D:Hyperostosis

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Disease Term
Synonyms Bone Hypertrophies, Bone Hypertrophy, HYPEROSTOSES, Hypertrophies Bone, Hypertrophy Bone
Documents 249
Hot Single Events 19
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperostosis. They are ordered first by their relevance to Hyperostosis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT225793 Ank Positive_regulation of Ppi-rs 1 0.06 1.77 0.06 93.80
2 INT225794 Il1 Negative_regulation of Gene_expression of Npp 1 0.02 0.99 0.28 56.16
3 INT225777 Il1 Negative_regulation of Npp 1 0.02 0.99 0.28 56.16
4 INT225798 Il1 Negative_regulation of Gene_expression of Ppi-rs 1 0.01 1 0.28 56.16
5 INT225796 Il1 Negative_regulation of Ppi-rs 1 0.01 1 0.28 56.16
6 INT225784 Il1 Negative_regulation of Gene_expression of Enpp1 1 0.08 0.99 0.28 56.16
7 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44 5.00
8 INT225776 Enpp1 Positive_regulation of Positive_regulation of Ppi-rs 1 0.08 1.67 0.28 5.00
9 INT239087 Binding of SST and Negative_regulation of Localization of GH1 1 0.19 0.36 0.24 5.00
10 INT225787 Ppi-rs Positive_regulation of Gene_expression of Ank 1 0.06 1.44 0.19 5.00
11 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14 5.00
12 INT225783 Enpp1 Regulation of Ppi-rs 1 0.07 0.68 0.13 5.00
13 INT225785 Enpp3 Regulation of Ppi-rs 1 0.00 0.69 0.11 5.00
14 INT225805 Binding of SNRNP70 and Enpp1 1 0.42 1.43 0.09 5.00
15 INT225781 Ppi-rs Positive_regulation of Gene_expression of Spp1 1 0.03 1 0.07 5.00
16 INT225799 Il1 Regulation of Ppi-rs 1 0.01 0.44 0.05 5.00
17 INT342887 Binding of IFNG and IFNGR1 1 0.02 0.65 0.05 5.00
18 INT225779 Il1 Regulation of Npp 1 0.03 0.43 0.05 5.00
19 INT342886 Binding of C3 and CD40 1 0.02 0.66 0.05 5.00
20 INT225790 Il1 Regulation of Gene_expression of Enpp1 1 0.07 0.43 0.05 5.00
21 INT225786 Enpp3 Positive_regulation of Ppi-rs 1 0.00 0.32 0.05 5.00
22 INT225780 Il1 Regulation of Gene_expression of Npp 1 0.03 0.43 0.05 5.00
23 INT225806 Il1 Regulation of ALPI 1 0.00 0.44 0.05 5.00
24 INT225808 SNRNP70 Regulation of Enpp1 1 0.30 0.71 0.04 5.00
25 INT225230 Ad Positive_regulation of Nf2 1 0.04 1.37 0.04 5.00
26 INT225791 Ppi-rs Positive_regulation of Spp1 1 0.02 0.49 0.04 5.00
27 INT225801 Binding of Enpp1 and Npp 1 0.17 0.46 0.04 5.00
28 INT225800 Binding of Insr and Enpp1 1 0.05 0.67 0.04 5.00
29 INT225774 SNRNP70 Regulation of Binding of Insr and Enpp1 1 0.03 0.77 0.04 5.00
30 INT264148 Binding of CLCN7 and Ostm1 1 0.17 0.72 0.03 5.00
31 INT225802 Binding of Enpp1 and Ppi-rs 1 0.04 1 0.03 5.00
32 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0 5.00
33 INT264143 TCIRG1 Regulation of BSND 1 0.02 0.74 0 5.00
34 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0 5.00
35 INT264144 CLCN7 Regulation of ADO 1 0.04 0.71 0 5.00
36 INT225807 Enpp2 Positive_regulation of ALPI 1 0.00 0.23 0 5.00
37 INT225782 Tnfrsf11b Regulation of Enpp1 1 0.12 0.74 0 5.00
38 INT225792 Gene_expression of Enpp2 Positive_regulation of Ppi-rs 1 0.01 0.21 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperostosis. They are ordered first by their pain relevance and then by number of times they were reported in Hyperostosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT135638 Binding of Dst 4 0.36 2.76 0.38 99.76
2 INT225213 Binding of Nlrp5 1 0.10 1.37 0.11 99.76
3 INT150309 Negative_regulation of Galnt3 1 0.25 0.67 0.1 98.28
4 INT2077 Positive_regulation of LOC298111 1 0.54 0.37 0.1 95.80
5 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 94.92
6 INT225221 Negative_regulation of Nf2 1 0.57 18.06 0.83 94.52
7 INT225224 Positive_regulation of Nf2 1 0.59 3.4 0.12 94.52
8 INT225217 Positive_regulation of Positive_regulation of Nf2 1 0.43 1.07 0.04 94.52
9 INT225218 Positive_regulation of Negative_regulation of Nf2 1 0.40 1.07 0.04 94.52
10 INT225771 Negative_regulation of Gene_expression of Enpp1 4 0.43 3.68 0.13 91.88
11 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 91.28
12 INT126158 Positive_regulation of Lefty1 4 0.15 4.51 0.89 91.04
