D:Hyperopia

From wiki-pain
Jump to: navigation, search

pChart

Disease Term
Synonyms Farsightedness, Hypermetropia
Documents 55
Hot Single Events 34
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperopia. They are ordered first by their relevance to Hyperopia and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT245722 Binding of Vsx2 and Mfrp 1 0.24 1.2 0 92.64
2 INT353104 Binding of amd and Gtf3a 1 0.01 1.53 0.03 60.80
3 INT353106 Binding of amd and C3 1 0.09 1.69 0 13.88
4 INT353109 Binding of VEGFA and Aes 1 0.02 3.93 0.43 5.00
5 INT286418 Gtf3a Positive_regulation of Akt1 1 0.01 0.45 0.1 5.00
6 INT353105 Binding of Aes and Rgs9bp 1 0.01 0.35 0.05 5.00
7 INT263538 Binding of GPR19 and RS1 1 0.00 0.22 0 5.00
8 INT225969 Binding of Aqp4 and Nefl 1 0.07 0.3 0 5.00
9 INT298688 Binding of OPA1 and MFN1 1 0.52 2.09 0 5.00
10 INT353108 Binding of VEGFA and Pgf 1 0.02 2.17 0 5.00
11 INT286415 Binding of Fos and Fosb 1 0.23 0.08 0 5.00
12 INT298687 Binding of OPA1 and PARL 1 0.50 2.09 0 5.00
13 INT263540 Binding of MECP2 and RS1 1 0.00 0.18 0 5.00
14 INT353107 Binding of VEGFA and Vegfb 1 0.02 1.08 0 5.00
15 INT286422 Binding of Cdc42ep5 and Dock4 1 0.01 0.84 0 5.00
16 INT286420 Binding of Fgf13 and Mapk8ip3 1 0.36 0 0 5.00
17 INT289426 Binding of ESR1 and RXFP1 1 0.01 0.18 0 5.00
18 INT353110 Binding of VEGFA and Eo 1 0.00 0.67 0 5.00
19 INT286419 Rbm39 Negative_regulation of Transcription of Fos 1 0.01 0.16 0 5.00
20 INT263539 Positive_regulation of Binding of MECP2 and RS1 1 0.00 0.18 0 5.00
21 INT286417 Rbm39 Negative_regulation of Jun 1 0.00 0.16 0 5.00
22 INT286416 Rbm39 Negative_regulation of Fos 1 0.01 0.16 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperopia. They are ordered first by their pain relevance and then by number of times they were reported in Hyperopia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT244912 Positive_regulation of Positive_regulation of QSER1 1 0.29 0.51 0.04 100.00
2 INT244915 Positive_regulation of TMTC3 1 0.29 0.51 0.04 100.00
3 INT244919 Positive_regulation of QSER1 1 0.29 0.5 0.04 100.00
4 INT244917 Positive_regulation of NLGN1 1 0.27 0.5 0.04 100.00
5 INT99365 Regulation of TMX1 1 0.22 1.3 0.29 99.32
6 INT83837 Gene_expression of CEACAM6 7 0.76 13.8 4.59 98.84
7 INT81262 Positive_regulation of Phlda2 9 0.43 3.76 2.47 98.16
8 INT130837 Gene_expression of Aqp4 205 0.78 151.23 29.63 98.12
9 INT262507 Gene_expression of Kcnj10 2 0.58 9.86 0.29 98.12
10 INT139863 Binding of amd 27 0.41 41.3 0.91 98.04
11 INT86006 Gene_expression of Aldh1a1 5 0.53 3.22 0.43 97.76
12 INT328660 Positive_regulation of Kcnj10 1 0.02 1.9 0 97.28
13 INT169748 Positive_regulation of Gene_expression of Aqp4 38 0.69 34.29 3.79 97.16
14 INT244901 Gene_expression of UTS2D 1 0.10 0.41 0 97.16
15 INT83835 Positive_regulation of CEACAM6 3 0.24 1.53 1.01 96.68
16 INT86011 Gene_expression of Aldh1a2 7 0.54 6.76 0.78 96.32
17 INT229940 Positive_regulation of amd 10 0.49 27.97 0.15 94.88
18 INT225966 Regulation of Gene_expression of Aqp4 18 0.62 20.39 2.3 93.36
19 INT328661 Regulation of Gene_expression of Kcnj10 1 0.01 1.3 0.08 93.20
20 INT247621 Gene_expression of PAMR1 4 0.06 1.49 0.44 93.08
21 INT328663 Positive_regulation of Gene_expression of Kcnj10 1 0.02 2.14 0 92.64
22 INT245717 Binding of Vsx2 2 0.27 1.2 0 92.64
23 INT245715 Binding of Mfrp 1 0.48 3.46 0 92.24
24 INT245716 Gene_expression of Mfrp 1 0.78 2.35 0 90.32
25 INT165821 Positive_regulation of Aqp4 27 0.70 24.37 3.22 89.12
26 INT243550 Gene_expression of PSPH 7 0.25 7.49 0.4 88.56
27 INT86005 Positive_regulation of Transcription of Aldh1a1 1 0.39 0.86 0 87.20
