D:Hypernatremia

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pChart

Disease Term
Synonyms Euvolemic Hypernatraemia, Euvolemic Hypernatremia, Hypernataremia With Euvolaemia, HYPERNATRAEMIA, Hypernatraemia With Hypovolaemia, Hypernatraemia With Hypovolemia, Hypernatremia With Euvolemia, HYPERNATREMIA WITH HYPERVOLAEMIA, HYPERNATREMIA WITH HYPERVOLEMIA, Hypernatremia With Hypovolemia, Hypernatremias
Documents 80
Hot Single Events 24
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypernatremia. They are ordered first by their relevance to Hypernatremia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT154523 Binding of Oxt and Crh 1 0.11 0 0.24 32.56
2 INT38936 Binding of Avp and Crh 7 0.40 0.82 1.04 32.00
3 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2 5.00
4 INT300956 Il4 Negative_regulation of IL8 1 0.02 0.37 0.48 5.00
5 INT300960 Il4 Negative_regulation of IL1B 1 0.03 0.37 0.48 5.00
6 INT300957 Binding of IL13 and Il4 1 0.01 0.58 0.48 5.00
7 INT300959 Il4 Negative_regulation of TNF 1 0.03 0.37 0.48 5.00
8 INT300955 Il4 Negative_regulation of Il6 1 0.03 0.37 0.48 5.00
9 INT287438 HTS Negative_regulation of Nfkb1 1 0.01 1.77 0.37 5.00
10 INT300958 IL1B Positive_regulation of Il6 1 0.04 0.25 0.25 5.00
11 INT284570 Binding of Avp and Il6 1 0.04 2.17 0.13 5.00
12 INT250730 Hmgb1 Positive_regulation of Localization of TNF 1 0.08 0.92 0.09 5.00
13 INT250729 Crlf1 Positive_regulation of Localization of TNF 1 0.02 0.92 0.09 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypernatremia. They are ordered first by their pain relevance and then by number of times they were reported in Hypernatremia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT477 Localization of Avp 813 0.81 131.58 300.4 99.68
2 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 99.56
3 INT987 Localization of TRH 37 0.78 10.53 11.1 99.28
4 INT937 Positive_regulation of Oxt 195 0.70 37.82 49.3 99.06
5 INT2838 Positive_regulation of Gene_expression of Oxt 27 0.67 6.25 6.83 99.06
6 INT14097 Positive_regulation of Son 22 0.61 5.14 6.55 99.06
7 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 98.56
8 INT13742 Gene_expression of Son 45 0.58 2.98 4.19 98.42
9 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 98.26
10 INT682 Negative_regulation of AVP 97 0.59 50.67 23.91 98.00
11 INT1261 Localization of Adh1 63 0.81 19.36 16.09 97.74
12 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 94.80
13 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 94.48
14 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 92.88
15 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 91.68
16 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 91.40
17 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 90.72
18 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16 90.60
19 INT812 Localization of INS 1026 0.81 515.6 145.31 90.32
20 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31 90.24
21 INT249 Localization of GHRH 215 0.80 78.02 51.87 89.96
22 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 88.92
23 INT214 Localization of AVP 370 0.81 208.51 91.09 82.16
24 INT72923 Positive_regulation of MCRS1 72 0.50 99.19 30.36 81.96
25 INT2442 Localization of Mb 38 0.80 24.74 6.33 79.76
26 INT11365 Positive_regulation of Localization of Mb 5 0.38 3.78 1.54 79.76
27 INT4261 Positive_regulation of Localization of Adh1 11 0.61 2.04 3.49 78.32
28 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 77.36
29 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 76.32
30 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72 75.92
31 INT3299 Positive_regulation of AGT 126 0.68 79.45 21.91 75.44
32 INT546 Binding of ALB 311 0.48 85.98 60.14 70.96
33 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 68.20
34 INT350 Localization of Th 79 0.80 10.26 41.17 61.36
35 INT403 Localization of Trh 241 0.81 28.55 81.45 59.60
36 INT154521 Localization of Fam19a5 1 0.03 0.12 0.25 57.12
37 INT58896 Localization of Adcyap1 35 0.81 4.57 14.77 55.92
38 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 52.48
39 INT9012 Localization of Vip 283 0.81 31.71 106.16 51.76
40 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 49.68
41 INT86717 Negative_regulation of Positive_regulation of NOS1 18 0.30 8.88 5.2 49.68
42 INT6107 Localization of Npy 180 0.81 26.76 81.67 49.28
43 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 49.24
44 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71 49.16
45 INT4920 Localization of Tac2 11 0.80 0.71 5.29 48.00
46 INT19511 Localization of Il6 212 0.81 118.17 67.67 46.00
47 INT10763 Localization of IL2 157 0.80 81.11 33.21 44.80
48 INT154522 Localization of LOC681066 1 0.03 0.06 0.25 44.80
49 INT292 Localization of Penk 876 0.81 88.44 669.14 43.36
