196.9 79.26 100.00
9 INT8747 Positive_regulation of Ins1 221 0.69 154.28 35.15 100.00
10 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 100.00
11 INT251 Regulation of INS 398 0.62 232.47 55.04 100.00
12 INT4360 Gene_expression of Hypism 29 0.22 38.1 4.07 100.00
13 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 100.00
14 INT14572 Binding of INS 205 0.48 175.43 13.38 100.00
15 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 100.00
16 INT1988 Positive_regulation of Localization of Ins1 254 0.69 59.25 68.37 100.00
17 INT32795 Positive_regulation of Hypism 17 0.15 20.16 1.73 100.00
18 INT18323 Negative_regulation of Localization of Ins1 122 0.58 45.74 23.04 100.00
19 INT3216 Positive_regulation of Localization of Ins1 170 0.69 56.78 35.63 100.00
20 INT70622 Binding of Hypism 9 0.04 14.9 0.59 100.00
21 INT3217 Regulation of Ins1 154 0.62 87.11 27.29 100.00
22 INT3656 Positive_regulation of Gene_expression of Ins1 74 0.54 44.94 17.36 100.00
23 INT18583 Positive_regulation of Gene_expression of Ins1 67 0.50 49.72 8.26 100.00
24 INT18322 Negative_regulation of Ins1 132 0.58 88.49 22.59 100.00
25 INT2275 Negative_regulation of Localization of Ins1 183 0.59 51.02 44.94 100.00
26 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 100.00
27 INT2217 Positive_regulation of Positive_regulation of Ins1 21 0.69 7.66 6.32 100.00
28 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 100.00
29 INT34669 Localization of Hypism 8 0.25 10.79 1.2 100.00
30 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86 100.00
31 INT230810 Phosphorylation of Ins1 59 0.69 41.15 4.51 100.00
32 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 100.00
33 INT144097 Negative_regulation of Hypism 4 0.18 2.88 0.3 100.00
34 INT67146 Positive_regulation of Gene_expression of Hypism 4 0.17 9.08 1.09 100.00
35 INT31412 Negative_regulation of Positive_regulation of Ins1 10 0.40 7.14 2.82 100.00
36 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15 100.00
37 INT56494 Localization of Ide 73 0.68 22.9 11.26 100.00
38 INT178261 Positive_regulation of Gene_expression of a 23 0.55 14.67 4.07 100.00
39 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27 100.00
40 INT25543 Regulation of Hypism 3 0.02 2.49 0.82 100.00
41 INT191970 Positive_regulation of Ide 29 0.51 12.94 1.4 100.00
42 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63 100.00
43 INT16130 Binding of IGF1 67 0.48 27.43 2.95 100.00
44 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5 100.00
45 INT56495 Positive_regulation of Localization of Ide 20 0.53 3.53 4.92 100.00
46 INT154603 Negative_regulation of Localization of Hypism 3 0.08 6.44 0.77 100.00
47 INT20345 Gene_expression of Dbi 136 0.78 56.41 46.2 100.00
48 INT25546 Gene_expression of Hapln1 8 0.14 5.58 0.99 100.00
49 INT183066 Positive_regulation of Transcription of INS 8 0.49 5.31 0.34 100.00
50 INT194343 Gene_expression of ABCC8 8 0.65 8.15 0.77 100.00
51 INT183046 Transcription of INS 25 0.70 11.14 1.13 100.00
52 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 100.00
53 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24 100.00
54 INT301563 Positive_regulation of Positive_regulation of Irs1 1 0.16 1.32 0.15 100.00
55 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75 100.00
56 INT130280 Positive_regulation of Gene_expression of Gad2 7 0.69 8.13 9.55 100.00
57 INT13897 Localization of Sst 65 0.81 14.91 32.24 100.00
58 INT31419 Positive_regulation of Localization of Sst 10 0.70 0.77 3.94 100.00
59 INT13896 Negative_regulation of Localization of Sst 8 0.59 0.77 3.5 100.00
60 INT183060 Regulation of Transcription of INS 2 0.44 0.34 0 100.00
61 INT46470 Positive_regulation of Regulation of Ins1 8 0.46 4.51 1.01 100.00
62 INT2364 Localization of Sct 134 0.80 26.21 41.47 100.00
63 INT109960 Positive_regulation of ABCC8 4 0.49 1.74 0.36 100.00
64 INT8741 Regulation of Positive_regulation of Ins1 5 0.41 1.36 1.67 100.00
65 INT7280 Positive_regulation of Localization of Sst 97 0.70 5.64 63.37 100.00
66 INT8691 Localization of Insr 85 0.80 9.27 30.32 100.00
67 INT61513 Positive_regulation of Gpx1 71 0.64 37.91 17.07 100.00
68 INT3870 Positive_regulation of Localization of Sct 18 0.58 1.9 8.48 100.00
69 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86 100.00
70 INT21606 Positive_regulation of Regulation of Ins1 8 0.41 3.9 2.97 100.00
71 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91 100.00