13 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 90.68
14 INT744 Positive_regulation of PTH 130 0.70 95.02 11.7 87.40
15 INT29393 Positive_regulation of APRT 18 0.67 5.28 2.13 87.40
16 INT80419 Gene_expression of Kdm5d 50 0.62 22.49 6.1 83.12
17 INT48203 Positive_regulation of Tgfb1 67 0.70 41.31 11.07 80.88
18 INT61120 Positive_regulation of Gene_expression of Tgfb1 34 0.70 21.15 6.93 80.88
19 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3 80.88
20 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 80.00
21 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 79.92
22 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 79.64
23 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83 79.40
24 INT123799 Regulation of Gene_expression of Galnt3 1 0.48 1.43 0.07 77.28
25 INT123800 Gene_expression of Galnt3 1 0.61 1.43 0.07 77.04
26 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 75.12
27 INT123801 Regulation of Regulation of GALNT3 1 0.18 1 0 75.00
28 INT64364 Regulation of GALNT3 3 0.42 1.31 0.39 75.00
29 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24 74.48
30 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 74.32
31 INT225767 Negative_regulation of Ank 1 0.40 2.51 0.34 73.76
32 INT17686 Negative_regulation of Hdl1 72 0.36 81.85 7.74 71.20
33 INT14572 Binding of INS 205 0.48 175.43 13.38 70.08
34 INT16130 Binding of IGF1 67 0.48 27.43 2.95 70.08
35 INT202702 Binding of IGF2BP3 2 0.36 3.82 0.08 70.08
36 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 68.08
37 INT28872 Positive_regulation of CSRP1 49 0.70 47.23 11.7 68.08
38 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 68.08
39 INT57274 Positive_regulation of Gene_expression of COL7A1 50 0.69 24.19 4.72 68.08
40 INT16349 Positive_regulation of alp 25 0.60 16.74 4.34 66.24
41 INT86369 Positive_regulation of Gene_expression of PCNA 40 0.67 26.66 3.57 66.24
42 INT250 Regulation of GHRH 65 0.61 17.46 23.19 65.00
43 INT56749 Gene_expression of PCNA 219 0.77 111.25 18.42 64.52
44 INT130797 Gene_expression of Fgf23 6 0.66 4.73 0.77 64.24
45 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 62.56
46 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31 60.56
47 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33 60.56
48 INT176519 Regulation of Gene_expression of Spp1 7 0.58 8.54 0.35 60.56
49 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96 60.20
50 INT225772 Regulation of Gene_expression of Enpp1 1 0.62 1.6 0.4 59.28
51 INT136690 Regulation of Negative_regulation of Tnf 5 0.45 3.58 0.78 57.20
52 INT141194 Regulation of Negative_regulation of Tnf 3 0.42 1.57 0.47 57.20
53 INT126577 Gene_expression of Ppi-rs 25 0.14 19.1 2.74 55.36
54 INT225759 Gene_expression of Npp 1 0.36 1.41 0.33 55.36
55 INT150307 Positive_regulation of Protein_catabolism of Fgf23 1 0.52 0.11 0 53.56
56 INT204170 Binding of Mri1 5 0.22 4.45 1.11 53.44
57 INT150308 Protein_catabolism of Fgf23 1 0.75 0.05 0 52.88
58 INT163623 Localization of Galnt3 2 0.63 1.42 0 50.00
59 INT163624 Localization of GALNT3 1 0.07 0.29 0 50.00
60 INT163625 Localization of GALNT6 1 0.05 0.28 0 50.00
61 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19 49.68
62 INT148070 Positive_regulation of Ppi-rs 14 0.08 9.46 1.67 48.88
63 INT225751 Positive_regulation of Positive_regulation of Ppi-rs 1 0.07 1.45 0.21 48.88
64 INT6810 Gene_expression of ENO2 70 0.78 54.8 8.35 46.96
65 INT126576 Regulation of Ppi-rs 8 0.10 6.05 1.68 44.24
66 INT2614 Gene_expression of CGA 187 0.78 105.89 24.77 42.80
67 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 41.52
68 INT225765 Regulation of Gene_expression of Cilp 1 0.25 1.57 0.15 40.72
69 INT225755 Positive_regulation of Gene_expression of Cilp 1 0.38 1.56 0.15 38.08
70 INT225763 Gene_expression of Cilp 1 0.43 1.56 0.15 38.08
71 INT252 Localization of GH1 529 0.80 227.4 122.05 30.24
72 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 25.00
73 INT49986 Transcription of Tnf 25 0.72 18.3 16.22 25.00
74 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 13.04