50 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 43.12
51 INT6365 Localization of Edn1 56 0.81 18.84 13.83 42.40
52 INT6637 Positive_regulation of Avpr2 2 0.10 1.02 0.34 41.76
53 INT7491 Localization of Pdyn 80 0.81 3.94 58.77 41.28
54 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 40.80
55 INT287 Localization of Cck 518 0.81 86.84 364.04 38.16
56 INT894 Binding of Avp 84 0.48 29.16 29.63 36.20
57 INT1562 Localization of Crh 499 0.81 126.74 236.68 31.28
58 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 31.28
59 INT16879 Binding of Crh 72 0.48 21.65 28.43 27.84
60 INT9660 Regulation of TNF 363 0.62 312.94 139.99 27.04
61 INT188613 Gene_expression of CYP8B1 2 0.58 1.04 0.41 26.64
62 INT1158 Regulation of Agt 106 0.61 29.4 30.29 25.36
63 INT4199 Binding of Agt 76 0.48 21.06 12.66 25.20
64 INT2893 Localization of Oxt 219 0.80 28.96 79.43 25.00
65 INT2066 Localization of Agt 56 0.80 9.95 16.25 25.00
66 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 25.00
67 INT9385 Localization of LDHA 74 0.81 31.67 10.5 25.00
68 INT11367 Localization of MB 9 0.78 9.34 1.24 25.00
69 INT1940 Localization of PIK3C2A 8 0.78 7.28 1.01 25.00
70 INT11366 Positive_regulation of Localization of MB 2 0.33 1.6 0.22 25.00
71 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 23.56
72 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 12.88
73 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
74 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
75 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
76 INT6852 Localization of TNF 883 0.81 705.95 270.84 5.00
77 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
78 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 5.00
79 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 5.00
80 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
81 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
82 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
83 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 5.00
84 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 5.00
85 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 5.00
86 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 5.00
87 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
88 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 5.00
89 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 5.00
90 INT4207 Regulation of Avp 267 0.62 63.72 115.33 5.00
91 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 5.00
92 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84 5.00
93 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
94 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 5.00
95 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
96 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 5.00
97 INT2149 Positive_regulation of Oxt 181 0.70 24.8 85.43 5.00
98 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 5.00
99 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 5.00
100 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 5.00
101 INT6849 Localization of IL1B 229 0.81 112.56 69.63 5.00
102 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
103 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
104 INT5941 Gene_expression of Oxt 164 0.76 22.63 65.47 5.00
105 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6 5.00
106 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 5.00
107 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 5.00
108 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 5.00
109 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
110 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92 5.00
111 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 5.00
112 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 5.00
113 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
114 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
115 INT18522 Positive_regulation of Gene_expression of IFNA1 248 0.67 160.85 44.87 5.00
116 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
117 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 5.00
118 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
119 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 5.00
120 INT685 Regulation of AVP 124 0.62 34.9 39.91 5.00
121 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 5.00
122 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
123 INT5743 Localization of NA 104 0.59 14.35 35.29 5.00
124 INT6484 Binding of IL1B 122 0.47 75.84 35.07 5.00
125 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84 5.00
126 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 5.00
127 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