28 INT86007 Transcription of Aldh1a1 2 0.54 1.41 0 87.20
29 INT208046 Positive_regulation of UTS2R 3 0.45 0.7 0.07 85.92
30 INT185407 Binding of PER1 13 0.42 9.32 2.6 82.80
31 INT215454 Regulation of amd 4 0.38 8.07 0.29 82.16
32 INT244927 Gene_expression of TMTC3 1 0.42 0.44 0.05 81.56
33 INT244911 Gene_expression of QSER1 1 0.42 0.44 0.05 81.56
34 INT306349 Transcription of SRGN 1 0.20 2.36 0.36 80.80
35 INT147880 Regulation of SRGN 28 0.33 13.99 0.9 79.36
36 INT244904 Positive_regulation of SHQ1 1 0.22 0.15 0.04 77.68
37 INT226298 Positive_regulation of Gene_expression of TGM1 4 0.24 2.66 0 77.60
38 INT112498 Gene_expression of TGM1 18 0.55 10.76 1.21 77.20
39 INT154636 Gene_expression of Prkra 1 0.58 0.57 0.13 77.16
40 INT244896 Positive_regulation of Cald1 1 0.01 0.32 0 76.56
41 INT244895 Negative_regulation of Cald1 1 0.01 0.32 0 76.56
42 INT32165 Binding of CALM1 92 0.48 24.19 29.57 74.84
43 INT29555 Positive_regulation of CALM1 58 0.69 14.09 17.37 74.84
44 INT347288 Positive_regulation of JPH1 1 0.13 0.74 0 74.56
45 INT346650 Gene_expression of PLK3 1 0.47 1.48 0 74.16
46 INT245713 Negative_regulation of Mfrp 1 0.43 0.85 0 73.68
47 INT146300 Binding of RS1 31 0.22 29.55 3.04 73.36
48 INT136280 Transcription of GAPDH 5 0.67 1.13 0.28 72.24
49 INT152841 Positive_regulation of Nefl 2 0.28 0.38 0.92 71.92
50 INT208142 Gene_expression of PITX1 3 0.65 9.36 0.73 68.48
51 INT289450 Regulation of Gene_expression of PITX1 1 0.04 0.71 0.09 68.48
52 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29 67.52
53 INT253 Regulation of PRL 184 0.62 47.27 65.79 66.32
54 INT128498 Regulation of CCND1 17 0.39 12.51 0.58 66.32
55 INT244914 Binding of CAPNS1 2 0.01 0.22 0.04 65.52
56 INT353103 Positive_regulation of ARMS2 1 0.05 1.47 0.03 64.92
57 INT139470 Positive_regulation of Htra1 2 0.48 1.58 0.03 64.92
58 INT353097 Positive_regulation of Plekha1 1 0.34 1.47 0.03 64.92
59 INT164966 Binding of Cle 2 0.32 0.91 0.19 63.12
60 INT276412 Positive_regulation of Gene_expression of Phlda2 2 0.09 0.65 0 63.12
61 INT155033 Gene_expression of Phlda2 18 0.30 9.45 0.5 62.48
62 INT46369 Positive_regulation of AK1 3 0.09 1.24 0.94 62.00
63 INT244910 Positive_regulation of UTS2D 1 0.09 0.2 0 61.04
64 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 56.76
65 INT244913 Regulation of Transcription of FOS 2 0.10 1.09 0.28 55.48
66 INT5847 Transcription of FOS 31 0.69 11.11 6.41 54.68
67 INT141344 Transcription of Egr1 11 0.70 5.59 1.34 54.68
68 INT244922 Transcription of SPTBN1 1 0.39 0.1 0.06 53.76
69 INT244900 Positive_regulation of Transcription of SPTBN1 1 0.26 0.1 0.06 53.76
70 INT244931 Gene_expression of OSBP2 1 0.46 0.17 0 53.20
71 INT110319 Positive_regulation of SRGN 10 0.40 6.2 0.56 52.88
72 INT280055 Positive_regulation of Gene_expression of SRGN 5 0.42 2.49 0.08 52.88
73 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 52.76
74 INT353102 Gene_expression of Htra1 1 0.46 1.29 0 52.08
75 INT105571 Gene_expression of SRGN 33 0.58 14.68 1.19 51.68
76 INT230159 Gene_expression of OSBP 37 0.76 1.17 0 49.44
77 INT346648 Regulation of Transcription of SERINC1 1 0.18 1.21 0 48.52
78 INT346647 Transcription of SERINC1 1 0.27 1.19 0 46.88
79 INT339592 Regulation of ARMS2 2 0.26 2.27 0 46.36
80 INT89048 Gene_expression of P2RX2 28 0.75 8.75 7.9 45.28
81 INT42810 Gene_expression of CALCRL 53 0.77 10.87 15.42 44.96
82 INT244926 Negative_regulation of Gene_expression of ABCC10 1 0.24 0.06 0 44.24
83 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 43.52
84 INT244897 Binding of Uts2r 7 0.11 1.8 0.84 43.08
85 INT244924 Gene_expression of ABCC10 1 0.44 0.05 0 41.68