75 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99 13.04
76 INT131916 Negative_regulation of ALPL 10 0.42 9.33 1.8 10.24
77 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 9.88
78 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
79 INT443 Localization of POMC 1020 0.81 284.52 443.17 5.00
80 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
81 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
82 INT425 Localization of PRL 455 0.81 189.64 144.8 5.00
83 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
84 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 5.00
85 INT7395 Localization of GNRH1 399 0.81 62.88 117.68 5.00
86 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 5.00
87 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 5.00
88 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
89 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
90 INT253 Regulation of PRL 184 0.62 47.27 65.79 5.00
91 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 5.00
92 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
93 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 5.00
94 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 5.00
95 INT249 Localization of GHRH 215 0.80 78.02 51.87 5.00
96 INT5118 Regulation of SST 97 0.62 34.35 51.74 5.00
97 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 5.00
98 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
99 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 5.00
100 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
101 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 5.00
102 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
103 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
104 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 5.00
105 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 5.00
106 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 5.00
107 INT691 Binding of SST 67 0.48 24.66 32.67 5.00
108 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39 5.00
109 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
110 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 5.00
111 INT7394 Positive_regulation of Localization of GNRH1 67 0.69 7.22 25.29 5.00
112 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 5.00
113 INT16303 Negative_regulation of Localization of GH1 89 0.59 37.31 22.15 5.00
114 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74 5.00
115 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 5.00
116 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 5.00
117 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4 5.00
118 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
119 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 5.00
120 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
121 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47 5.00
122 INT34590 Gene_expression of ALPP 199 0.75 89.85 15.1 5.00
123 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83 5.00
124 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67 5.00
125 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32 5.00
126 INT987 Localization of TRH 37 0.78 10.53 11.1 5.00
127 INT10009 Positive_regulation of TRH 31 0.67 8.94 11.03 5.00
128 INT110178 Phosphorylation of MAPK14 40 0.68 19.38 10.37 5.00
129 INT34777 Localization of IGF1 82 0.80 42.68 8.62 5.00
130 INT156827 Localization of MRI1 25 0.65 16.06 8.33 5.00
131 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 5.00
132 INT34741 Positive_regulation of Gene_expression of GH1 58 0.67 35.06 7.8 5.00
133 INT123459 Gene_expression of Tnfrsf11b 35 0.58 24.16 7.26 5.00
134 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24 5.00
135 INT10094 Negative_regulation of ALPP 36 0.37 20.45 6.45 5.00
136 INT173967 Gene_expression of Mri1 26 0.43 16.67 6.45 5.00
137 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33 5.00
138 INT9683 Binding of GH1 57 0.47 21.14 5.99 5.00
139 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82 5.00
