D:Hyperkinesis

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Generalized Hyperkinesia, Generalized Hyperkinesias, HYPERACTIVITY MOTOR, HYPERKINESIA, Hyperkinesia Generalized, Hyperkinesias Generalized, HYPERKINETIC MOVEMENT, HYPERKINETIC MOVEMENTS, MOTOR HYPERACTIVITY, Movement Hyperkinetic, Movements Hyperkinetic
Documents 162
Hot Single Events 45
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperkinesis. They are ordered first by their relevance to Hyperkinesis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01 98.00
2 INT342744 Ddc Regulation of Trh 1 0.02 0.37 0.18 25.28
3 INT202959 Binding of BAG3 and MCRS1 1 0.11 7.46 3.14 5.00
4 INT202965 Binding of STC2 and BAG3 1 0.02 7.86 2.96 5.00
5 INT202974 Binding of BAG3 and CPP 1 0.25 6.22 2.73 5.00
6 INT202963 Binding of STC2 and CPP 1 0.02 5.16 2.04 5.00
7 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65 5.00
8 INT202958 Binding of STC2 and MCRS1 1 0.01 3.48 1.44 5.00
9 INT202960 Binding of MCRS1 and CPP 1 0.14 2.49 1.13 5.00
10 INT202968 Binding of MCRS1 and CAP1 1 0.03 2.46 1.08 5.00
11 INT202967 MCRS1 Negative_regulation of CPP 2 0.14 2.2 0.73 5.00
12 INT202962 CPP Negative_regulation of Positive_regulation of BAG3 1 0.26 1.34 0.61 5.00
13 INT202971 Binding of BAG3 and CAP1 1 0.04 1.26 0.59 5.00
14 INT202973 Binding of CAP1 and CPP 1 0.05 1.24 0.58 5.00
15 INT202970 Binding of STC2 and CAP1 1 0.00 1.25 0.58 5.00
16 INT202972 Positive_regulation of MCRS1 Negative_regulation of CPP 1 0.16 1.64 0.57 5.00
17 INT202961 MCRS1 Negative_regulation of STC2 1 0.00 1.63 0.57 5.00
18 INT184878 Binding of Lmo1 and ADHD1 2 0.04 2.33 0.53 5.00
19 INT202957 CPP Negative_regulation of MCRS1 1 0.14 1.53 0.51 5.00
20 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48 5.00
21 INT202969 Positive_regulation of SGSM3 Positive_regulation of MCRS1 1 0.02 1.22 0.47 5.00
22 INT202964 SGSM3 Positive_regulation of MCRS1 1 0.03 1.21 0.47 5.00
23 INT138384 Binding of Htr1b and ADHD1 2 0.07 1.46 0.42 5.00
24 INT229105 Binding of GRIN1 and LMOD1 1 0.07 0.15 0.4 5.00
25 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34 5.00
26 INT258763 Binding of Drd5 and ADHD1 1 0.07 1.11 0.31 5.00
27 INT258764 Binding of Drd4 and ADHD1 1 0.08 1.11 0.31 5.00
28 INT258766 Binding of Csf2 and ADHD1 1 0.01 0.69 0.27 5.00
29 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25 5.00
30 INT321653 Binding of Phc1 and Datd 1 0.00 0.35 0.24 5.00
31 INT345209 Repin1 Positive_regulation of Positive_regulation of Trib3 1 0.00 0.88 0.18 5.00
32 INT275461 Binding of Atxn1 and Atxn2 1 0.39 1.1 0.17 5.00
33 INT258761 Binding of Slc6a3 and ADHD1 1 0.03 0.51 0.12 5.00
34 INT258767 Binding of Drd2 and ADHD1 1 0.11 1.14 0.11 5.00
35 INT258765 Lmo1 Regulation of ADHD1 1 0.05 1.98 0.09 5.00
36 INT280451 IER5 Positive_regulation of Phc1 1 0.00 0.56 0.09 5.00
37 INT258758 Binding of Drd4 and Lmo1 1 0.04 0.64 0.08 5.00
38 INT258756 Binding of Drd5 and Lmo1 1 0.03 0.64 0.08 5.00
39 INT258768 Drd2 Regulation of ADHD1 1 0.14 0.79 0.07 5.00
40 INT321651 Binding of Slc6a3 and Uts2r 1 0.04 0.06 0.05 5.00
41 INT321652 Binding of Slc6a3 and Slc6a4 1 0.26 0.07 0.05 5.00
42 INT321654 Binding of Slc6a4 and Uts2r 1 0.05 0.07 0.05 5.00
43 INT291199 Binding of VEGFA and Angpt1 1 0.08 0.69 0 5.00
44 INT264663 Binding of ESR1 and PRL 1 0.22 0.18 0 5.00
45 INT264662 ESR1 Regulation of Gene_expression of PRL 1 0.43 0.21 0 5.00
46 INT264661 ESR1 Positive_regulation of PRL 1 0.43 0.68 0 5.00
47 INT264664 Binding of AES and ESR1 1 0.15 0.18 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperkinesis. They are ordered first by their pain relevance and then by number of times they were reported in Hyperkinesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT967 Regulation of Gene_expression of MMVP1 1 0.23 1.05 0.19 100.00
2 INT968 Gene_expression of MMVP1 2 0.52 2.3 0.27 99.82
3 INT8489 Negative_regulation of Hrh3 5 0.38 1.01 1.83 99.44
4 INT4830 Binding of Trpv1 158 0.48 45.11 84.2 98.80
5 INT68789 Regulation of CFP 17 0.51 4.76 3.98 98.08
6 INT2761 Regulation of Gabrg1 119 0.61 18.8 60.52 97.08