86 INT69784 Binding of MYOC 8 0.48 5.67 0.21 41.20
87 INT245721 Localization of FRZB 6 0.78 4.3 0.6 34.04
88 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 32.04
89 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69 32.04
90 INT75501 Gene_expression of CCND1 90 0.76 60.86 5.93 32.04
91 INT145375 Transcription of CCND1 7 0.52 3.86 0.07 32.04
92 INT221830 Negative_regulation of Transcription of CCND1 3 0.18 2.15 0.03 32.04
93 INT245718 Positive_regulation of Mfrp 1 0.44 0.5 0 26.52
94 INT311457 Positive_regulation of Cle 1 0.22 1.22 0 25.80
95 INT225965 Localization of Aqp4 26 0.81 18.85 3.75 25.00
96 INT328662 Localization of Kcnj10 1 0.03 1.18 0.09 25.00
97 INT244903 Positive_regulation of ATE1 1 0.28 0.22 0.03 24.56
98 INT244906 Positive_regulation of SPTBN1 1 0.26 0 0 21.68
99 INT114742 Positive_regulation of GRB2 3 0.49 1.59 0 21.68
100 INT200754 Gene_expression of Rpe 35 0.51 6.3 0.58 20.24
101 INT139862 Negative_regulation of amd 8 0.35 10.15 0.6 20.08
102 INT244923 Negative_regulation of UTS2D 1 0.07 0.07 0.07 16.96
103 INT22068 Binding of CALCRL 53 0.41 6.14 17.32 16.44
104 INT244909 Positive_regulation of Gene_expression of SPTBN1 1 0.28 0 0 15.92
105 INT244902 Positive_regulation of Gene_expression of ABCC10 1 0.28 0 0 15.92
106 INT191211 Gene_expression of GRB2 5 0.62 0.96 0.32 14.96
107 INT244908 Gene_expression of SPTBN1 2 0.44 0.22 0.3 14.96
108 INT242208 Regulation of Gene_expression of SRGN 7 0.29 3.15 0.52 13.60
109 INT244928 Gene_expression of CD226 1 0.41 0 0 9.28
110 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
111 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
112 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 5.00
113 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 5.00
114 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
115 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 5.00
116 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 5.00
117 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
118 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73 5.00
119 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 5.00
120 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 5.00
121 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 5.00
122 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 5.00
123 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 5.00
124 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82 5.00
125 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
126 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 5.00
127 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 5.00
128 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
129 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
130 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41 5.00
131 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34 5.00
132 INT20462 Binding of ESR1 210 0.44 102.7 26.34 5.00
133 INT57874 Gene_expression of Egr1 113 0.78 68.46 24.95 5.00
134 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05 5.00
135 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
136 INT11275 Regulation of Fos 37 0.60 5.79 18.18 5.00
137 INT132997 Localization of Mmp9 59 0.80 45.9 17.61 5.00
138 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 5.00
139 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 5.00
140 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45 5.00
141 INT20071 Positive_regulation of HTR2A 33 0.67 10.89 14 5.00
142 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55 5.00
143 INT70816 Negative_regulation of Fos 32 0.58 13 11.18 5.00