140 INT167755 Gene_expression of Enpp2 12 0.77 57.31 5.3 5.00
141 INT78515 Negative_regulation of Mag 10 0.54 9.4 5.06 5.00
142 INT4378 Regulation of Gene_expression of GH1 26 0.47 10.2 4.61 5.00
143 INT171989 Gene_expression of Ank 8 0.78 11.76 4.36 5.00
144 INT9677 Negative_regulation of Gene_expression of GH1 46 0.48 23.32 3.68 5.00
145 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68 5.00
146 INT48726 Gene_expression of IGFBP1 27 0.67 9.45 3.36 5.00
147 INT146890 Gene_expression of Cfd 15 0.66 4.42 3.28 5.00
148 INT180250 Positive_regulation of GLUL 23 0.29 7.57 3.23 5.00
149 INT126575 Negative_regulation of Ppi-rs 21 0.14 12.94 3.2 5.00
150 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 5.00
151 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85 5.00
152 INT85078 Positive_regulation of PCNA 36 0.49 17.06 2.81 5.00
153 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55 5.00
154 INT9089 Positive_regulation of Ceacam1 17 0.69 7.09 2.49 5.00
155 INT97152 Protein_catabolism of COL1A1 11 0.74 8.03 2.3 5.00
156 INT15607 Localization of GNRHR 14 0.62 7.56 2.3 5.00
157 INT176517 Negative_regulation of Gene_expression of Spp1 18 0.59 15.31 2.28 5.00
158 INT107597 Binding of Enpp1 5 0.37 3.35 2.23 5.00
159 INT3823 Positive_regulation of ALPI 27 0.69 19.49 2.15 5.00
160 INT53434 Positive_regulation of T 7 0.07 3.67 2.09 5.00
161 INT49250 Regulation of Atp6v0d2 5 0.08 1.54 2.04 5.00
162 INT216848 Gene_expression of TCIRG1 8 0.52 2.59 1.95 5.00
163 INT155015 Positive_regulation of HLA-DOA 6 0.23 4.45 1.92 5.00
164 INT239093 Gene_expression of PTTG1 84 0.65 83.94 1.87 5.00
165 INT105162 Gene_expression of Ad 47 0.12 46.53 1.83 5.00
166 INT183937 Positive_regulation of Ank 3 0.50 3.39 1.81 5.00
167 INT224529 Positive_regulation of Gene_expression of Enpp1 15 0.70 12.75 1.81 5.00
168 INT57018 Gene_expression of GANAB 9 0.08 3.76 1.79 5.00
169 INT78938 Binding of IGFBP3 40 0.45 27.95 1.73 5.00
170 INT105325 Gene_expression of ENPP2 5 0.75 1.32 1.72 5.00
171 INT48616 Positive_regulation of IGFBP1 14 0.43 5.62 1.56 5.00
172 INT182297 Positive_regulation of Phosphorylation of MAPK14 7 0.42 3.36 1.53 5.00
173 INT174156 Localization of Trp53 16 0.72 13.52 1.18 5.00
174 INT173578 Negative_regulation of CTSK 8 0.44 6.29 1.15 5.00
175 INT128987 Negative_regulation of Ccnd1 24 0.52 15.78 1.15 5.00
176 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92 5.00
177 INT114875 Negative_regulation of Cdk4 4 0.35 4.01 0.86 5.00
178 INT109007 Positive_regulation of Ccnd1 23 0.53 9.5 0.86 5.00
179 INT192300 Positive_regulation of Gene_expression of IGFBP1 6 0.60 2.85 0.81 5.00
180 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79 5.00
181 INT221201 Binding of Ppi-rs 5 0.04 4.02 0.78 5.00
182 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76 5.00
183 INT225757 Positive_regulation of Gene_expression of Ank 1 0.64 4.71 0.75 5.00
184 INT225769 Positive_regulation of Gene_expression of Enpp2 3 0.69 16.67 0.74 5.00
185 INT11657 Gene_expression of ALPI 11 0.71 5.13 0.74 5.00
186 INT183399 Gene_expression of Cyp2b10 17 0.39 18.39 0.71 5.00
187 INT158836 Positive_regulation of Localization of TRH 7 0.49 2.61 0.67 5.00
188 INT35098 Localization of Enpp1 4 0.75 0.81 0.67 5.00
189 INT225754 Positive_regulation of Gene_expression of Ppi-rs 1 0.07 3.96 0.66 5.00
190 INT202848 Gene_expression of Nf2 5 0.59 4.93 0.63 5.00
191 INT178752 Binding of IGFBP1 8 0.15 4.58 0.61 5.00
192 INT160705 Positive_regulation of Enpp3 2 0.20 1.26 0.56 5.00
193 INT259408 Gene_expression of Atp6v0d2 5 0.09 2.01 0.54 5.00
194 INT55047 Gene_expression of GNRHR 8 0.78 5.2 0.53 5.00
195 INT40583 Regulation of ALPI 4 0.45 1.87 0.48 5.00
196 INT183939 Negative_regulation of Gene_expression of Ank 2 0.43 1.81 0.47 5.00
197 INT225762 Positive_regulation of Npp 1 0.32 2.61 0.47 5.00
198 INT225758 Localization of Ppi-rs 1 0.08 3.18 0.45 5.00
199 INT90090 Gene_expression of ADO 4 0.58 1.41 0.42 5.00
200 INT225768 Positive_regulation of Enpp2 7 0.69 8.11 0.37 5.00
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