7 INT49566 Positive_regulation of LMOD1 16 0.61 5.74 5.92 96.84
8 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 96.68
9 INT31780 Binding of DIO2 17 0.36 10.07 10 96.00
10 INT7506 Negative_regulation of Ltp 267 0.46 91.01 176.8 95.84
11 INT85233 Localization of SGSM3 11 0.78 10.91 3.41 95.84
12 INT188844 Gene_expression of AES 44 0.58 33.94 5.85 95.12
13 INT82709 Negative_regulation of Slc37a4 17 0.34 3.41 8.6 94.48
14 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 93.94
15 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 93.44
16 INT797 Regulation of Penk 812 0.62 111.13 542.24 92.92
17 INT65034 Regulation of Fgf1 7 0.61 2.42 2.34 92.92
18 INT1376 Binding of Trh 121 0.48 20 69.86 92.24
19 INT88765 Regulation of Tms 2 0.23 0.34 0.34 92.20
20 INT25263 Negative_regulation of Hrh1 11 0.58 3.35 4.61 91.76
21 INT81972 Positive_regulation of Dse 20 0.57 16.5 2.99 91.48
22 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72 90.56
23 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 90.56
24 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 90.56
25 INT48143 Gene_expression of Fgf1 32 0.78 8.2 3.72 90.56
26 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 90.56
27 INT108759 Gene_expression of Olr404 1 0.03 0.33 0.15 90.24
28 INT9084 Positive_regulation of Nppb 74 0.70 69.77 11.85 89.12
29 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 88.88
30 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 88.84
31 INT4803 Transcription of Penk 435 0.72 59.09 182.4 88.64
32 INT16326 Transcription of Gad1 58 0.71 15.78 20.45 88.64
33 INT20579 Transcription of Akr1d1 9 0.04 2.91 8.37 88.64
34 INT184895 Gene_expression of MCRS1 46 0.42 56.03 19.44 87.60
35 INT98384 Negative_regulation of Negative_regulation of Abat 4 0.37 2.28 3.41 86.72
36 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 86.16
37 INT89109 Regulation of Transcription of Trh 2 0.45 1.98 0.74 85.88
38 INT258710 Regulation of Negative_regulation of Ddc 2 0.25 1.28 0.66 85.88
39 INT86464 Binding of LMOD1 31 0.44 10.23 10.46 85.72
40 INT6323 Positive_regulation of Gabrg1 213 0.70 45.08 124.34 85.48
41 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96 85.08
42 INT339 Regulation of Trh 156 0.62 39.27 83.55 83.00
43 INT989 Negative_regulation of Trh 90 0.59 15.45 43.63 83.00
44 INT7923 Transcription of Trh 14 0.72 4.44 6.32 82.76
45 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31 80.84
46 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 78.92
47 INT6115 Positive_regulation of Pigm 82 0.64 16.96 25.73 77.80
48 INT7786 Positive_regulation of Ptgdr 26 0.47 5.62 14.99 77.80
49 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 75.92
50 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 75.00
51 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 75.00
52 INT235157 Gene_expression of Atxn2 3 0.68 6.74 1.23 74.80
53 INT460 Negative_regulation of Atxn2 4 0.43 0.85 1.21 74.80
54 INT175710 Regulation of Slc37a4 2 0.26 1.03 0.35 73.80
55 INT321649 Regulation of Regulation of Chtf8 1 0.00 0.68 0.31 73.80
56 INT798 Positive_regulation of Gene_expression of Penk 394 0.70 78.53 203.07 73.72
57 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 73.68
58 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 72.52
59 INT321645 Regulation of Chtf8 1 0.00 0.61 0.31 72.00
60 INT229110 Positive_regulation of Positive_regulation of DIO2 3 0.26 1.08 2.31 70.00
61 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 69.28
62 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46 69.16
63 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 68.52
64 INT123927 Positive_regulation of Gene_expression of Angpt1 12 0.48 10.18 0.71 66.56
65 INT123926 Gene_expression of Angpt1 28 0.54 21.74 1.47 66.56
66 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 65.76
67 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 65.76
68 INT3637 Positive_regulation of Localization of Trh 33 0.70 2.13 10.55 65.68
69 INT403 Localization of Trh 241 0.81 28.55 81.45 65.36
70 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 63.92