72 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54 100.00
73 INT18844 Binding of IAPP 11 0.36 11.01 1.45 100.00
74 INT81733 Transcription of Ins1 9 0.50 6.27 1.41 100.00
75 INT130279 Positive_regulation of Transcription of Ins1 1 0.24 0.1 0.73 100.00
76 INT44079 Regulation of HBA1 3 0.12 0.98 0.62 100.00
77 INT174753 Gene_expression of Apoa2 15 0.75 13.82 0.41 100.00
78 INT152617 Negative_regulation of Gene_expression of Hypism 1 0.01 1.15 0.34 100.00
79 INT282406 Positive_regulation of Positive_regulation of Hypism 1 0.13 2.15 0.28 100.00
80 INT92589 Positive_regulation of IGF1R 4 0.38 0.98 0.11 100.00
81 INT185406 Regulation of ABCC8 2 0.13 2.21 0.05 100.00
82 INT199871 Positive_regulation of YBX1 2 0.03 1.24 0 100.00
83 INT215947 Positive_regulation of Gene_expression of INSR 2 0.14 0.25 0 100.00
84 INT168750 Positive_regulation of Localization of SERPINA4 1 0.04 0.52 0 100.00
85 INT168751 Localization of SERPINA4 1 0.06 0.52 0 100.00
86 INT351111 Positive_regulation of LRIF1 1 0.02 0.31 0 100.00
87 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97 99.98
88 INT82461 Gene_expression of Gad2 40 0.78 19.12 22.79 99.98
89 INT14665 Localization of Rit2 4 0.62 0.26 0.79 99.98
90 INT301529 Positive_regulation of Gene_expression of Srebf1 7 0.42 1.59 0.32 99.98
91 INT301523 Positive_regulation of Gene_expression of Irs2 1 0.09 0.68 0.08 99.98
92 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.96
93 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 99.96
94 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 99.96
95 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 99.96
96 INT10841 Positive_regulation of Gene_expression of Gh 101 0.59 45.39 16.96 99.96
97 INT16608 Positive_regulation of FFAR1 40 0.37 18.48 3.59 99.96
98 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 99.92
99 INT174986 Gene_expression of AIRN 20 0.57 6.13 0.64 99.92
100 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 99.90
101 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72 99.90
102 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56 99.90
103 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07 99.90
104 INT14562 Negative_regulation of Igfbp1 7 0.26 4.32 1.5 99.90
105 INT1005 Localization of Sst 385 0.81 26.31 244.56 99.90
106 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76 99.90
107 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43 99.90
108 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14 99.88
109 INT19428 Gene_expression of MTRF1 42 0.08 27.17 10.43 99.86
110 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 99.84
111 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53 99.80
112 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47 99.80
113 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 99.80
114 INT5048 Binding of Edn1 55 0.47 18.86 19.16 99.80
115 INT134316 Positive_regulation of RT1-Hb-ps1 6 0.32 8.44 1.76 99.80
116 INT176174 Gene_expression of Srebf1 16 0.66 6.53 0.82 99.78
117 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13 99.76
118 INT1893 Localization of Gh 1041 0.79 340.23 256.58 99.74
119 INT183039 Negative_regulation of Gene_expression of NEUROG3 1 0.25 0.71 0 99.74
120 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 99.72
121 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 99.68
122 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 99.68
123 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55 99.68
124 INT72110 Gene_expression of Glp1r 48 0.78 22.46 6.17 99.60
125 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 99.60
126 INT183034 Gene_expression of NEUROG3 1 0.45 1.25 0.03 99.58
127 INT224964 Localization of Ghrl 30 0.59 7.71 8.77 99.58
128 INT55251 Gene_expression of a 142 0.67 81.21 23.03 99.56
129 INT2257 Localization of Gip 31 0.74 11.08 7.92 99.52
130 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 99.52
131 INT4036 Positive_regulation of Localization of Gip 3 0.45 1.92 0.9 99.52
132 INT13608 Negative_regulation of Localization of Ggh 5 0.45 1.97 2.43 99.48
133 INT1000 Localization of Ggh 31 0.75 2.74 16.41 99.48
134 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13 99.46
135 INT184301 Negative_regulation of Bglap 16 0.56 11.22 1.22 99.44
136 INT236138 Negative_regulation of Ptpn1 10 0.55 5.83 1.04 99.44
137 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 99.36
