D:Hypersensitivity Vasculitis

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Disease Term
Synonyms ALLERGIC ANGIITIS, Allergic Vasculitis, Angiitides Hypersensitivity, ANGIITIDES LEUKOCYTOCLASTIC, Angiitis Hypersensitivity, Angiitis Leukocytoclastic, Collagen Vascular Disease, Cutaneous Vasculitis, Hypersensitivity Angiitides, Hypersensitivity Angiitis, Hypersensitivity Vasculitides
Documents 253
Hot Single Events 57
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hypersensitivity Vasculitis. They are ordered first by their relevance to Hypersensitivity Vasculitis and then by their general relevance to pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT192109 PAH Positive_regulation of Binding of COL7A1 1 0.04 1.45 0.2 100.00
2 INT242340 Binding of COL7A1 and PAH 1 0.00 1.35 0 100.00
3 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 5.00
4 INT188318 MCPH1 Positive_regulation of Pah 3 0.02 3 0.85 5.00
5 INT190702 CD40 Positive_regulation of Gene_expression of F3 1 0.00 1.4 0.55 5.00
6 INT269962 Bcl2 Negative_regulation of Bcl2l11 1 0.15 2.14 0.34 5.00
7 INT303030 Binding of Ednra and MCPH1 1 0.00 1.02 0.32 5.00
8 INT303005 Binding of Ednra and Pah 1 0.06 1.02 0.32 5.00
9 INT321601 Binding of C3 and PRTN3 1 0.00 0.99 0.27 5.00
10 INT321602 Binding of C4A and PRTN3 1 0.00 0.99 0.27 5.00
11 INT303029 Binding of TEK and Angpt1 1 0.26 1.82 0.22 5.00
12 INT249665 Binding of GOPC and PSS 1 0.02 3.13 0.21 5.00
13 INT303028 Binding of Pah and MCPH1 1 0.02 1.13 0.16 5.00
14 INT331628 Binding of HLA-DQA2 and Pain1 1 0.01 2.13 0.14 5.00
15 INT331627 Binding of HLA-DRB3 and Pain1 1 0.00 2.15 0.14 5.00
16 INT303003 Gene_expression of Ptgis Positive_regulation of Pah 1 0.36 1.67 0.13 5.00
17 INT303007 Binding of Pah and Ptgis 1 0.26 0.99 0.12 5.00
18 INT331612 ETV4 Positive_regulation of Gene_expression of TGFB1 1 0.00 1.32 0.12 5.00
19 INT209952 Binding of SNRNP70 and IGKV2-19 1 0.00 0.47 0.11 5.00
20 INT336341 Binding of RTCA and ELOVL1 1 0.02 2.15 0.07 5.00
21 INT331626 Edn1 Positive_regulation of Itk 1 0.00 0.57 0.07 5.00
22 INT331629 Binding of TGFB1 and Positive_regulation of Gene_expression of Itk 1 0.00 0.84 0.07 5.00
23 INT186860 MIR181A2HG Regulation of Cd86 1 0.02 1.05 0.07 5.00
24 INT303027 Gene_expression of MCPH1 Positive_regulation of Pah 1 0.02 0.83 0.07 5.00
25 INT186814 MIR181A2HG Regulation of ICAM1 1 0.01 1.05 0.07 5.00
26 INT213207 Negative_regulation of ASAP2 Negative_regulation of PVR 1 0.01 0.45 0.04 5.00
27 INT303026 Gene_expression of MCPH1 Positive_regulation of Gene_expression of Ptgis 1 0.02 0.78 0.04 5.00
28 INT303008 Gene_expression of Pah Positive_regulation of Gene_expression of Ptgis 1 0.31 0.78 0.04 5.00
29 INT213206 ASAP2 Negative_regulation of PVR 1 0.01 0.44 0.04 5.00
30 INT303010 Ptgis Positive_regulation of Rock2 1 0.05 1.23 0.03 5.00
31 INT331611 NKX2-1 Regulation of Transcription of SFTPB 1 0.01 0.49 0 5.00
32 INT249666 Binding of CD81 and GOPC 1 0.06 1.31 0 5.00
33 INT249664 Binding of CD81 and CHCHD2 1 0.00 2.51 0 5.00
34 INT209951 Binding of KCNJ13 and SNRNP70 1 0.00 0 0 5.00
35 INT303004 Adm Positive_regulation of Gsk3b 1 0.04 0.97 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hypersensitivity Vasculitis. They are ordered first by their pain relevance and then by number of times they were reported in Hypersensitivity Vasculitis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 100.00
2 INT2144 Localization of COL7A1 36 0.74 20.92 4.67 100.00
3 INT22781 Binding of COL7A1 76 0.48 41.59 6.66 100.00
4 INT43907 Binding of CD79A 28 0.48 28.11 3.04 100.00
5 INT9110 Binding of PAH 32 0.41 42.1 3.1 99.98
6 INT97149 Binding of Dpyd 3 0.14 1.73 0.25 99.80
7 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 99.76
8 INT756 Gene_expression of C3 138 0.75 100.6 19.2 99.72
9 INT2828 Positive_regulation of Ptger3 26 0.68 8.01 9.63 99.62
10 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53 99.34
11 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 99.14
12 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58 98.96
13 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 98.96
14 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 98.82
15 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 98.56
16 INT61025 Negative_regulation of Negative_regulation of Il6 3 0.43 1.15 0.56 97.88
17 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 97.86
18 INT2725 Positive_regulation of FCER2 23 0.69 23.08 4.7 97.86
19 INT317746 Positive_regulation of Gene_expression of FCER2 2 0.01 4.09 0.3 97.86
20 INT32421 Gene_expression of FCER2 19 0.73 17.23 2.53 97.66
21 INT62064 Negative_regulation of Gene_expression of Il1rn 6 0.32 4.81 2.53 97.60
22 INT49606 Gene_expression of Il1rn 30 0.66 15.78 14.82 97.60
23 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 97.52
24 INT15870 Regulation of PSS 6 0.25 3.22 0.85 97.16
25 INT17511 Negative_regulation of PRTN3 19 0.41 12 3.3 96.92
26 INT17489 Regulation of F13A1 28 0.45 15.79 4.93 96.52
27 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 95.76
28 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31 95.76
29 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77 95.44
30 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 95.44
31 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 95.36
32 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 94.88
33 INT73100 Negative_regulation of PADI4 3 0.57 3.42 0.37 94.72
34 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 94.64
35 INT15610 Localization of GOPC 223 0.65 68.26 28.7 94.64
36 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63 94.28
37 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 93.44
38 INT8775 Binding of IGHE 167 0.48 102.61 23.54 92.80
39 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68 92.20
40 INT20280 Positive_regulation of Esr1 32 0.69 18.37 5.69 91.92
41 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 91.36
42 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78 90.00
43 INT66804 Negative_regulation of Negative_regulation of Tnf 4 0.56 2.79 2.26 89.44
44 INT329699 Positive_regulation of HMHA1 1 0.04 1.56 0.09 89.44
45 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57 89.40
46 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 89.24
47 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 88.68
48 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 87.80
49 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 87.40
50 INT16389 Gene_expression of Plg 80 0.67 36.88 6.74 86.32
51 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54 85.36
52 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 85.04
53 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24 81.60
54 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 81.00
55 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 81.00
56 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 81.00
57 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 81.00
58 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 79.36
59 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 74.92
60 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 74.92
61 INT83886 Negative_regulation of HMOX2 27 0.43 11.69 10.78 72.48
62 INT50855 Gene_expression of TRIM21 4 0.65 3.07 0.71 71.56
63 INT67981 Positive_regulation of CCL2 165 0.70 136.84 61.85 71.12
64 INT193358 Localization of ST3GAL4 2 0.52 1.65 0.05 70.88
65 INT314365 Binding of epi 1 0.03 4.91 2.7 66.96
66 INT23994 Positive_regulation of epi 5 0.64 1.65 2.15 66.96
67 INT3880 Negative_regulation of Serping1 54 0.58 37.19 4.75 65.44
68 INT145772 Regulation of C4a 3 0.38 1.99 0.92 64.72
69 INT14690 Localization of CSF2 124 0.80 85.17 27.26 64.12
70 INT255194 Binding of Fbn1 2 0.35 4.26 0.34 64.12
71 INT22965 Positive_regulation of Pah 42 0.61 41.41 8.84 64.08
72 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 63.52
73 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 62.52
74 INT62496 Binding of CSF1 6 0.36 4.55 1.14 61.20
75 INT1735 Gene_expression of HSD11B1 199 0.75 257.87 11.5 59.60
76 INT194298 Gene_expression of DHPS 1 0.62 8.84 0.37 59.32
77 INT18025 Binding of Pah 32 0.45 30.72 7.93 58.52
78 INT255191 Negative_regulation of Fbn1 1 0.37 1.2 0.25 57.36
79 INT51646 Binding of IL3 3 0.37 3.26 0.56 55.00
80 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 54.84
81 INT191534 Negative_regulation of EGFL7 10 0.06 7.52 1.98 54.48
82 INT20205 Binding of IgG 108 0.46 66.68 8.57 53.92
83 INT170054 Negative_regulation of Gopc 280 0.38 117.89 42.4 53.68
84 INT30531 Gene_expression of C2 15 0.66 5.5 1.99 53.52
85 INT4137 Positive_regulation of C3 73 0.69 48.57 12.63 53.12
86 INT246352 Positive_regulation of Regulation of C3 1 0.03 1.05 0.03 53.12
87 INT46637 Gene_expression of CXCL10 172 0.78 121.94 57.74 52.92
88 INT94335 Positive_regulation of CXCL10 71 0.58 50.69 23 52.92
89 INT92237 Positive_regulation of Gene_expression of CXCL10 43 0.70 43.67 13.65 52.92
90 INT16385 Regulation of C3 20 0.41 9.98 1.92 52.76
91 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 52.52
92 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 52.52
93 INT81498 Positive_regulation of Gene_expression of CCL2 107 0.70 53.89 45.22 52.52
94 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 52.52
95 INT10057 Gene_expression of Ldlr 35 0.67 23.99 3.05 51.04
96 INT204122 Gene_expression of GJA8 13 0.47 22.98 3.04 48.48
97 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88 46.36
98 INT127460 Positive_regulation of Gene_expression of PAH 5 0.43 4.3 0.5 46.36
99 INT1734 Negative_regulation of HSD11B1 116 0.57 125.13 10.52 46.20
100 INT194299 Binding of DHPS 1 0.39 2.22 0.17 45.36
101 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 45.04
102 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63 44.88
103 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 43.68
104 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 43.08
105 INT89104 Binding of TGFB1 29 0.44 13.67 5.12 41.92
106 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 41.00
107 INT255189 Positive_regulation of Localization of Fbn1 1 0.45 1.03 0.19 40.88
108 INT255190 Positive_regulation of Gene_expression of Fbn1 1 0.68 1.03 0.19 40.88
109 INT23468 Gene_expression of Fbn1 7 0.76 8.04 0.76 40.36
110 INT202924 Localization of Fbn1 2 0.69 1.12 0.19 39.76
111 INT47949 Positive_regulation of ELOVL1 19 0.42 29.78 3.3 38.88
112 INT51840 Positive_regulation of Localization of CD40LG 8 0.69 9.59 1.58 38.88
113 INT32783 Gene_expression of Pah 33 0.60 30.55 6.86 38.72
114 INT57720 Localization of IGHG3 33 0.74 20.24 6.25 38.00
115 INT45753 Localization of CD40LG 45 0.79 32.31 5.28 38.00
116 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 37.20
117 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 36.52
118 INT56301 Positive_regulation of IL4 68 0.56 54.51 18.65 36.52
119 INT85415 Positive_regulation of IL9 10 0.28 6.93 4.71 36.52
120 INT151230 Positive_regulation of IL7 14 0.37 11.89 4.56 36.52
121 INT188398 Positive_regulation of IL15 8 0.19 4.64 1.06 36.52
122 INT170444 Binding of Gopc 172 0.39 45.05 20.71 30.64
123 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 29.28
124 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 28.84
125 INT12087 Regulation of Localization of TNF 44 0.62 28.71 15.17 27.40
126 INT6852 Localization of TNF 883 0.81 705.95 270.84 26.88
127 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 26.08
128 INT54763 Binding of Il6 82 0.48 63.27 12.89 25.52
129 INT62497 Binding of Il4 7 0.26 4.19 3.88 25.04
130 INT48141 Binding of Csf3 18 0.39 9.93 1.71 25.00
131 INT132419 Positive_regulation of ANXA5 9 0.59 5.22 2.38 23.96
132 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69 20.64
133 INT250628 Negative_regulation of MCPH1 8 0.17 7.05 1.27 18.72
134 INT51803 Negative_regulation of Pde7a 14 0.59 14.98 4.85 17.32
135 INT106745 Localization of CRP 65 0.81 66.44 15.21 15.68
136 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 15.28
137 INT204129 Positive_regulation of Gene_expression of GJA8 1 0.30 0.85 0 14.12
138 INT95641 Regulation of Fbn1 3 0.45 3.67 0.91 9.60
139 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 8.28
140 INT204120 Positive_regulation of GJA8 2 0.30 1.51 0.63 8.28
141 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 7.16
142 INT10870 Regulation of IgG 67 0.59 43.27 12.74 5.76
143 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 5.00
144 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 5.00
145 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
146 INT6481 Binding of TNF 624 0.48 510.2 214.82 5.00
147 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 5.00
148 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66 5.00
149 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 5.00
150 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 5.00
151 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 5.00
152 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
153 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 5.00
154 INT12339 Localization of IL8 437 0.81 251.87 117.39 5.00
155 INT12082 Localization of IL6 365 0.81 241.78 105.78 5.00
156 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
157 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62 5.00
158 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
159 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 5.00
160 INT7180 Negative_regulation of Trib3 180 0.51 68.48 88.01 5.00
161 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 5.00
162 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 5.00
163 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 5.00
164 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
165 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 5.00
166 INT12720 Positive_regulation of Il1 246 0.70 195.97 72.05 5.00
167 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 5.00
168 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
169 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 5.00
170 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
171 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
172 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03 5.00
173 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 5.00
174 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 5.00
175 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02 5.00
176 INT19775 Localization of Il1 183 0.78 145.5 50.91 5.00
177 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 5.00
178 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 5.00
179 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 5.00
180 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 5.00
181 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5 5.00
182 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32 5.00
183 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 5.00
184 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 5.00
185 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 5.00
186 INT9094 Gene_expression of COL7A1 277 0.77 143.42 38.73 5.00
187 INT72651 Gene_expression of TH1L 114 0.75 80.15 35.15 5.00
188 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 5.00
189 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07 5.00
190 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 5.00
191 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 5.00
192 INT34729 Positive_regulation of IFN1@ 233 0.67 128.04 30.38 5.00
193 INT90792 Localization of Il10 144 0.80 87.88 30.03 5.00
194 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
195 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
196 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68 5.00
197 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 5.00
198 INT100861 Binding of CRP 179 0.48 175.2 26.45 5.00
199 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 5.00
200 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 5.00
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