128 INT73498 Gene_expression of IL13 117 0.44 83.85 32.26 5.00
129 INT9655 Regulation of Il6 98 0.62 70.92 31.95 5.00
130 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 5.00
131 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 5.00
132 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
133 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
134 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
135 INT69157 Gene_expression of IL5 127 0.77 102.58 26.81 5.00
136 INT3760 Positive_regulation of ALB 142 0.70 87.46 26.7 5.00
137 INT70048 Positive_regulation of Gene_expression of IL10 90 0.55 71.34 25.66 5.00
138 INT5622 Gene_expression of Nppa 101 0.78 49.46 25.31 5.00
139 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96 5.00
140 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26 5.00
141 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 5.00
142 INT74423 Localization of IL10 91 0.80 61.6 22.95 5.00
143 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 5.00
144 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 5.00
145 INT20379 Localization of Il4 85 0.73 51.22 20.55 5.00
146 INT51474 Binding of Il6 55 0.48 44.99 20.52 5.00
147 INT7470 Positive_regulation of Gene_expression of Avp 37 0.70 19.55 19.96 5.00
148 INT5499 Transcription of Avp 52 0.72 7.98 19.87 5.00
149 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59 5.00
150 INT37835 Negative_regulation of CPP 61 0.51 31.34 18.57 5.00
151 INT15470 Regulation of CPP 42 0.48 26.1 18.25 5.00
152 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
153 INT34057 Negative_regulation of Gene_expression of IFNA1 65 0.58 43.46 17.25 5.00
154 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 5.00
155 INT653 Negative_regulation of Localization of REN 67 0.59 20.33 16.7 5.00
156 INT11685 Regulation of CSF2 99 0.59 58.82 15.9 5.00
157 INT3793 Regulation of CEBPZ 59 0.61 20.91 15.83 5.00
158 INT5536 Regulation of NA 74 0.59 16.61 15.36 5.00
159 INT9191 Localization of EDN1 94 0.81 57.01 14.78 5.00
160 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 5.00
161 INT47909 Binding of CPP 32 0.48 24.9 13.79 5.00
162 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 5.00
163 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 5.00
164 INT173505 Localization of Hand2 63 0.57 45.32 13.66 5.00
165 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 5.00
166 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55 5.00
167 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
168 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 5.00
169 INT398 Localization of AGT 45 0.78 16.97 11.54 5.00
170 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37 5.00
171 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75 5.00
172 INT11936 Positive_regulation of Positive_regulation of Il6 34 0.50 26.85 10.59 5.00
173 INT58904 Localization of TH1L 40 0.68 27.11 10.52 5.00
174 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42 5.00
175 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 5.00
176 INT62166 Positive_regulation of Gene_expression of Gpt 64 0.50 39.13 9.69 5.00
177 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37 5.00
178 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 5.00
179 INT860 Regulation of ALB 48 0.60 25.11 8.95 5.00
180 INT684 Binding of AVP 38 0.48 13.9 8.85 5.00
181 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15 5.00
182 INT22834 Negative_regulation of CYP21A2 28 0.58 23.07 7.13 5.00
183 INT11591 Gene_expression of IgG2a 53 0.65 23.14 6.73 5.00
184 INT10785 Gene_expression of Prl 35 0.78 20.64 6.7 5.00
185 INT4208 Regulation of Got1 23 0.44 6.72 6.62 5.00
186 INT25022 Binding of PAEP 66 0.42 22.83 6.59 5.00
187 INT934 Regulation of Gtf3a 25 0.35 11.35 6.34 5.00
188 INT99506 Negative_regulation of Bcl2l1 25 0.58 15.7 6.09 5.00
189 INT75832 Positive_regulation of Positive_regulation of IL8 30 0.70 20.77 6.05 5.00
190 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84 5.00
191 INT37834 Negative_regulation of Positive_regulation of CPP 14 0.58 6.22 5.69 5.00
192 INT22943 Positive_regulation of Positive_regulation of Gpt 23 0.47 16.09 5.55 5.00
193 INT80657 Gene_expression of SLC17A5 50 0.75 39.98 5.44 5.00
194 INT23010 Positive_regulation of CYP19A1 28 0.58 24.18 5.37 5.00
195 INT181596 Binding of IL1R1 9 0.36 7.99 4.32 5.00
196 INT94427 Positive_regulation of Positive_regulation of NOS2 14 0.47 11.15 4.3 5.00
197 INT103463 Localization of CPP 16 0.66 9.63 4.08 5.00
198 INT29138 Positive_regulation of Localization of IL2 25 0.50 10.06 3.89 5.00
199 INT105975 Gene_expression of ACACA 16 0.75 5.73 3.86 5.00
200 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7 5.00
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