138 INT272140 Negative_regulation of Shbg 1 0.33 1.92 0.24 99.36
139 INT62809 Positive_regulation of Localization of SLC2A4 3 0.70 0.8 0.14 99.36
140 INT3894 Negative_regulation of Localization of Gcg 18 0.52 2.7 5.77 99.36
141 INT277389 Positive_regulation of Gene_expression of SLC2A4 4 0.61 2.87 0.14 99.36
142 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4 99.34
143 INT15684 Positive_regulation of Serpine1 65 0.70 43.51 13.67 99.34
144 INT57599 Positive_regulation of Btg1 2 0.03 2 0.09 99.34
145 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 99.32
146 INT2378 Negative_regulation of SERPINE1 47 0.59 34.55 9.9 99.32
147 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98 99.28
148 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 99.28
149 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 99.28
150 INT99430 Positive_regulation of Gene_expression of Slc2a4 18 0.66 10.45 7.79 99.28
151 INT78845 Binding of Pparg 16 0.44 11.67 3.53 99.24
152 INT207840 Positive_regulation of Negative_regulation of GCG 1 0.36 0.1 0 99.24
153 INT17035 Positive_regulation of TFPI 55 0.61 34.88 14.18 99.20
154 INT252 Localization of GH1 529 0.80 227.4 122.05 99.20
155 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 99.20
156 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03 99.18
157 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 99.18
158 INT150529 Positive_regulation of Negative_regulation of Adipoq 2 0.37 1.76 0.18 99.18
159 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22 99.18
160 INT207842 Gene_expression of KL 3 0.34 2.88 0 99.18
161 INT207843 Positive_regulation of Gene_expression of KL 2 0.26 1.1 0 99.18
162 INT3658 Regulation of Gcg 28 0.53 12.89 8.58 99.16
163 INT1473 Localization of Gcg 95 0.80 17.35 30.31 99.16
164 INT183038 Positive_regulation of Gene_expression of FOXA3 1 0.40 1.85 0.08 99.16
165 INT207830 Localization of GAD2 10 0.65 0.49 1.97 99.16
166 INT207835 Positive_regulation of Localization of GAD2 1 0.01 0.1 0.65 99.16
167 INT253030 Binding of HPP1 1 0.03 1.43 0.04 99.16
168 INT11635 Positive_regulation of Gene_expression of SERPINE1 35 0.68 24.57 4.26 99.14
169 INT229317 Gene_expression of SLC2A4 10 0.69 6.88 0.2 99.10
170 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.08
171 INT48131 Gene_expression of Slc2a4 32 0.78 14.64 10.16 99.08
172 INT235312 Negative_regulation of Gpr83 7 0.37 3.75 0.06 99.08
173 INT56493 Regulation of Localization of Ide 15 0.47 3.53 3.82 99.04
174 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1 98.96
175 INT184303 Positive_regulation of Bglap 16 0.66 8.66 1.25 98.92
176 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 98.92
177 INT212983 Positive_regulation of Positive_regulation of Nos3 9 0.51 7.08 1.23 98.92
178 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35 98.88
179 INT84068 Negative_regulation of Gene_expression of IGFBP1 3 0.42 2.74 0.69 98.86
180 INT240825 Gene_expression of Irs2 14 0.78 3.88 0.32 98.86
181 INT255035 Gene_expression of SCAND1 1 0.05 0.24 0 98.82
182 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58 98.78
183 INT44080 Positive_regulation of HBA1 7 0.25 2.23 0.6 98.76
184 INT5096 Positive_regulation of Gtf3a 79 0.60 42.26 20.62 98.74
185 INT77227 Positive_regulation of Phosphorylation of Eif4ebp1 11 0.05 2.44 1.67 98.74
186 INT255920 Gene_expression of ATF2 3 0.75 1.52 0.33 98.74
187 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 98.72
188 INT11361 Gene_expression of SERPINE1 183 0.78 136.45 27.97 98.72
189 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 98.72
190 INT159432 Gene_expression of hs 3 0.16 5 0.27 98.72
191 INT219564 Positive_regulation of Zglp1 18 0.46 5.19 2.87 98.68
192 INT218284 Gene_expression of Grb10 15 0.72 1.85 0.18 98.68
193 INT107291 Positive_regulation of Ghrl 58 0.67 44.6 9.68 98.68
194 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 98.68
195 INT67611 Positive_regulation of Pparg 39 0.69 18.33 13.23 98.68
196 INT219592 Positive_regulation of Positive_regulation of Zglp1 3 0.31 0.1 0.46 98.68
197 INT62830 Gene_expression of VCAM1 149 0.78 125.23 32.4 98.66
198 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 98.66
199 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56 98.66
200 INT170554 Binding of Renbp 17 0.17 12.36 0.45 98.66
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