144 INT75137 Regulation of Akt1 74 0.48 37.89 9.7 5.00
145 INT57876 Positive_regulation of Egr1 46 0.70 25.6 9.41 5.00
146 INT61264 Regulation of Jun 36 0.61 18.42 8.71 5.00
147 INT22481 Gene_expression of CADM1 28 0.65 30.26 8.5 5.00
148 INT64816 Transcription of Jun 31 0.69 16.01 7.64 5.00
149 INT79502 Gene_expression of Pvalb 26 0.78 2.83 7.46 5.00
150 INT15528 Positive_regulation of GCG 38 0.63 20.47 6.14 5.00
151 INT84909 Positive_regulation of SUGT1 22 0.08 22.01 5.43 5.00
152 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41 5.00
153 INT90202 Protein_catabolism of MMP2 15 0.94 7.47 5.41 5.00
154 INT95759 Gene_expression of DIO3 5 0.51 2.55 5.28 5.00
155 INT14681 Negative_regulation of GCG 31 0.57 13.55 4.98 5.00
156 INT26167 Positive_regulation of Hrasls 18 0.23 8.67 4.87 5.00
157 INT84911 Gene_expression of SUGT1 43 0.11 19.85 4.54 5.00
158 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
159 INT117936 Regulation of Gene_expression of Egr1 18 0.60 9.37 4.45 5.00
160 INT47766 Transcription of Fos 25 0.69 8.78 4.42 5.00
161 INT98357 Binding of Gnas 11 0.41 1.87 4.35 5.00
162 INT143337 Binding of Aqp4 30 0.40 23.73 4.24 5.00
163 INT11277 Localization of Fos 22 0.78 6.58 4.19 5.00
164 INT61118 Gene_expression of Nefl 11 0.75 4.02 4.02 5.00
165 INT43931 Binding of CFH 49 0.48 31.85 3.96 5.00
166 INT86769 Positive_regulation of Gene_expression of Rbm39 11 0.25 5.6 3.8 5.00
167 INT98624 Regulation of Aqp4 27 0.62 30.76 3.77 5.00
168 INT25251 Binding of Fos 19 0.36 7.96 3.73 5.00
169 INT96777 Localization of Pdgfa 12 0.79 5.86 3.52 5.00
170 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42 5.00
171 INT69990 Negative_regulation of Nefl 11 0.59 2.82 3.38 5.00
172 INT168003 Localization of Fgf2 24 0.80 12.52 3.31 5.00
173 INT113996 Gene_expression of RS1 23 0.72 7.7 3.16 5.00
174 INT10132 Negative_regulation of Serpinf1 14 0.58 11.72 3.14 5.00
175 INT167556 Binding of MECP2 7 0.27 4.57 2.6 5.00
176 INT96640 Negative_regulation of Gene_expression of Egr1 13 0.43 7.22 2.48 5.00
177 INT74262 Negative_regulation of Egr1 15 0.57 7.51 2.41 5.00
178 INT148576 Gene_expression of rs 26 0.37 8.96 2.17 5.00
179 INT15243 Regulation of Egr1 19 0.61 7.6 2.13 5.00
180 INT109975 Positive_regulation of Kras 14 0.45 12.72 1.68 5.00
181 INT50077 Gene_expression of Myb 21 0.66 7.68 1.54 5.00
182 INT164480 Negative_regulation of Gene_expression of Aqp4 14 0.58 10.84 1.52 5.00
183 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51 5.00
184 INT10873 Localization of Twist1 21 0.74 10.43 1.37 5.00
185 INT69785 Positive_regulation of MYOC 8 0.70 6.24 1.36 5.00
186 INT22871 Gene_expression of ELN 30 0.68 14.86 1.33 5.00
187 INT26464 Localization of DNAH8 15 0.80 4.3 1.33 5.00
188 INT272274 Localization of NARFL 24 0.60 27.55 1.18 5.00
189 INT58174 Gene_expression of Junb 9 0.78 1.38 1.09 5.00
190 INT167182 Binding of Psd 9 0.41 13.08 1.06 5.00
191 INT228770 Gene_expression of amd 16 0.57 21.49 1.05 5.00
192 INT80305 Gene_expression of IGKV2-30 6 0.04 3.68 1.01 5.00
193 INT83834 Transcription of CEACAM6 2 0.28 0.1 0.93 5.00
194 INT39369 Binding of NARFL 14 0.29 16.7 0.93 5.00
195 INT272414 Positive_regulation of Positive_regulation of NARFL 9 0.37 12.88 0.84 5.00
196 INT239497 Binding of Aes 8 0.29 3.61 0.84 5.00
197 INT173082 Positive_regulation of Binding of VEGFA 20 0.48 11.16 0.79 5.00
198 INT231685 Binding of CD47 12 0.47 1.55 0.73 5.00
199 INT272415 Negative_regulation of Gene_expression of NARFL 14 0.34 17.62 0.73 5.00
200 INT40698 Positive_regulation of Aes 3 0.32 3.84 0.65 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox