D:Hyperoxaluria

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pChart

Disease Term
Synonyms D Glycerate Dehydrogenase Deficiency, Glyceric Aciduria, Glycolic Aciduria, Hepatic Agt Deficiency, Hp2, OXALOSIS, OXALURIA, Peroxisomal Alanine Glyoxylate Aminotransferase Deficiency
Documents 59
Hot Single Events 12
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperoxaluria. They are ordered first by their relevance to Hyperoxaluria and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86 5.00
2 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12 5.00
3 INT260811 Binding of ITGA4 and ITGAL 1 0.02 0 0.03 5.00
4 INT270316 Binding of AMBP and NHS 1 0.20 0.91 0 5.00
5 INT283062 ERCC8 Positive_regulation of CFH 1 0.02 1.88 0 5.00
6 INT283061 Binding of ERCC8 and LDLR 1 0.00 0.44 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperoxaluria. They are ordered first by their pain relevance and then by number of times they were reported in Hyperoxaluria. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 99.24
2 INT95446 Gene_expression of PHC2 2 0.32 1.59 0.3 99.24
3 INT1533 Negative_regulation of AGT 105 0.42 46.54 16.92 98.92
4 INT135056 Positive_regulation of MTSS1 1 0.21 0.69 0 97.28
5 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 96.80
6 INT148596 Negative_regulation of Lipf 1 0.17 1.06 0.11 95.04
7 INT14477 Positive_regulation of TPSAB1 10 0.69 5.88 1.46 93.16
8 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 92.04
9 INT170282 Negative_regulation of Gene_expression of APCS 2 0.11 0.6 0.34 86.72
10 INT102729 Gene_expression of APCS 20 0.65 8.86 2.52 84.64
11 INT179176 Negative_regulation of Asl 1 0.30 0.79 0.1 83.96
12 INT179177 Positive_regulation of Negative_regulation of Asl 1 0.35 0.37 0 83.96
13 INT86670 Negative_regulation of AGXT 6 0.57 2.24 1.18 75.00
14 INT3777 Positive_regulation of NARFL 256 0.56 302.43 25.74 69.56
15 INT101891 Negative_regulation of Cftr 25 0.58 24.09 9.55 69.04
16 INT12339 Localization of IL8 437 0.81 251.87 117.39 67.04
17 INT9884 Localization of CD79A 41 0.78 21.75 3.06 59.88
18 INT66785 Positive_regulation of Tcra-V4.1 1 0.01 0.44 0.14 55.80
19 INT66791 Regulation of TPSAB1 1 0.00 0.56 0.18 50.28
20 INT66794 Binding of Vcam1 14 0.48 7.84 1.87 41.52
21 INT18995 Binding of CEL 23 0.47 14.46 4.5 39.28
22 INT66792 Binding of TPSAB1 7 0.16 4.93 1.45 38.16
23 INT38671 Positive_regulation of KRT20 62 0.53 40.17 5.6 37.40
24 INT38673 Negative_regulation of KRT20 38 0.42 22.49 2.77 33.04
25 INT19134 Gene_expression of TPSAB1 16 0.66 11.61 2.48 31.52
26 INT56376 Negative_regulation of AMBP 29 0.35 21.49 2.59 30.92
27 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 5.00
28 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 5.00
29 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
30 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
31 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
32 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
33 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
34 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
35 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 5.00
36 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 5.00
37 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
38 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 5.00
39 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
40 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 5.00
41 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
42 INT52350 Gene_expression of CD14 184 0.75 71.37 33.13 5.00
43 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
44 INT65698 Localization of CCL2 118 0.81 77.54 32.69 5.00
45 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 5.00
46 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
47 INT3330 Gene_expression of AGT 149 0.76 98.65 22.73 5.00
48 INT116856 Gene_expression of TNFSF10 110 0.75 115.76 21.48 5.00
49 INT756 Gene_expression of C3 138 0.75 100.6 19.2 5.00
50 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 5.00
51 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 5.00
52 INT1981 Negative_regulation of NARFL 219 0.47 223.48 16.41 5.00
53 INT170754 Localization of IFN1@ 121 0.78 66.78 15.6 5.00
54 INT153776 Positive_regulation of IL17A 42 0.64 34.58 14.82 5.00
55 INT107585 Gene_expression of CCR2 35 0.71 26.44 14.75 5.00
56 INT1982 Regulation of NARFL 119 0.49 116.2 14.35 5.00
57 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21 5.00
58 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 5.00
59 INT120828 Localization of CXCL10 29 0.68 18.01 12.17 5.00
60 INT80756 Gene_expression of CD86 77 0.77 46.68 11.36 5.00
61 INT15804 Gene_expression of ISG20 83 0.75 44.33 10.58 5.00
62 INT159631 Positive_regulation of DCPS 60 0.27 43.23 10.3 5.00
63 INT170333 Binding of IFN1@ 68 0.47 49.01 9.72 5.00
64 INT117543 Regulation of Gene_expression of CD14 21 0.59 6.66 7.67 5.00
65 INT11823 Positive_regulation of GGT1 53 0.67 45.84 7.55 5.00
66 INT116717 Gene_expression of CCR7 37 0.76 34.1 7.48 5.00
67 INT117544 Regulation of CD14 24 0.45 5.85 6.66 5.00
68 INT11048 Gene_expression of CD69 59 0.67 42.85 6.4 5.00
69 INT11826 Positive_regulation of LDLR 62 0.62 45.09 6.21 5.00
70 INT17551 Positive_regulation of Gene_expression of HLA-DRA 31 0.70 15.39 6 5.00
71 INT52907 Regulation of Gene_expression of HLA-DRA 28 0.34 5.94 5.96 5.00
72 INT5490 Binding of CA2 52 0.36 9.73 5.53 5.00
73 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08 5.00
74 INT149093 Positive_regulation of TNFSF10 31 0.49 34.61 4.56 5.00
75 INT170604 Negative_regulation of Gene_expression of GOPC 50 0.35 12.71 4.51 5.00
76 INT272273 Gene_expression of NARFL 89 0.54 121.19 4.47 5.00
77 INT97139 Gene_expression of CD83 43 0.70 22.05 3.91 5.00
78 INT148085 Binding of CXCL10 14 0.32 10.22 3.81 5.00
79 INT81695 Gene_expression of OSM 14 0.75 7.29 3.58 5.00
80 INT16236 Negative_regulation of CFH 31 0.57 19.59 3.36 5.00
81 INT93915 Positive_regulation of Gene_expression of CD40 14 0.44 12.45 3.35 5.00
82 INT97138 Positive_regulation of Gene_expression of CD14 17 0.48 9.07 3.35 5.00
83 INT16234 Positive_regulation of CFH 25 0.50 26.05 3.33 5.00
84 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 5.00
85 INT93913 Positive_regulation of CD40 21 0.58 23.47 3.1 5.00
86 INT180971 Protein_catabolism of GOPC 21 0.77 6.15 2.98 5.00
87 INT155486 Positive_regulation of Gene_expression of CD86 16 0.69 14.6 2.86 5.00
88 INT126514 Positive_regulation of CCR7 16 0.43 16.21 2.79 5.00
89 INT75685 Regulation of CD86 12 0.58 3.55 2.66 5.00
90 INT19621 Positive_regulation of CD86 23 0.69 14 2.58 5.00
91 INT232510 Negative_regulation of Gene_expression of CXCR4 18 0.58 20.27 2.54 5.00
92 INT1829 Gene_expression of CFH 71 0.75 64.24 2.49 5.00
93 INT95898 Gene_expression of CAPG 14 0.39 10.51 2.33 5.00
94 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08 5.00
95 INT104931 Binding of TNFSF10 15 0.36 17.44 2.07 5.00
96 INT107987 Gene_expression of MRC1 27 0.75 36.94 1.99 5.00
97 INT88701 Gene_expression of MMD 15 0.44 6.04 1.94 5.00
98 INT14149 Binding of C6orf25 11 0.48 9.04 1.71 5.00
99 INT103799 Positive_regulation of CAPG 8 0.34 5.16 1.52 5.00
100 INT204181 Gene_expression of CD209 22 0.64 30.66 1.47 5.00
101 INT272274 Localization of NARFL 24 0.60 27.55 1.18 5.00
102 INT23199 Binding of LDLR 22 0.47 17.08 1.16 5.00
103 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1 5.00
104 INT46044 Positive_regulation of Gene_expression of C3 23 0.53 20.07 1.06 5.00
105 INT99966 Negative_regulation of Positive_regulation of NARFL 13 0.37 13.32 0.98 5.00
106 INT37170 Binding of APCS 6 0.36 4.79 0.97 5.00
107 INT82702 Positive_regulation of Positive_regulation of LDLR 4 0.45 1.08 0.95 5.00
108 INT39369 Binding of NARFL 14 0.29 16.7 0.93 5.00
109 INT170603 Negative_regulation of Gene_expression of CD40 5 0.32 2.18 0.78 5.00
110 INT272415 Negative_regulation of Gene_expression of NARFL 14 0.34 17.62 0.73 5.00
111 INT23146 Negative_regulation of Aprt 8 0.56 7.53 0.71 5.00
112 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69 5.00
113 INT155485 Regulation of Gene_expression of CD86 7 0.61 3.73 0.6 5.00
114 INT238245 Gene_expression of Atp5s 4 0.75 7.57 0.6 5.00
115 INT89217 Negative_regulation of ADAMTS13 8 0.50 12.32 0.51 5.00
116 INT94456 Binding of CD1A 3 0.36 2.71 0.48 5.00
117 INT173170 Gene_expression of PPA1 5 0.06 3.11 0.47 5.00
118 INT238502 Regulation of CD40 6 0.28 3.7 0.44 5.00
119 INT122156 Binding of CA1 3 0.47 1.52 0.44 5.00
120 INT272272 Positive_regulation of Gene_expression of NARFL 17 0.40 18.85 0.31 5.00
121 INT274273 Regulation of Gene_expression of NARFL 3 0.10 4.39 0.2 5.00
122 INT170592 Regulation of Gene_expression of CD40 4 0.17 0 0.11 5.00
123 INT179175 Positive_regulation of Asl 1 0.38 0.39 0.09 5.00
124 INT272530 Negative_regulation of Localization of NARFL 3 0.09 2.98 0.07 5.00
125 INT260818 Positive_regulation of Binding of CD1A 1 0.14 0.23 0.04 5.00
126 INT260808 Negative_regulation of Gene_expression of Cd3e 2 0.21 0.81 0.04 5.00
127 INT107989 Positive_regulation of Gene_expression of MRC1 2 0.45 0.06 0.03 5.00
128 INT260819 Binding of OSM 2 0.12 0.66 0.03 5.00
129 INT283060 Positive_regulation of Atp5s 1 0.20 1.81 0 5.00
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