71 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 63.52
72 INT275454 Positive_regulation of Atxn2 1 0.50 1.37 0.53 63.28
73 INT5015 Regulation of Gene_expression of Trh 9 0.62 6.47 4.25 63.24
74 INT2323 Gene_expression of Trh 146 0.78 29.92 49.5 62.20
75 INT86474 Negative_regulation of Fgf1 6 0.58 0.64 0.88 61.72
76 INT200442 Positive_regulation of Gene_expression of AES 5 0.42 5.12 0.48 60.72
77 INT96038 Positive_regulation of Rasgrp1 2 0.30 0.55 0.17 60.08
78 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 56.08
79 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87 51.60
80 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 50.40
81 INT162253 Gene_expression of BAG3 30 0.59 20.16 7.18 49.28
82 INT162254 Regulation of BAG3 28 0.41 18.12 4.75 49.28
83 INT202978 Gene_expression of STC2 11 0.50 13.46 4.06 49.28
84 INT202983 Regulation of STC2 1 0.03 11.98 3.33 49.28
85 INT15470 Regulation of CPP 42 0.48 26.1 18.25 46.64
86 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 46.64
87 INT92756 Negative_regulation of Binding of LMOD1 4 0.54 3.83 3.08 46.48
88 INT349609 Regulation of Regulation of LMOD1 1 0.41 0.65 0.63 44.16
89 INT49568 Regulation of LMOD1 6 0.43 2.57 5 43.68
90 INT103021 Transcription of Slc6a4 16 0.70 3.93 3.77 42.52
91 INT1327 Regulation of Localization of Trh 45 0.62 6.05 22.09 41.96
92 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 36.20
93 INT125027 Positive_regulation of Kdr 15 0.50 7.73 0.24 36.20
94 INT126521 Positive_regulation of Mapkapk2 13 0.49 5.9 0.17 36.20
95 INT290923 Positive_regulation of Angpt1 3 0.48 3.62 0.14 36.20
96 INT291186 Positive_regulation of Tek 1 0.24 2.27 0.03 36.20
97 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35 35.56
98 INT135262 Gene_expression of Tek 8 0.52 6.81 0.68 35.56
99 INT202385 Gene_expression of Mapkapk2 4 0.57 2.86 0.64 35.56
100 INT200373 Binding of Omd 7 0.34 7.03 0.34 33.04
101 INT315710 Localization of lg 7 0.32 1.72 0.6 32.48
102 INT95048 Negative_regulation of ADHD1 61 0.51 56.01 5.62 32.32
103 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13 32.20
104 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 30.52
105 INT53062 Gene_expression of Ddc 31 0.77 11.59 9.63 30.36
106 INT55699 Regulation of Binding of DIO2 2 0.24 1.91 1.16 29.04
107 INT349613 Regulation of Binding of LMOD1 1 0.41 0.53 0.74 29.04
108 INT29794 Regulation of DIO2 13 0.44 5.02 6.84 28.24
109 INT315704 Gene_expression of lg 4 0.33 0.84 0.06 25.68
110 INT251 Regulation of INS 398 0.62 232.47 55.04 19.84
111 INT75530 Regulation of SGSM3 11 0.60 7.22 4.48 18.40
112 INT38859 Gene_expression of SGSM3 14 0.75 12.98 4.09 18.40
113 INT143316 Negative_regulation of Slc18a2 7 0.50 3.17 2.52 15.08
114 INT63772 Gene_expression of LMOD1 26 0.75 3.77 5.84 14.16
115 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 14.08
116 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 14.08
117 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 11.28
118 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
119 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 5.00
120 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
121 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 5.00
122 INT3440 Negative_regulation of Localization of Abat 221 0.57 33.94 180.36 5.00
123 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 5.00
124 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
125 INT7628 Gene_expression of Ltp 273 0.77 70.21 147.87 5.00
126 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
127 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 5.00
128 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
129 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
130 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 5.00
131 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
132 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 5.00
133 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 5.00
134 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91 5.00
135 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
136 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
137 INT96533 Gene_expression of Slc1a3 72 0.78 26.85 55.31 5.00
138 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 5.00
139 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 5.00
140 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 5.00
141 INT5704 Binding of Slc3a1 78 0.43 8.52 51.78 5.00
142 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32 5.00
143 INT2783 Gene_expression of Slc3a1 86 0.65 8.84 45.4 5.00
144 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
145 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 5.00
146 INT9298 Positive_regulation of Gtpbp4 64 0.69 12.29 41.97 5.00
147 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 5.00
148 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 5.00
149 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 5.00
150 INT14137 Localization of Oprm1 56 0.81 2.88 36.09 5.00
151 INT13501 Binding of Drd2 65 0.48 23.76 35.6 5.00
152 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 5.00
153 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28 5.00
154 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 5.00
155 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
156 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
157 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 5.00
158 INT28 Regulation of Gast 106 0.62 26.37 29.85 5.00
159 INT6660 Positive_regulation of Jun 148 0.69 67.58 29.73 5.00
160 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
161 INT53384 Positive_regulation of FosB 41 0.69 8.43 28.91 5.00
162 INT2650 Positive_regulation of Slc3a1 50 0.57 2.95 27.52 5.00
163 INT2609 Localization of ELANE 111 0.81 50.22 26.63 5.00
164 INT12681 Regulation of Trib3 76 0.53 23.92 26.58 5.00
165 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
166 INT7899 Positive_regulation of Gene_expression of Homer1 41 0.70 7.29 25.98 5.00
167 INT12392 Regulation of Slc3a1 45 0.36 7.57 25.66 5.00
168 INT12484 Binding of Drd2 45 0.48 15.17 24.72 5.00
169 INT48536 Positive_regulation of Grm8 46 0.61 14.31 23.56 5.00
170 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 5.00
171 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 5.00
172 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 5.00
173 INT15326 Phosphorylation of Trib3 83 0.55 30.96 22.27 5.00
174 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 5.00
175 INT61825 Negative_regulation of Slc6a3 47 0.59 6.52 21.27 5.00
176 INT171820 Localization of Fig4 144 0.65 27.38 20.88 5.00
177 INT68683 Regulation of Gene_expression of VEGFA 143 0.62 104.19 20.14 5.00
178 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85 5.00
179 INT135629 Binding of COMT 33 0.48 16.68 19.37 5.00
180 INT37835 Negative_regulation of CPP 61 0.51 31.34 18.57 5.00
181 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 5.00
182 INT7952 Localization of Slc3a1 32 0.81 1.28 15.69 5.00
183 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
184 INT116465 Gene_expression of Birc5 241 0.78 192.31 15.32 5.00
185 INT54356 Regulation of Slc6a3 48 0.58 5.86 15.24 5.00
186 INT47909 Binding of CPP 32 0.48 24.9 13.79 5.00
187 INT20264 Gene_expression of Chkb 29 0.46 13.14 13.65 5.00
188 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 5.00
189 INT65172 Negative_regulation of Ntrk2 35 0.59 9.89 13.08 5.00
190 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61 5.00
191 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43 5.00
192 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
193 INT10654 Negative_regulation of SGSM3 31 0.57 12.24 11.7 5.00
194 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8 5.00
195 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69 5.00
196 INT104441 Binding of NOVA2 72 0.42 16.41 10.51 5.00
197 INT74828 Regulation of Slc1a2 12 0.61 3.92 10.3 5.00
198 INT4297 Negative_regulation of CFP 21 0.42 12.7 10.29 5.00
199 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 5.00
200 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox